ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
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| Clone Name | bags29c01 |
|---|---|
| Clone Library Name | barley_pub |
>KC1A_XENLA (P67963) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 102 bits (254), Expect(2) = 8e-29 Identities = 53/135 (39%), Positives = 84/135 (62%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+ IT G EVA+KLE ++++ +E ++Y+ L G Sbjct: 21 RKIGSGSFGDIYLAINITNGE--------EVAVKLESQKARHPQL--LYESKLYKILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++ DY +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFIHRDIKPDNFLMG 145 Score = 44.3 bits (103), Expect(2) = 8e-29 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + ++ GT RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAH 193
>KC1A_MOUSE (Q8BK63) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 102 bits (254), Expect(2) = 8e-29 Identities = 53/135 (39%), Positives = 84/135 (62%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+ IT G EVA+KLE ++++ +E ++Y+ L G Sbjct: 21 RKIGSGSFGDIYLAINITNGE--------EVAVKLESQKARHPQL--LYESKLYKILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++ DY +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFIHRDIKPDNFLMG 145 Score = 44.3 bits (103), Expect(2) = 8e-29 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + ++ GT RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAH 193
>KC1A_HUMAN (P48729) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 102 bits (254), Expect(2) = 8e-29 Identities = 53/135 (39%), Positives = 84/135 (62%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+ IT G EVA+KLE ++++ +E ++Y+ L G Sbjct: 21 RKIGSGSFGDIYLAINITNGE--------EVAVKLESQKARHPQL--LYESKLYKILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++ DY +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFIHRDIKPDNFLMG 145 Score = 44.3 bits (103), Expect(2) = 8e-29 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + ++ GT RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAH 193
>KC1A_CHICK (P67962) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 337 Score = 102 bits (254), Expect(2) = 8e-29 Identities = 53/135 (39%), Positives = 84/135 (62%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+ IT G EVA+KLE ++++ +E ++Y+ L G Sbjct: 21 RKIGSGSFGDIYLAINITNGE--------EVAVKLESQKARHPQL--LYESKLYKILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++ DY +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFIHRDIKPDNFLMG 145 Score = 44.3 bits (103), Expect(2) = 8e-29 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + ++ GT RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAH 193
>KC1A_SHEEP (P67829) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 102 bits (254), Expect(2) = 8e-29 Identities = 53/135 (39%), Positives = 84/135 (62%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+ IT G EVA+KLE ++++ +E ++Y+ L G Sbjct: 21 RKIGSGSFGDIYLAINITNGE--------EVAVKLESQKARHPQL--LYESKLYKILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++ DY +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFIHRDIKPDNFLMG 145 Score = 44.3 bits (103), Expect(2) = 8e-29 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + ++ GT RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAH 193
>KC1A_RABIT (P67828) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 102 bits (254), Expect(2) = 8e-29 Identities = 53/135 (39%), Positives = 84/135 (62%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+ IT G EVA+KLE ++++ +E ++Y+ L G Sbjct: 21 RKIGSGSFGDIYLAINITNGE--------EVAVKLESQKARHPQL--LYESKLYKILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++ DY +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFIHRDIKPDNFLMG 145 Score = 44.3 bits (103), Expect(2) = 8e-29 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + ++ GT RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAH 193
>KC1A_BOVIN (P67827) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 102 bits (254), Expect(2) = 8e-29 Identities = 53/135 (39%), Positives = 84/135 (62%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+ IT G EVA+KLE ++++ +E ++Y+ L G Sbjct: 21 RKIGSGSFGDIYLAINITNGE--------EVAVKLESQKARHPQL--LYESKLYKILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++ DY +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFIHRDIKPDNFLMG 145 Score = 44.3 bits (103), Expect(2) = 8e-29 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + ++ GT RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAH 193
>KC1E_MOUSE (Q9JMK2) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 105 bits (262), Expect(2) = 1e-28 Identities = 57/139 (41%), Positives = 83/139 (59%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G I G EVA+KLE ++K E + Y+ Sbjct: 9 YRLGRKIGSGSFGDIYLGANIASGE--------EVAIKLECVKTKHPQLH--IESKFYKM 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 + G GIPS+ + G +GDY ++VM++LGPSL D++N + S V +A + IS +E Sbjct: 59 MQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 369 LHSKGFVHGDVKPENFLLG 425 +HSK F+H DVKP+NFL+G Sbjct: 119 IHSKNFIHRDVKPDNFLMG 137 Score = 40.8 bits (94), Expect(2) = 1e-28 Identities = 17/42 (40%), Positives = 29/42 (69%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +++ID GLA K++ A + QH+ Y + ++ GT RYAS++ H Sbjct: 145 VYIIDFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTH 185
>KC1E_HUMAN (P49674) Casein kinase I isoform epsilon (EC 2.7.11.1)| (CKI-epsilon) (CKIe) Length = 416 Score = 105 bits (262), Expect(2) = 1e-28 Identities = 57/139 (41%), Positives = 83/139 (59%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G I G EVA+KLE ++K E + Y+ Sbjct: 9 YRLGRKIGSGSFGDIYLGANIASGE--------EVAIKLECVKTKHPQLH--IESKFYKM 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 + G GIPS+ + G +GDY ++VM++LGPSL D++N + S V +A + IS +E Sbjct: 59 MQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 369 LHSKGFVHGDVKPENFLLG 425 +HSK F+H DVKP+NFL+G Sbjct: 119 IHSKNFIHRDVKPDNFLMG 137 Score = 40.8 bits (94), Expect(2) = 1e-28 Identities = 17/42 (40%), Positives = 29/42 (69%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +++ID GLA K++ A + QH+ Y + ++ GT RYAS++ H Sbjct: 145 VYIIDFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTH 185
>KC1D_RAT (Q06486) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| Length = 415 Score = 105 bits (262), Expect(2) = 1e-28 Identities = 56/139 (40%), Positives = 84/139 (60%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G I G EVA+KLE ++K E ++Y+ Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAGE--------EVAIKLECVKTKHPQLH--IESKIYKM 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 + G GIP++ + G +GDY ++VM++LGPSL D++N + S V +A + IS +E Sbjct: 59 MQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 369 LHSKGFVHGDVKPENFLLG 425 +HSK F+H DVKP+NFL+G Sbjct: 119 IHSKNFIHRDVKPDNFLMG 137 Score = 40.8 bits (94), Expect(2) = 1e-28 Identities = 17/42 (40%), Positives = 29/42 (69%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +++ID GLA K++ A + QH+ Y + ++ GT RYAS++ H Sbjct: 145 VYIIDFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTH 185
>KC1D_MOUSE (Q9DC28) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 105 bits (262), Expect(2) = 1e-28 Identities = 56/139 (40%), Positives = 84/139 (60%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G I G EVA+KLE ++K E ++Y+ Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAGE--------EVAIKLECVKTKHPQLH--IESKIYKM 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 + G GIP++ + G +GDY ++VM++LGPSL D++N + S V +A + IS +E Sbjct: 59 MQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 369 LHSKGFVHGDVKPENFLLG 425 +HSK F+H DVKP+NFL+G Sbjct: 119 IHSKNFIHRDVKPDNFLMG 137 Score = 40.8 bits (94), Expect(2) = 1e-28 Identities = 17/42 (40%), Positives = 29/42 (69%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +++ID GLA K++ A + QH+ Y + ++ GT RYAS++ H Sbjct: 145 VYIIDFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTH 185
>KC1D_HUMAN (P48730) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) Length = 415 Score = 105 bits (262), Expect(2) = 1e-28 Identities = 56/139 (40%), Positives = 84/139 (60%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G I G EVA+KLE ++K E ++Y+ Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAGE--------EVAIKLECVKTKHPQLH--IESKIYKM 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 + G GIP++ + G +GDY ++VM++LGPSL D++N + S V +A + IS +E Sbjct: 59 MQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEY 118 Query: 369 LHSKGFVHGDVKPENFLLG 425 +HSK F+H DVKP+NFL+G Sbjct: 119 IHSKNFIHRDVKPDNFLMG 137 Score = 40.8 bits (94), Expect(2) = 1e-28 Identities = 17/42 (40%), Positives = 29/42 (69%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +++ID GLA K++ A + QH+ Y + ++ GT RYAS++ H Sbjct: 145 VYIIDFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTH 185
>KC1AL_HUMAN (Q8N752) Casein kinase I isoform alpha-like (EC 2.7.11.1)| (CKI-alpha-like) (CK1) Length = 337 Score = 100 bits (248), Expect(2) = 2e-28 Identities = 55/135 (40%), Positives = 82/135 (60%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG VY+G T G EVA+KLE ++ K +E ++Y L G Sbjct: 21 RKIGSGSFGDVYLGITTTNGE--------EVAVKLESQKVKHPQL--LYESKLYTILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP +H+ G++ D +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFLHRDIKPDNFLMG 145 Score = 45.4 bits (106), Expect(2) = 2e-28 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + + GT+RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKHLI-GTVRYASINAH 193
>KC1A_RAT (P97633) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) Length = 325 Score = 100 bits (250), Expect(2) = 2e-28 Identities = 53/135 (39%), Positives = 83/135 (61%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+ IT G EVA+KLE ++++ +E ++Y+ L G Sbjct: 21 RKIGSGSFGDIYLAINITNGE--------EVAVKLESQKARHPQL--LYESKLYKILQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G+ DY +LVMD+LGPSL D++N + + V +A + IS +E +H+K Sbjct: 71 VGIPHIRWYGQGKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 130 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 131 NFIHRDIKPDNFLMG 145 Score = 44.3 bits (103), Expect(2) = 2e-28 Identities = 21/43 (48%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + QH+ Y + ++ GT RYAS++AH Sbjct: 152 KLFLIDFGLAKKYRDNRTRQHIPYREDKNL-TGTARYASINAH 193
>KC1_TOXGO (Q6QNM1) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 105 bits (262), Expect(2) = 4e-28 Identities = 56/140 (40%), Positives = 87/140 (62%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G I G EVA+KLE +SK +E ++Y+ Sbjct: 9 YRLGRKIGSGSFGDIYIGANILTGD--------EVAIKLESIKSKHPQL--LYESKLYKL 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G GIP VH+ G +GDY ++V+D+LGPSL D+++ + +S V +A + ++ +E Sbjct: 59 LAGGIGIPMVHWYGIEGDYNVMVIDLLGPSLEDLFSICNRKLSLKTVLMLADQMLNRIEF 118 Query: 369 LHSKGFVHGDVKPENFLLGQ 428 +HSK F+H D+KP+NFL+G+ Sbjct: 119 VHSKNFIHRDIKPDNFLIGR 138 Score = 38.9 bits (89), Expect(2) = 4e-28 Identities = 16/42 (38%), Positives = 28/42 (66%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +++ID GLA K++ + QH+ Y + ++ GT RYAS++ H Sbjct: 145 VYIIDFGLAKKYRDPKTQQHIPYREGKNL-TGTARYASINTH 185
>YKL1_CAEEL (P42168) Putative casein kinase I C03C10.1 in chromosome III (EC| 2.7.11.1) Length = 341 Score = 100 bits (249), Expect(2) = 6e-28 Identities = 53/135 (39%), Positives = 80/135 (59%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +YV +T G EVA+KLE R++ +E +VY+ L G Sbjct: 20 RKIGSGSFGDIYVSINVTNGE--------EVAIKLESNRARHPQL--LYESKVYRILQGG 69 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G + +Y +LVMD+LGPSL D++N + + V +A + I +E +H K Sbjct: 70 VGIPHIRWYGTEREYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIGRIEYVHVK 129 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 130 NFIHRDIKPDNFLMG 144 Score = 43.1 bits (100), Expect(2) = 6e-28 Identities = 20/43 (46%), Positives = 30/43 (69%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + + H+ Y + ++ GT RYAS++AH Sbjct: 151 KLFLIDFGLAKKYRDSRTRTHIPYREDKNL-TGTARYASINAH 192
>HHP1_SCHPO (P40235) Casein kinase I homolog hhp1 (EC 2.7.11.1)| Length = 365 Score = 106 bits (264), Expect(2) = 4e-27 Identities = 58/139 (41%), Positives = 84/139 (60%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G + G EVA+KLE R+K +E++VY+ Sbjct: 11 YRIGRKIGSGSFGDIYLGTNVVSGE--------EVAIKLESTRAKHPQL--EYEYRVYRI 60 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L+G GIP V + G + DY +VMD+LGPSL D++N + S V +A + IS +E Sbjct: 61 LSGGVGIPFVRWFGVECDYNAMVMDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEF 120 Query: 369 LHSKGFVHGDVKPENFLLG 425 +HSK F+H D+KP+NFL+G Sbjct: 121 IHSKSFLHRDIKPDNFLMG 139 Score = 34.7 bits (78), Expect(2) = 4e-27 Identities = 15/40 (37%), Positives = 25/40 (62%) Frame = +1 Query: 460 LIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +ID GLA K++ + H+ Y + ++ GT RYAS++ H Sbjct: 149 IIDFGLAKKYRDHKTHLHIPYRENKNL-TGTARYASINTH 187
>KC12_YEAST (P23292) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 546 Score = 99.0 bits (245), Expect(2) = 5e-27 Identities = 52/144 (36%), Positives = 87/144 (60%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y +K+G+G FG ++ G + G VA+K E R+++ E++ Y+ Sbjct: 76 YKIGKKIGEGSFGVLFEGTNMINGLP--------VAIKFEPRKTEAPQLKD--EYRTYKI 125 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G GIP +Y G++G + ILV+D+LGPSL D+++ G+ S V +AV+ I+++E Sbjct: 126 LAGTPGIPQEYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSVKTVVQVAVQMITLIED 185 Query: 369 LHSKGFVHGDVKPENFLLGQPGSP 440 LH+ ++ D+KP+NFL+G+PG P Sbjct: 186 LHAHDLIYRDIKPDNFLIGRPGQP 209 Score = 41.6 bits (96), Expect(2) = 5e-27 Identities = 17/47 (36%), Positives = 29/47 (61%) Frame = +1 Query: 439 PDEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 PD K+ LID G+A +++ + QH+ Y ++ + GT RY S++ H Sbjct: 209 PDANKVHLIDFGMAKQYRDPKTKQHIPYREKKSL-SGTARYMSINTH 254
>KC11_YEAST (P23291) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 538 Score = 100 bits (248), Expect(2) = 7e-27 Identities = 52/144 (36%), Positives = 87/144 (60%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y +K+G+G FG ++ G + G VA+K E R+++ E++ Y+ Sbjct: 69 YKIGKKIGEGSFGVLFEGTNMINGVP--------VAIKFEPRKTEAPQLRD--EYKTYKI 118 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 LNG IP +Y G++G + ILV+D+LGPSL D+++ G+ S V +AV+ I+++E Sbjct: 119 LNGTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIED 178 Query: 369 LHSKGFVHGDVKPENFLLGQPGSP 440 LH+ ++ D+KP+NFL+G+PG P Sbjct: 179 LHAHDLIYRDIKPDNFLIGRPGQP 202 Score = 40.0 bits (92), Expect(2) = 7e-27 Identities = 16/47 (34%), Positives = 28/47 (59%) Frame = +1 Query: 439 PDEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 PD + LID G+A +++ + QH+ Y ++ + GT RY S++ H Sbjct: 202 PDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSL-SGTARYMSINTH 247
>KC1D_ARATH (P42158) Casein kinase I isoform delta-like (EC 2.7.11.1)| (CKI-delta) Length = 450 Score = 100 bits (248), Expect(2) = 7e-27 Identities = 54/135 (40%), Positives = 85/135 (62%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG++Y+G I E+A+KLE+ ++K +E ++Y+ L G Sbjct: 13 RKIGSGSFGEIYLGTNIHTNE--------ELAIKLENVKTKHPQL--LYESKLYRILQGG 62 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 G+P+V + G +GDY +LVMD+LGPSL D++N + +S V +A + I+ +E HSK Sbjct: 63 TGVPNVKWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKSVLMLADQMINRVEFFHSK 122 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 123 SFLHRDLKPDNFLMG 137 Score = 40.0 bits (92), Expect(2) = 7e-27 Identities = 16/43 (37%), Positives = 31/43 (72%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 ++++ID GLA K++ +++ QH+ Y + ++ GT RYAS++ H Sbjct: 144 QVYIIDFGLAKKYRDSTTHQHIPYRENKNL-TGTARYASMNTH 185
>DCO_DROME (O76324) Discs overgrown protein kinase (EC 2.7.11.1) (Protein| double-time) Length = 440 Score = 100 bits (249), Expect(2) = 7e-27 Identities = 54/139 (38%), Positives = 83/139 (59%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G I G EVA+KLE R+K E + Y++ Sbjct: 9 YRLGRKIGSGSFGDIYLGTTINTGE--------EVAIKLECIRTKHPQLH--IESKFYKT 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 + G GIP + + G +GDY ++VM++LGPSL D++N + S V +A + IS ++ Sbjct: 59 MQGGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDY 118 Query: 369 LHSKGFVHGDVKPENFLLG 425 +HS+ F+H D+KP+NFL+G Sbjct: 119 IHSRDFIHRDIKPDNFLMG 137 Score = 39.7 bits (91), Expect(2) = 7e-27 Identities = 17/42 (40%), Positives = 29/42 (69%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +++ID GLA K++ A S +H+ Y + ++ GT RYAS++ H Sbjct: 145 VYIIDFGLAKKFRDARSLKHIPYRENKNL-TGTARYASINTH 185
>KC1_PLAYO (Q7RBX5) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 97.8 bits (242), Expect(2) = 3e-25 Identities = 53/140 (37%), Positives = 82/140 (58%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y +KLG G FG +YV + I E A+KLE RSK +E ++Y+ Sbjct: 9 YALGKKLGSGSFGDIYVAKDIV--------TMEEFAVKLESTRSKHPQL--LYESKLYKI 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G G+P V++ G +GD+ I+V+D+LGPSL D++ + S V A + ++ +E Sbjct: 59 LGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTADQMLNRIEY 118 Query: 369 LHSKGFVHGDVKPENFLLGQ 428 +HSK F+H D+KP+NFL+G+ Sbjct: 119 VHSKNFIHRDIKPDNFLIGR 138 Score = 37.0 bits (84), Expect(2) = 3e-25 Identities = 16/42 (38%), Positives = 27/42 (64%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + +ID GLA K++ + S H+ Y + ++ GT RYAS++ H Sbjct: 145 IHIIDFGLAKKYRDSRSHTHIPYKEGKNL-TGTARYASINTH 185
>KC1_PLAF7 (Q8IHZ9) Casein kinase I (EC 2.7.11.1)| Length = 323 Score = 97.8 bits (242), Expect(2) = 3e-25 Identities = 53/140 (37%), Positives = 82/140 (58%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y +KLG G FG +YV + I E A+KLE RSK +E ++Y+ Sbjct: 9 YALGKKLGSGSFGDIYVAKDIV--------TMEEFAVKLESTRSKHPQL--LYESKLYKI 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G G+P V++ G +GD+ I+V+D+LGPSL D++ + S V A + ++ +E Sbjct: 59 LGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVLMTADQMLNRIEY 118 Query: 369 LHSKGFVHGDVKPENFLLGQ 428 +HSK F+H D+KP+NFL+G+ Sbjct: 119 VHSKNFIHRDIKPDNFLIGR 138 Score = 37.0 bits (84), Expect(2) = 3e-25 Identities = 16/42 (38%), Positives = 27/42 (64%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + +ID GLA K++ + S H+ Y + ++ GT RYAS++ H Sbjct: 145 IHIIDFGLAKKYRDSRSHTHIPYKEGKNL-TGTARYASINTH 185
>RAG8_KLULA (P40230) Casein kinase I homolog RAG8 (EC 2.7.11.1)| Length = 536 Score = 95.5 bits (236), Expect(2) = 4e-25 Identities = 49/144 (34%), Positives = 85/144 (59%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y +K+G+G FG ++ G + VA+K E R++ E++ Y+ Sbjct: 77 YKIGKKIGEGSFGVLFEGVNMINNVP--------VAIKFEPRKTDAPQLKD--EYRTYKI 126 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L+G GIP +Y G++G + ILV+D+LGPSL D+++ G+ S V +A++ I+++E+ Sbjct: 127 LSGSEGIPQAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRRFSIKTVVHVAIQMITLIEE 186 Query: 369 LHSKGFVHGDVKPENFLLGQPGSP 440 LH ++ D+KP+NFL+G+P P Sbjct: 187 LHDHDLIYRDIKPDNFLIGRPNQP 210 Score = 38.9 bits (89), Expect(2) = 4e-25 Identities = 17/55 (30%), Positives = 30/55 (54%) Frame = +1 Query: 415 FCLVNLDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 F + + PD + LID G+A ++ + QH+ Y ++ + GT RY S++ H Sbjct: 202 FLIGRPNQPDANMVHLIDFGMAKLYRDPKTKQHIPYREKKSL-SGTARYMSINTH 255
>HRR25_YEAST (P29295) Casein kinase I homolog HRR25 (EC 2.7.11.1)| Length = 494 Score = 98.6 bits (244), Expect(2) = 8e-25 Identities = 51/135 (37%), Positives = 81/135 (60%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y G + G EVA+KLE RS+ +E +VY+ L+G Sbjct: 13 RKIGSGSFGDIYHGTNLISGE--------EVAIKLESIRSRHPQLD--YESRVYRYLSGG 62 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + GR+G+Y +V+D+LGPSL D++N + S V +A++ ++ +H + Sbjct: 63 VGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGR 122 Query: 381 GFVHGDVKPENFLLG 425 F+H D+KP+NFL+G Sbjct: 123 SFIHRDIKPDNFLMG 137 Score = 34.7 bits (78), Expect(2) = 8e-25 Identities = 15/40 (37%), Positives = 26/40 (65%) Frame = +1 Query: 460 LIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +ID GL+ K++ ++ +H+ Y + + GT RYASV+ H Sbjct: 147 VIDFGLSKKYRDFNTHRHIPYRENKSL-TGTARYASVNTH 185
>KC1A_DROME (P54367) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (DmCK1) Length = 337 Score = 90.9 bits (224), Expect(2) = 1e-24 Identities = 52/141 (36%), Positives = 79/141 (56%), Gaps = 2/141 (1%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLE--HRRSKGCSYGPPFEWQVY 182 Y RK+G G FG +Y+G I G EVA+K+E H R Y E ++Y Sbjct: 20 YRVIRKIGSGSFGDIYLGMSIQSGE--------EVAIKMESAHARHPQLLY----EAKLY 67 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 + L+G G P + + G++ ++ LVMD+LGPSL D++N + + V + + I L Sbjct: 68 RILSGGVGFPRIRHHGKEKNFNTLVMDLLGPSLEDLFNFCTRHFTIKTVLMLVDQMIGRL 127 Query: 363 EKLHSKGFVHGDVKPENFLLG 425 E +H K F+H D+KP+NFL+G Sbjct: 128 EYIHLKCFIHRDIKPDNFLMG 148 Score = 42.0 bits (97), Expect(2) = 1e-24 Identities = 20/43 (46%), Positives = 29/43 (67%) Frame = +1 Query: 451 KLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 KLFLID GLA K++ + H+ Y + ++ GT RYAS++AH Sbjct: 155 KLFLIDFGLAKKFRDPHTRHHIVYREDKNL-TGTARYASINAH 196
>CKI1_SCHPO (P40233) Casein kinase I homolog 1 (EC 2.7.11.1)| Length = 446 Score = 100 bits (248), Expect(2) = 2e-24 Identities = 53/143 (37%), Positives = 85/143 (59%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y R++G+G FG ++ G + +VA+K E RRS E++ Y+ Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQ--------QVAIKFEPRRSDAPQLRD--EYRTYKL 61 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L GC GIP+V+Y G++G + ILV+D+LGPSL D+ + G+ S VA A + ++ ++ Sbjct: 62 LAGCTGIPNVYYFGQEGLHNILVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQS 121 Query: 369 LHSKGFVHGDVKPENFLLGQPGS 437 +H K V+ D+KP+NFL+G+P S Sbjct: 122 IHEKSLVYRDIKPDNFLIGRPNS 144 Score = 32.0 bits (71), Expect(2) = 2e-24 Identities = 11/42 (26%), Positives = 26/42 (61%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 ++++D G+ ++ + QH+ Y ++ ++ GT RY S++ H Sbjct: 150 IYVVDFGMVKFYRDPVTKQHIPYREKKNL-SGTARYMSINTH 190
>CKI2_SCHPO (P40234) Casein kinase I homolog 2 (EC 2.7.11.1)| Length = 435 Score = 93.6 bits (231), Expect(2) = 8e-24 Identities = 51/143 (35%), Positives = 84/143 (58%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G+G FG ++ G + +A+K E ++S+ E++ Y+ Sbjct: 12 YRVGRKIGEGSFGVIFDGMNLLNNQL--------IAIKFEPKKSEAPQLRD--EYRTYKL 61 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G GIP+V+Y G++G + ILV+D+LGPSL D++ G+ S VA A + +S ++ Sbjct: 62 LVGNAGIPNVYYFGQEGLHNILVIDLLGPSLEDLFEWCGRRFSVKTVAMTAKQMLSRVQT 121 Query: 369 LHSKGFVHGDVKPENFLLGQPGS 437 +H K V+ D+KP+NFL+G+P S Sbjct: 122 IHEKNLVYRDIKPDNFLIGRPSS 144 Score = 36.2 bits (82), Expect(2) = 8e-24 Identities = 13/42 (30%), Positives = 26/42 (61%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 ++++D G+A ++ + QH+ Y +R + GT RY S++ H Sbjct: 150 VYMVDFGMAKYYRDPKTKQHIPYSERKSL-SGTARYMSINTH 190
>KC1_PLAF4 (O15726) Casein kinase I (EC 2.7.11.1)| Length = 324 Score = 97.8 bits (242), Expect(2) = 8e-24 Identities = 53/140 (37%), Positives = 82/140 (58%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y +KLG G FG +YV + I E A+KLE RSK +E ++Y+ Sbjct: 9 YALGKKLGSGSFGDIYVAKDIV--------TMEEFAVKLESTRSKHPQL--LYESKLYKI 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G G+P V++ G +GD+ I+V+D+LGPSL D++ + S V A + ++ +E Sbjct: 59 LGGGIGVPKVYWYGIEGDFTIMVLDLLGPSLEDLFTLCNRKFSLKTVRMTADQMLNRIEY 118 Query: 369 LHSKGFVHGDVKPENFLLGQ 428 +HSK F+H D+KP+NFL+G+ Sbjct: 119 VHSKNFIHRDIKPDNFLIGR 138 Score = 32.0 bits (71), Expect(2) = 8e-24 Identities = 15/42 (35%), Positives = 25/42 (59%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + +ID GLA K++ + S Y + ++ GT RYAS++ H Sbjct: 145 IHIIDFGLAKKYRDSRSHTSYPYKEGKNL-TGTARYASINTH 185
>HHP2_SCHPO (P40236) Casein kinase I homolog hhp2 (EC 2.7.11.1)| Length = 400 Score = 95.1 bits (235), Expect(2) = 1e-23 Identities = 52/138 (37%), Positives = 81/138 (58%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FGQ+Y+G G +VA+KLE +++ + +E++VY Sbjct: 12 YRIGRKIGSGSFGQIYLGLNTVNGE--------QVAVKLEPLKAR--HHQLEYEFRVYNI 61 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G GIP++ + G Y +VMD+LGPSL D++ G+ + V +A + IS +E Sbjct: 62 LKGNIGIPTIRWFGVTNSYNAMVMDLLGPSLEDLFCYCGRKFTLKTVLLLADQLISRIEY 121 Query: 369 LHSKGFVHGDVKPENFLL 422 +HSK F+H D+KP+NFL+ Sbjct: 122 VHSKSFLHRDIKPDNFLM 139 Score = 33.9 bits (76), Expect(2) = 1e-23 Identities = 15/40 (37%), Positives = 24/40 (60%) Frame = +1 Query: 460 LIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +ID GLA K++ + H+ Y ++ GT RYAS++ H Sbjct: 148 MIDFGLAKKYRDFKTHVHIPYRDNKNL-TGTARYASINTH 186
>KC1B_BOVIN (P35507) Casein kinase I isoform beta (EC 2.7.11.1) (CKI-beta)| Length = 336 Score = 90.5 bits (223), Expect(2) = 3e-23 Identities = 50/135 (37%), Positives = 78/135 (57%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 R++G G FG VY+ +T +VA+KLE ++ E ++Y L G Sbjct: 21 REIGFGSFGHVYLAIDLTNHE--------QVAVKLESENTRQPRL--LHEKELYNFLQGG 70 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++ DY +LVMD+LGPSL D++N + S V +A + IS +E +HS+ Sbjct: 71 VGIPQIRWYGQETDYNVLVMDLLGPSLEDLFNFCSRRFSMKTVLMLADQMISRIEYVHSR 130 Query: 381 GFVHGDVKPENFLLG 425 +H D+KP+NFL+G Sbjct: 131 NLIHRDIKPDNFLMG 145 Score = 37.4 bits (85), Expect(2) = 3e-23 Identities = 20/47 (42%), Positives = 28/47 (59%) Frame = +1 Query: 439 PDEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 P KKLFL+D GLA K++ + QH+ + + F GT AS+ AH Sbjct: 148 PQWKKLFLVDFGLAKKYRDNRTGQHIPH-RSGKSFIGTPFCASISAH 193
>KC13_YEAST (P39962) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 524 Score = 86.3 bits (212), Expect(2) = 4e-22 Identities = 49/149 (32%), Positives = 78/149 (52%), Gaps = 9/149 (6%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGA-SRTGPDAYE--------VALKLEHRRSKGCSYGP 161 Y K+G+G FG ++ G I ++TG VA+K E R S Sbjct: 14 YAVGPKIGEGSFGVIFEGENILHSCQAQTGSKRDSSIIMANEPVAIKFEPRHSDAPQLRD 73 Query: 162 PFEWQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIA 341 E++ Y+ LNGC GIP +Y G++G + IL++D+LGPSL D++ G+ S +A Sbjct: 74 --EFRAYRILNGCVGIPHAYYFGQEGMHNILIIDLLGPSLEDLFEWCGRKFSVKTTCMVA 131 Query: 342 VESISILEKLHSKGFVHGDVKPENFLLGQ 428 + I + +H ++ D+KP+NFL+ Q Sbjct: 132 KQMIDRVRAIHDHDLIYRDIKPDNFLISQ 160 Score = 37.7 bits (86), Expect(2) = 4e-22 Identities = 14/46 (30%), Positives = 28/46 (60%) Frame = +1 Query: 442 DEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 D ++++D G+A +++ + QH+ Y +R + GT RY S++ H Sbjct: 181 DPNLIYMVDFGMAKQYRDPRTKQHIPYRERKSL-SGTARYMSINTH 225
>KC1G3_RAT (Q62763) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 448 Score = 91.7 bits (226), Expect(2) = 7e-22 Identities = 51/139 (36%), Positives = 82/139 (58%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L Sbjct: 47 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPMKSRAPQLH--LEYRFYKQLGSG 96 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP V+Y G G Y +V+++LGPSL D+++ + S V IA++ IS +E +HSK Sbjct: 97 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSK 156 Query: 381 GFVHGDVKPENFLLGQPGS 437 ++ DVKPENFL+G+PG+ Sbjct: 157 NLIYRDVKPENFLIGRPGN 175 Score = 31.6 bits (70), Expect(2) = 7e-22 Identities = 13/45 (28%), Positives = 26/45 (57%) Frame = +1 Query: 445 EKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 ++ + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 178 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSL-TGTARYMSINTH 221
>KC1G3_HUMAN (Q9Y6M4) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) Length = 447 Score = 91.7 bits (226), Expect(2) = 7e-22 Identities = 51/139 (36%), Positives = 82/139 (58%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L Sbjct: 47 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPMKSRAPQLH--LEYRFYKQLGSG 96 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP V+Y G G Y +V+++LGPSL D+++ + S V IA++ IS +E +HSK Sbjct: 97 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSK 156 Query: 381 GFVHGDVKPENFLLGQPGS 437 ++ DVKPENFL+G+PG+ Sbjct: 157 NLIYRDVKPENFLIGRPGN 175 Score = 31.6 bits (70), Expect(2) = 7e-22 Identities = 13/45 (28%), Positives = 26/45 (57%) Frame = +1 Query: 445 EKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 ++ + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 178 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSL-TGTARYMSINTH 221
>KC1G3_BOVIN (P35509) Casein kinase I isoform gamma-3 (EC 2.7.11.1) (CKI-gamma| 3) (Fragment) Length = 276 Score = 91.7 bits (226), Expect(2) = 7e-22 Identities = 51/139 (36%), Positives = 82/139 (58%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L Sbjct: 33 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPMKSRAPQLH--LEYRFYKQLGSG 82 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP V+Y G G Y +V+++LGPSL D+++ + S V IA++ IS +E +HSK Sbjct: 83 DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSK 142 Query: 381 GFVHGDVKPENFLLGQPGS 437 ++ DVKPENFL+G+PG+ Sbjct: 143 NLIYRDVKPENFLIGRPGN 161 Score = 31.6 bits (70), Expect(2) = 7e-22 Identities = 13/45 (28%), Positives = 26/45 (57%) Frame = +1 Query: 445 EKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 ++ + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 164 QQVIHIIDFGLAKEYIDPETKKHIPYREHKSL-TGTARYMSINTH 207
>CKI3_SCHPO (O74135) Casein kinase I homolog 3 (EC 2.7.11.1)| Length = 439 Score = 101 bits (252), Expect = 1e-21 Identities = 55/143 (38%), Positives = 86/143 (60%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y +K+G+G FG ++ G + +ALK E R+S+ E+ Y+ Sbjct: 15 YRVGKKIGEGSFGMLFQGVNLINNQP--------IALKFESRKSEVPQLRD--EYLTYKL 64 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G GIPSV+Y G++G Y +LVMD+LGPSL D+++ G+ S VA IA + I+ ++ Sbjct: 65 LMGLPGIPSVYYYGQEGMYNLLVMDLLGPSLEDLFDYCGRRFSPKTVAMIAKQMITRIQS 124 Query: 369 LHSKGFVHGDVKPENFLLGQPGS 437 +H + F++ D+KP+NFL+G PGS Sbjct: 125 VHERHFIYRDIKPDNFLIGFPGS 147
>KC1_EIMTE (Q6QNL9) Casein kinase I (EC 2.7.11.1)| Length = 335 Score = 99.8 bits (247), Expect = 5e-21 Identities = 51/140 (36%), Positives = 89/140 (63%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y RK+G G FG +Y+G I+ G EVA+KLE RS+ +E ++Y+ Sbjct: 9 YRLGRKIGSGSFGDIYLGTNISTGD--------EVAIKLESVRSRHPQL--IYESKLYKI 58 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L G GIP++++ G +GDY ++++++LGPSL D+++ + +S V +A + ++ +E Sbjct: 59 LTGGIGIPTLYWYGIEGDYNVMIIELLGPSLEDLFSICNRKLSLKTVLMLADQMLNRIEF 118 Query: 369 LHSKGFVHGDVKPENFLLGQ 428 +HS+ F+H D+KP+NFL+G+ Sbjct: 119 VHSRHFIHRDIKPDNFLIGR 138
>KC1G2_RAT (Q62762) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 88.6 bits (218), Expect(2) = 6e-21 Identities = 48/139 (34%), Positives = 83/139 (59%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L+ Sbjct: 50 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPIKSRAPQLH--LEYRFYKQLSTT 99 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 G+P V+Y G G Y +V+++LGPSL D+++ + + V IA++ I+ +E +H+K Sbjct: 100 EGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTK 159 Query: 381 GFVHGDVKPENFLLGQPGS 437 ++ DVKPENFL+G+PGS Sbjct: 160 SLIYRDVKPENFLVGRPGS 178 Score = 31.6 bits (70), Expect(2) = 6e-21 Identities = 13/45 (28%), Positives = 25/45 (55%) Frame = +1 Query: 445 EKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 181 QHSIHIIDFGLAKEYIDPETKKHIPYREHKSL-TGTARYMSINTH 224
>KC1G2_MOUSE (Q8BVP5) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 88.6 bits (218), Expect(2) = 6e-21 Identities = 48/139 (34%), Positives = 83/139 (59%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L+ Sbjct: 50 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPIKSRAPQLH--LEYRFYKQLSTT 99 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 G+P V+Y G G Y +V+++LGPSL D+++ + + V IA++ I+ +E +H+K Sbjct: 100 EGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTK 159 Query: 381 GFVHGDVKPENFLLGQPGS 437 ++ DVKPENFL+G+PGS Sbjct: 160 SLIYRDVKPENFLVGRPGS 178 Score = 31.6 bits (70), Expect(2) = 6e-21 Identities = 13/45 (28%), Positives = 25/45 (55%) Frame = +1 Query: 445 EKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 181 QHSIHIIDFGLAKEYIDPETKKHIPYREHKSL-TGTARYMSINTH 224
>KC1G2_HUMAN (P78368) Casein kinase I isoform gamma-2 (EC 2.7.11.1) (CKI-gamma| 2) Length = 415 Score = 88.2 bits (217), Expect(2) = 1e-20 Identities = 47/139 (33%), Positives = 83/139 (59%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L+ Sbjct: 50 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPIKSRAPQLH--LEYRFYKQLSAT 99 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 G+P V+Y G G Y +V+++LGPSL D+++ + + V IA++ I+ +E +H+K Sbjct: 100 EGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTK 159 Query: 381 GFVHGDVKPENFLLGQPGS 437 ++ DVKPENFL+G+PG+ Sbjct: 160 SLIYRDVKPENFLVGRPGT 178 Score = 31.2 bits (69), Expect(2) = 1e-20 Identities = 13/42 (30%), Positives = 24/42 (57%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 184 IHIIDFGLAKEYIDPETKKHIPYREHKSL-TGTARYMSINTH 224
>KIN20_CAEEL (Q20471) Casein kinase I isoform delta (EC 2.7.11.1) (Protein| kinase 20) Length = 497 Score = 94.4 bits (233), Expect = 2e-19 Identities = 50/135 (37%), Positives = 82/135 (60%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G G FG +Y+G+ I EVA+KLE +SK E ++Y+ + G Sbjct: 195 RKIGSGSFGDIYLGQNIQTNE--------EVAVKLECVKSKHPQLH--IESRLYRIMLGG 244 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 GIP + + G++GDY ++VM++LGPSL D++N + S V +A + +S +E +H + Sbjct: 245 IGIPEIRWCGQEGDYNVMVMELLGPSLEDLFNFCQRKFSLKTVLLLADQMLSRVEFIHCR 304 Query: 381 GFVHGDVKPENFLLG 425 ++H D+KP+NFL+G Sbjct: 305 DYIHRDIKPDNFLMG 319
>KC1A_PIG (O19175) Casein kinase I isoform alpha (EC 2.7.11.1) (CKI-alpha)| (CK1) (Fragment) Length = 125 Score = 87.4 bits (215), Expect(2) = 3e-18 Identities = 43/106 (40%), Positives = 71/106 (66%) Frame = +3 Query: 108 EVALKLEHRRSKGCSYGPPFEWQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWD 287 EVA+KLE ++++ +E ++Y+ L G GIP + + G++ DY +LVMD+LGPSL D Sbjct: 3 EVAVKLESQKARHPQL--LYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLED 60 Query: 288 VWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPENFLLG 425 ++N + + V +A + IS +E +H+K F+H D+KP+NFL+G Sbjct: 61 LFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMG 106 Score = 23.9 bits (50), Expect(2) = 3e-18 Identities = 10/13 (76%), Positives = 11/13 (84%) Frame = +1 Query: 451 KLFLIDLGLASKW 489 KLFLID GLA K+ Sbjct: 113 KLFLIDFGLAKKY 125
>KC1G1_HUMAN (Q9HCP0) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 422 Score = 82.0 bits (201), Expect = 1e-15 Identities = 47/140 (33%), Positives = 81/140 (57%), Gaps = 1/140 (0%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L Sbjct: 48 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPIKSRAPQLH--LEYRFYKQLGSA 97 Query: 201 -YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHS 377 G+P V+Y G G Y +V+++LGPSL D+++ + + V IA++ +S +E +HS Sbjct: 98 GEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHS 157 Query: 378 KGFVHGDVKPENFLLGQPGS 437 K ++ DVKPENFL+G+ G+ Sbjct: 158 KNLIYRDVKPENFLIGRQGN 177 Score = 32.3 bits (72), Expect = 1.0 Identities = 15/57 (26%), Positives = 29/57 (50%) Frame = +1 Query: 409 KTFCLVNLDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + F + + E + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 168 ENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSL-TGTARYMSINTH 223
>KC1G1_RAT (Q62761) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 390 Score = 82.0 bits (201), Expect = 1e-15 Identities = 47/140 (33%), Positives = 81/140 (57%), Gaps = 1/140 (0%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L Sbjct: 48 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPIKSRAPQLH--LEYRFYKQLGSA 97 Query: 201 -YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHS 377 G+P V+Y G G Y +V+++LGPSL D+++ + + V IA++ +S +E +HS Sbjct: 98 GEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHS 157 Query: 378 KGFVHGDVKPENFLLGQPGS 437 K ++ DVKPENFL+G+ G+ Sbjct: 158 KNLIYRDVKPENFLIGRQGN 177 Score = 32.3 bits (72), Expect = 1.0 Identities = 15/57 (26%), Positives = 29/57 (50%) Frame = +1 Query: 409 KTFCLVNLDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + F + + E + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 168 ENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSL-TGTARYMSINTH 223
>KC1G1_MOUSE (Q8BTH8) Casein kinase I isoform gamma-1 (EC 2.7.11.1) (CKI-gamma| 1) Length = 459 Score = 82.0 bits (201), Expect = 1e-15 Identities = 47/140 (33%), Positives = 81/140 (57%), Gaps = 1/140 (0%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G G FG++ +G+ + VA+KLE +S+ E++ Y+ L Sbjct: 48 KKIGCGNFGELRLGKNLYTNEY--------VAIKLEPIKSRAPQLH--LEYRFYKQLGSA 97 Query: 201 -YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHS 377 G+P V+Y G G Y +V+++LGPSL D+++ + + V IA++ +S +E +HS Sbjct: 98 GEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHS 157 Query: 378 KGFVHGDVKPENFLLGQPGS 437 K ++ DVKPENFL+G+ G+ Sbjct: 158 KNLIYRDVKPENFLIGRQGN 177 Score = 32.7 bits (73), Expect = 0.77 Identities = 15/57 (26%), Positives = 29/57 (50%) Frame = +1 Query: 409 KTFCLVNLDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 + F + + E + +ID GLA ++ + +H+ Y + + GT RY S++ H Sbjct: 168 ENFLIGRQGNKKEHVIHIIDFGLAKEYVDPETKKHIPYREHKSL-TGTARYMSINTH 223
>VPK1_VACCV (P16913) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 46.2 bits (108), Expect(2) = 6e-10 Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 12/146 (8%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRS---KGCSYGPPFEWQVYQSLNG 197 +GKGGFG +Y T + Y V ++ + S + Y + V + Sbjct: 22 IGKGGFGSIYT----------TNDNNYVVKIEPKANGSLFTEQAFYTRVLKPSVIEEWKK 71 Query: 198 CYGIPSVH---------YKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 + I V YK +Y LV++ LG L V + + V I +E Sbjct: 72 SHNIKHVGLITCKAFGLYKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLIGIEI 131 Query: 351 ISILEKLHSKGFVHGDVKPENFLLGQ 428 ++ ++ +H +G+ HGD+K N +L Q Sbjct: 132 LNTIQFMHEQGYSHGDIKASNIVLDQ 157 Score = 36.6 bits (83), Expect(2) = 6e-10 Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 1/51 (1%) Frame = +1 Query: 430 LDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPD-IFRGTIRYASVHAH 579 LD D+ KL+L+D GL SK+ S+ +HV + + P+ + GT+ + + +H Sbjct: 155 LDQIDKNKLYLVDYGLVSKF--MSNGEHVPFIRNPNKMDNGTLEFTPIDSH 203
>VPK1_VACCA (O57252) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 46.2 bits (108), Expect(2) = 6e-10 Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 12/146 (8%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRS---KGCSYGPPFEWQVYQSLNG 197 +GKGGFG +Y T + Y V ++ + S + Y + V + Sbjct: 22 IGKGGFGSIYT----------TNDNNYVVKIEPKANGSLFTEQAFYTRVLKPSVIEEWKK 71 Query: 198 CYGIPSVH---------YKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 + I V YK +Y LV++ LG L V + + V I +E Sbjct: 72 SHNIKHVGLITCKAFGLYKSINVEYRFLVINRLGADLDAVIRANNNRLPKRSVMLIGIEI 131 Query: 351 ISILEKLHSKGFVHGDVKPENFLLGQ 428 ++ ++ +H +G+ HGD+K N +L Q Sbjct: 132 LNTIQFMHEQGYSHGDIKASNIVLDQ 157 Score = 36.6 bits (83), Expect(2) = 6e-10 Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 1/51 (1%) Frame = +1 Query: 430 LDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPD-IFRGTIRYASVHAH 579 LD D+ KL+L+D GL SK+ S+ +HV + + P+ + GT+ + + +H Sbjct: 155 LDQIDKNKLYLVDYGLVSKF--MSNGEHVPFIRNPNKMDNGTLEFTPIDSH 203
>VPK1_VACCC (P20505) Serine/threonine-protein kinase 1 (EC 2.7.11.1) (Vaccinia| protein kinase 1) Length = 300 Score = 45.8 bits (107), Expect(2) = 8e-10 Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 12/146 (8%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRS---KGCSYGPPFEWQVYQSLNG 197 +GKGGFG +Y T + Y V ++ + S + Y + V + Sbjct: 22 IGKGGFGSIYT----------TNDNNYVVKIEPKANGSLFTEQAFYTRVLKPSVIEEWKK 71 Query: 198 CYGIPSVH---------YKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 + I V YK +Y LV++ LG L V + + V I +E Sbjct: 72 SHNIKHVGLITCKAFGLYKSINVEYRFLVINRLGVDLDAVIRANNNRLPKRSVMLIGIEI 131 Query: 351 ISILEKLHSKGFVHGDVKPENFLLGQ 428 ++ ++ +H +G+ HGD+K N +L Q Sbjct: 132 LNTIQFMHEQGYSHGDIKASNIVLDQ 157 Score = 36.6 bits (83), Expect(2) = 8e-10 Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 1/51 (1%) Frame = +1 Query: 430 LDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPD-IFRGTIRYASVHAH 579 LD D+ KL+L+D GL SK+ S+ +HV + + P+ + GT+ + + +H Sbjct: 155 LDQIDKNKLYLVDYGLVSKF--MSNGEHVPFIRNPNKMDNGTLEFTPIDSH 203
>TTBK2_MOUSE (Q3UVR3) Tau-tubulin kinase 2| Length = 1243 Score = 47.4 bits (111), Expect(2) = 1e-09 Identities = 37/137 (27%), Positives = 62/137 (45%), Gaps = 1/137 (0%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G GGFG++Y + + VALK+E + E V + L G Sbjct: 25 RKIGGGGFGEIYDALDMLTREN--------VALKVESAQQP--KQVLKMEVAVLKKLQGK 74 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVAC-IAVESISILEKLHS 377 + GR + +VM + G +L D+ S + + + + + +E +HS Sbjct: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGKQILESIESIHS 134 Query: 378 KGFVHGDVKPENFLLGQ 428 GF+H D+KP NF +G+ Sbjct: 135 VGFLHRDIKPSNFAMGR 151 Score = 34.7 bits (78), Expect(2) = 1e-09 Identities = 18/44 (40%), Positives = 28/44 (63%) Frame = +1 Query: 448 KKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +K F++D GLA ++ +S V + FRGT+RYAS++AH Sbjct: 157 RKCFMLDFGLARQF--TNSCGDVRPPRAVAGFRGTVRYASINAH 198
>V212_FOWPV (Q9J523) Probable serine/threonine-protein kinase FPV212 (EC| 2.7.11.1) Length = 303 Score = 45.4 bits (106), Expect(2) = 1e-09 Identities = 40/156 (25%), Positives = 67/156 (42%), Gaps = 16/156 (10%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF------- 167 +I ++LG GGFG VY + K+E + S G F Sbjct: 25 WILGKQLGSGGFGLVY--------QVSCKSKEIDCVAKIELKESGGLFCEINFYNRVMKN 76 Query: 168 -----EWQVYQSLNGCYGIPSVHYKG----RQGDYYILVMDMLGPSLWDVWNSMGQAMSS 320 W Q ++ GIPS H G + +Y ++ LG L ++ + + + Sbjct: 77 KTSLDTWMKEQKID-YIGIPSFHGFGITIYKNVEYRFAIIQRLGRDLENILSEK-EKFNI 134 Query: 321 HMVACIAVESISILEKLHSKGFVHGDVKPENFLLGQ 428 ++ +A++ + IL+ +HSK F HGD+K N L G+ Sbjct: 135 TVIKKLAIKILDILKFIHSKEFSHGDIKAGNILFGK 170 Score = 36.2 bits (82), Expect(2) = 1e-09 Identities = 18/47 (38%), Positives = 31/47 (65%), Gaps = 1/47 (2%) Frame = +1 Query: 442 DEKKLFLIDLGLASKWKKASSSQHVEYDQRP-DIFRGTIRYASVHAH 579 D+ K++L+D GLA+K+ +S+ +H EY P + GT+ + S+ AH Sbjct: 171 DDDKVYLVDYGLATKY--SSNGKHKEYTINPKNRHNGTMAFTSIDAH 215
>TTBK1_HUMAN (Q5TCY1) Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau| kinase) Length = 1321 Score = 46.2 bits (108), Expect(2) = 3e-09 Identities = 36/137 (26%), Positives = 62/137 (45%), Gaps = 1/137 (0%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +K+G GGFG++Y + + VALK+E + E V + L G Sbjct: 38 KKIGGGGFGEIYEAMDLLTREN--------VALKVESAQQP--KQVLKMEVAVLKKLQGK 87 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVAC-IAVESISILEKLHS 377 + GR + +VM + G +L D+ S + + + + + +E +HS Sbjct: 88 DHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHS 147 Query: 378 KGFVHGDVKPENFLLGQ 428 GF+H D+KP NF +G+ Sbjct: 148 VGFLHRDIKPSNFAMGR 164 Score = 34.3 bits (77), Expect(2) = 3e-09 Identities = 17/44 (38%), Positives = 27/44 (61%) Frame = +1 Query: 448 KKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +K +++D GLA ++ + V + FRGT+RYASV+AH Sbjct: 170 RKCYMLDFGLARQYTNTTGD--VRPPRNVAGFRGTVRYASVNAH 211
>TTBK2_HUMAN (Q6IQ55) Tau-tubulin kinase 2 (EC 2.7.11.1)| Length = 1244 Score = 47.0 bits (110), Expect(2) = 3e-09 Identities = 37/137 (27%), Positives = 62/137 (45%), Gaps = 1/137 (0%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 RK+G GGFG++Y + + VALK+E + E V + L G Sbjct: 25 RKIGGGGFGEIYDALDMLTREN--------VALKVESAQQP--KQVLKMEVAVLKKLQGK 74 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVAC-IAVESISILEKLHS 377 + GR + +VM + G +L D+ S + + + + + +E +HS Sbjct: 75 DHVCRFIGCGRNDRFNYVVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHS 134 Query: 378 KGFVHGDVKPENFLLGQ 428 GF+H D+KP NF +G+ Sbjct: 135 VGFLHRDIKPSNFAMGR 151 Score = 33.5 bits (75), Expect(2) = 3e-09 Identities = 17/44 (38%), Positives = 28/44 (63%) Frame = +1 Query: 448 KKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +K +++D GLA ++ +S V + FRGT+RYAS++AH Sbjct: 157 RKCYMLDFGLARQF--TNSCGDVRPPRAVAGFRGTVRYASINAH 198
>YKL2_CAEEL (P42169) Putative casein kinase I C03C10.2 in chromosome III (EC| 2.7.11.1) Length = 363 Score = 54.7 bits (130), Expect(2) = 4e-09 Identities = 36/136 (26%), Positives = 69/136 (50%), Gaps = 3/136 (2%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHR-RSKGCSYGPPFEWQVYQSLNGCY 203 +G GG+GQ+++ + R A+K+E + R++ + E QV + G Sbjct: 78 IGNGGYGQIFMVMDVKKNDER--------AMKIEPKLRAEVITKRMIMEQQVLMKMQGKT 129 Query: 204 GIPSVHYKGRQGDYYILVMDMLGPSLWDVW--NSMGQAMSSHMVACIAVESISILEKLHS 377 IP+++ G + ++M +L ++ D + +G+ +S V IA ++++ L+ +H Sbjct: 130 HIPTMYASGFNDQFNFIIMQLLSMNVGDFRKRSPLGR-LSKETVGRIAYQTLNALKDIHD 188 Query: 378 KGFVHGDVKPENFLLG 425 G+VH DVKP N G Sbjct: 189 MGYVHRDVKPANICFG 204 Score = 25.4 bits (54), Expect(2) = 4e-09 Identities = 17/43 (39%), Positives = 23/43 (53%), Gaps = 1/43 (2%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDI-FRGTIRYASVHAH 579 L+L+D GL ++K S V R + F+GT RY SV H Sbjct: 213 LYLLDFGLVRRFKTESG---VCIPWRINAGFKGTERYVSVRVH 252
>VRK1_MOUSE (Q80X41) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) (Serine/threonine-protein kinase 51PK) Length = 440 Score = 45.8 bits (107), Expect(2) = 4e-08 Identities = 41/152 (26%), Positives = 66/152 (43%), Gaps = 20/152 (13%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF-EWQVYQSLN--- 194 +G+GGFG +Y+ T + G DA +K+E + GP F E + YQ Sbjct: 43 IGQGGFGCIYLAD--TNSSKPVGSDA-PCVVKVEPSDN-----GPLFTELKFYQRAAKPE 94 Query: 195 -----------GCYGIP-----SVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHM 326 G+P +H K + Y ++MD G L ++ + + S Sbjct: 95 QIQKWIRTHKLKYLGVPKYWGSGLHDKNGK-SYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 Query: 327 VACIAVESISILEKLHSKGFVHGDVKPENFLL 422 V +++ + ILE +H +VHGD+K N LL Sbjct: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185 Score = 30.8 bits (68), Expect(2) = 4e-08 Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 1/51 (1%) Frame = +1 Query: 430 LDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPD-IFRGTIRYASVHAH 579 L H + +++L+D GLA ++ H EY + P GT+ + S+ AH Sbjct: 185 LSHKNPDQVYLVDYGLA--YRYCPDGVHKEYKEDPKRCHDGTLEFTSIDAH 233
>KPK2_PLAFK (Q02595) Probable serine/threonine-protein kinase 2 (EC 2.7.11.1)| Length = 510 Score = 54.7 bits (130), Expect = 2e-07 Identities = 44/145 (30%), Positives = 70/145 (48%), Gaps = 1/145 (0%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y+ ++K+GKG F Y+G I G V +K E +SK E +V + Sbjct: 111 YVLNKKIGKGSFSTAYIGTNILYGN--------RVVVK-EVDKSKVKESNVYTEIEVLRK 161 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI-LE 365 + Y I + ++G Y+++ + G L++ N+ G + VA A++ + I LE Sbjct: 162 VMHKYIIKLISAYEQEGFVYLVLEYLKGGELFEYLNNNGPY--TEQVAKKAMKRVLIALE 219 Query: 366 KLHSKGFVHGDVKPENFLLGQPGSP 440 LHS G VH D+K EN +L P P Sbjct: 220 ALHSNGVVHRDLKMENLMLENPNDP 244
>VRK1_BRARE (Q7ZUS1) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 425 Score = 45.8 bits (107), Expect(2) = 2e-07 Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 17/149 (11%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGA-------------SRTGPDAYEVALKLEHRRSKGCSYGPPF 167 +G+GGFG +Y+ + G S GP E LK R +K G Sbjct: 44 VGQGGFGLLYLANEDSSGPVTADAPYVIKVEPSDNGPLFSE--LKFYMRAAKPDLIGAWM 101 Query: 168 EWQVYQSLNGCYGIPSVHYKG---RQGDYY-ILVMDMLGPSLWDVWNSMGQAMSSHMVAC 335 + + + L G+P G + G Y +VMD G L ++ G+ S +V Sbjct: 102 KSKKMEYL----GVPKYWGSGFHEKNGKRYRFMVMDRFGTDLQKLFEGNGKKFSRKLVLQ 157 Query: 336 IAVESISILEKLHSKGFVHGDVKPENFLL 422 + + + ILE +H +VH D+K N LL Sbjct: 158 LGLRLLDILEYIHDHEYVHADIKASNLLL 186 Score = 28.5 bits (62), Expect(2) = 2e-07 Identities = 17/51 (33%), Positives = 27/51 (52%), Gaps = 1/51 (1%) Frame = +1 Query: 430 LDHPDEKKLFLIDLGLASKWKKASSSQHVEYDQRPD-IFRGTIRYASVHAH 579 L + + ++FL+D GLA ++ A EY + P GTI + S+ AH Sbjct: 186 LSYTNPNQVFLVDYGLA--YRYAPEGVPKEYKEDPKRCHDGTIEFTSIDAH 234
>YMX8_CAEEL (P34516) Putative serine/threonine-protein kinase K06H7.1 (EC| 2.7.11.1) Length = 346 Score = 46.2 bits (108), Expect(2) = 2e-07 Identities = 37/143 (25%), Positives = 62/143 (43%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y +KLG+GG G V+ T ALK+E + S+ E Q+ Sbjct: 20 YKVVQKLGEGGCGSVFK-------VEDTSEKGQHYALKVEFK-SQDAGNILKMEVQILSQ 71 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 L + G++ Y +VM +LG SL + G ++ I + + +++ Sbjct: 72 LISKKHVAKCVASGKKERYSYMVMTLLGESLDSLLKKHGPFLNVSTQVRIGICILFGIKQ 131 Query: 369 LHSKGFVHGDVKPENFLLGQPGS 437 +H G++H D+KP N +G GS Sbjct: 132 VHDIGYLHRDLKPANVAMGCKGS 154 Score = 27.7 bits (60), Expect(2) = 2e-07 Identities = 15/47 (31%), Positives = 22/47 (46%), Gaps = 1/47 (2%) Frame = +1 Query: 442 DEKKLFLIDLGLASKW-KKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 DE+ ++D GLA ++ + + FRGT RY SV H Sbjct: 156 DERYFLVLDFGLARQYIADEDDGLKMRRPREKTYFRGTARYCSVAMH 202
>CEK1_SCHPO (P38938) Serine/threonine-protein kinase cek1 (EC 2.7.11.1)| Length = 1338 Score = 52.4 bits (124), Expect = 9e-07 Identities = 38/140 (27%), Positives = 63/140 (45%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVA-LKLEHRRSKGCSYGPPFEWQVYQSLNG 197 + + KG FG VY+ ++ T G D + + LK + +K E + S Sbjct: 593 KPISKGAFGSVYLAQKRTTG------DYFAIKILKKSNMIAKNQVINVRAERAILMSQGE 646 Query: 198 CYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLH 374 + ++Y + DY LVM+ L G + +MG + + E++ L LH Sbjct: 647 SPFVAKLYYTFQSKDYLYLVMEYLNGGDCGSLLKTMG-VLDLDWIRTYIAETVLCLGDLH 705 Query: 375 SKGFVHGDVKPENFLLGQPG 434 +G +H D+KPEN L+ Q G Sbjct: 706 DRGIIHRDIKPENLLISQNG 725
>VRK2_HUMAN (Q86Y07) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 508 Score = 51.6 bits (122), Expect = 2e-06 Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 21/160 (13%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF-EWQVYQ 185 ++ +K+G GGFG +Y + ++ DA V +K+E++ + GP F E + YQ Sbjct: 29 WVLGKKIGSGGFGLIY----LAFPTNKPEKDARHV-VKVEYQEN-----GPLFSELKFYQ 78 Query: 186 SL--NGC------------------YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMG 305 + C YG +KGR Y +VM+ LG L + G Sbjct: 79 RVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRS--YRFMVMERLGIDLQKISGQNG 136 Query: 306 QAMSSHMVACIAVESISILEKLHSKGFVHGDVKPENFLLG 425 S ++ + + + +LE +H +VHGD+K N LLG Sbjct: 137 TFKKSTVLQ-LGIRMLDVLEYIHENEYVHGDIKAANLLLG 175
>KS6B1_RAT (P67999) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGG+G+V+ R++TG + TG A +V K R+ + E + + + Sbjct: 95 RVLGKGGYGKVFQVRKVTG--ANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH 152 Query: 198 CYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI-LEKLH 374 + + ++ G Y+++ + G L+ G M AC + IS+ L LH Sbjct: 153 PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMED--TACFYLAEISMALGHLH 210 Query: 375 SKGFVHGDVKPENFLLGQPG 434 KG ++ D+KPEN +L G Sbjct: 211 QKGIIYRDLKPENIMLNHQG 230
>KS6B1_RABIT (P67998) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGG+G+V+ R++TG + TG A +V K R+ + E + + + Sbjct: 95 RVLGKGGYGKVFQVRKVTG--ANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH 152 Query: 198 CYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI-LEKLH 374 + + ++ G Y+++ + G L+ G M AC + IS+ L LH Sbjct: 153 PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMED--TACFYLAEISMALGHLH 210 Query: 375 SKGFVHGDVKPENFLLGQPG 434 KG ++ D+KPEN +L G Sbjct: 211 QKGIIYRDLKPENIMLNHQG 230
>KS6B1_MOUSE (Q8BSK8) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (p70-S6K) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGG+G+V+ R++TG + TG A +V K R+ + E + + + Sbjct: 95 RVLGKGGYGKVFQVRKVTG--ANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH 152 Query: 198 CYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI-LEKLH 374 + + ++ G Y+++ + G L+ G M AC + IS+ L LH Sbjct: 153 PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMED--TACFYLAEISMALGHLH 210 Query: 375 SKGFVHGDVKPENFLLGQPG 434 KG ++ D+KPEN +L G Sbjct: 211 QKGIIYRDLKPENIMLNHQG 230
>KS6B1_HUMAN (P23443) Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1)| (Ribosomal protein S6 kinase I) (S6K) (S6K1) (70 kDa ribosomal protein S6 kinase 1) (p70 S6 kinase alpha) (p70(S6K)-alpha) (p70-S6K) (p70-alpha) Length = 525 Score = 48.9 bits (115), Expect = 1e-05 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGG+G+V+ R++TG + TG A +V K R+ + E + + + Sbjct: 95 RVLGKGGYGKVFQVRKVTG--ANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKH 152 Query: 198 CYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI-LEKLH 374 + + ++ G Y+++ + G L+ G M AC + IS+ L LH Sbjct: 153 PFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMED--TACFYLAEISMALGHLH 210 Query: 375 SKGFVHGDVKPENFLLGQPG 434 KG ++ D+KPEN +L G Sbjct: 211 QKGIIYRDLKPENIMLNHQG 230
>CDPK3_ORYSA (P53684) Calcium-dependent protein kinase, isoform 11 (EC 2.7.11.1)| (CDPK 11) Length = 542 Score = 47.8 bits (112), Expect = 2e-05 Identities = 43/144 (29%), Positives = 62/144 (43%), Gaps = 4/144 (2%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRR---SKGCSYGPPFEW 173 + YI RKLG+G FG Y+ I G E A K +R +K E Sbjct: 77 EHYIIGRKLGQGQFGTTYLCTEINTGC--------EYACKTIPKRKLITKEDVEDVRREI 128 Query: 174 QVYQSLNGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVES 350 Q+ L+G + ++ G +VM++ G L+D G I + Sbjct: 129 QIMHHLSGHKNVVAIKDVYEDGQAVHIVMELCAGGELFDRIQEKGHYSERKAAELIRI-I 187 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 +SI+ HS G +H D+KPENFLL Sbjct: 188 VSIVAMCHSLGVMHRDLKPENFLL 211
>PIM2_HUMAN (Q9P1W9) Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1)| (Pim-2h) Length = 311 Score = 47.0 bits (110), Expect = 4e-05 Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 12/144 (8%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGP-------PFEWQVYQ 185 LGKGGFG V+ G R+T D +VA+K+ R ++ + P P E + Sbjct: 38 LGKGGFGTVFAGHRLT--------DRLQVAIKVIPR-NRVLGWSPLSDSVTCPLEVALLW 88 Query: 186 SLNGCYGIPSV-----HYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 + G P V ++ ++G +L + L+D G + C + Sbjct: 89 KVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGP-LGEGPSRCFFGQV 147 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 ++ ++ HS+G VH D+K EN L+ Sbjct: 148 VAAIQHCHSRGVVHRDIKDENILI 171
>VRK2_MOUSE (Q8BN21) Serine/threonine-protein kinase VRK2 (EC 2.7.11.1)| (Vaccinia-related kinase 2) Length = 503 Score = 46.6 bits (109), Expect = 5e-05 Identities = 42/155 (27%), Positives = 66/155 (42%), Gaps = 21/155 (13%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF-EWQVYQ---- 185 + +G GGFG +Y + ++ DA V +KLE++ + GP F E + YQ Sbjct: 33 KMIGSGGFGLIY----LAFPTNKPNKDARHV-IKLEYQEN-----GPLFSELKFYQRAAK 82 Query: 186 ----------------SLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMS 317 + YG +KGR Y +VM+ LG L + + G Sbjct: 83 RECIQKWIQQRKLDYLGIPVFYGFGLTDFKGRS--YRFMVMERLGIDLQKLLDQNG-GFK 139 Query: 318 SHMVACIAVESISILEKLHSKGFVHGDVKPENFLL 422 V + + + +LE +H +VHGD+K N LL Sbjct: 140 KLTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLL 174
>PKN2_MYXXA (P54736) Serine/threonine-protein kinase pkn2 (EC 2.7.11.1)| Length = 830 Score = 46.2 bits (108), Expect = 7e-05 Identities = 39/140 (27%), Positives = 65/140 (46%), Gaps = 4/140 (2%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHR---RSKGCSYGPPFEWQVYQSL 191 R LG GG G+VY+G +++ G +VA+K+ H G + E ++ ++ Sbjct: 17 RPLGSGGMGEVYLGEQVSLGR--------KVAIKVLHHDLHAQAGMAERFKREARLLSAV 68 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 + V + G GD+ LVM+ + G SL+DV M + + L Sbjct: 69 EHPAVVRIVDF-GESGDHACLVMEFVEGESLYDVLTP--GPMPPGRALPLLQQLAEGLAA 125 Query: 369 LHSKGFVHGDVKPENFLLGQ 428 +H KG +H D+KPEN + + Sbjct: 126 IHDKGIIHRDLKPENVFISK 145
>ICK_HUMAN (Q9UPZ9) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (hICK) (MAK-related kinase) (MRK) (Laryngeal cancer kinase 2) (LCK2) Length = 632 Score = 45.4 bits (106), Expect = 1e-04 Identities = 33/149 (22%), Positives = 60/149 (40%), Gaps = 8/149 (5%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y T R+LG G +G V +GR I G +A+K R+ + W+ + Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESGEL--------IAIKKMKRKF--------YSWEECMN 47 Query: 189 LNGCYGIPSVHYKG--------RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAV 344 L + +++ R+ D+ + + + +L+ + + + I Sbjct: 48 LREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMY 107 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQP 431 + + L +H GF H D+KPEN L P Sbjct: 108 QILQGLAFIHKHGFFHRDLKPENLLCMGP 136
>PIM2_MOUSE (Q62070) Serine/threonine-protein kinase Pim-2 (EC 2.7.11.1)| Length = 370 Score = 45.1 bits (105), Expect = 1e-04 Identities = 38/144 (26%), Positives = 62/144 (43%), Gaps = 12/144 (8%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRR----------SKGCSYGPPFEWQ 176 LGKGGFG V+ G R+T D +VA+K+ R S C W+ Sbjct: 97 LGKGGFGTVFAGHRVT--------DRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLWK 148 Query: 177 VYQSLNGCYGIPSV--HYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 V + NG G+ + ++ +G +L M L+D G + + Sbjct: 149 VGEG-NGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKG-PLGESCSRSFFTQV 206 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 ++ ++ H++G VH D+K EN L+ Sbjct: 207 VAAVQHCHARGVVHRDIKDENILI 230
>DMPK_MOUSE (P54265) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 631 Score = 45.1 bits (105), Expect = 1e-04 Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 1/77 (1%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDM-LGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 I +H+ + +Y LVM+ +G L + + G+ + + M E + ++ +H G Sbjct: 131 ITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLG 190 Query: 384 FVHGDVKPENFLLGQPG 434 +VH D+KP+N LL + G Sbjct: 191 YVHRDIKPDNILLDRCG 207
>DMPK_HUMAN (Q09013) Myotonin-protein kinase (EC 2.7.11.1) (Myotonic dystrophy| protein kinase) (MDPK) (DM-kinase) (DMK) (DMPK) (MT-PK) Length = 639 Score = 45.1 bits (105), Expect = 1e-04 Identities = 22/77 (28%), Positives = 41/77 (53%), Gaps = 1/77 (1%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDM-LGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 I +H+ + +Y LVM+ +G L + + G+ + + M E + ++ +H G Sbjct: 141 ITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLG 200 Query: 384 FVHGDVKPENFLLGQPG 434 +VH D+KP+N LL + G Sbjct: 201 YVHRDIKPDNILLDRCG 217
>GRK1_CAEEL (Q09537) G protein-coupled receptor kinase 1 (EC 2.7.11.16)| Length = 642 Score = 45.1 bits (105), Expect = 1e-04 Identities = 39/140 (27%), Positives = 61/140 (43%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 R LGKGGFG+V + G + +K H + + E Q+ Q +N Sbjct: 207 RVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLN-----EKQILQRINSP 261 Query: 201 YGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLH 374 + + S+ Y D LV+ ++ G + ++N M V A E L+ LH Sbjct: 262 F-VVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGFDEKRVQFYAAEITLGLQHLH 320 Query: 375 SKGFVHGDVKPENFLLGQPG 434 S+ ++ D+KPEN LL G Sbjct: 321 SERILYRDLKPENILLDDFG 340
>NHK1_DROME (Q7KRY6) Nucleosomal histone kinase 1 (EC 2.7.11.1) (Protein| baellchen) Length = 599 Score = 44.7 bits (104), Expect = 2e-04 Identities = 38/154 (24%), Positives = 61/154 (39%), Gaps = 21/154 (13%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG--- 197 +G GGFG++Y A + G Y+ +K E + GP F + N Sbjct: 53 IGVGGFGEIYA-------ACKVGEKNYDAVVKCEPHGN-----GPLFVEMHFYLRNAKLE 100 Query: 198 ------------CYGIP------SVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSH 323 G+P SV G + + +VM G L G+ + Sbjct: 101 DIKQFMQKHGLKSLGMPYILANGSVEVNGEK--HRFIVMPRYGSDLTKFLEQNGKRLPEG 158 Query: 324 MVACIAVESISILEKLHSKGFVHGDVKPENFLLG 425 V +A++ + + + +HS G+VH D+K N LLG Sbjct: 159 TVYRLAIQMLDVYQYMHSNGYVHADLKAANILLG 192
>PKN1_MYXXA (P33973) Serine/threonine-protein kinase pkn1 (EC 2.7.11.1)| Length = 693 Score = 44.3 bits (103), Expect = 3e-04 Identities = 35/139 (25%), Positives = 62/139 (44%), Gaps = 5/139 (3%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQ----- 185 R+LG+GG G VY+G ++ G+ VA+K+ H + P + + Sbjct: 63 RRLGRGGMGAVYLGEHVSIGS--------RVAVKVLHAH---LTMYPELVQRFHAEARAV 111 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILE 365 +L G I S+ L+M+ L + W +G +++ V + + L+ Sbjct: 112 NLIGHENIVSIFDMDATPPRPYLIMEFLDGAPLSAW--VGTPLAAGAVVSVLSQVCDALQ 169 Query: 366 KLHSKGFVHGDVKPENFLL 422 H++G VH D+KP+N L Sbjct: 170 AAHARGIVHRDLKPDNIFL 188
>STE20_YEAST (Q03497) Serine/threonine-protein kinase STE20 (EC 2.7.11.1)| Length = 939 Score = 44.3 bits (103), Expect = 3e-04 Identities = 24/67 (35%), Positives = 38/67 (56%) Frame = +3 Query: 234 QGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPEN 413 +GD ++++ M G SL DV ++ + + E++S LE LHSKG +H D+K +N Sbjct: 687 KGDLWVIMEYMEGGSLTDVVTHC--ILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDN 744 Query: 414 FLLGQPG 434 LL G Sbjct: 745 ILLSMEG 751
>ICK_RAT (Q62726) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (MAK-related kinase) (MRK) Length = 629 Score = 44.3 bits (103), Expect = 3e-04 Identities = 32/149 (21%), Positives = 60/149 (40%), Gaps = 8/149 (5%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y T ++LG G +G V +GR I G +A+K R+ + W+ + Sbjct: 4 YTTIKQLGDGTYGSVLLGRSIESGEL--------IAIKKMKRKF--------YSWEECMN 47 Query: 189 LNGCYGIPSVHYKG--------RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAV 344 L + +++ R+ D+ + + + +L+ + + + I Sbjct: 48 LREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMY 107 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQP 431 + + L +H GF H D+KPEN L P Sbjct: 108 QILQGLAFIHKHGFFHRDLKPENLLCMGP 136
>ICK_MOUSE (Q9JKV2) Serine/threonine-protein kinase ICK (EC 2.7.11.22)| (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK) Length = 629 Score = 44.3 bits (103), Expect = 3e-04 Identities = 32/149 (21%), Positives = 60/149 (40%), Gaps = 8/149 (5%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y T ++LG G +G V +GR I G +A+K R+ + W+ + Sbjct: 4 YTTIKQLGDGTYGSVLLGRSIESGEL--------IAIKKMKRKF--------YSWEECMN 47 Query: 189 LNGCYGIPSVHYKG--------RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAV 344 L + +++ R+ D+ + + + +L+ + + + I Sbjct: 48 LREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMY 107 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQP 431 + + L +H GF H D+KPEN L P Sbjct: 108 QILQGLAFIHKHGFFHRDLKPENLLCMGP 136
>VRK1_HUMAN (Q99986) Serine/threonine-protein kinase VRK1 (EC 2.7.11.1)| (Vaccinia-related kinase 1) Length = 396 Score = 43.9 bits (102), Expect = 3e-04 Identities = 40/152 (26%), Positives = 65/152 (42%), Gaps = 20/152 (13%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF-EWQVYQSLN--- 194 +G+GGFG +Y+ + G DA +K+E + GP F E + YQ Sbjct: 43 IGQGGFGCIYLAD--MNSSESVGSDA-PCVVKVEPSDN-----GPLFTELKFYQRAAKPE 94 Query: 195 -----------GCYGIP-----SVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHM 326 G+P +H K + Y ++MD G L ++ + + S Sbjct: 95 QIQKWIRTRKLKYLGVPKYWGSGLHDKNGK-SYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 Query: 327 VACIAVESISILEKLHSKGFVHGDVKPENFLL 422 V +++ + ILE +H +VHGD+K N LL Sbjct: 154 VLQLSLRILDILEYIHEHEYVHGDIKASNLLL 185
>YOO3_CAEEL (P34635) Putative serine/threonine-protein kinase ZK507.3 (EC| 2.7.11.1) Length = 374 Score = 43.9 bits (102), Expect = 3e-04 Identities = 37/141 (26%), Positives = 63/141 (44%), Gaps = 7/141 (4%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCY 203 +LGKGG+G V + I D E A+K E + + S E V S + C Sbjct: 30 ELGKGGYGTV--NKVIKVNEEGFAIDDKEYAMKTEQKFASKHSSRLKIERNVMASYSKCD 87 Query: 204 GIPSVHYK-----GRQGDYYILVMDMLGPSLWDVWNSM--GQAMSSHMVACIAVESISIL 362 H+ G+ + +VM ++GPSL ++ S ++ C ++++ + Sbjct: 88 AQCKEHFPELIDFGQSPVWKWIVMTIVGPSLEELKMKYKPSDIPPSTILQC-GLQTMKAI 146 Query: 363 EKLHSKGFVHGDVKPENFLLG 425 H GF+H D+KP N+ +G Sbjct: 147 HDFHQIGFLHRDIKPANYCIG 167
>KS6B2_HUMAN (Q9UBS0) Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K2)| (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (p70 S6 kinase beta) (S6K-beta) (p70-beta) (S6 kinase-related kinase) (SRK) (Serin Length = 482 Score = 43.9 bits (102), Expect = 3e-04 Identities = 37/140 (26%), Positives = 67/140 (47%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGG+G+V+ R++ G + G A +V K + R+ + E + +S+ Sbjct: 71 RVLGKGGYGKVFQVRKVQG--TNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKH 128 Query: 198 CYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI-LEKLH 374 + + + G Y+++ + G L+ G + AC + I++ L LH Sbjct: 129 PFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLED--TACFYLAEITLALGHLH 186 Query: 375 SKGFVHGDVKPENFLLGQPG 434 S+G ++ D+KPEN +L G Sbjct: 187 SQGIIYRDLKPENIMLSSQG 206
>BUB1_YEAST (P41695) Checkpoint serine/threonine-protein kinase BUB1 (EC| 2.7.11.1) Length = 1021 Score = 43.9 bits (102), Expect = 3e-04 Identities = 19/45 (42%), Positives = 29/45 (64%), Gaps = 2/45 (4%) Frame = +3 Query: 312 MSSHMVACIAVESISILEKLHSKGFVHGDVKPENFL--LGQPGSP 440 M ++ I VE + +LEK+H G +HGD+KP+N + L +PG P Sbjct: 805 MDEYLCMFITVELMKVLEKIHEVGIIHGDLKPDNCMIRLEKPGEP 849
>PIM1_BRARE (Q9YHZ5) Serine/threonine-protein kinase Pim-1 (EC 2.7.11.1)| Length = 310 Score = 43.9 bits (102), Expect = 3e-04 Identities = 45/155 (29%), Positives = 65/155 (41%), Gaps = 17/155 (10%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALK-LEHRRSKGCSYGP------PF 167 Y LG GGFG VY G RI+ D +VA+K + R + S P P Sbjct: 30 YTMGNLLGSGGFGSVYSGHRIS--------DGQKVAIKQISRDRIQQWSKMPGEVNPVPN 81 Query: 168 EWQVYQSLNGCYG--------IPSVHYKGRQGDYYILVMD--MLGPSLWDVWNSMGQAMS 317 E + QSL G G I + + G Y++V + L+D G+ + Sbjct: 82 EIALLQSLGGGSGSVPGHRGIIRMLDWFEIPGQEYLIVFEKPQHCQDLFDFITERGR-LD 140 Query: 318 SHMVACIAVESISILEKLHSKGFVHGDVKPENFLL 422 + + I ++ HSKG VH D+K EN L+ Sbjct: 141 ESLARRFLKQVIEAVQFCHSKGIVHRDIKDENILV 175
>V226_FOWPV (Q9J509) Probable serine/threonine-protein kinase FPV226 (EC| 2.7.11.1) Length = 292 Score = 35.4 bits (80), Expect(2) = 3e-04 Identities = 36/146 (24%), Positives = 67/146 (45%), Gaps = 11/146 (7%) Frame = +3 Query: 18 DRKLGKGGFGQVYVGRRITGGASRTGPDAYEV-ALKLEHRRSKGCSYGPPFE------WQ 176 D+ +G GGFG VY T AS T +V +L S+ Y ++ W+ Sbjct: 17 DKLIGCGGFGCVYS----TQCASNTRQAVIKVESLNNTTMVSEVLVYNNIYDKNRIALWK 72 Query: 177 VYQSLNGCYGIPSVH----YKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAV 344 Y++++ GIP + +K Y ++++ L + ++ + + ++ I Sbjct: 73 NYKNIDHL-GIPMYYGCGSFKRNTMYYRFILLERLVENTKELLKRVKKPKP--LIKNIMK 129 Query: 345 ESISILEKLHSKGFVHGDVKPENFLL 422 + + LE +H G HGD+KPEN ++ Sbjct: 130 DMLYTLEYIHEHGISHGDIKPENIMV 155 Score = 27.7 bits (60), Expect(2) = 3e-04 Identities = 16/42 (38%), Positives = 26/42 (61%), Gaps = 1/42 (2%) Frame = +1 Query: 457 FLIDLGLASKWKKASSSQHVEY-DQRPDIFRGTIRYASVHAH 579 +LID G+ S + + +HV+Y + + RGT+ YAS+ AH Sbjct: 162 YLIDYGIVSYF--IVNGKHVKYYKESKNWHRGTLYYASLDAH 201
>YQI1_CAEEL (Q09503) Hypothetical protein C45G9.1 in chromosome III| Length = 290 Score = 38.5 bits (88), Expect(2) = 3e-04 Identities = 19/76 (25%), Positives = 44/76 (57%), Gaps = 3/76 (3%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDMLGPSLWDVWNS---MGQAMSSHMVACIAVESISILEKLHS 377 IP+++ G++ ++ +VM +LG +L D+ ++ + + S + + ++ + L+ +H Sbjct: 18 IPNLNLYGKKMNFSYMVMTLLGRNLQDLESTNFVVNKGFSRGTWSRVGIQWVYALKYVHY 77 Query: 378 KGFVHGDVKPENFLLG 425 GF+H +V +N LG Sbjct: 78 NGFIHRNVNTQNLFLG 93 Score = 24.6 bits (52), Expect(2) = 3e-04 Identities = 16/62 (25%), Positives = 28/62 (45%), Gaps = 3/62 (4%) Frame = +1 Query: 403 SQKTFCLVNLDHPDEKKLFLIDLGLASKWKKASSSQH---VEYDQRPDIFRGTIRYASVH 573 +Q F D K + ++D GL + + + ++ V + FRG+ RYAS + Sbjct: 87 TQNLFLGNEKDSERAKIIHILDFGLGRPFARYHARENKWIVRIARHSAEFRGSFRYASPN 146 Query: 574 AH 579 H Sbjct: 147 VH 148
>STE20_CANAL (Q92212) Serine/threonine-protein kinase STE20 homolog (EC 2.7.11.1)| Length = 1230 Score = 43.5 bits (101), Expect = 4e-04 Identities = 22/68 (32%), Positives = 38/68 (55%) Frame = +3 Query: 234 QGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPEN 413 +GD ++++ M G SL D+ M+ + + E++ L+ LHSKG +H D+K +N Sbjct: 1021 KGDLWVIMEYMEGGSLTDIVTH--SVMTEGQIGVVCRETLKGLKFLHSKGVIHRDIKSDN 1078 Query: 414 FLLGQPGS 437 LL G+ Sbjct: 1079 ILLNMDGN 1086
>M4K3_RAT (Q924I2) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragment) Length = 862 Score = 43.5 bits (101), Expect = 4e-04 Identities = 42/145 (28%), Positives = 65/145 (44%), Gaps = 7/145 (4%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS---- 188 +++G G +G VY R + TG A +KLE P ++ V Q Sbjct: 9 QRIGSGTYGDVYKARNVN-----TGELAAIKVIKLE----------PGEDFAVVQQEIIM 53 Query: 189 LNGCYGIPSVHYKG---RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 + C V Y G R+ +I + G SL D+++ G +S +A ++ E++ Sbjct: 54 MKDCKHANIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRETLQG 112 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L LHSKG +H D+K N LL G Sbjct: 113 LYYLHSKGKMHRDIKGANILLTDNG 137
>PAK1_MOUSE (O88643) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) (CDC42/RAC effector kinase PAK-A) Length = 545 Score = 43.1 bits (100), Expect = 6e-04 Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 5/148 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y K+G+G G VY + G EVA+K + + + P E + + Sbjct: 270 YTPFEKIGQGASGTVYTAMDVATGQ--------EVAIKQMNLQQQ-----PKKELIINEI 316 Query: 189 L----NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 L N I + GD +VM+ L G SL DV M +A + E + Sbjct: 317 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECL 374 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPGS 437 LE LHS +H D+K +N LLG GS Sbjct: 375 QALEFLHSNQVIHRDIKSDNILLGMDGS 402
>PAK1_HUMAN (Q13153) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P65-PAK) (Alpha-PAK) Length = 545 Score = 43.1 bits (100), Expect = 6e-04 Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 5/148 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y K+G+G G VY + G EVA+K + + + P E + + Sbjct: 270 YTRFEKIGQGASGTVYTAMDVATGQ--------EVAIKQMNLQQQ-----PKKELIINEI 316 Query: 189 L----NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 L N I + GD +VM+ L G SL DV M +A + E + Sbjct: 317 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECL 374 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPGS 437 LE LHS +H D+K +N LLG GS Sbjct: 375 QALEFLHSNQVIHRDIKSDNILLGMDGS 402
>MRCKG_MOUSE (Q80UW5) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 43.1 bits (100), Expect = 6e-04 Identities = 23/77 (29%), Positives = 36/77 (46%), Gaps = 1/77 (1%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 + ++HY + +Y LVMD G L + + + + E + + LH G Sbjct: 131 VTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLG 190 Query: 384 FVHGDVKPENFLLGQPG 434 +VH DVKP+N LL G Sbjct: 191 YVHRDVKPDNILLDMNG 207
>PAK1_RAT (P35465) Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK-1) (P68-PAK) (Alpha-PAK) (Protein kinase MUK2) Length = 544 Score = 43.1 bits (100), Expect = 6e-04 Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 5/148 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y K+G+G G VY + G EVA+K + + + P E + + Sbjct: 269 YTRFEKIGQGASGTVYTAMDVATGQ--------EVAIKQMNLQQQ-----PKKELIINEI 315 Query: 189 L----NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 L N I + GD +VM+ L G SL DV M +A + E + Sbjct: 316 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECL 373 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPGS 437 LE LHS +H D+K +N LLG GS Sbjct: 374 QALEFLHSNQVIHRDIKSDNILLGMDGS 401
>CDC7_HUMAN (O00311) Cell division cycle 7-related protein kinase (EC 2.7.11.1)| (CDC7-related kinase) (HsCdc7) (huCdc7) Length = 574 Score = 43.1 bits (100), Expect = 6e-04 Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 2/134 (1%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCY 203 K+G+G F VY+ + GP E + L+H E Q G Sbjct: 63 KIGEGTFSSVYLAT----AQLQVGP---EEKIALKHLIPTSHPIRIAAELQCLTVAGGQD 115 Query: 204 GIPSVHYKGRQGDYYILVMDMLG-PSLWDVWNSMG-QAMSSHMVACIAVESISILEKLHS 377 + V Y R+ D+ ++ M L S D+ NS+ Q + +M+ L+++H Sbjct: 116 NVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYML-----NLFKALKRIHQ 170 Query: 378 KGFVHGDVKPENFL 419 G VH DVKP NFL Sbjct: 171 FGIVHRDVKPSNFL 184
>CBK1_PNECA (Q6TGC6) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 507 Score = 43.1 bits (100), Expect = 6e-04 Identities = 35/140 (25%), Positives = 61/140 (43%) Frame = +3 Query: 15 TDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLN 194 T + +GKG FG+V + ++I G A + LK E + ++ E V + Sbjct: 128 TVKVIGKGAFGEVRLVQKIDTGKIY----AMKTLLKSEMFKKDQLAHVKA-ERDVLAESD 182 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLH 374 + + S++Y + Y L+M+ L S + E I +E +H Sbjct: 183 SPW-VVSLYYSFQDSQYLYLIMEFLPGGDLMTMLIKYDTFSEDVTRFYIAECILAIEAVH 241 Query: 375 SKGFVHGDVKPENFLLGQPG 434 GF+H D+KP+N L+ + G Sbjct: 242 KLGFIHRDIKPDNILIDKTG 261
>Y31E_CAEEL (Q8MYQ1) Putative serine/threonine-protein kinase F31E3.2 (EC| 2.7.11.1) Length = 441 Score = 39.7 bits (91), Expect(2) = 7e-04 Identities = 39/150 (26%), Positives = 66/150 (44%), Gaps = 6/150 (4%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRR---SKGCSYGPPFEW 173 + ++ +R+LG+G FG VY AS + A+K++ +R SK E Sbjct: 124 KSFVLERQLGRGSFGVVYC-------ASAIHDSERKFAIKMQEKREIISKRAVLQVKREA 176 Query: 174 QVYQSLNGCYGIPSVHYKGRQGDY-YILVMDMLGPS--LWDVWNSMGQAMSSHMVACIAV 344 + + L I + + + Y L+ G + L+ VW G ++S + I Sbjct: 177 SIQRLLPSHPFIARTYSTWQTRTHLYSLLQYPTGSTGDLFSVWRQRG-SLSEAAIRLIGA 235 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQPG 434 E S ++ LH ++ DVK EN +L Q G Sbjct: 236 ELASAIDFLHQNDVIYRDVKLENVVLDQWG 265 Score = 22.3 bits (46), Expect(2) = 7e-04 Identities = 10/16 (62%), Positives = 12/16 (75%) Frame = +1 Query: 460 LIDLGLASKWKKASSS 507 LID GLA K K+ SS+ Sbjct: 269 LIDFGLAKKLKQGSST 284
>CDPK1_ORYSA (P53682) Calcium-dependent protein kinase, isoform 1 (EC 2.7.11.1)| (CDPK 1) Length = 534 Score = 42.7 bits (99), Expect = 7e-04 Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 2/142 (1%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 + Y R+LG+G FG+ Y+ I+ G A + LK + R E Q+ Sbjct: 71 ELYTLGRELGQGQFGKTYLCTEISTGCQY----ACKTILK-SNLRCVSDIEDVRREIQIM 125 Query: 183 QSLNGCYGIPSVH--YKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESIS 356 L+G I ++ Y+ Q + ++ + G L+ G I + + Sbjct: 126 HHLSGQKNIVTIKDTYEDEQAVHIVMEL-CAGGELFSKIQKRGHYSERKAAELIKI-IVG 183 Query: 357 ILEKLHSKGFVHGDVKPENFLL 422 I+E HS G +H D+KPENFLL Sbjct: 184 IIETCHSHGVMHRDLKPENFLL 205
>MAK_RAT (P20793) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 622 Score = 42.7 bits (99), Expect = 7e-04 Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 8/149 (5%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y T R+LG G +G V +G+ G VA+K R+ + W + Sbjct: 4 YTTMRQLGDGTYGSVLMGKSNESGEL--------VAIKRMKRKF--------YSWDECMN 47 Query: 189 LNGCYGIPSVHYKG--------RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAV 344 L + +++ R+ D+ + + + +L+ + + ++ I Sbjct: 48 LREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMY 107 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQP 431 + + L +H GF H D+KPEN L P Sbjct: 108 QILQGLAFIHKHGFFHRDMKPENLLCMGP 136
>GRK1_CAEBR (Q622Z7) G protein-coupled receptor kinase 1 (EC 2.7.11.16)| Length = 640 Score = 42.7 bits (99), Expect = 7e-04 Identities = 38/140 (27%), Positives = 60/140 (42%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 R LGKGGFG+V + G + +K H + + E Q+ Q +N Sbjct: 206 RVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLN-----EKQILQKVNSP 260 Query: 201 YGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLH 374 + + S+ Y D LV+ ++ G + ++N M V A E L+ LH Sbjct: 261 F-VVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGFDEKRVQFYAAEITLGLQHLH 319 Query: 375 SKGFVHGDVKPENFLLGQPG 434 + ++ D+KPEN LL G Sbjct: 320 LEHILYRDLKPENILLDDFG 339
>KS6A6_HUMAN (Q9UK32) Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1)| (S6K-alpha 6) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4) Length = 745 Score = 42.7 bits (99), Expect = 7e-04 Identities = 40/141 (28%), Positives = 67/141 (47%), Gaps = 5/141 (3%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEV-ALKLEHRRSKGCS--YGPPFEWQVYQSLNG 197 LG+G FG+V++ R+ +TGPDA ++ A+K+ + S E + +N Sbjct: 79 LGQGSFGKVFLVRK------KTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNH 132 Query: 198 CYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEKL 371 + I +HY + L++D L DV+ + + + + V E L+ L Sbjct: 133 PF-IVKLHYAFQTEGKLYLILDFLRGG--DVFTRLSKEVLFTEEDVKFYLAELALALDHL 189 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H G V+ D+KPEN LL + G Sbjct: 190 HQLGIVYRDLKPENILLDEIG 210
>M4K3_MOUSE (Q99JP0) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) (Fragments) Length = 681 Score = 42.7 bits (99), Expect = 7e-04 Identities = 42/145 (28%), Positives = 65/145 (44%), Gaps = 7/145 (4%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS---- 188 +++G G +G VY R + TG A +KLE P ++ V Q Sbjct: 20 QRIGSGTYGDVYKARNVN-----TGELAAIKVIKLE----------PGEDFAVVQQEIIM 64 Query: 189 LNGCYGIPSVHYKG---RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 + C V Y G R+ +I + G SL D+++ G +S +A ++ E++ Sbjct: 65 MKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRETLQG 123 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L LHSKG +H D+K N LL G Sbjct: 124 LYYLHSKGKMHRDIKGANILLTDNG 148
>MAK_HUMAN (P20794) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) Length = 623 Score = 42.7 bits (99), Expect = 7e-04 Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 8/149 (5%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y T R+LG G +G V +G+ G VA+K R+ + W + Sbjct: 4 YTTMRQLGDGTYGSVLMGKSNESGEL--------VAIKRMKRKF--------YSWDECMN 47 Query: 189 LNGCYGIPSVHYKG--------RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAV 344 L + +++ R+ D+ + + + +L+ + + ++ I Sbjct: 48 LREVKSLKKLNHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMY 107 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQP 431 + + L +H GF H D+KPEN L P Sbjct: 108 QILQGLAFIHKHGFFHRDMKPENLLCMGP 136
>PCTK2_HUMAN (Q00537) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 42.7 bits (99), Expect = 7e-04 Identities = 41/148 (27%), Positives = 61/148 (41%), Gaps = 4/148 (2%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALK---LEHRRSKGCSYGPPFE 170 + YI KLG+G + VY GR ++T VALK LEH C+ E Sbjct: 190 ETYIKLEKLGEGTYATVYKGRSKLTENL---------VALKEIRLEHEEGAPCT--AIRE 238 Query: 171 WQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 + + L I ++H LV + L L + G MS H V + Sbjct: 239 VSLLKDLKHA-NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQI 297 Query: 351 ISILEKLHSKGFVHGDVKPENFLLGQPG 434 + L H + +H D+KP+N L+ + G Sbjct: 298 LRGLAYCHRRKVLHRDLKPQNLLINEKG 325
>M4K3_HUMAN (Q8IVH8) Mitogen-activated protein kinase kinase kinase kinase 3| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3) (Germinal center kinase-related protein kinase) (GLK) Length = 894 Score = 42.7 bits (99), Expect = 7e-04 Identities = 42/145 (28%), Positives = 65/145 (44%), Gaps = 7/145 (4%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS---- 188 +++G G +G VY R + TG A +KLE P ++ V Q Sbjct: 20 QRIGSGTYGDVYKARNVN-----TGELAAIKVIKLE----------PGEDFAVVQQEIIM 64 Query: 189 LNGCYGIPSVHYKG---RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 + C V Y G R+ +I + G SL D+++ G +S +A ++ E++ Sbjct: 65 MKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRETLQG 123 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L LHSKG +H D+K N LL G Sbjct: 124 LYYLHSKGKMHRDIKGANILLTDNG 148
>KS6A2_HUMAN (Q15349) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (MAP kinase-activated protein kinase 1c) (MAPKAPK1C) Length = 733 Score = 40.4 bits (93), Expect(2) = 0.001 Identities = 38/142 (26%), Positives = 65/142 (45%), Gaps = 6/142 (4%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITG---GASRTGPDAYEVALKLEHR-RSKGCSYGPPFEWQVYQSLN 194 LG+G +G+V++ R++ G G + LK+ R RSK E + +N Sbjct: 65 LGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSK-------MERDILAEVN 117 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEK 368 + I +HY + L++D L D++ + + + + V E L+ Sbjct: 118 HPF-IVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALALDH 174 Query: 369 LHSKGFVHGDVKPENFLLGQPG 434 LHS G ++ D+KPEN LL + G Sbjct: 175 LHSLGIIYRDLKPENILLDEEG 196 Score = 31.2 bits (69), Expect = 2.2 Identities = 25/71 (35%), Positives = 38/71 (53%), Gaps = 3/71 (4%) Frame = +3 Query: 237 GDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESIS-ILEKLHSKGFVHGDVKPE 410 G + LVM+++ G L D + Q S A + +I+ ++ LHS+G VH D+KP Sbjct: 479 GKFVYLVMELMRGGELLD--RILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPS 536 Query: 411 NFLL-GQPGSP 440 N L + GSP Sbjct: 537 NILYRDESGSP 547 Score = 21.2 bits (43), Expect(2) = 0.001 Identities = 12/40 (30%), Positives = 20/40 (50%) Frame = +1 Query: 442 DEKKLFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRY 561 +E + + D GL S + +++D+R F GTI Y Sbjct: 194 EEGHIKITDFGL--------SKEAIDHDKRAYSFCGTIEY 225
>AFSK_STRGR (P54742) Serine/threonine protein kinase afsK (EC 2.7.11.1)| Length = 807 Score = 42.4 bits (98), Expect = 0.001 Identities = 36/141 (25%), Positives = 59/141 (41%), Gaps = 4/141 (2%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVA----LKLEHRRSKGCSYGPPFEWQVYQSL 191 +LG GG G VY+ R +G E+A ++ R E + +++ Sbjct: 21 RLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTR----------EVEAARAV 70 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 +G Y V R ++ + PSL ++ N G M + V +A L+ + Sbjct: 71 SGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGP-MPTQAVRWLAAGIAQALQSI 129 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H G VH D+KP N L+ + G Sbjct: 130 HGAGLVHRDLKPSNVLVVEDG 150
>KS6A5_HUMAN (O75582) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RSKL) Length = 802 Score = 42.4 bits (98), Expect = 0.001 Identities = 36/137 (26%), Positives = 60/137 (43%), Gaps = 1/137 (0%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGP-DAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCY 203 LG G +G+V++ R+I+G TG A +V K + + E QV + + Sbjct: 55 LGTGAYGKVFLVRKISG--HDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSP 112 Query: 204 GIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 + ++HY + L++D + S + + H V E + LE LH G Sbjct: 113 FLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLG 172 Query: 384 FVHGDVKPENFLLGQPG 434 ++ D+K EN LL G Sbjct: 173 IIYRDIKLENILLDSNG 189 Score = 29.3 bits (64), Expect = 8.5 Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 4/82 (4%) Frame = +3 Query: 186 SLNGCYGIPSV---HYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 +L C G P++ H + LVM++L G L++ + S + I + + Sbjct: 471 ALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKK-KHFSETEASYIMRKLV 529 Query: 354 SILEKLHSKGFVHGDVKPENFL 419 S + +H G VH D+KPEN L Sbjct: 530 SAVSHMHDVGVVHRDLKPENLL 551
>MRCKB_RAT (Q7TT49) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 2/84 (2%) Frame = +3 Query: 189 LNG-CYGIPSVHYKGRQGDYYILVMDM-LGPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 +NG C I ++HY + +Y LVMD +G L + + + M E + + Sbjct: 129 VNGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 188 Query: 363 EKLHSKGFVHGDVKPENFLLGQPG 434 + +H +VH D+KP+N LL G Sbjct: 189 DSIHQLHYVHRDIKPDNVLLDVNG 212
>MRCKB_MOUSE (Q7TT50) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1713 Score = 42.4 bits (98), Expect = 0.001 Identities = 25/84 (29%), Positives = 41/84 (48%), Gaps = 2/84 (2%) Frame = +3 Query: 189 LNG-CYGIPSVHYKGRQGDYYILVMDM-LGPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 +NG C I ++HY + +Y LVMD +G L + + + M E + + Sbjct: 129 VNGDCQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 188 Query: 363 EKLHSKGFVHGDVKPENFLLGQPG 434 + +H +VH D+KP+N LL G Sbjct: 189 DSIHQLHYVHRDIKPDNVLLDVNG 212
>PAK2_RAT (Q64303) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p62-PAK) Length = 524 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/68 (38%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 237 GDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPEN 413 GD +VM+ L G SL DV M +A + E + LE LH+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDVVTET--CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 414 FLLGQPGS 437 LLG GS Sbjct: 374 VLLGMEGS 381
>PAK2_RABIT (Q29502) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (Gamma-PAK) (p21-activated protein kinase I) (PAKI) Length = 524 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/68 (38%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 237 GDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPEN 413 GD +VM+ L G SL DV M +A + E + LE LH+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDVVTET--CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 414 FLLGQPGS 437 LLG GS Sbjct: 374 VLLGMEGS 381
>PAK2_MOUSE (Q8CIN4) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) Length = 524 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/68 (38%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 237 GDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPEN 413 GD +VM+ L G SL DV M +A + E + LE LH+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDVVTET--CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 414 FLLGQPGS 437 LLG GS Sbjct: 374 VLLGMEGS 381
>PAK2_HUMAN (Q13177) Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1)| (p21-activated kinase 2) (PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase) Length = 524 Score = 42.4 bits (98), Expect = 0.001 Identities = 26/68 (38%), Positives = 35/68 (51%), Gaps = 1/68 (1%) Frame = +3 Query: 237 GDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPEN 413 GD +VM+ L G SL DV M +A + E + LE LH+ +H D+K +N Sbjct: 316 GDELFVVMEYLAGGSLTDVVTET--CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDN 373 Query: 414 FLLGQPGS 437 LLG GS Sbjct: 374 VLLGMEGS 381
>PCTK2_RAT (O35831) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 42.4 bits (98), Expect = 0.001 Identities = 41/148 (27%), Positives = 61/148 (41%), Gaps = 4/148 (2%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALK---LEHRRSKGCSYGPPFE 170 + YI KLG+G + VY GR ++T VALK LEH C+ E Sbjct: 190 ETYIKLEKLGEGTYATVYKGRSKLTENL---------VALKEIRLEHEEGAPCT--AIRE 238 Query: 171 WQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 + + L I ++H LV + L L + G MS H V + Sbjct: 239 VSLLKDLKHA-NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGSIMSMHNVKLFLYQI 297 Query: 351 ISILEKLHSKGFVHGDVKPENFLLGQPG 434 + L H + +H D+KP+N L+ + G Sbjct: 298 LRGLAYCHRRKVLHRDLKPQNLLINERG 325
>PCTK2_MOUSE (Q8K0D0) Serine/threonine-protein kinase PCTAIRE-2 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 2) Length = 523 Score = 42.4 bits (98), Expect = 0.001 Identities = 41/148 (27%), Positives = 61/148 (41%), Gaps = 4/148 (2%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALK---LEHRRSKGCSYGPPFE 170 + YI KLG+G + VY GR ++T VALK LEH C+ E Sbjct: 190 ETYIKLEKLGEGTYATVYKGRSKLTENL---------VALKEIRLEHEEGAPCT--AIRE 238 Query: 171 WQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 + + L I ++H LV + L L + G MS H V + Sbjct: 239 VSLLKDLKHA-NIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQI 297 Query: 351 ISILEKLHSKGFVHGDVKPENFLLGQPG 434 + L H + +H D+KP+N L+ + G Sbjct: 298 LRGLAYCHRRKVLHRDLKPQNLLINERG 325
>AFSK_STRCO (P54741) Serine/threonine protein kinase afsK (EC 2.7.11.1)| Length = 799 Score = 42.4 bits (98), Expect = 0.001 Identities = 36/141 (25%), Positives = 59/141 (41%), Gaps = 4/141 (2%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVA----LKLEHRRSKGCSYGPPFEWQVYQSL 191 +LG GG G VY+ R +G E+A ++ R E + +++ Sbjct: 21 RLGAGGMGLVYLARSASGRRVAIKTVRTELAEDQLFRVRFTR----------EVEAARAV 70 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 +G Y V R ++ + PSL ++ N G M + V +A L+ + Sbjct: 71 SGFYTAAVVDADPRAAVPWLATAYVPAPSLEEIVNECGP-MPAQAVRWLAAGVAEALQSI 129 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H G VH D+KP N L+ + G Sbjct: 130 HGAGLVHRDLKPSNVLVVEDG 150
>CDC7_MOUSE (Q9Z0H0) Cell division cycle 7-related protein kinase (EC 2.7.11.1)| (CDC7-related kinase) (muCdc7) Length = 564 Score = 42.4 bits (98), Expect = 0.001 Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 2/134 (1%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCY 203 K+G+G F VY+ A+ + +E + L+H E Q G Sbjct: 57 KIGEGTFSSVYL-------ATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCLTVAGGQD 109 Query: 204 GIPSVHYKGRQGDYYILVMDMLG-PSLWDVWNSMG-QAMSSHMVACIAVESISILEKLHS 377 + + Y R+ D+ ++ M L S D+ NS+ Q + +M L+++H Sbjct: 110 NVMGLKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMYNLFVA-----LKRIHQ 164 Query: 378 KGFVHGDVKPENFL 419 G VH DVKP NFL Sbjct: 165 FGIVHRDVKPSNFL 178
>ATG1_CANGA (Q6FL58) Serine/threonine-protein kinase ATG1 (EC 2.7.11.1)| (Autophagy-related protein 1) Length = 942 Score = 42.4 bits (98), Expect = 0.001 Identities = 42/168 (25%), Positives = 64/168 (38%), Gaps = 27/168 (16%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHR---RSKGCSYGPPFEWQV 179 Y+ ++++GKG F VY G T S +A+K R ++K E + Sbjct: 11 YVVEKEIGKGSFATVYRGHVTTDPKSH-------IAVKAVARSKLKNKKLLENLEIEIAI 63 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDMLG------------------PSLWDVWNSMG 305 + + + + + + D+Y LVMD P L V+N Sbjct: 64 LKKIKHPHIVGLIDCERTTTDFY-LVMDYCALGDLTFLIKKRKELENNHPLLQTVFNKYP 122 Query: 306 QAMSSH------MVACIAVESISILEKLHSKGFVHGDVKPENFLLGQP 431 H V C + S L+ L SK VH D+KP+N LL P Sbjct: 123 PPSKEHNGLNRAFVVCYLQQLASALKFLRSKNLVHRDIKPQNLLLATP 170
>PAK3_RAT (Q62829) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (p65-PAK) Length = 544 Score = 42.0 bits (97), Expect = 0.001 Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 5/148 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y K+G+G G VY I G EVA+K + + + P E + + Sbjct: 268 YTRFEKIGQGASGTVYTALDIATGQ--------EVAIKQMNLQQQ-----PKKELIINEI 314 Query: 189 L----NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 L N I + GD +VM+ L G SL DV M +A + E + Sbjct: 315 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECL 372 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPGS 437 L+ LHS +H D+K +N LLG GS Sbjct: 373 QALDFLHSNQVIHRDIKSDNILLGMDGS 400
>MAK_MOUSE (Q04859) Serine/threonine-protein kinase MAK (EC 2.7.11.22) (Male| germ cell-associated kinase) (Protein kinase RCK) Length = 622 Score = 42.0 bits (97), Expect = 0.001 Identities = 32/149 (21%), Positives = 59/149 (39%), Gaps = 8/149 (5%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y T ++LG G +G V +G+ G VA+K R+ + W + Sbjct: 4 YTTMKQLGDGTYGSVLMGKSNESGEL--------VAIKRMKRKF--------YSWDECMN 47 Query: 189 LNGCYGIPSVHYKG--------RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAV 344 L + +++ R+ D+ V + + +L+ + + ++ I Sbjct: 48 LREVKSLKKLNHANVIKLKEVIRENDHLYFVFEYMKENLYQLMKDRNKLFPESVIRNIMY 107 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQP 431 + + L +H GF H D+KPEN L P Sbjct: 108 QILQGLAFIHKHGFFHRDMKPENLLCMGP 136
>MRCKG_HUMAN (Q6DT37) Serine/threonine-protein kinase MRCK gamma (EC 2.7.11.1)| (CDC42-binding protein kinase gamma) (Myotonic dystrophy kinase-related CDC42-binding kinase gamma) (Myotonic dystrophy protein kinase-like alpha) (MRCK gamma) (DMPK-like gamma Length = 1551 Score = 42.0 bits (97), Expect = 0.001 Identities = 23/77 (29%), Positives = 36/77 (46%), Gaps = 1/77 (1%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 + ++HY + +Y LVMD G L + + + + E + + LH G Sbjct: 131 VTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLG 190 Query: 384 FVHGDVKPENFLLGQPG 434 +VH DVKP+N LL G Sbjct: 191 YVHRDVKPDNVLLDVNG 207
>PAK3_PONPY (Q7YQL3) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 42.0 bits (97), Expect = 0.001 Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 5/148 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y K+G+G G VY I G EVA+K + + + P E + + Sbjct: 283 YTRFEKIGQGASGTVYTALDIATGQ--------EVAIKQMNLQQQ-----PKKELIINEI 329 Query: 189 L----NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 L N I + GD +VM+ L G SL DV M +A + E + Sbjct: 330 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECL 387 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPGS 437 L+ LHS +H D+K +N LLG GS Sbjct: 388 QALDFLHSNQVIHRDIKSDNILLGMDGS 415
>PAK3_PANTR (Q7YQL4) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) Length = 559 Score = 42.0 bits (97), Expect = 0.001 Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 5/148 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y K+G+G G VY I G EVA+K + + + P E + + Sbjct: 283 YTRFEKIGQGASGTVYTALDIATGQ--------EVAIKQMNLQQQ-----PKKELIINEI 329 Query: 189 L----NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 L N I + GD +VM+ L G SL DV M +A + E + Sbjct: 330 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECL 387 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPGS 437 L+ LHS +H D+K +N LLG GS Sbjct: 388 QALDFLHSNQVIHRDIKSDNILLGMDGS 415
>PAK3_MOUSE (Q61036) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (CDC42/RAC effector kinase PAK-B) Length = 559 Score = 42.0 bits (97), Expect = 0.001 Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 5/148 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y K+G+G G VY I G EVA+K + + + P E + + Sbjct: 283 YTRFEKIGQGASGTVYTALDIATGQ--------EVAIKQMNLQQQ-----PKKELIINEI 329 Query: 189 L----NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 L N I + GD +VM+ L G SL DV M +A + E + Sbjct: 330 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECL 387 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPGS 437 L+ LHS +H D+K +N LLG GS Sbjct: 388 QALDFLHSNQVIHRDIKSDNILLGMDGS 415
>PAK3_HUMAN (O75914) Serine/threonine-protein kinase PAK 3 (EC 2.7.11.1)| (p21-activated kinase 3) (PAK-3) (Beta-PAK) (Oligophrenin-3) Length = 559 Score = 42.0 bits (97), Expect = 0.001 Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 5/148 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y K+G+G G VY I G EVA+K + + + P E + + Sbjct: 283 YTRFEKIGQGASGTVYTALDIATGQ--------EVAIKQMNLQQQ-----PKKELIINEI 329 Query: 189 L----NGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 L N I + GD +VM+ L G SL DV M +A + E + Sbjct: 330 LVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET--CMDEGQIAAVCRECL 387 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPGS 437 L+ LHS +H D+K +N LLG GS Sbjct: 388 QALDFLHSNQVIHRDIKSDNILLGMDGS 415
>PKNL_MYCTU (O53510) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 42.0 bits (97), Expect = 0.001 Identities = 41/146 (28%), Positives = 61/146 (41%), Gaps = 4/146 (2%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPP---FEWQV 179 Y+ K+ GG VY G + VALK+ R G E + Sbjct: 19 YLVQAKIASGGTSTVYRGLDVRLDRP--------VALKVMDSRYAGDEQFLTRFRLEARA 70 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESIS 356 LN + +V+ +G+ G + LVM+++ G +L ++ G M H V + + Sbjct: 71 VARLNN-RALVAVYDQGKDGRHPFLVMELIEGGTLRELLIERGP-MPPHAVVAVLRPVLG 128 Query: 357 ILEKLHSKGFVHGDVKPENFLLGQPG 434 L H G VH DVKPEN L+ G Sbjct: 129 GLAAAHRAGLVHRDVKPENILISDDG 154
>PKNL_MYCBO (Q7TYY6) Probable serine/threonine-protein kinase pknL (EC| 2.7.11.1) Length = 399 Score = 42.0 bits (97), Expect = 0.001 Identities = 41/146 (28%), Positives = 61/146 (41%), Gaps = 4/146 (2%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPP---FEWQV 179 Y+ K+ GG VY G + VALK+ R G E + Sbjct: 19 YLVQAKIASGGTSTVYRGLDVRLDRP--------VALKVMDARYAGDEQFLTRFRLEARA 70 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESIS 356 LN + +V+ +G+ G + LVM+++ G +L ++ G M H V + + Sbjct: 71 VARLNN-RALVAVYDQGKDGRHPFLVMELIEGGTLRELLIERGP-MPPHAVVAVLRPVLG 128 Query: 357 ILEKLHSKGFVHGDVKPENFLLGQPG 434 L H G VH DVKPEN L+ G Sbjct: 129 GLAAAHRAGLVHRDVKPENILISDDG 154
>BUB1_MOUSE (O08901) Mitotic checkpoint serine/threonine-protein kinase BUB1| (EC 2.7.11.1) (MBUB1) (BUB1A) Length = 1058 Score = 42.0 bits (97), Expect = 0.001 Identities = 16/44 (36%), Positives = 29/44 (65%) Frame = +3 Query: 294 NSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPENFLLG 425 N+ + M +V A+ + ++E++HS +HGD+KP+NF+LG Sbjct: 857 NTSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILG 900
>GPRK2_DROME (P32866) G protein-coupled receptor kinase 2 (EC 2.7.11.16)| Length = 714 Score = 42.0 bits (97), Expect = 0.001 Identities = 45/145 (31%), Positives = 64/145 (44%), Gaps = 7/145 (4%) Frame = +3 Query: 21 RKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALKLEHRR---SKGCSYGPPFEWQVYQS 188 R LGKGGFG+V + R TG KLE +R KG S E Q+ Q Sbjct: 313 RVLGKGGFGEVCACQVRATG--------KMYACKKLEKKRIKKRKGESM-VLIEKQILQK 363 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQ-AMSSHMVACIAVESISI 359 +N + + ++ Y D LV+ ++ G + ++N G+ A E Sbjct: 364 INSPF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGGEPGFELERARFYAAEVACG 422 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L+ LH +G V+ D KPEN LL G Sbjct: 423 LQHLHKQGIVYRDCKPENILLDDHG 447
>CDPK2_ORYSA (P53683) Calcium-dependent protein kinase, isoform 2 (EC 2.7.11.1)| (CDPK 2) Length = 533 Score = 42.0 bits (97), Expect = 0.001 Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 6/144 (4%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRR---SKGCSYGPPFEWQV 179 Y ++LG+G FG Y+ I G + A K +R SK E Q+ Sbjct: 85 YSLGKELGRGQFGVTYLCTEIASGK--------QYACKSISKRKLVSKADKEDIRREIQI 136 Query: 180 YQSLNGCYGIPSVHYKGRQGD---YYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 Q L+G I V ++G D ++++ G L+D + G S A I Sbjct: 137 MQHLSGQQNI--VEFRGAYEDKSNVHVVMELCAGGELFDRIIAKGH-YSERAAATICRAV 193 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 ++++ H G +H D+KPENFLL Sbjct: 194 VNVVNICHFMGVMHRDLKPENFLL 217
>SHK1_SCHPO (P50527) Serine/threonine-protein kinase pak1/shk1 (EC 2.7.11.1)| Length = 658 Score = 41.6 bits (96), Expect = 0.002 Identities = 37/140 (26%), Positives = 61/140 (43%), Gaps = 3/140 (2%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVALK---LEHRRSKGCSYGPPFEWQVYQSLN 194 K+G+G G VY R++ S VA+K + + K + + N Sbjct: 391 KIGQGASGDVYSARQVGTNLS--------VAIKKMNINQQPKKEFIVNEILVMKSHHHKN 442 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLH 374 I + YK + ++++ M G SL +V + +S +A I E++ L+ LH Sbjct: 443 IVNFIDTFFYKS---ELWMVMEYMRGGSLTEVVTN--NTLSEGQIAAICKETLEGLQHLH 497 Query: 375 SKGFVHGDVKPENFLLGQPG 434 G VH D+K +N LL G Sbjct: 498 ENGIVHRDIKSDNILLSLQG 517
>GRK7_SPETR (Q9Z2G7) G protein-coupled receptor kinase 7 precursor (EC| 2.7.11.16) (G protein-coupled receptor kinase GRK7) Length = 548 Score = 41.6 bits (96), Expect = 0.002 Identities = 39/146 (26%), Positives = 64/146 (43%), Gaps = 3/146 (2%) Frame = +3 Query: 9 YITD-RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQ 185 Y T+ R LGKGGFG+V + TG L + + KG E ++ + Sbjct: 185 YFTEFRVLGKGGFGEVCAVQ-----VRNTGKMYACKKLDKKRLKKKGGEKMALLEKEILE 239 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESISI 359 +N + I S+ Y + LVM ++ G + ++N + ++ V + Sbjct: 240 KVNSPF-IVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLAMSRVIFYTAQMTCG 298 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPGS 437 + LH G V+ D+KPEN LL G+ Sbjct: 299 VLHLHGLGIVYRDLKPENVLLDDLGN 324
>KS6A5_MOUSE (Q8C050) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1) (Nuclear| mitogen-and stress-activated protein kinase 1) (90 kDa ribosomal protein S6 kinase 5) (RSK-like protein kinase) (RLSK) Length = 863 Score = 41.6 bits (96), Expect = 0.002 Identities = 38/144 (26%), Positives = 61/144 (42%), Gaps = 8/144 (5%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGG------ASRTGPDAYEV--ALKLEHRRSKGCSYGPPFEWQVY 182 LG G +G+V++ R+I+G A + A V A EH R+ E QV Sbjct: 54 LGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRT---------ERQVL 104 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 + + + ++HY + L++D + S + + H V E + L Sbjct: 105 EHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLAL 164 Query: 363 EKLHSKGFVHGDVKPENFLLGQPG 434 E LH G ++ D+K EN LL G Sbjct: 165 EHLHKLGIIYRDIKLENILLDSNG 188
>KAPC_ENCCU (Q8SRK8) Probable cAMP-dependent protein kinase catalytic subunit| (EC 2.7.11.11) Length = 322 Score = 41.6 bits (96), Expect = 0.002 Identities = 32/136 (23%), Positives = 54/136 (39%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCYG 206 +G G FG+V++ R + S + L R + E + + + GC Sbjct: 13 VGVGAFGKVHLVRLKSSPTSVFAMKMLDFGEILRQRLADQLEN----EISILKRIYGCPF 68 Query: 207 IPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGF 386 + ++ G L+M+ +G W M A E IS L +H +G Sbjct: 69 VAKLYSTDFHGGKVGLIMEYVGGGELFYWLKKCGRFDEQMARFYAAEIISALRFIHGRGI 128 Query: 387 VHGDVKPENFLLGQPG 434 ++ D+KPEN L+ G Sbjct: 129 LYRDLKPENILITSTG 144
>CDPK_DAUCA (P28582) Calcium-dependent protein kinase (EC 2.7.11.1) (CDPK)| Length = 532 Score = 41.6 bits (96), Expect = 0.002 Identities = 45/144 (31%), Positives = 66/144 (45%), Gaps = 6/144 (4%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRR-SKGCSYGPPFEWQVYQ 185 Y ++LG+G FG VY + G Y L+ + SK E Q+ Q Sbjct: 81 YTLGKELGRGQFGCVYQCTENSSG------QLYACKSILKRKLVSKNDKEDIKREIQILQ 134 Query: 186 SLNGCYGIPSVHYKG----RQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVES 350 L+G I V +KG RQ + LVM++ G L+D + G S A I + Sbjct: 135 HLSGQPNI--VEFKGVFEDRQSVH--LVMELCAGGELFDRIIAQGH-YSERAAATICRQI 189 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 ++++ H G +H D+KPENFLL Sbjct: 190 VNVVHVCHFMGVMHRDLKPENFLL 213
>BUB1_SCHPO (O94751) Checkpoint serine/threonine-protein kinase bub1 (EC| 2.7.11.1) Length = 1044 Score = 41.6 bits (96), Expect = 0.002 Identities = 44/147 (29%), Positives = 63/147 (42%), Gaps = 14/147 (9%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRI----TGGASRTGPDAYE---VALKLEHRRSKGCSYGPPFEWQVY 182 KLG+G F VY+ + G S+ G + E ALK+E S Y Sbjct: 723 KLGQGAFAPVYLVKSKIETENGDVSQGGAENNESKLFALKIETPPSCFEFYLTRQAMTRL 782 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGP-SLWDVWNSM------GQAMSSHMVACIA 341 + L I VH D L+MD S+ D+ NSM M +V + Sbjct: 783 KGLRETNSILPVHQLHMFHDTSHLLMDYRPQGSILDLVNSMHNSTFSSSGMDEILVVFFS 842 Query: 342 VESISILEKLHSKGFVHGDVKPENFLL 422 +E + I+E LH+ +HGD+K +N LL Sbjct: 843 IEFLRIIEALHTHKIIHGDLKADNALL 869
>KAD5_SCHPO (Q09831) Probable serine/threonine-protein kinase C4G8.05 (EC| 2.7.11.1) Length = 566 Score = 41.6 bits (96), Expect = 0.002 Identities = 41/139 (29%), Positives = 65/139 (46%), Gaps = 3/139 (2%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEH-RRSKGCSYGPPFEWQVYQSLNGCY 203 LGKG G+VY+ R G A +V K E +R+K S E + + N + Sbjct: 201 LGKGDVGRVYLVREKKSGKFY----AMKVLSKQEMIKRNK--SKRAFAEQHILATSNHPF 254 Query: 204 GIPSVHYKGRQGDYYILVMD--MLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHS 377 I ++++ + +Y L M+ M G + G+ +S + E + LE LH Sbjct: 255 -IVTLYHSFQSDEYLYLCMEYCMGGEFFRALQRRPGRCLSENEAKFYIAEVTAALEYLHL 313 Query: 378 KGFVHGDVKPENFLLGQPG 434 GF++ D+KPEN LL + G Sbjct: 314 MGFIYRDLKPENILLHESG 332
>CTRO_HUMAN (O14578) Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK)| (Rho-interacting, serine/threonine-protein kinase 21) Length = 2027 Score = 41.6 bits (96), Expect = 0.002 Identities = 22/77 (28%), Positives = 38/77 (49%), Gaps = 1/77 (1%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 IP + Y + ++ LVM+ G L + N + +++ E I + +H G Sbjct: 157 IPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMG 216 Query: 384 FVHGDVKPENFLLGQPG 434 +VH D+KPEN L+ + G Sbjct: 217 YVHRDIKPENILVDRTG 233
>PK1_STRTO (Q9KIG4) Serine/threonine-protein kinase PK-1 (EC 2.7.11.1)| (stoPK-1) Length = 641 Score = 41.6 bits (96), Expect = 0.002 Identities = 27/77 (35%), Positives = 37/77 (48%), Gaps = 1/77 (1%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 + V +G G Y L M+ + G +L DV G A+ I ++ L H G Sbjct: 78 VVQVFDQGTDGAYVYLAMEYIAGCTLRDVLRERG-ALQPRAALDILEPVLAALGAAHRAG 136 Query: 384 FVHGDVKPENFLLGQPG 434 FVH D+KPEN L+G G Sbjct: 137 FVHRDMKPENVLIGDDG 153
>GRK5_BOVIN (P43249) G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK5) Length = 590 Score = 41.6 bits (96), Expect = 0.002 Identities = 41/141 (29%), Positives = 63/141 (44%), Gaps = 3/141 (2%) Frame = +3 Query: 21 RKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGGFG+V + R TG A + K ++ KG S E Q+ + +N Sbjct: 190 RVLGKGGFGEVCACQVRATGKMY-----ACKRLEKKRIKKRKGESMALN-EKQILEKVNS 243 Query: 198 CYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 + + ++ Y D LV+ ++ G + ++N A E + LE L Sbjct: 244 RF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H + V+ D+KPEN LL G Sbjct: 303 HHENIVYRDLKPENILLDDYG 323
>CBK1_DEBHA (Q6BLJ9) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 716 Score = 41.6 bits (96), Expect = 0.002 Identities = 35/141 (24%), Positives = 62/141 (43%), Gaps = 1/141 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQV-YVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQV 179 + + T + +GKG FG+V V +R TG A + LK E + ++ E V Sbjct: 313 EDFNTVKVIGKGAFGEVRLVQKRDTGKIY-----AMKTLLKSEMYKKDQLAHVKA-ERDV 366 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 + + + S++Y + Y L+M+ L Q + + E + Sbjct: 367 LAGSDSPW-VVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDITRFYMAECVLA 425 Query: 360 LEKLHSKGFVHGDVKPENFLL 422 +E +H GF+H D+KP+N L+ Sbjct: 426 IEAIHKLGFIHRDIKPDNILI 446
>CBK1_CANGA (Q6FP74) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 773 Score = 41.2 bits (95), Expect = 0.002 Identities = 36/141 (25%), Positives = 62/141 (43%), Gaps = 1/141 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQV-YVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQV 179 + + T + +GKG FG+V V ++ TG A + LK E + ++ E V Sbjct: 368 EDFHTVQVIGKGAFGEVRLVQKKDTGKIY-----AMKTLLKSEMYKKDQLAHVKA-ERDV 421 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 + + I S++Y + Y L+M+ L Q + + E I Sbjct: 422 LAGTDSPW-IVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILA 480 Query: 360 LEKLHSKGFVHGDVKPENFLL 422 +E +H GF+H D+KP+N L+ Sbjct: 481 IETIHKLGFIHRDIKPDNILI 501
>KS6A2_MOUSE (Q9WUT3) Ribosomal protein S6 kinase alpha-2 (EC 2.7.11.1)| (S6K-alpha 2) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) (Protein-tyrosine kinase Mpk-9) (MAP kinase-activated protein kinase 1c) (M Length = 733 Score = 41.2 bits (95), Expect = 0.002 Identities = 38/142 (26%), Positives = 65/142 (45%), Gaps = 6/142 (4%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITG---GASRTGPDAYEVALKLEHR-RSKGCSYGPPFEWQVYQSLN 194 LG+G +G+V++ R++TG G + LK+ R RSK E + +N Sbjct: 65 LGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSK-------MERDILAEVN 117 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEK 368 + I +HY + L++D L D++ + + + + V E L+ Sbjct: 118 HPF-IVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALALDH 174 Query: 369 LHSKGFVHGDVKPENFLLGQPG 434 LH G ++ D+KPEN LL + G Sbjct: 175 LHGLGIIYRDLKPENILLDEEG 196 Score = 33.5 bits (75), Expect = 0.45 Identities = 25/71 (35%), Positives = 39/71 (54%), Gaps = 3/71 (4%) Frame = +3 Query: 237 GDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESIS-ILEKLHSKGFVHGDVKPE 410 G Y LVM+++ G L D + Q S A + +I+ ++ LHS+G VH D+KP Sbjct: 479 GKYVYLVMELMRGGELLD--RILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPS 536 Query: 411 NFL-LGQPGSP 440 N L + + G+P Sbjct: 537 NILYMDESGNP 547
>KS6A3_MOUSE (P18654) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (MAP kinase-activated protein kinase 1b) (MAPKAPK1B) Length = 740 Score = 41.2 bits (95), Expect = 0.002 Identities = 38/142 (26%), Positives = 67/142 (47%), Gaps = 6/142 (4%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASR---TGPDAYEVALKLEHR-RSKGCSYGPPFEWQVYQSLN 194 LG+G FG+V++ ++I+G +R + LK+ R R+K E + +N Sbjct: 74 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK-------MERDILVEVN 126 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEK 368 + I +HY + L++D L D++ + + + + V E L+ Sbjct: 127 HPF-IVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALALDH 183 Query: 369 LHSKGFVHGDVKPENFLLGQPG 434 LHS G ++ D+KPEN LL + G Sbjct: 184 LHSLGIIYRDLKPENILLDEEG 205 Score = 30.0 bits (66), Expect = 5.0 Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 2/67 (2%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESIS-ILEKLHSKGFVHGDVKPENFL- 419 Y++ M G L D + Q S A + +I+ +E LH++G VH D+KP N L Sbjct: 490 YVVTELMKGGELLD--KILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILY 547 Query: 420 LGQPGSP 440 + + G+P Sbjct: 548 VDESGNP 554
>KS6A3_HUMAN (P51812) Ribosomal protein S6 kinase alpha-3 (EC 2.7.11.1)| (S6K-alpha 3) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protei Length = 740 Score = 41.2 bits (95), Expect = 0.002 Identities = 38/142 (26%), Positives = 67/142 (47%), Gaps = 6/142 (4%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASR---TGPDAYEVALKLEHR-RSKGCSYGPPFEWQVYQSLN 194 LG+G FG+V++ ++I+G +R + LK+ R R+K E + +N Sbjct: 74 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTK-------MERDILVEVN 126 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEK 368 + I +HY + L++D L D++ + + + + V E L+ Sbjct: 127 HPF-IVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALALDH 183 Query: 369 LHSKGFVHGDVKPENFLLGQPG 434 LHS G ++ D+KPEN LL + G Sbjct: 184 LHSLGIIYRDLKPENILLDEEG 205 Score = 30.0 bits (66), Expect = 5.0 Identities = 22/67 (32%), Positives = 35/67 (52%), Gaps = 2/67 (2%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESIS-ILEKLHSKGFVHGDVKPENFL- 419 Y++ M G L D + Q S A + +I+ +E LH++G VH D+KP N L Sbjct: 490 YVVTELMKGGELLD--KILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILY 547 Query: 420 LGQPGSP 440 + + G+P Sbjct: 548 VDESGNP 554
>MDE3_SCHPO (O43077) Sporulation protein kinase mde3 (EC 2.7.11.1)| (Mei4-dependent protein 3) Length = 559 Score = 41.2 bits (95), Expect = 0.002 Identities = 40/144 (27%), Positives = 65/144 (45%), Gaps = 6/144 (4%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYE-VALKLEHRRSKGCSYGPPFEWQVYQ 185 Y+ +KLG G FG VY+ +R + YE VA+K SK + + Sbjct: 21 YLVKQKLGDGSFGTVYLAQR------KEKNGLYETVAVKKLKNSSKPKPKHELLKLRESL 74 Query: 186 SLNGCYGIPS-VHYKGRQGDYY---ILVMDMLGPSLWDVWNS-MGQAMSSHMVACIAVES 350 +L P + D Y LVM+ + +L+ ++ G+ + I ++ Sbjct: 75 ALRKISKHPCLIDLLETFMDPYRNIFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQI 134 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 IS +E +H GF+H D+KPEN L+ Sbjct: 135 ISGIEHIHKHGFMHRDIKPENILV 158
>PMYT1_HUMAN (Q99640) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 499 Score = 41.2 bits (95), Expect = 0.002 Identities = 23/67 (34%), Positives = 33/67 (49%) Frame = +3 Query: 234 QGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPEN 413 +G L ++ GPSL + G ++ V +++ L LHS+G VH DVKP N Sbjct: 179 EGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPAN 238 Query: 414 FLLGQPG 434 LG G Sbjct: 239 IFLGPRG 245
>PAK1_CAEEL (Q17850) Serine/threonine-protein kinase pak-1 (EC 2.7.11.1)| (p21-activated kinase 1) (PAK1) (CePAK) Length = 572 Score = 41.2 bits (95), Expect = 0.002 Identities = 22/66 (33%), Positives = 36/66 (54%) Frame = +3 Query: 240 DYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPENFL 419 + ++++ + G SL DV M ++A + E + LE LHS+ +H D+K +N L Sbjct: 364 ELWVVMEYLAGGSLTDVVTEC--QMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNIL 421 Query: 420 LGQPGS 437 LG GS Sbjct: 422 LGMDGS 427
>IPL1_YEAST (P38991) Spindle assembly checkpoint kinase (EC 2.7.11.1) (Aurora| kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 41.2 bits (95), Expect = 0.002 Identities = 37/138 (26%), Positives = 62/138 (44%), Gaps = 3/138 (2%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALK-LEHRRSKGCSYGPPF--EWQVYQSL 191 +KLGKG FG+VY R + G Y ALK +E + F E ++ SL Sbjct: 108 KKLGKGKFGKVYCVRHRSTG--------YICALKVMEKEEIIKYNLQKQFRREVEIQTSL 159 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 N S Y + Y+L+ ++ ++ + G + + + + + L+ + Sbjct: 160 NHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGP-FNDILASDYIYQIANALDYM 218 Query: 372 HSKGFVHGDVKPENFLLG 425 H K +H D+KPEN L+G Sbjct: 219 HKKNIIHRDIKPENILIG 236
>PMYT1_MOUSE (Q9ESG9) Membrane-associated tyrosine- and threonine-specific| cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) Length = 490 Score = 41.2 bits (95), Expect = 0.002 Identities = 23/67 (34%), Positives = 33/67 (49%) Frame = +3 Query: 234 QGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPEN 413 +G L ++ GPSL + G ++ V + + L+ LHS+G VH DVKP N Sbjct: 170 EGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDILLALDHLHSQGLVHLDVKPAN 229 Query: 414 FLLGQPG 434 LG G Sbjct: 230 IFLGPRG 236
>KS6A5_PONPY (Q5R4K3) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 802 Score = 41.2 bits (95), Expect = 0.002 Identities = 36/137 (26%), Positives = 59/137 (43%), Gaps = 1/137 (0%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGP-DAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCY 203 LG G +G+V++ R+I+G TG A +V K + + E QV + Sbjct: 55 LGTGAYGKVFLVRKISG--HDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHTRQSP 112 Query: 204 GIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 + ++HY + L++D + S + + H V E + LE LH G Sbjct: 113 FLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLG 172 Query: 384 FVHGDVKPENFLLGQPG 434 ++ D+K EN LL G Sbjct: 173 IIYRDIKLENILLDSNG 189 Score = 29.3 bits (64), Expect = 8.5 Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 4/82 (4%) Frame = +3 Query: 186 SLNGCYGIPSV---HYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESI 353 +L C G P++ H + LVM++L G L++ + S + I + + Sbjct: 471 ALKLCEGHPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKK-KHFSETEASYIMRKLV 529 Query: 354 SILEKLHSKGFVHGDVKPENFL 419 S + +H G VH D+KPEN L Sbjct: 530 SAVSHMHDVGVVHRDLKPENLL 551
>KCC2_YEAST (P22517) Calcium/calmodulin-dependent protein kinase II (EC| 2.7.11.17) Length = 447 Score = 41.2 bits (95), Expect = 0.002 Identities = 40/138 (28%), Positives = 61/138 (44%), Gaps = 1/138 (0%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQ 185 YI R LG G FG V R+++ T D A ++ LK + + E + Q Sbjct: 47 YIFGRTLGAGSFGVVRQARKLS-----TNEDVAIKILLKKALQGNNVQLQMLYEELSILQ 101 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILE 365 L+ + + + +YI+ G L+D S G+ V I V+ + +E Sbjct: 102 KLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEII-VQILGAVE 160 Query: 366 KLHSKGFVHGDVKPENFL 419 +HSK VH D+KPEN L Sbjct: 161 YMHSKNVVHRDLKPENVL 178
>PIM3_HUMAN (Q86V86) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| Length = 326 Score = 40.8 bits (94), Expect = 0.003 Identities = 41/150 (27%), Positives = 67/150 (44%), Gaps = 10/150 (6%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALK--LEHRRSKGCSYG---PPF 167 + Y LG GGFG VY G RI D VA+K ++ R ++ S G P Sbjct: 38 KAYQVGAVLGSGGFGTVYAGSRIA--------DGLPVAVKHVVKERVTEWGSLGGATVPL 89 Query: 168 EWQVYQSL---NGCYGIPSVHYKGRQGDYYILVMDMLGPS--LWDVWNSMGQAMSSHMVA 332 E + + + G G+ + + D ++LV++ P+ L+D G A+ + Sbjct: 90 EVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERG-ALDEPLAR 148 Query: 333 CIAVESISILEKLHSKGFVHGDVKPENFLL 422 + ++ + HS G VH D+K EN L+ Sbjct: 149 RFFAQVLAAVRHCHSCGVVHRDIKDENLLV 178
>CDPK_SOYBN (P28583) Calcium-dependent protein kinase SK5 (EC 2.7.11.1) (CDPK)| Length = 508 Score = 40.8 bits (94), Expect = 0.003 Identities = 40/144 (27%), Positives = 59/144 (40%), Gaps = 5/144 (3%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVY-VGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEW-- 173 + Y RKLG+G FG + RR +GG + A K +R C W Sbjct: 32 EVYEVGRKLGQGQFGTTFECTRRASGG---------KFACKSIPKRKLLCKEDYEDVWRE 82 Query: 174 -QVYQSLNGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVE 347 Q+ L+ + + LVM++ G L+D G S A + Sbjct: 83 IQIMHHLSEHANVVRIEGTYEDSTAVHLVMELCEGGELFDRIVQKGH-YSERQAARLIKT 141 Query: 348 SISILEKLHSKGFVHGDVKPENFL 419 + ++E HS G +H D+KPENFL Sbjct: 142 IVEVVEACHSLGVMHRDLKPENFL 165
>CBK1_ASHGO (Q754N7) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 719 Score = 40.8 bits (94), Expect = 0.003 Identities = 35/141 (24%), Positives = 62/141 (43%), Gaps = 1/141 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQV-YVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQV 179 + + T + +GKG FG+V V ++ TG A + LK E + ++ E V Sbjct: 308 EDFHTVKVIGKGAFGEVRLVQKKDTGKIY-----AMKTLLKSEMYKKDQLAHVKA-ERDV 361 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 + + + S++Y + Y L+M+ L Q + + E I Sbjct: 362 LAGSDSPW-VVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQIFTEDVTRFYMAECILA 420 Query: 360 LEKLHSKGFVHGDVKPENFLL 422 +E +H GF+H D+KP+N L+ Sbjct: 421 IEAIHKLGFIHRDIKPDNILI 441
>KC1D_RABIT (P81123) Casein kinase I isoform delta (EC 2.7.11.1) (CKI-delta)| (CKId) (Fragment) Length = 81 Score = 40.8 bits (94), Expect = 0.003 Identities = 17/42 (40%), Positives = 29/42 (69%) Frame = +1 Query: 454 LFLIDLGLASKWKKASSSQHVEYDQRPDIFRGTIRYASVHAH 579 +++ID GLA K++ A + QH+ Y + ++ GT RYAS++ H Sbjct: 18 VYIIDFGLAKKYRDARTHQHIPYRENKNL-TGTARYASINTH 58
>CBK1_YEAST (P53894) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1) (Cell| wall biosynthesis kinase) Length = 756 Score = 40.8 bits (94), Expect = 0.003 Identities = 35/141 (24%), Positives = 62/141 (43%), Gaps = 1/141 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQV-YVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQV 179 + + T + +GKG FG+V V ++ TG A + LK E + ++ E V Sbjct: 350 EDFHTVKVIGKGAFGEVRLVQKKDTGKIY-----AMKTLLKSEMYKKDQLAHVKA-ERDV 403 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 + + + S++Y + Y L+M+ L Q + + E I Sbjct: 404 LAGSDSPW-VVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILA 462 Query: 360 LEKLHSKGFVHGDVKPENFLL 422 +E +H GF+H D+KP+N L+ Sbjct: 463 IETIHKLGFIHRDIKPDNILI 483
>GRK5_RAT (Q62833) G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK5) Length = 590 Score = 40.8 bits (94), Expect = 0.003 Identities = 41/141 (29%), Positives = 63/141 (44%), Gaps = 3/141 (2%) Frame = +3 Query: 21 RKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGGFG+V + R TG A + K ++ KG S E Q+ + +N Sbjct: 190 RVLGKGGFGEVCACQVRATGKMY-----ACKRLEKKRIKKRKGESMALN-EKQILEKVNS 243 Query: 198 CYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 + + ++ Y D LV+ ++ G + ++N A E + LE L Sbjct: 244 QF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H + V+ D+KPEN LL G Sbjct: 303 HRENTVYRDLKPENILLDDYG 323
>GRK5_MOUSE (Q8VEB1) G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK5) Length = 590 Score = 40.8 bits (94), Expect = 0.003 Identities = 41/141 (29%), Positives = 63/141 (44%), Gaps = 3/141 (2%) Frame = +3 Query: 21 RKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGGFG+V + R TG A + K ++ KG S E Q+ + +N Sbjct: 190 RVLGKGGFGEVCACQVRATGKMY-----ACKRLEKKRIKKRKGESMALN-EKQILEKVNS 243 Query: 198 CYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 + + ++ Y D LV+ ++ G + ++N A E + LE L Sbjct: 244 QF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H + V+ D+KPEN LL G Sbjct: 303 HRENTVYRDLKPENILLDDYG 323
>GRK5_HUMAN (P34947) G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK5) Length = 590 Score = 40.8 bits (94), Expect = 0.003 Identities = 41/141 (29%), Positives = 63/141 (44%), Gaps = 3/141 (2%) Frame = +3 Query: 21 RKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNG 197 R LGKGGFG+V + R TG A + K ++ KG S E Q+ + +N Sbjct: 190 RVLGKGGFGEVCACQVRATGKMY-----ACKRLEKKRIKKRKGESMALN-EKQILEKVNS 243 Query: 198 CYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 + + ++ Y D LV+ ++ G + ++N A E + LE L Sbjct: 244 QF-VVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H + V+ D+KPEN LL G Sbjct: 303 HRENTVYRDLKPENILLDDYG 323
>KIN82_YEAST (P25341) Probable serine/threonine-protein kinase KIN82 (EC| 2.7.11.1) Length = 720 Score = 40.4 bits (93), Expect = 0.004 Identities = 37/146 (25%), Positives = 62/146 (42%), Gaps = 2/146 (1%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 Q + R LG+G G+VY+ R R + + + +H K Q Sbjct: 322 QSFEKIRLLGQGDVGKVYLMRE------RDTNQIFALKVLNKHEMIKRKKIKRVLTEQEI 375 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMD--MLGPSLWDVWNSMGQAMSSHMVACIAVESIS 356 + + I ++++ + DY L M+ M G + + ++ A E ++ Sbjct: 376 LATSDHPFIVTLYHSFQTKDYLYLCMEYCMGGEFFRALQTRKSKCIAEEDAKFYASEVVA 435 Query: 357 ILEKLHSKGFVHGDVKPENFLLGQPG 434 LE LH GF++ D+KPEN LL Q G Sbjct: 436 ALEYLHLLGFIYRDLKPENILLHQSG 461
>CBK1_YARLI (Q6CFS5) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 588 Score = 40.4 bits (93), Expect = 0.004 Identities = 33/144 (22%), Positives = 63/144 (43%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 + ++T + +GKG FG+V + ++ G A + LK E + ++ E V Sbjct: 205 EDFVTVKVIGKGAFGEVRLVQKRDNGKIY----AMKTMLKKEMDMKEQWAHVKA-ERDVL 259 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 + + I S+++ + Y L+M+ L S + E + + Sbjct: 260 ADSDSPW-IVSLYFSFQDDLYLYLIMEFLPGGDLMTMLIKYDVFSEDITRFYIAECVLAI 318 Query: 363 EKLHSKGFVHGDVKPENFLLGQPG 434 E +H GF+H D+KP+N L+ + G Sbjct: 319 EAIHKLGFIHRDIKPDNILIDKTG 342
>KAPC_DICDI (P34099) cAMP-dependent protein kinase catalytic subunit (EC| 2.7.11.11) Length = 648 Score = 40.4 bits (93), Expect = 0.004 Identities = 43/147 (29%), Positives = 65/147 (44%), Gaps = 9/147 (6%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGG---ASRTGPDAYEVALK-LEHRRSKGC---SYGPPFEWQV 179 R LG G FG+VY+ + G A + AY V LK +EH S+ S PF + Sbjct: 340 RVLGTGTFGKVYLIQNTKDGCYYAMKCLNKAYVVQLKQVEHLNSEKSILSSIHHPFIVNL 399 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESI 353 YQ+ + Y+L + G +V+ + ++M S+ A E + Sbjct: 400 YQAFQD------------EKKLYLLFEYVAGG---EVFTHLRKSMKFSNSTAKFYAAEIV 444 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPG 434 LE LH + V+ D+KPEN L+ G Sbjct: 445 LALEFLHKQNIVYRDLKPENLLIDNQG 471
>MRCKB_HUMAN (Q9Y5S2) Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1)| (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta) Length = 1711 Score = 40.4 bits (93), Expect = 0.004 Identities = 24/84 (28%), Positives = 41/84 (48%), Gaps = 2/84 (2%) Frame = +3 Query: 189 LNG-CYGIPSVHYKGRQGDYYILVMDM-LGPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 +NG C I ++HY + ++ LVMD +G L + + + M E + + Sbjct: 129 VNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAI 188 Query: 363 EKLHSKGFVHGDVKPENFLLGQPG 434 + +H +VH D+KP+N LL G Sbjct: 189 DSIHQLHYVHRDIKPDNVLLDVNG 212
>GRK7_HUMAN (Q8WTQ7) G protein-coupled receptor kinase 7 precursor (EC| 2.7.11.16) (G protein-coupled receptor kinase GRK7) Length = 553 Score = 40.0 bits (92), Expect = 0.005 Identities = 38/146 (26%), Positives = 64/146 (43%), Gaps = 3/146 (2%) Frame = +3 Query: 9 YITD-RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQ 185 Y T+ R LGKGGFG+V + TG L + + KG E ++ + Sbjct: 190 YFTEFRVLGKGGFGEVCAVQ-----VKNTGKMYACKKLDKKRLKKKGGEKMALLEKEILE 244 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESISI 359 ++ + I S+ Y + LVM ++ G + ++N + + V + + Sbjct: 245 KVSSPF-IVSLAYAFESKTHLCLVMSLMNGGDLKFHIYNVGTRGLDMSRVIFYSAQIACG 303 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPGS 437 + LH G V+ D+KPEN LL G+ Sbjct: 304 MLHLHELGIVYRDMKPENVLLDDLGN 329
>CTRO_MOUSE (P49025) Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK)| (Rho-interacting, serine/threonine-protein kinase 21) Length = 2055 Score = 40.0 bits (92), Expect = 0.005 Identities = 22/77 (28%), Positives = 35/77 (45%), Gaps = 1/77 (1%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 IP + Y + + LVM+ G + N + M+ E I + +H G Sbjct: 157 IPQLQYAFQDKNNLYLVMEYQPGGDFLSLLNRYEDQLDESMIQFYLAELILAVHSVHQMG 216 Query: 384 FVHGDVKPENFLLGQPG 434 +VH D+KPEN L+ + G Sbjct: 217 YVHRDIKPENILIDRTG 233
>KCC1_YEAST (P27466) Calcium/calmodulin-dependent protein kinase I (EC| 2.7.11.17) Length = 446 Score = 40.0 bits (92), Expect = 0.005 Identities = 37/138 (26%), Positives = 61/138 (44%), Gaps = 1/138 (0%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQ 185 Y+ + LG G FG V + + TG D A ++ +K + +K E + Q Sbjct: 37 YVFGKTLGAGTFGVVRQAKN-----TETGEDVAVKILIKKALKGNKVQLEALYDELDILQ 91 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILE 365 L+ + + + +YI+ G L+D G+ V I VE +S ++ Sbjct: 92 RLHHPNIVAFKDWFESKDKFYIITQLAKGGELFDRILKKGKFTEEDAVR-ILVEILSAVK 150 Query: 366 KLHSKGFVHGDVKPENFL 419 +HS+ VH D+KPEN L Sbjct: 151 YMHSQNIVHRDLKPENLL 168
>KS6A5_CHICK (Q5F3L1) Ribosomal protein S6 kinase alpha-5 (EC 2.7.11.1)| Length = 789 Score = 40.0 bits (92), Expect = 0.005 Identities = 37/144 (25%), Positives = 61/144 (42%), Gaps = 8/144 (5%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGG------ASRTGPDAYEV--ALKLEHRRSKGCSYGPPFEWQVY 182 LG G +G+V++ R+++G A + A V A EH R+ E QV Sbjct: 45 LGTGAYGKVFLVRKVSGHDAGKLYAMKVLKKATIVQKAKTTEHTRT---------ERQVL 95 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 + + + ++HY + L++D + S + S + V E + L Sbjct: 96 EHIRQSPFLVTLHYAFQTDTKLHLILDYINGGELFTHLSQRERFSENEVQIYIGEIVLAL 155 Query: 363 EKLHSKGFVHGDVKPENFLLGQPG 434 E LH G ++ D+K EN LL G Sbjct: 156 EHLHKLGIIYRDIKLENILLDSDG 179 Score = 29.3 bits (64), Expect = 8.5 Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 5/83 (6%) Frame = +3 Query: 186 SLNGCYGIPSV---HYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVES 350 +L C G P+V H + LVM++L G L + Q S + I Sbjct: 461 ALKLCEGHPNVVKLHEVYHDQLHTFLVMELLKGGELLERIQKK--QHFSETEASHIMRRL 518 Query: 351 ISILEKLHSKGFVHGDVKPENFL 419 +S + +H G VH D+KPEN L Sbjct: 519 VSAVSHMHDVGVVHRDLKPENLL 541
>PKN2_CLOPE (Q8XJL8) Probable serine/threonine protein kinase CPE1738 (EC| 2.7.11.1) Length = 685 Score = 40.0 bits (92), Expect = 0.005 Identities = 23/70 (32%), Positives = 36/70 (51%), Gaps = 1/70 (1%) Frame = +3 Query: 228 GRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVK 404 G Q D +VM+ + G +L D+ G A+ + I ++ LE H G +H DVK Sbjct: 77 GTQDDINYIVMEYVEGKTLKDIIKEKG-ALPYEVAISIGIKVAKALECAHKSGIIHRDVK 135 Query: 405 PENFLLGQPG 434 P+N L+ + G Sbjct: 136 PQNILVTEEG 145
>KGS9_YEAST (P43637) Probable serine/threonine-protein kinase YGL179C (EC| 2.7.11.1) Length = 560 Score = 40.0 bits (92), Expect = 0.005 Identities = 40/155 (25%), Positives = 61/155 (39%), Gaps = 18/155 (11%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYG------PPFEWQVYQS 188 LG G +G+V + R + GA VA+K+ +R K Y P Q + Sbjct: 56 LGNGQYGKVKLARDLGTGAL--------VAIKILNRFEKRSGYSLQLKVENPRVNQEIEV 107 Query: 189 LNGCYGIPSVHYKGRQGD------YYILVMDMLGPSLWDVWNSMG------QAMSSHMVA 332 + C+ V D Y +L GP W N M ++ Sbjct: 108 MKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKAVGPSILTFQQSR 167 Query: 333 CIAVESISILEKLHSKGFVHGDVKPENFLLGQPGS 437 + ++ +S LE LHS+G H D+KP N L+ G+ Sbjct: 168 KVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGT 202
>KAPCG_HUMAN (P22612) cAMP-dependent protein kinase, gamma-catalytic subunit (EC| 2.7.11.11) (PKA C-gamma) Length = 350 Score = 40.0 bits (92), Expect = 0.005 Identities = 37/140 (26%), Positives = 67/140 (47%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 R LG G FG+V + R G G A ++ K + + K + E ++ Q+++ Sbjct: 47 RTLGMGSFGRVMLVRHQETG----GHYAMKILNKQKVVKMKQVEHILN-EKRILQAIDFP 101 Query: 201 YGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACI-AVESISILEKLH 374 + + + + + Y LVM+ + G ++ +G+ H AC A + + ++ LH Sbjct: 102 F-LVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPH--ACFYAAQVVLAVQYLH 158 Query: 375 SKGFVHGDVKPENFLLGQPG 434 S +H D+KPEN L+ Q G Sbjct: 159 SLDLIHRDLKPENLLIDQQG 178
>MP2K6_MOUSE (P70236) Dual specificity mitogen-activated protein kinase kinase 6| (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3) Length = 334 Score = 40.0 bits (92), Expect = 0.005 Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 4/72 (5%) Frame = +3 Query: 231 RQGDYYILVMDMLGPSLWDVWNSM---GQAMSSHMVACIAVESISILEKLHSK-GFVHGD 398 R+GD +I M+++ SL + + GQ + ++ IAV + LE LHSK +H D Sbjct: 121 REGDVWIC-MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRD 179 Query: 399 VKPENFLLGQPG 434 VKP N L+ G Sbjct: 180 VKPSNVLINTLG 191
>MP2K6_HUMAN (P52564) Dual specificity mitogen-activated protein kinase kinase 6| (EC 2.7.12.2) (MAP kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3) Length = 334 Score = 40.0 bits (92), Expect = 0.005 Identities = 26/72 (36%), Positives = 39/72 (54%), Gaps = 4/72 (5%) Frame = +3 Query: 231 RQGDYYILVMDMLGPSLWDVWNSM---GQAMSSHMVACIAVESISILEKLHSK-GFVHGD 398 R+GD +I M+++ SL + + GQ + ++ IAV + LE LHSK +H D Sbjct: 121 REGDVWIC-MELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRD 179 Query: 399 VKPENFLLGQPG 434 VKP N L+ G Sbjct: 180 VKPSNVLINALG 191
>KS6B2_MOUSE (Q9Z1M4) Ribosomal protein S6 kinase beta-2 (EC 2.7.11.1) (S6K-beta| 2) (70 kDa ribosomal protein S6 kinase 2) (p70-S6KB) (p70 ribosomal S6 kinase beta) (p70 S6Kbeta) (S6K2) Length = 485 Score = 40.0 bits (92), Expect = 0.005 Identities = 36/141 (25%), Positives = 64/141 (45%), Gaps = 5/141 (3%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF----EWQVYQSLN 194 LGKGG+G+V+ R++ G + G A+K+ + CS E + +S+ Sbjct: 73 LGKGGYGKVFQVRKVQG--TNLGKI---YAMKVLRKAKIVCSAKDTAHTRAERNILESVK 127 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI-LEKL 371 + + + G Y+++ + G L+ G + AC + I++ L L Sbjct: 128 HPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLED--TACFYLAEITLALGHL 185 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 HS G ++ D+KPEN +L G Sbjct: 186 HSHGIIYRDLKPENIMLSSQG 206
>ULK1_MOUSE (O70405) Serine/threonine-protein kinase ULK1 (EC 2.7.11.1)| (Unc-51-like kinase 1) (Serine/threonine-protein kinase Unc51.1) Length = 1051 Score = 40.0 bits (92), Expect = 0.005 Identities = 36/137 (26%), Positives = 61/137 (44%), Gaps = 1/137 (0%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGP-PFEWQVYQSLNGCY 203 +G G F V+ GR R D EVA+K ++++ S E ++ + L Sbjct: 22 IGHGAFAVVFKGRH------REKHDL-EVAVKCINKKNLAKSQTLLGKEIKILKELKHEN 74 Query: 204 GIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 + ++ Y+++ G L D ++M + +S V + + LHSKG Sbjct: 75 IVALYDFQEMANSVYLVMEYCNGGDLADYLHTM-RTLSEDTVRLFLQQIAGAMRLLHSKG 133 Query: 384 FVHGDVKPENFLLGQPG 434 +H D+KP+N LL PG Sbjct: 134 IIHRDLKPQNILLSNPG 150
>BUB1_HUMAN (O43683) Mitotic checkpoint serine/threonine-protein kinase BUB1 (EC| 2.7.11.1) (hBUB1) (BUB1A) Length = 1085 Score = 39.7 bits (91), Expect = 0.006 Identities = 15/44 (34%), Positives = 28/44 (63%) Frame = +3 Query: 294 NSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPENFLLG 425 N+ + M +V A+ + ++E++H +HGD+KP+NF+LG Sbjct: 883 NTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILG 926
>STK16_RAT (P57760) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) Length = 304 Score = 39.7 bits (91), Expect = 0.006 Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 3/79 (3%) Frame = +3 Query: 213 SVHYKGRQGDYYILVMDMLGPSLWDVWNSM---GQAMSSHMVACIAVESISILEKLHSKG 383 S+ +G + + ++L+ +LW+ + G ++ + + + LE +H+KG Sbjct: 83 SLKERGAKHEAWLLLPFFKRGTLWNEIERLKDQGNFLTEDQILPLLLGICRGLEAIHAKG 142 Query: 384 FVHGDVKPENFLLGQPGSP 440 + H D+KP N LLG G P Sbjct: 143 YAHRDLKPTNILLGDEGQP 161
>PKNJ_MYCTU (P65732) Probable serine/threonine-protein kinase pknJ (EC| 2.7.11.1) Length = 589 Score = 39.7 bits (91), Expect = 0.006 Identities = 40/145 (27%), Positives = 62/145 (42%), Gaps = 5/145 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDA--YEVALKLEHRRSKGCSYGPPF--EWQ 176 Y +R LG GG G VY+ R PD E L S+ + F E Sbjct: 14 YRIERMLGAGGMGTVYLARN---------PDLPRSEALKVLAAELSRDLDFRARFVREAD 64 Query: 177 VYQSLNGCYGIPSVHYKGR-QGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESI 353 V L+ I +VH +G+ +G +I + + G + D + M++ + E Sbjct: 65 VAAGLDHP-NIVAVHQRGQFEGRLWIAMQFVDGGNAEDALRAA--TMTTARAVYVIGEVA 121 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQ 428 L+ H +G +H D+KP NFLL + Sbjct: 122 KALDYAHQQGVIHRDIKPANFLLSR 146
>PKNJ_MYCBO (P65733) Probable serine/threonine-protein kinase pknJ (EC| 2.7.11.1) Length = 589 Score = 39.7 bits (91), Expect = 0.006 Identities = 40/145 (27%), Positives = 62/145 (42%), Gaps = 5/145 (3%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDA--YEVALKLEHRRSKGCSYGPPF--EWQ 176 Y +R LG GG G VY+ R PD E L S+ + F E Sbjct: 14 YRIERMLGAGGMGTVYLARN---------PDLPRSEALKVLAAELSRDLDFRARFVREAD 64 Query: 177 VYQSLNGCYGIPSVHYKGR-QGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESI 353 V L+ I +VH +G+ +G +I + + G + D + M++ + E Sbjct: 65 VAAGLDHP-NIVAVHQRGQFEGRLWIAMQFVDGGNAEDALRAA--TMTTARAVYVIGEVA 121 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQ 428 L+ H +G +H D+KP NFLL + Sbjct: 122 KALDYAHQQGVIHRDIKPANFLLSR 146
>SPKD_SYNY3 (P54735) Serine/threonine-protein kinase D (EC 2.7.11.1)| Length = 505 Score = 39.7 bits (91), Expect = 0.006 Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 1/73 (1%) Frame = +3 Query: 207 IPSVH-YKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 IP ++ Y ++Y++ + G SL ++ +SS I ++ L+ +HSKG Sbjct: 77 IPKLYSYFSNDNEFYLVQEYIQGVSLNEI-----APISSEQAKTILSSLLTTLKYIHSKG 131 Query: 384 FVHGDVKPENFLL 422 +H D+KPEN +L Sbjct: 132 IIHRDIKPENIIL 144
>GSK3H_DROME (P83101) Putative glycogen synthase kinase-3 homolog (EC 2.7.11.26)| (GSK-3) (Protein gasket) Length = 501 Score = 39.3 bits (90), Expect = 0.008 Identities = 43/147 (29%), Positives = 63/147 (42%), Gaps = 11/147 (7%) Frame = +3 Query: 15 TDRKL-GKGGFGQVYVGRRITGGASRTGPDAYEVALK--LEHRRSKGCSYGPPFEWQVYQ 185 TD K+ G G FG V+ + + P VA+K L+ RR K E Q+ + Sbjct: 34 TDAKVVGNGSFGVVFQAKMV--------PSNEMVAIKKVLQDRRFKNR------ELQIMR 79 Query: 186 SLNGCYGIPSVHYKGRQGD-----YYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 L I + G+ Y LVM+ L +L+ V +A + V + + Sbjct: 80 KLRHDNIITLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQYARAKQTLPVNFVRLYM 139 Query: 351 ISILEK---LHSKGFVHGDVKPENFLL 422 +L LHS GF H D+KP+N LL Sbjct: 140 YQLLRSMGYLHSLGFCHRDIKPQNMLL 166
>M4K5_HUMAN (Q9Y4K4) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS) Length = 846 Score = 39.3 bits (90), Expect = 0.008 Identities = 41/151 (27%), Positives = 65/151 (43%), Gaps = 7/151 (4%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 Q Y +++G G +G VY R + TG A +KLE P ++ + Sbjct: 18 QDYELVQRVGSGTYGDVYKARNV-----HTGELAAVKIIKLE----------PGDDFSLI 62 Query: 183 QS----LNGCYGIPSVHYKGR---QGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIA 341 Q + C V Y G + +I + G SL D+++ G +S +A + Sbjct: 63 QQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP-LSELQIAYVC 121 Query: 342 VESISILEKLHSKGFVHGDVKPENFLLGQPG 434 E++ L LH+KG +H D+K N LL G Sbjct: 122 RETLQGLAYLHTKGKMHRDIKGANILLTDHG 152
>PKNH_MYCTU (Q11053) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 626 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/144 (27%), Positives = 58/144 (40%), Gaps = 6/144 (4%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF------E 170 Y R LG+GG G+VY + VA+KL + S P F E Sbjct: 16 YHLKRLLGRGGMGEVYEAEHTV--------KEWTVAVKL---MTAEFSKDPVFRERMKRE 64 Query: 171 WQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 ++ L + +P Y G ++ + + G L V G VA I + Sbjct: 65 ARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSVLKRFGPLTPPRAVAIIT-QI 123 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 S L+ H+ G +H DVKP+N L+ Sbjct: 124 ASALDAAHADGVMHRDVKPQNILI 147
>DSK1_SCHPO (P36616) Protein kinase dsk1 (EC 2.7.11.1) (Dis1-suppressing| protein kinase) Length = 544 Score = 39.3 bits (90), Expect = 0.008 Identities = 42/151 (27%), Positives = 69/151 (45%), Gaps = 13/151 (8%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS 188 Y+ +RKLG G F V++ A R A +V EH R E ++ Q Sbjct: 81 YVVERKLGWGHFSTVWLA--YDRAAKRRV--ALKVVRSAEHYRETSID-----EIRILQK 131 Query: 189 LN-------GCYGIPSVH----YKGRQGDYYILVMDMLGPSLWDVWNSMG-QAMSSHMVA 332 + G I S+ ++G G + +V ++LG +L + S G + + +V Sbjct: 132 IREGDEKHLGKKHIISLLDYFVHRGPNGAHVCMVFEVLGENLLSLIQSYGHRGVPVGIVK 191 Query: 333 CIAVESISILEKLHSK-GFVHGDVKPENFLL 422 IA + + L+ LH + G +H D+KPEN L+ Sbjct: 192 QIAYQLLIALDYLHRECGIIHTDLKPENVLI 222
>M3K14_HUMAN (Q99558) Mitogen-activated protein kinase kinase kinase 14 (EC| 2.7.11.25) (NF-kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) (HsNIK) Length = 947 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/144 (27%), Positives = 66/144 (45%), Gaps = 6/144 (4%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCY 203 +LG+G FG+V+ R+ +TG ++LE R+ + L C Sbjct: 405 RLGRGSFGEVH---RMED--KQTGFQCAVKKVRLEVFRA--------------EELMACA 445 Query: 204 GIPS-----VHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILE 365 G+ S ++ R+G + + M++L G SL + G + + +++ LE Sbjct: 446 GLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLG-QALEGLE 504 Query: 366 KLHSKGFVHGDVKPENFLLGQPGS 437 LHS+ +HGDVK +N LL GS Sbjct: 505 YLHSRRILHGDVKADNVLLSSDGS 528
>PKNH_MYCBO (Q7U095) Probable serine/threonine-protein kinase pknH (EC| 2.7.11.1) Length = 596 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/144 (27%), Positives = 58/144 (40%), Gaps = 6/144 (4%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF------E 170 Y R LG+GG G+VY + VA+KL + S P F E Sbjct: 16 YHLKRLLGRGGMGEVYEAEHTV--------KEWTVAVKL---MTAEFSKDPVFRERMKRE 64 Query: 171 WQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 ++ L + +P Y G ++ + + G L V G VA I + Sbjct: 65 ARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSVLKRFGPLTPPRAVAIIT-QI 123 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 S L+ H+ G +H DVKP+N L+ Sbjct: 124 ASALDAAHADGVMHRDVKPQNILI 147
>PIM3_RAT (O70444) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| (Protein kinase Kid-1) (Kinase induced by depolarization) Length = 326 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/142 (27%), Positives = 65/142 (45%), Gaps = 10/142 (7%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALK--LEHRRSKGCSYG---PPFEWQVYQSL 191 LG GGFG VY G RI D VA+K ++ R ++ S G P E + + + Sbjct: 46 LGSGGFGTVYAGSRIA--------DGLPVAVKHVVKERVTEWGSLGGMAVPLEVVLLRKV 97 Query: 192 ---NGCYGIPSVHYKGRQGDYYILVMDMLGPS--LWDVWNSMGQAMSSHMVACIAVESIS 356 G G+ + + D ++LV++ P+ L+D G A+ + + ++ Sbjct: 98 GAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERG-ALDEPLARRFFAQVLA 156 Query: 357 ILEKLHSKGFVHGDVKPENFLL 422 + H+ G VH D+K EN L+ Sbjct: 157 AVRHCHNCGVVHRDIKDENLLV 178
>PIM3_MOUSE (P58750) Serine/threonine-protein kinase Pim-3 (EC 2.7.11.1)| Length = 326 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/142 (27%), Positives = 65/142 (45%), Gaps = 10/142 (7%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALK--LEHRRSKGCSYG---PPFEWQVYQSL 191 LG GGFG VY G RI D VA+K ++ R ++ S G P E + + + Sbjct: 46 LGSGGFGTVYAGSRIA--------DGLPVAVKHVVKERVTEWGSLGGVAVPLEVVLLRKV 97 Query: 192 ---NGCYGIPSVHYKGRQGDYYILVMDMLGPS--LWDVWNSMGQAMSSHMVACIAVESIS 356 G G+ + + D ++LV++ P+ L+D G A+ + + ++ Sbjct: 98 GAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERG-ALDEPLARRFFAQVLA 156 Query: 357 ILEKLHSKGFVHGDVKPENFLL 422 + H+ G VH D+K EN L+ Sbjct: 157 AVRHCHNCGVVHRDIKDENLLV 178
>CDPK2_PLAF7 (Q8ICR0) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 508 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/139 (28%), Positives = 63/139 (45%), Gaps = 2/139 (1%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF-EWQVYQ 185 YI D KLG+G +G VY G + Y + E ++ + + F E ++ + Sbjct: 71 YIIDEKLGQGTYGCVYKG------IDKVTNQLYAIK---EEKKDRLKNINRFFQEIEIMK 121 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 L+ I ++ +Y L+M++ G L+D G + + A I + S + Sbjct: 122 KLDHP-NIVKLYETYENDNYIYLIMELCSGRELFDSIIENG-SFTEKNAATIMKQIFSAI 179 Query: 363 EKLHSKGFVHGDVKPENFL 419 LHS VH D+KPENFL Sbjct: 180 FYLHSLNIVHRDLKPENFL 198
>M4K4_HUMAN (O95819) Mitogen-activated protein kinase kinase kinase kinase 4| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (HPK/GCK-like kinase HGK) (Nck-interacting kinase) Length = 1239 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 7/139 (5%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRT-----GPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSL 191 +G G +GQVY GR + G + E +KLE K S+ ++++ Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSH--------HRNI 82 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDMLGP-SLWD-VWNSMGQAMSSHMVACIAVESISILE 365 YG D LVM+ G S+ D V N+ G + +A I+ E + L Sbjct: 83 ATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLA 142 Query: 366 KLHSKGFVHGDVKPENFLL 422 LH +H D+K +N LL Sbjct: 143 HLHIHHVIHRDIKGQNVLL 161
>GRK6_RAT (P97711) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 39.3 bits (90), Expect = 0.008 Identities = 47/145 (32%), Positives = 66/145 (45%), Gaps = 7/145 (4%) Frame = +3 Query: 21 RKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF---EWQVYQS 188 R LGKGGFG+V + R TG KLE +R K G E Q+ + Sbjct: 190 RVLGKGGFGEVCACQVRATG--------KMYACKKLEKKRIKKRK-GEAMALNEKQILEK 240 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACI-AVESISI 359 +N + + S+ Y D LV+ ++ G + +++ MGQA A A E Sbjct: 241 VNSRF-VVSLAYAYETKDALCLVLTLMNGGDLKFHIYH-MGQAGFPEARAVFYAAEICCG 298 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 LE LH + V+ D+KPEN LL G Sbjct: 299 LEDLHRERIVYRDLKPENILLDDHG 323
>GRK6_MOUSE (O70293) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 39.3 bits (90), Expect = 0.008 Identities = 47/145 (32%), Positives = 66/145 (45%), Gaps = 7/145 (4%) Frame = +3 Query: 21 RKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF---EWQVYQS 188 R LGKGGFG+V + R TG KLE +R K G E Q+ + Sbjct: 190 RVLGKGGFGEVCACQVRATG--------KMYACKKLEKKRIKKRK-GEAMALNEKQILEK 240 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACI-AVESISI 359 +N + + S+ Y D LV+ ++ G + +++ MGQA A A E Sbjct: 241 VNSRF-VVSLAYAYETKDALCLVLTLMNGGDLKFHIYH-MGQAGFPEARAVFYAAEICCG 298 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 LE LH + V+ D+KPEN LL G Sbjct: 299 LEDLHRERIVYRDLKPENILLDDHG 323
>GRK6_HUMAN (P43250) G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G| protein-coupled receptor kinase GRK6) Length = 576 Score = 39.3 bits (90), Expect = 0.008 Identities = 47/145 (32%), Positives = 66/145 (45%), Gaps = 7/145 (4%) Frame = +3 Query: 21 RKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF---EWQVYQS 188 R LGKGGFG+V + R TG KLE +R K G E Q+ + Sbjct: 190 RVLGKGGFGEVCACQVRATG--------KMYACKKLEKKRIKKRK-GEAMALNEKQILEK 240 Query: 189 LNGCYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACI-AVESISI 359 +N + + S+ Y D LV+ ++ G + +++ MGQA A A E Sbjct: 241 VNSRF-VVSLAYAYETKDALCLVLTLMNGGDLKFHIYH-MGQAGFPEARAVFYAAEICCG 298 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 LE LH + V+ D+KPEN LL G Sbjct: 299 LEDLHRERIVYRDLKPENILLDDHG 323
>STK36_MOUSE (Q69ZM6) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1268 Score = 39.3 bits (90), Expect = 0.008 Identities = 36/138 (26%), Positives = 60/138 (43%), Gaps = 2/138 (1%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCYG 206 +G+G FG+VY GR+ A VALK + + + ++ + + G + Sbjct: 10 IGEGSFGRVYKGRKKYS--------AQVVALKFIPKLGRSEKELRNLQREI-EIMRGLWH 60 Query: 207 IPSVHYKG--RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 VH ++V D L+ + G+ + V IA + +S L LHS Sbjct: 61 PNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGK-LPEDQVQAIAAQLVSALYYLHSH 119 Query: 381 GFVHGDVKPENFLLGQPG 434 +H D+KP+N LL + G Sbjct: 120 RILHRDMKPQNILLAKGG 137
>SID2_SCHPO (Q09898) Serine/threonine-protein kinase sid2 (EC 2.7.11.1)| Length = 607 Score = 39.3 bits (90), Expect = 0.008 Identities = 16/41 (39%), Positives = 23/41 (56%) Frame = +3 Query: 312 MSSHMVACIAVESISILEKLHSKGFVHGDVKPENFLLGQPG 434 + H A E ++ LH G++H D+KPENFL+G G Sbjct: 303 LRDHHAKFYATEMFLAIDALHQLGYIHRDLKPENFLVGASG 343
>PCTK3_PONPY (Q5RD01) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/148 (26%), Positives = 62/148 (41%), Gaps = 4/148 (2%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGR-RITGGASRTGPDAYEVALK---LEHRRSKGCSYGPPFE 170 + Y+ KLG+G + V+ GR ++T VALK LEH C+ E Sbjct: 140 ETYVKLDKLGEGTYATVFKGRSKLTENL---------VALKEIRLEHEEGAPCT--AIRE 188 Query: 171 WQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 + ++L I ++H LV + L L + G MS H V + Sbjct: 189 VSLLKNLKHA-NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQL 247 Query: 351 ISILEKLHSKGFVHGDVKPENFLLGQPG 434 + L H + +H D+KP+N L+ + G Sbjct: 248 LRGLAYCHHRKILHRDLKPQNLLINERG 275
>KGP24_DROME (Q03043) cGMP-dependent protein kinase, isozyme 2 forms| cD4/T1/T3A/T3B (EC 2.7.11.12) (CGK) (Foraging protein) Length = 1088 Score = 39.3 bits (90), Expect = 0.008 Identities = 20/66 (30%), Positives = 33/66 (50%), Gaps = 3/66 (4%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQ---AMSSHMVACIAVESISILEKLHSKGFVHGDVKPENF 416 Y+L+ LG LW + G + + AC+ + + LHS+ ++ D+KPEN Sbjct: 852 YMLMESCLGGELWTILRDKGNFDDSTTRFYTACV----VEAFDYLHSRNIIYRDLKPENL 907 Query: 417 LLGQPG 434 LL + G Sbjct: 908 LLNERG 913
>STK16_MOUSE (O88697) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (Protein kinase Krct) Length = 304 Score = 39.3 bits (90), Expect = 0.008 Identities = 21/79 (26%), Positives = 40/79 (50%), Gaps = 3/79 (3%) Frame = +3 Query: 213 SVHYKGRQGDYYILVMDMLGPSLWDVWNSM---GQAMSSHMVACIAVESISILEKLHSKG 383 S+ +G + + ++L+ +LW+ + G ++ + + + LE +H+KG Sbjct: 83 SLKERGAKHEAWLLLPFFKKGTLWNEIERLKDQGSFLTEDQILPLLLGISRGLEAIHAKG 142 Query: 384 FVHGDVKPENFLLGQPGSP 440 + H D+KP N LLG G P Sbjct: 143 YAHRDLKPTNILLGDEGQP 161
>STK16_HUMAN (O75716) Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Protein| kinase PKL12) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (TGF-beta-stimulated factor 1) (TSF-1) (hPSK) Length = 304 Score = 39.3 bits (90), Expect = 0.008 Identities = 20/75 (26%), Positives = 38/75 (50%), Gaps = 3/75 (4%) Frame = +3 Query: 225 KGRQGDYYILVMDMLGPSLWDVWNSM---GQAMSSHMVACIAVESISILEKLHSKGFVHG 395 +G + + ++L+ +LW+ + G ++ + + + LE +H+KG+ H Sbjct: 87 RGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHR 146 Query: 396 DVKPENFLLGQPGSP 440 D+KP N LLG G P Sbjct: 147 DLKPTNILLGDEGQP 161
>KGP25_DROME (P32023) cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 (EC| 2.7.11.12) (CGK) (Foraging protein) Length = 934 Score = 39.3 bits (90), Expect = 0.008 Identities = 20/66 (30%), Positives = 33/66 (50%), Gaps = 3/66 (4%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQ---AMSSHMVACIAVESISILEKLHSKGFVHGDVKPENF 416 Y+L+ LG LW + G + + AC+ + + LHS+ ++ D+KPEN Sbjct: 698 YMLMESCLGGELWTILRDKGNFDDSTTRFYTACV----VEAFDYLHSRNIIYRDLKPENL 753 Query: 417 LLGQPG 434 LL + G Sbjct: 754 LLNERG 759
>PKNA_ANASP (P54734) Serine/threonine-protein kinase pknA (EC 2.7.11.1)| Length = 564 Score = 39.3 bits (90), Expect = 0.008 Identities = 35/151 (23%), Positives = 63/151 (41%), Gaps = 13/151 (8%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASR-----------TGPDAYEVALKLEHRRSKGCSY 155 Y + LG GGFG+ ++ ++R P Y++ + R Sbjct: 9 YRVIKTLGSGGFGETFLAEDSQMPSNRRCVVKQLRPIHNNPQIYQLVQERFQR------- 61 Query: 156 GPPFEWQVYQSLNGCYG-IPSVH-YKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMV 329 E + + L G IP+++ Y +Y++ + G +L G +S V Sbjct: 62 ----EAAILEDLGSYSGQIPTLYAYFQSNTQFYVVQEWVEGDTLTAKLKQQG-VLSESAV 116 Query: 330 ACIAVESISILEKLHSKGFVHGDVKPENFLL 422 I + + +LE +HSK +H D+KP+N +L Sbjct: 117 RDILINLLPVLEYVHSKRIIHRDIKPDNIIL 147
>PK2_DICDI (P28178) Protein kinase 2 (EC 2.7.11.1)| Length = 479 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/141 (27%), Positives = 61/141 (43%), Gaps = 5/141 (3%) Frame = +3 Query: 27 LGKGGFGQVYV----GRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLN 194 +GKG FG+V G DA ++ H +S E + Q ++ Sbjct: 159 IGKGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHTKS---------EKTILQCIS 209 Query: 195 GCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 + I ++HY + D +V+D + G L+ G+ S V A E +S L+ L Sbjct: 210 HPF-IVNLHYAFQTKDKLYMVLDFVNGGELFFHLKREGR-FSEPRVKIYAAEIVSALDHL 267 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H + V+ D+KPEN LL G Sbjct: 268 HKQDIVYRDLKPENILLDSEG 288
>CDPK2_MAIZE (P49101) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (CDPK 2)| Length = 513 Score = 39.3 bits (90), Expect = 0.008 Identities = 40/144 (27%), Positives = 63/144 (43%), Gaps = 6/144 (4%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRR---SKGCSYGPPFEWQV 179 Y ++LG+G FG Y+ I G + A K +R SK E Q+ Sbjct: 65 YSFGKELGRGQFGVTYLCTEIASGR--------QYACKSISKRKLVSKADREDIRREIQI 116 Query: 180 YQSLNGCYGIPSVHYKGRQGD---YYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVES 350 Q L+G I V ++G D ++++ G L+D + G + A I Sbjct: 117 MQHLSGQPNI--VEFRGAYEDKSNVHVVMELCAGGELFDRIIAKGH-YTERAAATICRAV 173 Query: 351 ISILEKLHSKGFVHGDVKPENFLL 422 ++++ H G +H D+KPENFLL Sbjct: 174 VNVVNICHFMGVMHRDLKPENFLL 197
>DYRK3_HUMAN (O43781) Dual specificity tyrosine-phosphorylation-regulated kinase| 3 (EC 2.7.12.1) Length = 588 Score = 39.3 bits (90), Expect = 0.008 Identities = 36/147 (24%), Positives = 61/147 (41%), Gaps = 11/147 (7%) Frame = +3 Query: 27 LGKGGFGQV----------YVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQ 176 +GKG FGQV YV ++ R A E LEH + + + Sbjct: 215 IGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKT-------- 266 Query: 177 VYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWD-VWNSMGQAMSSHMVACIAVESI 353 S+N + + S ++ ++ + ++L L++ + + Q S +V A + Sbjct: 267 --GSMNVIHMLESFTFR----NHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSIL 320 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPG 434 L+ LH +H D+KPEN LL G Sbjct: 321 QSLDALHKNKIIHCDLKPENILLKHHG 347
>ARK1_SCHPO (O59790) Serine/threonine-protein kinase ark1 (EC 2.7.11.1)| (Aurora-related kinase 1) Length = 355 Score = 39.3 bits (90), Expect = 0.008 Identities = 42/151 (27%), Positives = 66/151 (43%), Gaps = 13/151 (8%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQV------- 179 + LGKG FG+VY+ + +TG + VALK H+ S E QV Sbjct: 93 KPLGKGKFGRVYLAKE-----KKTG---FIVALKTLHKSELVQS---KIEKQVRREIEIQ 141 Query: 180 ----YQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQA--MSSHMVACIA 341 ++++ YG H+ + Y IL G +++ + +A S + + Sbjct: 142 SNLRHKNILRLYG----HFHDEKRIYLILEFAGRG----ELYQHLRRAKRFSEEVASKYI 193 Query: 342 VESISILEKLHSKGFVHGDVKPENFLLGQPG 434 + + L LH K +H D+KPEN LLG G Sbjct: 194 FQMANALSYLHKKHVIHRDIKPENILLGIDG 224
>CDPK2_PLAFK (O15865) Calcium-dependent protein kinase 2 (EC 2.7.11.1) (PfCDPK2)| Length = 512 Score = 39.3 bits (90), Expect = 0.008 Identities = 39/139 (28%), Positives = 63/139 (45%), Gaps = 2/139 (1%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPF-EWQVYQ 185 YI D KLG+G +G VY G + Y + E ++ + + F E ++ + Sbjct: 71 YIIDEKLGQGTYGCVYKG------IDKVTNQLYAIK---EEKKDRLKNINRFFQEIEIMK 121 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISIL 362 L+ I ++ +Y L+M++ G L+D G + + A I + S + Sbjct: 122 KLDHP-NIVKLYETYENDNYIYLIMELCSGRELFDSIIENG-SFTEKNAATIMKQIFSAI 179 Query: 363 EKLHSKGFVHGDVKPENFL 419 LHS VH D+KPENFL Sbjct: 180 FYLHSLNIVHRDLKPENFL 198
>YP141_YEAST (Q03002) Putative serine/threonine-protein kinase YPL141C (EC| 2.7.11.1) Length = 865 Score = 38.9 bits (89), Expect = 0.011 Identities = 37/145 (25%), Positives = 64/145 (44%), Gaps = 7/145 (4%) Frame = +3 Query: 9 YITDRKLGKGGFGQVYVG--RRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 YI LG+G FG+V +G + + ++ T +VA+KL R S Y E ++Y Sbjct: 41 YILGSTLGEGEFGKVKLGWPKNFSNSSNSTFDFPKQVAIKLIKRDSISNDYRK--EVKIY 98 Query: 183 QSLNGCY-----GIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVE 347 + +N I + + Y +V++ + + + + + + Sbjct: 99 REINALKHLSHPNIVKLEEVLQNSRYIGIVLEYACGGEFYKYIQKKRRLKEMNACRLFSQ 158 Query: 348 SISILEKLHSKGFVHGDVKPENFLL 422 IS + +HSKG VH D+K EN LL Sbjct: 159 LISGVHYIHSKGLVHRDLKLENLLL 183
>MASTL_MOUSE (Q8C0P0) Microtubule-associated serine/threonine-protein| kinase-like (EC 2.7.11.1) Length = 865 Score = 38.9 bits (89), Expect = 0.011 Identities = 36/148 (24%), Positives = 65/148 (43%), Gaps = 10/148 (6%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGG---ASRTGPDAYEVALKLEHR----RSKGCSYGPPFEWQV 179 + + +G FG+VY+G++ GG A + A V + H+ R PF + Sbjct: 38 KPISRGAFGKVYLGQK--GGKLYAVKVVKKADMVNKNMTHQVQAERDALALSKSPFVVHL 95 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDMLG---PSLWDVWNSMGQAMSSHMVACIAVES 350 Y SL I Y+++ ++G SL ++ + M+ ++ +A+ Sbjct: 96 YYSLQSASNI------------YLIMEYLIGGDVKSLLHIYGYFDEEMAIKYISEVALA- 142 Query: 351 ISILEKLHSKGFVHGDVKPENFLLGQPG 434 L+ LH G +H D+KP+N L+ G Sbjct: 143 ---LDYLHRHGIIHRDLKPDNMLISNEG 167
>STK36_HUMAN (Q9NRP7) Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused| homolog) Length = 1315 Score = 38.9 bits (89), Expect = 0.011 Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 2/138 (1%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCYG 206 +G+G FG+VY GRR A VALK + + + ++ + + G Sbjct: 10 IGEGSFGRVYKGRRKYS--------AQVVALKFIPKLGRSEKELRNLQREI-EIMRGLRH 60 Query: 207 IPSVHYKG--RQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 VH ++V D L+ + G+ + V IA + +S L LHS Sbjct: 61 PNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGK-LPEDQVQAIAAQLVSALYYLHSH 119 Query: 381 GFVHGDVKPENFLLGQPG 434 +H D+KP+N LL + G Sbjct: 120 RILHRDMKPQNILLAKGG 137
>RAN1_SCHPO (P08092) Negative regulator of sexual conjugation and meiosis (EC| 2.7.11.1) Length = 470 Score = 38.9 bits (89), Expect = 0.011 Identities = 15/37 (40%), Positives = 25/37 (67%) Frame = +3 Query: 315 SSHMVACIAVESISILEKLHSKGFVHGDVKPENFLLG 425 +SH++ + ++ IS +E HS G H D+KPEN ++G Sbjct: 116 NSHLIKTVFLQLISAVEHCHSVGIYHRDLKPENIMVG 152
>MINK1_MOUSE (Q9JM52) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1308 Score = 38.9 bits (89), Expect = 0.011 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 7/139 (5%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRT-----GPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSL 191 +G G +GQVY GR + G + E +K E K S+ ++++ Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH--------HRNI 82 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDMLGP-SLWD-VWNSMGQAMSSHMVACIAVESISILE 365 YG D LVM+ G S+ D V N+ G A+ +A I E + L Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142 Query: 366 KLHSKGFVHGDVKPENFLL 422 LH+ +H D+K +N LL Sbjct: 143 HLHAHKVIHRDIKGQNVLL 161
>CDC2_RAT (P39951) Cell division control protein 2 homolog (EC 2.7.11.22) (EC| 2.7.11.23) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1) Length = 297 Score = 38.9 bits (89), Expect = 0.011 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 2/147 (1%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 + YI K+G+G +G VY GR T TG ++LE +G E + Sbjct: 2 EDYIKIEKIGEGTYGVVYKGRHRT-----TGQIVAMKKIRLESEE-EGVPSTAIREISLL 55 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSM--GQAMSSHMVACIAVESIS 356 + L I S+ Q L+ + L L +S+ GQ M S +V + + Sbjct: 56 KELRHP-NIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLYQILQ 114 Query: 357 ILEKLHSKGFVHGDVKPENFLLGQPGS 437 + HS+ +H D+KP+N L+ G+ Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGT 141
>CBK1_KLULA (P31034) Serine/threonine-protein kinase CBK1 (EC 2.7.11.1)| Length = 718 Score = 38.9 bits (89), Expect = 0.011 Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 5/137 (3%) Frame = +3 Query: 27 LGKGGFGQV-YVGRRITGG--ASRT--GPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSL 191 +GKG FG+V V ++ TG A +T + Y + + G W V Sbjct: 309 IGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYNKDQLAHVKAERDVLAGSDSPWVV---- 364 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 S++Y + Y L+M+ L Q + + E I +E + Sbjct: 365 -------SLYYSFQDSQYLYLIMEFLPGGDLMTMLIRWQIFTEDVTRFYMAECILAIEVI 417 Query: 372 HSKGFVHGDVKPENFLL 422 H GF+H D+KP+N L+ Sbjct: 418 HKLGFIHRDIKPDNILI 434
>TNIK_MOUSE (P83510) Traf2 and NCK-interacting kinase (EC 2.7.11.1) (Fragments)| Length = 916 Score = 38.9 bits (89), Expect = 0.011 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 9/141 (6%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASR-------TGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQ 185 +G G +GQVY GR + G TG + E+ ++ + ++ ++ Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLK----------KYSHHR 80 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDMLGP-SLWD-VWNSMGQAMSSHMVACIAVESISI 359 ++ YG D LVM+ G S+ D + N+ G + +A I E + Sbjct: 81 NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140 Query: 360 LEKLHSKGFVHGDVKPENFLL 422 L LH +H D+K +N LL Sbjct: 141 LSHLHQHKVIHRDIKGQNVLL 161
>KGP1A_RABIT (O77676) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 3/66 (4%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSS---HMVACIAVESISILEKLHSKGFVHGDVKPENF 416 Y+L+ LG LW + G S AC+ + LHSKG ++ D+KPEN Sbjct: 434 YMLMEACLGGELWTILRDRGSFEDSTTRFYTACV----VEAFAYLHSKGIIYRDLKPENL 489 Query: 417 LLGQPG 434 +L G Sbjct: 490 ILDHRG 495
>KGP1A_HUMAN (Q13976) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 3/66 (4%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSS---HMVACIAVESISILEKLHSKGFVHGDVKPENF 416 Y+L+ LG LW + G S AC+ + LHSKG ++ D+KPEN Sbjct: 434 YMLMEACLGGELWTILRDRGSFEDSTTRFYTACV----VEAFAYLHSKGIIYRDLKPENL 489 Query: 417 LLGQPG 434 +L G Sbjct: 490 ILDHRG 495
>KGP1A_BOVIN (P00516) cGMP-dependent protein kinase 1, alpha isozyme (EC| 2.7.11.12) (CGK 1 alpha) (cGKI-alpha) Length = 670 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 3/66 (4%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSS---HMVACIAVESISILEKLHSKGFVHGDVKPENF 416 Y+L+ LG LW + G S AC+ + LHSKG ++ D+KPEN Sbjct: 434 YMLMEACLGGELWTILRDRGSFEDSTTRFYTACV----VEAFAYLHSKGIIYRDLKPENL 489 Query: 417 LLGQPG 434 +L G Sbjct: 490 ILDHRG 495
>KPCD1_HUMAN (Q15139) Serine/threonine-protein kinase D1 (EC 2.7.11.13)| (nPKC-D1) (Protein kinase D) (Protein kinase C mu type) (nPKC-mu) Length = 912 Score = 38.9 bits (89), Expect = 0.011 Identities = 39/137 (28%), Positives = 61/137 (44%), Gaps = 2/137 (1%) Frame = +3 Query: 18 DRKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQSLN 194 D LG G FG VY G+ +TG D A ++ KL + E + Q+L+ Sbjct: 586 DEVLGSGQFGIVYGGKH-----RKTGRDVAIKIIDKLRFPTKQESQLRN--EVAILQNLH 638 Query: 195 GCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 G+ ++ + +VM+ L G L + +S + H+ + + + L L Sbjct: 639 HP-GVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHL 697 Query: 372 HSKGFVHGDVKPENFLL 422 H K VH D+KPEN LL Sbjct: 698 HFKNIVHCDLKPENVLL 714
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 38.9 bits (89), Expect = 0.011 Identities = 29/136 (21%), Positives = 55/136 (40%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCYG 206 +GKG FG VY+ +T G ++ E + L+ Sbjct: 1181 IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKDLDHLNI 1240 Query: 207 IPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGF 386 + + ++ + Y + + + G S+ + G+ ++ + + + L LHSKG Sbjct: 1241 VQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGR-FDEPLIKHLTTQVLKGLAYLHSKGI 1299 Query: 387 VHGDVKPENFLLGQPG 434 +H D+K +N LL Q G Sbjct: 1300 LHRDMKADNLLLDQDG 1315
>ROCK1_RAT (Q63644) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (p150 RhoA-binding kinase ROK beta) (Liver regeneration-related protein LRRG199) Length = 1369 Score = 38.9 bits (89), Expect = 0.011 Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 1/145 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 + Y + +G+G FG+V + R ++ Y + L + K +E + Sbjct: 74 EDYEVVKVIGRGAFGEVQLVRH------KSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI 127 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQA-MSSHMVACIAVESISI 359 + + + Y + Y +VM+ + D+ N M + E + Sbjct: 128 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLA 185 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L+ +HS GF+H DVKP+N LL + G Sbjct: 186 LDAIHSMGFIHRDVKPDNMLLDKSG 210
>NRC2_NEUCR (O42626) Serine/threonine-protein kinase nrc-2 (EC 2.7.11.1)| (Nonrepressible conidiation protein 2) Length = 623 Score = 38.9 bits (89), Expect = 0.011 Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 2/146 (1%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 Q + + +GKG G+VY+ + G A +V K E + E ++ Sbjct: 240 QSFDKIKLIGKGDVGKVYLVKEKKSGRLY----AMKVLSKKEMIKRNKIKRALA-EQEIL 294 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDML--GPSLWDVWNSMGQAMSSHMVACIAVESIS 356 + N + I ++++ + DY L M+ G + G+ + A E + Sbjct: 295 ATSNHPF-IVTLYHSFQSEDYLYLCMEYCSGGEFFRALQTRPGKCIPEDDARFYAAEVTA 353 Query: 357 ILEKLHSKGFVHGDVKPENFLLGQPG 434 LE LH GF++ D+KPEN LL Q G Sbjct: 354 ALEYLHLMGFIYRDLKPENILLHQSG 379
>MINK1_HUMAN (Q8N4C8) Misshapen-like kinase 1 (EC 2.7.11.1) (Mitogen-activated| protein kinase kinase kinase kinase 6) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (GCK family kinase MiNK) Length = 1332 Score = 38.9 bits (89), Expect = 0.011 Identities = 39/139 (28%), Positives = 59/139 (42%), Gaps = 7/139 (5%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRT-----GPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSL 191 +G G +GQVY GR + G + E +K E K S+ ++++ Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH--------HRNI 82 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDMLGP-SLWD-VWNSMGQAMSSHMVACIAVESISILE 365 YG D LVM+ G S+ D V N+ G A+ +A I E + L Sbjct: 83 ATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLA 142 Query: 366 KLHSKGFVHGDVKPENFLL 422 LH+ +H D+K +N LL Sbjct: 143 HLHAHKVIHRDIKGQNVLL 161
>TNIK_HUMAN (Q9UKE5) TRAF2 and NCK-interacting kinase (EC 2.7.11.1)| Length = 1360 Score = 38.9 bits (89), Expect = 0.011 Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 9/141 (6%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASR-------TGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQ 185 +G G +GQVY GR + G TG + E+ ++ + ++ ++ Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLK----------KYSHHR 80 Query: 186 SLNGCYGIPSVHYKGRQGDYYILVMDMLGP-SLWD-VWNSMGQAMSSHMVACIAVESISI 359 ++ YG D LVM+ G S+ D + N+ G + +A I E + Sbjct: 81 NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 140 Query: 360 LEKLHSKGFVHGDVKPENFLL 422 L LH +H D+K +N LL Sbjct: 141 LSHLHQHKVIHRDIKGQNVLL 161
>ROCK1_RABIT (O77819) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (cAMP-dependent protein kinase ROCK-I) (CePKA) (Corneal epithelial Rho-associated-Ser/Thr kinase 1) (HEB Length = 1354 Score = 38.9 bits (89), Expect = 0.011 Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 1/145 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 + Y + +G+G FG+V + R ++ Y + L + K +E + Sbjct: 74 EDYEVVKVIGRGAFGEVQLVRH------KSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI 127 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQA-MSSHMVACIAVESISI 359 + + + Y + Y +VM+ + D+ N M + E + Sbjct: 128 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLA 185 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L+ +HS GF+H DVKP+N LL + G Sbjct: 186 LDAIHSMGFIHRDVKPDNMLLDKSG 210
>ROCK1_MOUSE (P70335) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) Length = 1354 Score = 38.9 bits (89), Expect = 0.011 Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 1/145 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 + Y + +G+G FG+V + R ++ Y + L + K +E + Sbjct: 74 EDYEVVKVIGRGAFGEVQLVRH------KSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI 127 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQA-MSSHMVACIAVESISI 359 + + + Y + Y +VM+ + D+ N M + E + Sbjct: 128 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLA 185 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L+ +HS GF+H DVKP+N LL + G Sbjct: 186 LDAIHSMGFIHRDVKPDNMLLDKSG 210
>ROCK1_HUMAN (Q13464) Rho-associated protein kinase 1 (EC 2.7.11.1)| (Rho-associated, coiled-coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen) Length = 1354 Score = 38.9 bits (89), Expect = 0.011 Identities = 33/145 (22%), Positives = 60/145 (41%), Gaps = 1/145 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVY 182 + Y + +G+G FG+V + R ++ Y + L + K +E + Sbjct: 74 EDYEVVKVIGRGAFGEVQLVRH------KSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI 127 Query: 183 QSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQA-MSSHMVACIAVESISI 359 + + + Y + Y +VM+ + D+ N M + E + Sbjct: 128 MAFANSPWVVQLFYAFQDDRYLYMVMEYMPGG--DLVNLMSNYDVPEKWARFYTAEVVLA 185 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L+ +HS GF+H DVKP+N LL + G Sbjct: 186 LDAIHSMGFIHRDVKPDNMLLDKSG 210
>DYRK2_HUMAN (Q92630) Dual specificity tyrosine-phosphorylation-regulated kinase| 2 (EC 2.7.12.1) Length = 528 Score = 38.9 bits (89), Expect = 0.011 Identities = 35/147 (23%), Positives = 62/147 (42%), Gaps = 11/147 (7%) Frame = +3 Query: 27 LGKGGFGQV----------YVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQ 176 +GKG FGQV +V ++ R A E LEH R + Sbjct: 155 IGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD-------- 206 Query: 177 VYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWD-VWNSMGQAMSSHMVACIAVESI 353 ++N + + + ++ ++ + ++L +L++ + + Q S +V A + Sbjct: 207 --NTMNVIHMLENFTFR----NHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSIL 260 Query: 354 SILEKLHSKGFVHGDVKPENFLLGQPG 434 L+ LH +H D+KPEN LL Q G Sbjct: 261 QCLDALHKNRIIHCDLKPENILLKQQG 287
>KGP1B_MOUSE (Q9Z0Z0) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 3/66 (4%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSS---HMVACIAVESISILEKLHSKGFVHGDVKPENF 416 Y+L+ LG LW + G S AC+ + LHSKG ++ D+KPEN Sbjct: 450 YMLMEACLGGELWTILRDRGSFEDSTTRFYTACV----VEAFAYLHSKGIIYRDLKPENL 505 Query: 417 LLGQPG 434 +L G Sbjct: 506 ILDHRG 511
>KGP1B_HUMAN (P14619) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 3/66 (4%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSS---HMVACIAVESISILEKLHSKGFVHGDVKPENF 416 Y+L+ LG LW + G S AC+ + LHSKG ++ D+KPEN Sbjct: 450 YMLMEACLGGELWTILRDRGSFEDSTTRFYTACV----VEAFAYLHSKGIIYRDLKPENL 505 Query: 417 LLGQPG 434 +L G Sbjct: 506 ILDHRG 511
>KGP1B_BOVIN (P21136) cGMP-dependent protein kinase 1, beta isozyme (EC| 2.7.11.12) (cGK 1 beta) (cGKI-beta) Length = 686 Score = 38.9 bits (89), Expect = 0.011 Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 3/66 (4%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSS---HMVACIAVESISILEKLHSKGFVHGDVKPENF 416 Y+L+ LG LW + G S AC+ + LHSKG ++ D+KPEN Sbjct: 450 YMLMEACLGGELWTILRDRGSFEDSTTRFYTACV----VEAFAYLHSKGIIYRDLKPENL 505 Query: 417 LLGQPG 434 +L G Sbjct: 506 ILDHRG 511
>KPK1_PHAVU (P15792) Protein kinase PVPK-1 (EC 2.7.11.1)| Length = 609 Score = 38.5 bits (88), Expect = 0.014 Identities = 41/140 (29%), Positives = 63/140 (45%), Gaps = 2/140 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 +KLG G G VY+ +RT A +V K E K E ++ QSL+ Sbjct: 233 KKLGCGDIGSVYLAEL---SGTRTS-FAMKVMNKTELANRKKLLRAQT-EREILQSLDHP 287 Query: 201 YGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSM-GQAMSSHMVACIAVESISILEKLH 374 + +P+++ + LVM+ G L + G+ S H V E + LE LH Sbjct: 288 F-LPTLYTHFETEIFSCLVMEFCPGGDLHALRQRQPGKYFSEHAVRFYVAEVLLSLEYLH 346 Query: 375 SKGFVHGDVKPENFLLGQPG 434 G ++ D+KPEN L+ + G Sbjct: 347 MLGIIYRDLKPENVLVREDG 366
>KS6A_CAEEL (Q21734) Putative ribosomal protein S6 kinase alpha (EC 2.7.11.1)| Length = 784 Score = 38.5 bits (88), Expect = 0.014 Identities = 35/138 (25%), Positives = 60/138 (43%), Gaps = 2/138 (1%) Frame = +3 Query: 27 LGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCYG 206 LG+G FG+V++ R++ G R Y + + + E + ++ + Sbjct: 110 LGQGSFGKVFLVRKVRG---RDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISHPF- 165 Query: 207 IPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEKLHSK 380 I +HY + L++D L D++ + + + + V E LE LHS Sbjct: 166 IVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSL 223 Query: 381 GFVHGDVKPENFLLGQPG 434 G V+ D+KPEN LL G Sbjct: 224 GIVYRDLKPENILLDADG 241
>KS6A1_MOUSE (P18653) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 724 Score = 38.5 bits (88), Expect = 0.014 Identities = 37/142 (26%), Positives = 65/142 (45%), Gaps = 6/142 (4%) Frame = +3 Query: 27 LGKGGFGQVYVGRRIT---GGASRTGPDAYEVALKLEHR-RSKGCSYGPPFEWQVYQSLN 194 LG+G FG+V++ R++T G + LK+ R R+K E + +N Sbjct: 68 LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK-------MERDILADVN 120 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEK 368 + + +HY + L++D L D++ + + + + V E L+ Sbjct: 121 HPF-VVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALGLDH 177 Query: 369 LHSKGFVHGDVKPENFLLGQPG 434 LHS G ++ D+KPEN LL + G Sbjct: 178 LHSLGIIYRDLKPENILLDEEG 199 Score = 33.5 bits (75), Expect = 0.45 Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 2/67 (2%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESIS-ILEKLHSKGFVHGDVKPENFL- 419 Y++ M G L D + Q S A + +IS +E LHS+G VH D+KP N L Sbjct: 475 YLVTELMRGGELLD--KILRQKFFSEREASFVLHTISKTVEYLHSQGVVHRDLKPSNILY 532 Query: 420 LGQPGSP 440 + + G+P Sbjct: 533 VDESGNP 539
>BUR1_YARLI (Q6C842) Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC| 2.7.11.23) Length = 706 Score = 38.5 bits (88), Expect = 0.014 Identities = 36/146 (24%), Positives = 60/146 (41%), Gaps = 9/146 (6%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVALK--LEHRRSKGCSYGPPFEWQVYQSLNG 197 K+G+G FG+V+ +IT VALK L H +G E ++ + L Sbjct: 43 KIGEGTFGEVFRAEQIT--------TKRHVALKKILLHSEKEGFPVTALREIRILKLLRH 94 Query: 198 CYGIPSVHYKGRQGDY-------YILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESIS 356 IP V +GD +V + L + + +S + C ++ + Sbjct: 95 ENVIPLVDLAVERGDQSKKERGCVYMVTPYMDHDLAGLLGNQSVQLSPAHIKCYMLQLLE 154 Query: 357 ILEKLHSKGFVHGDVKPENFLLGQPG 434 + LH+K F+H D+K N L+ G Sbjct: 155 GIGYLHAKKFLHRDIKAANILVNDQG 180
>PDPK1_RAT (O55173) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (Protein kinase B kinase) (PkB kinase) Length = 559 Score = 38.5 bits (88), Expect = 0.014 Identities = 16/28 (57%), Positives = 20/28 (71%) Frame = +3 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQ 428 E +S LE LH KG +H D+KPEN LL + Sbjct: 191 EIVSALEYLHGKGIIHRDLKPENILLNE 218
>PDPK1_MOUSE (Q9Z2A0) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (mPDK1) Length = 559 Score = 38.5 bits (88), Expect = 0.014 Identities = 16/28 (57%), Positives = 20/28 (71%) Frame = +3 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQ 428 E +S LE LH KG +H D+KPEN LL + Sbjct: 191 EIVSALEYLHGKGIIHRDLKPENILLNE 218
>AURKB_RAT (O55099) Serine/threonine-protein kinase 12 (EC 2.7.11.1) (Aurora-| and Ipl1-like midbody-associated protein 1) (AIM-1) (Aurora-B) Length = 343 Score = 38.5 bits (88), Expect = 0.014 Identities = 38/141 (26%), Positives = 54/141 (38%), Gaps = 3/141 (2%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHR---RSKGCSYGPPFEWQVYQSL 191 R LGKG FG VY+ R + VALK+ + +G + E ++ L Sbjct: 84 RPLGKGKFGNVYLARE--------KKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHL 135 Query: 192 NGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 + +Y Q Y+++ L+ G A I E L Sbjct: 136 KHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSG-TFDEQRTATIMEELSDALMYC 194 Query: 372 HSKGFVHGDVKPENFLLGQPG 434 H K +H D+KPEN LLG G Sbjct: 195 HKKKVIHRDIKPENLLLGLQG 215
>KS6A1_RAT (Q63531) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 38.5 bits (88), Expect = 0.014 Identities = 37/142 (26%), Positives = 65/142 (45%), Gaps = 6/142 (4%) Frame = +3 Query: 27 LGKGGFGQVYVGRRIT---GGASRTGPDAYEVALKLEHR-RSKGCSYGPPFEWQVYQSLN 194 LG+G FG+V++ R++T G + LK+ R R+K E + +N Sbjct: 68 LGQGSFGKVFLVRKVTRPDNGHLYAMKVLKKATLKVRDRVRTK-------MERDILADVN 120 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEK 368 + + +HY + L++D L D++ + + + + V E L+ Sbjct: 121 HPF-VVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALGLDH 177 Query: 369 LHSKGFVHGDVKPENFLLGQPG 434 LHS G ++ D+KPEN LL + G Sbjct: 178 LHSLGIIYRDLKPENILLDEEG 199 Score = 32.7 bits (73), Expect = 0.77 Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 2/67 (2%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESIS-ILEKLHSKGFVHGDVKPENFL- 419 Y++ M G L D + Q S A + +IS +E LHS+G VH D+KP N L Sbjct: 486 YLVTELMRGGELLD--KILRQKFFSEREASFVLYTISKTVEYLHSQGVVHRDLKPSNILY 543 Query: 420 LGQPGSP 440 + + G+P Sbjct: 544 VDESGNP 550
>KS6A1_HUMAN (Q15418) Ribosomal protein S6 kinase alpha-1 (EC 2.7.11.1)| (S6K-alpha 1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (Ribosomal S6 kinase 1) (RSK-1) (pp90RSK1) (MAP kinase-activated protein kinase 1a) (MAPKAPK1A) Length = 735 Score = 38.5 bits (88), Expect = 0.014 Identities = 37/142 (26%), Positives = 65/142 (45%), Gaps = 6/142 (4%) Frame = +3 Query: 27 LGKGGFGQVYVGRRIT---GGASRTGPDAYEVALKLEHR-RSKGCSYGPPFEWQVYQSLN 194 LG+G FG+V++ R++T G + LK+ R R+K E + +N Sbjct: 68 LGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTK-------MERDILADVN 120 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAM--SSHMVACIAVESISILEK 368 + + +HY + L++D L D++ + + + + V E L+ Sbjct: 121 HPF-VVKLHYAFQTEGKLYLILDFLRGG--DLFTRLSKEVMFTEEDVKFYLAELALGLDH 177 Query: 369 LHSKGFVHGDVKPENFLLGQPG 434 LHS G ++ D+KPEN LL + G Sbjct: 178 LHSLGIIYRDLKPENILLDEEG 199 Score = 32.0 bits (71), Expect = 1.3 Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 2/67 (2%) Frame = +3 Query: 246 YILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESIS-ILEKLHSKGFVHGDVKPENFL- 419 Y++ M G L D + Q S A + +I +E LHS+G VH D+KP N L Sbjct: 486 YLVTELMRGGELLD--KILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILY 543 Query: 420 LGQPGSP 440 + + G+P Sbjct: 544 VDESGNP 550
>RIPK5_BRARE (Q4VSN1) Receptor-interacting serine/threonine-protein kinase 5 (EC| 2.7.11.1) (Dusty protein kinase) (Dusty PK) Length = 885 Score = 38.5 bits (88), Expect = 0.014 Identities = 40/142 (28%), Positives = 66/142 (46%), Gaps = 8/142 (5%) Frame = +3 Query: 21 RKLGKGGFGQVYV-----GRRITGGASRTGPDAY---EVALKLEHRRSKGCSYGPPFEWQ 176 R+LG+G +G VY+ GR S PD ++AL+ + RS P E Sbjct: 618 RELGRGQYGVVYLCDSWAGRHPCALKSVVPPDDKHWNDLALEFHYTRSL-----PKHERL 672 Query: 177 VYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESIS 356 V +L+G + Y G +L+M+ L D++ + +S IA++ + Sbjct: 673 V--NLHG--SVIDHSYSGGSSIAVLLIMERLHR---DLYTGLKAGLSLKERLLIALDVVE 725 Query: 357 ILEKLHSKGFVHGDVKPENFLL 422 + LHS+G +H D+K +N LL Sbjct: 726 GIRFLHSQGLLHRDIKLKNVLL 747
>ARBK1_MESAU (Q64682) Beta-adrenergic receptor kinase 1 (EC 2.7.11.15)| (Beta-ARK-1) (G-protein-coupled receptor kinase 2) Length = 689 Score = 38.5 bits (88), Expect = 0.014 Identities = 34/138 (24%), Positives = 56/138 (40%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGC 200 R +G+GGFG+VY R+ G + +K++ + + S C Sbjct: 195 RIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS---LVSTGDC 251 Query: 201 YGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSK 380 I + Y R D ++D++ S S + A E I LE +H++ Sbjct: 252 PFIVCMSYAFRTPDNLSFILDLMNGGDLHYHLSQHGVFSEADMRSYAAEIILGLEHMHNR 311 Query: 381 GFVHGDVKPENFLLGQPG 434 V+ D+KP N LL + G Sbjct: 312 FVVYRDLKPANILLDEHG 329
>PDPK1_HUMAN (O15530) 3-phosphoinositide-dependent protein kinase 1 (EC| 2.7.11.1) (hPDK1) Length = 556 Score = 38.5 bits (88), Expect = 0.014 Identities = 16/28 (57%), Positives = 20/28 (71%) Frame = +3 Query: 345 ESISILEKLHSKGFVHGDVKPENFLLGQ 428 E +S LE LH KG +H D+KPEN LL + Sbjct: 188 EIVSALEYLHGKGIIHRDLKPENILLNE 215
>KRB2_VACCC (P21098) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 38.1 bits (87), Expect = 0.018 Identities = 23/72 (31%), Positives = 35/72 (48%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGF 386 IP ++ G DY V+ LG + S AC+ + I+ LE +HS+GF Sbjct: 84 IPDLYGIGETDDYMFFVIKNLGRVF------APKDTESVFEACVTM--INTLEFIHSRGF 135 Query: 387 VHGDVKPENFLL 422 HG ++P N L+ Sbjct: 136 THGKIEPRNILI 147
>KRB2_VACCA (O57259) Probable serine/threonine-protein kinase B12 (EC 2.7.11.1)| Length = 283 Score = 38.1 bits (87), Expect = 0.018 Identities = 23/72 (31%), Positives = 35/72 (48%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGF 386 IP ++ G DY V+ LG + S AC+ + I+ LE +HS+GF Sbjct: 84 IPDLYGIGETDDYMFFVIKNLGRVF------APKDTESVFEACVTM--INTLEFIHSRGF 135 Query: 387 VHGDVKPENFLL 422 HG ++P N L+ Sbjct: 136 THGKIEPRNILI 147
>MRCKA_RAT (O54874) Serine/threonine-protein kinase MRCK alpha (EC 2.7.11.1)| (CDC42-binding protein kinase alpha) (Myotonic dystrophy kinase-related CDC42-binding kinase alpha) (Myotonic dystrophy protein kinase-like alpha) (MRCK alpha) Length = 1732 Score = 38.1 bits (87), Expect = 0.018 Identities = 20/77 (25%), Positives = 36/77 (46%), Gaps = 1/77 (1%) Frame = +3 Query: 207 IPSVHYKGRQGDYYILVMDM-LGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKG 383 I ++HY + + LVMD +G L + + + M E + ++ +H Sbjct: 137 ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLH 196 Query: 384 FVHGDVKPENFLLGQPG 434 +VH D+KP+N L+ G Sbjct: 197 YVHRDIKPDNILMDMNG 213
>SNF1_CANGA (Q00372) Carbon catabolite derepressing protein kinase (EC| 2.7.11.1) Length = 612 Score = 38.1 bits (87), Expect = 0.018 Identities = 38/138 (27%), Positives = 61/138 (44%), Gaps = 2/138 (1%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRR--SKGCSYGPPFEWQVYQSLN 194 + LG+G FG+V + +T G +VALK+ +++ +K G Y L Sbjct: 43 KTLGEGSFGKVKLAYHVTTGQ--------KVALKIINKKVLAKSDMQGRIEREISYLRLL 94 Query: 195 GCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLH 374 I ++ + D I+V++ G L+D + MS + IS +E H Sbjct: 95 RHPHIIKLYDVIKSKDEIIMVIEYAGNELFD-YIVQRNKMSEQEARRFFQQIISAVEYCH 153 Query: 375 SKGFVHGDVKPENFLLGQ 428 VH D+KPEN LL + Sbjct: 154 RHKIVHRDLKPENLLLDE 171
>PK1_ASFM2 (P34206) Serine/threonine-protein kinase (EC 2.7.11.1)| Length = 299 Score = 38.1 bits (87), Expect = 0.018 Identities = 21/88 (23%), Positives = 44/88 (50%) Frame = +3 Query: 159 PPFEWQVYQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACI 338 P E V ++L G+ + Y+IL+++ + S+ + + + + I Sbjct: 74 PGNEVVVMKALQDTPGVIKLIEYTENAMYHILIIEYIPNSIDLLHYHYFKKLEENEAKKI 133 Query: 339 AVESISILEKLHSKGFVHGDVKPENFLL 422 + I I++ ++ KGF+HGD+K EN ++ Sbjct: 134 IFQMILIIQNIYEKGFIHGDIKDENLII 161
>M3K14_MOUSE (Q9WUL6) Mitogen-activated protein kinase kinase kinase 14 (EC| 2.7.11.25) (NF-kappa beta-inducing kinase) (Serine/threonine-protein kinase NIK) Length = 942 Score = 38.1 bits (87), Expect = 0.018 Identities = 37/144 (25%), Positives = 65/144 (45%), Gaps = 6/144 (4%) Frame = +3 Query: 24 KLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQSLNGCY 203 ++G+G FG+V+ + +TG ++LE R + L C Sbjct: 407 RVGRGSFGEVHRMKD-----KQTGFQCAVKKVRLEVFR--------------VEELVACA 447 Query: 204 GIPS-----VHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILE 365 G+ S ++ R+G + + M++L G SL + MG + + +++ LE Sbjct: 448 GLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLG-QALEGLE 506 Query: 366 KLHSKGFVHGDVKPENFLLGQPGS 437 LH++ +HGDVK +N LL GS Sbjct: 507 YLHTRRILHGDVKADNVLLSSDGS 530
>KPCD2_HUMAN (Q9BZL6) Serine/threonine-protein kinase D2 (EC 2.7.11.13)| (nPKC-D2) Length = 878 Score = 38.1 bits (87), Expect = 0.018 Identities = 41/137 (29%), Positives = 59/137 (43%), Gaps = 2/137 (1%) Frame = +3 Query: 18 DRKLGKGGFGQVYVGRRITGGASRTGPD-AYEVALKLEHRRSKGCSYGPPFEWQVYQSLN 194 D LG G FG VY G+ +TG D A +V KL + E + QSL Sbjct: 554 DEVLGSGQFGVVYGGKH-----RKTGRDVAVKVIDKLRFPTKQESQLRN--EVAILQSLR 606 Query: 195 GCYGIPSVHYKGRQGDYYILVMDML-GPSLWDVWNSMGQAMSSHMVACIAVESISILEKL 371 GI ++ + +VM+ L G L + +S + + + + + L L Sbjct: 607 HP-GIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHL 665 Query: 372 HSKGFVHGDVKPENFLL 422 H K VH D+KPEN LL Sbjct: 666 HFKNIVHCDLKPENVLL 682
>CLA4_CANAL (O14427) Serine/threonine-protein kinase CLA4 (EC 2.7.11.1)| Length = 971 Score = 38.1 bits (87), Expect = 0.018 Identities = 18/66 (27%), Positives = 36/66 (54%) Frame = +3 Query: 240 DYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEKLHSKGFVHGDVKPENFL 419 + ++++ M G SL ++ + ++ +A I E++ L+ LH K +H D+K +N L Sbjct: 751 ELWVIMEYMQGGSLTEIIENNDFKLNEKQIATICFETLKGLQHLHKKHIIHRDIKSDNVL 810 Query: 420 LGQPGS 437 L G+ Sbjct: 811 LDAYGN 816
>AURKB_MOUSE (O70126) Serine/threonine-protein kinase 12 (EC 2.7.11.1)| (Aurora-related kinase 2) (Serine/threonine-protein kinase 5) (STK-1) (Aurora-B) Length = 345 Score = 38.1 bits (87), Expect = 0.018 Identities = 40/142 (28%), Positives = 56/142 (39%), Gaps = 4/142 (2%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHR---RSKGCSYGPPFEWQVYQSL 191 R LGKG FG VY+ R + VALK+ + +G + E ++ L Sbjct: 86 RPLGKGKFGNVYLARE--------KKSRFIVALKILFKSQIEKEGVEHQLRREIEIQAHL 137 Query: 192 NGCYGIPSVHY-KGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISILEK 368 + +Y +Q Y IL G ++ S + A I E L Sbjct: 138 KHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKS--RTFDEQRTATIMEELSDALTY 195 Query: 369 LHSKGFVHGDVKPENFLLGQPG 434 H K +H D+KPEN LLG G Sbjct: 196 CHKKKVIHRDIKPENLLLGLQG 217
>PCTK3_HUMAN (Q07002) Serine/threonine-protein kinase PCTAIRE-3 (EC 2.7.11.22)| (PCTAIRE-motif protein kinase 3) Length = 472 Score = 38.1 bits (87), Expect = 0.018 Identities = 35/145 (24%), Positives = 61/145 (42%), Gaps = 1/145 (0%) Frame = +3 Query: 3 QXYITDRKLGKGGFGQVYVGRRITGGASRTGPDAYEVA-LKLEHRRSKGCSYGPPFEWQV 179 + Y+ KLG+G + V+ GR S+ + + ++LEH C+ E + Sbjct: 140 ETYVKLDKLGEGTYATVFKGR------SKLMENLVALKEIRLEHEEGAPCT--AIREVSL 191 Query: 180 YQSLNGCYGIPSVHYKGRQGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 ++L I ++H LV + L L + G MS H V + + Sbjct: 192 LKNLKHA-NIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRG 250 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L H + +H D+KP+N L+ + G Sbjct: 251 LAYCHHRKILHRDLKPQNLLINERG 275
>M4K5_MOUSE (Q8BPM2) Mitogen-activated protein kinase kinase kinase kinase 5| (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) Length = 847 Score = 38.1 bits (87), Expect = 0.018 Identities = 39/145 (26%), Positives = 63/145 (43%), Gaps = 7/145 (4%) Frame = +3 Query: 21 RKLGKGGFGQVYVGRRITGGASRTGPDAYEVALKLEHRRSKGCSYGPPFEWQVYQS---- 188 +++G G +G VY R + TG A +KLE P ++ + Q Sbjct: 24 QRVGSGTYGDVYKARNV-----HTGELAAVKIIKLE----------PGDDFSLIQQEIFM 68 Query: 189 LNGCYGIPSVHYKGR---QGDYYILVMDMLGPSLWDVWNSMGQAMSSHMVACIAVESISI 359 + C V Y G + +I + G SL D+++ G +S +A + E++ Sbjct: 69 VKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGP-LSEMQIAYVCRETLQG 127 Query: 360 LEKLHSKGFVHGDVKPENFLLGQPG 434 L LH+KG +H D+K N LL G Sbjct: 128 LAYLHTKGKMHRDIKGANILLTDHG 152 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 93,179,941 Number of Sequences: 219361 Number of extensions: 2131654 Number of successful extensions: 7805 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 7006 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7551 length of database: 80,573,946 effective HSP length: 106 effective length of database: 57,321,680 effective search space used: 4929664480 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
