ナショナルバイオリソースプロジェクト
-Barley Genetic Resources Database-
menu 
| Clone Name | baak16f05 |
|---|---|
| Clone Library Name | barley_pub |
>HT1_ARATH (Q2MHE4) Serine/threonine-protein kinase HT1 (EC 2.7.11.1) (High| leaf temperature protein 1) Length = 390 Score = 206 bits (525), Expect = 3e-53 Identities = 94/197 (47%), Positives = 137/197 (69%), Gaps = 1/197 (0%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQ 213 N+VQFI AC KPP CI+TE+MS G++ YL+K + + ++ +A+D+S+GM YLH Sbjct: 146 NIVQFIAACKKPPVYCIITEYMSQGNLRMYLNKKEPYSLSIETVLRLALDISRGMEYLHS 205 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDH 393 +IHRDLK+ NLL+++ VKVADFG + ++ Q GTYRWMAPE+I+ KPY Sbjct: 206 QGVIHRDLKSNNLLLNDEMRVKVADFGTSCLETQCREAKGNMGTYRWMAPEMIKEKPYTR 265 Query: 394 KADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQ 573 K DV+SFGI+LWEL T +P++ +TP+QAA V +K RP +P + L L+++CW + Sbjct: 266 KVDVYSFGIVLWELTTALLPFQGMTPVQAAFAVAEKNERPPLPASCQPALAHLIKRCWSE 325 Query: 574 DPAERPDFSEILEALKK 624 +P++RPDFS I+ L+K Sbjct: 326 NPSKRPDFSNIVAVLEK 342
>CTR1_ARATH (Q05609) Serine/threonine-protein kinase CTR1 (EC 2.7.11.1)| Length = 821 Score = 169 bits (429), Expect = 5e-42 Identities = 87/202 (43%), Positives = 132/202 (65%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPAL--VGVAMDVSKGMSYLH 210 N+V F+GA T+PP L IVTE++S GS+Y LHK +L + +A DV+KGM+YLH Sbjct: 607 NIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLH 666 Query: 211 QNN--IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMT-AETGTYRWMAPEVIEHK 381 N I+HRDLK+ NLL+D+ VKV DFG++R+K + + + + GT WMAPEV+ + Sbjct: 667 NRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDE 726 Query: 382 PYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 P + K+DV+SFG++LWEL T + P+ L P Q V K R IP+N + ++ +++ Sbjct: 727 PSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEG 786 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW +P +RP F+ I++ L+ + Sbjct: 787 CWTNEPWKRPSFATIMDLLRPL 808
>KYK2_DICDI (P18161) Tyrosine-protein kinase 2 (EC 2.7.10.2) (Fragment)| Length = 410 Score = 164 bits (416), Expect = 2e-40 Identities = 85/206 (41%), Positives = 128/206 (62%), Gaps = 9/206 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKH-----KGIFKLPALVGVAMDVSKGMS 201 N+V FIGAC KP CI+TE+M+GGS+Y+ LH K + P ++ +A D++ G+ Sbjct: 164 NIVMFIGACYKPA--CIITEYMAGGSLYNILHNPNSSTPKVKYSFPLVLKMATDMALGLL 221 Query: 202 YLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY---RWMAPEVI 372 +LH I+HRDL + N+L+DE G +K++DFG++ K + G MT G RW PE+ Sbjct: 222 HLHSITIVHRDLTSQNILLDELGNIKISDFGLSAEKSREGSMTMTNGGICNPRWRPPELT 281 Query: 373 EHKP-YDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTE 549 ++ Y K DV+ F +++WE+LTG+IP+ L Q + V GLRP IP+ +L Sbjct: 282 KNLGHYSEKVDVYCFSLVVWEILTGEIPFSDLDGSQRSAQVAYAGLRPPIPEYCDPELKL 341 Query: 550 LLQKCWQQDPAERPDFSEILEALKKI 627 LL +CW+ DP +RP F+ I+ LK+I Sbjct: 342 LLTQCWEADPNDRPPFTYIVNKLKEI 367
>YR831_MIMIV (Q7T6Y2) Putative serine/threonine-protein kinase/receptor R831| precursor (EC 2.7.11.1) Length = 1624 Score = 162 bits (409), Expect = 1e-39 Identities = 89/203 (43%), Positives = 127/203 (62%), Gaps = 6/203 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH----KHKGIFKLPALVGVAMDVSKGMSY 204 N+V FIGAC K P +CIVTE+M G++ D L K KL L G AM G+ Y Sbjct: 1420 NIVTFIGACIKKPNICIVTEYMRMGNLRDVLKNPDIKITFANKLKLLYGAAM----GIDY 1475 Query: 205 LHQNN--IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEH 378 LH +N I+HRD+K AN+L+DE+ VK+ADFG AR+K + MT GT W APEVI Sbjct: 1476 LHSSNPMIVHRDIKPANILVDEHFNVKIADFGFARIKEDNTTMT-RCGTPCWTAPEVIRG 1534 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQ 558 + Y KADVFSFG+++WE+LTGK P+ ++ ++ +++ G RP IP + + +L++ Sbjct: 1535 EKYCEKADVFSFGVVMWEVLTGKEPFAECNFMKVSLDILEGG-RPIIPSDCPHEFAKLIK 1593 Query: 559 KCWQQDPAERPDFSEILEALKKI 627 KCW +RP +E+++ L I Sbjct: 1594 KCWHAKAHKRPTMTEVVQQLMLI 1616 Score = 155 bits (392), Expect = 9e-38 Identities = 90/208 (43%), Positives = 125/208 (60%), Gaps = 11/208 (5%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM--DVSKGMSYLH 210 NVV F+ A TK P +CIV EFMS GS+YD L I ++P + + M SKGM +LH Sbjct: 842 NVVLFMAASTKSPNMCIVMEFMSLGSLYDLLGNEL-IPEIPYALKIKMAYQASKGMHFLH 900 Query: 211 QNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE---TGTYRWMAPEVI-EH 378 + I+HRDLK+ NLL+D VKV+DFG+ +VK + GT W+APE++ + Sbjct: 901 SSGIVHRDLKSLNLLLDSKWNVKVSDFGLTKVKSELDKKKTNDNIIGTIHWIAPEILNDS 960 Query: 379 KPYDH-KADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNA----HAKL 543 D+ ADV+SFGI+LWELLT + PY+ +TP AV V++ G+RP I A + Sbjct: 961 TEVDYILADVYSFGIILWELLTREQPYKGMTPAAIAVSVIRDGMRPPISDEAVTAHSIEY 1020 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+++CW D RP F EI+ L I Sbjct: 1021 IDLIKQCWHSDTIIRPTFLEIMTRLSNI 1048
>MLTK_HUMAN (Q9NYL2) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase Length = 800 Score = 160 bits (404), Expect = 4e-39 Identities = 80/201 (39%), Positives = 125/201 (62%), Gaps = 4/201 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQ 213 N++QF G +PP IVTE+ S GS+YDY++ ++ + ++ A DV+KGM YLH Sbjct: 64 NIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHM 123 Query: 214 N---NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKP 384 +IHRDLK+ N+++ +G++K+ DFG +R + M+ GT+ WMAPEVI+ P Sbjct: 124 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQSLP 182 Query: 385 YDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 D +S+G++LWE+LT ++P++ L LQ A VV+K R TIP + ELL +C Sbjct: 183 VSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242 Query: 565 WQQDPAERPDFSEILEALKKI 627 W+ D +RP F +I+ L+ + Sbjct: 243 WEADAKKRPSFKQIISILESM 263
>MLTK_MOUSE (Q9ESL4) Mitogen-activated protein kinase kinase kinase MLT (EC| 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper-and sterile alpha motif kinase ZAK) (Sterile alpha motif- and leucine zipper-containing kinase AZK) ( Length = 802 Score = 160 bits (404), Expect = 4e-39 Identities = 80/201 (39%), Positives = 125/201 (62%), Gaps = 4/201 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQ 213 N++QF G +PP IVTE+ S GS+YDY++ ++ + ++ A DV+KGM YLH Sbjct: 64 NIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHM 123 Query: 214 N---NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKP 384 +IHRDLK+ N+++ +G++K+ DFG +R + M+ GT+ WMAPEVI+ P Sbjct: 124 EAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSL-VGTFPWMAPEVIQSLP 182 Query: 385 YDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 D +S+G++LWE+LT ++P++ L LQ A VV+K R TIP + ELL +C Sbjct: 183 VSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQC 242 Query: 565 WQQDPAERPDFSEILEALKKI 627 W+ D +RP F +I+ L+ + Sbjct: 243 WEADAKKRPSFKQIISILESM 263
>TNI3K_RAT (Q7TQP6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 834 Score = 159 bits (403), Expect = 5e-39 Identities = 88/201 (43%), Positives = 124/201 (61%), Gaps = 6/201 (2%) Frame = +1 Query: 40 VVQFIGACTKPP-RLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQ- 213 VVQF+GAC P + IVT+++SGGS++ LH+ K I L + + +A+DV+KGM YLH Sbjct: 520 VVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSL 579 Query: 214 -NNIIHRDLKTANLLMDENGMVKVADFGVARV--KVQSGVMTAETGTYRWMAPEVIEH-K 381 IIHRDL + N+L+ E+G VADFG +R + MT + G RWMAPEV Sbjct: 580 TQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCT 639 Query: 382 PYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y KADVFS+ + LWELLTG+IP+ +L P AA + +RP I + ++ LL + Sbjct: 640 RYTIKADVFSYSLCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIR 699 Query: 562 CWQQDPAERPDFSEILEALKK 624 W P RP+FSE++ L++ Sbjct: 700 GWNACPEGRPEFSEVVSKLEE 720
>TNI3K_MOUSE (Q5GIG6) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 833 Score = 158 bits (400), Expect = 1e-38 Identities = 87/201 (43%), Positives = 123/201 (61%), Gaps = 6/201 (2%) Frame = +1 Query: 40 VVQFIGACTKPP-RLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQ- 213 VVQF+GAC P + IVT+++SGGS++ LH+ K I L + + +A+DV+KGM YLH Sbjct: 519 VVQFVGACLDDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHSL 578 Query: 214 -NNIIHRDLKTANLLMDENGMVKVADFGVARV--KVQSGVMTAETGTYRWMAPEVIEH-K 381 IIHRDL + N+L+ E+G VADFG +R + MT + G RWMAPEV Sbjct: 579 TQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCT 638 Query: 382 PYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y KADVFS+ + LWELL G+IP+ +L P AA + +RP I + ++ LL + Sbjct: 639 RYTIKADVFSYALCLWELLIGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLMR 698 Query: 562 CWQQDPAERPDFSEILEALKK 624 W P RP+FSE++ L++ Sbjct: 699 GWNACPEGRPEFSEVVRKLEE 719
>TNI3K_HUMAN (Q59H18) Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1)| (TNNI3-interacting kinase) (Cardiac ankyrin repeat kinase) Length = 936 Score = 158 bits (399), Expect = 1e-38 Identities = 86/201 (42%), Positives = 124/201 (61%), Gaps = 6/201 (2%) Frame = +1 Query: 40 VVQFIGACTKPP-RLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQ- 213 V+QF+GAC P + IVT+++SGGS++ LH+ K I L + + +A+DV+KGM YLH Sbjct: 622 VIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNL 681 Query: 214 -NNIIHRDLKTANLLMDENGMVKVADFGVARV--KVQSGVMTAETGTYRWMAPEVIEH-K 381 IIHRDL + N+L+ E+G VADFG +R + MT + G RWMAPEV Sbjct: 682 TQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCT 741 Query: 382 PYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y KADVFS+ + LWE+LTG+IP+ +L P AA + +RP I + ++ LL + Sbjct: 742 RYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIR 801 Query: 562 CWQQDPAERPDFSEILEALKK 624 W P RP+FSE++ L++ Sbjct: 802 GWNACPEGRPEFSEVVMKLEE 822
>M3K10_HUMAN (Q02779) Mitogen-activated protein kinase kinase kinase 10 (EC| 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST) Length = 954 Score = 152 bits (385), Expect = 6e-37 Identities = 87/210 (41%), Positives = 122/210 (58%), Gaps = 13/210 (6%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLP--ALVGVAMDVSKGMSYLH 210 N++ GAC PP LC+V E+ GG++ L + +P LV A+ V++GM+YLH Sbjct: 156 NIIALRGACLNPPHLCLVMEYARGGALSRVLAGRR----VPPHVLVNWAVQVARGMNYLH 211 Query: 211 QNN---IIHRDLKTANLLMDE--------NGMVKVADFGVARVKVQSGVMTAETGTYRWM 357 + IIHRDLK+ N+L+ E + ++K+ DFG+AR ++ M+A GTY WM Sbjct: 212 NDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSA-AGTYAWM 270 Query: 358 APEVIEHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 APEVI + +DV+SFG+LLWELLTG++PY + L A GV L IP Sbjct: 271 APEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPE 330 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 LL++CW DP RPDF IL+ L+ I Sbjct: 331 PFARLLEECWDPDPHGRPDFGSILKRLEVI 360
>M3K12_RAT (Q63796) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 152 bits (383), Expect = 1e-36 Identities = 74/191 (38%), Positives = 113/191 (59%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F G CT+ P CI+ EF + G +Y+ L + + LV +M ++ GM+YLH + Sbjct: 205 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTP-SLLVDWSMGIAGGMNYLHLH 263 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDHK 396 IIHRDLK+ N+L+ + +VK++DFG ++ + GT WMAPEVI ++P K Sbjct: 264 KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 D++SFG++LWELLTG+IPY+ + GV L +P + LL++CW + Sbjct: 324 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRK 383 Query: 577 PAERPDFSEIL 609 P RP F +IL Sbjct: 384 PRNRPSFRQIL 394
>M3K12_HUMAN (Q12852) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 859 Score = 151 bits (382), Expect = 1e-36 Identities = 74/191 (38%), Positives = 112/191 (58%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F G CT+ P CI+ EF + G +Y+ L + + LV +M ++ GM+YLH + Sbjct: 172 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTP-SLLVDWSMGIAGGMNYLHLH 230 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDHK 396 IIHRDLK+ N+L+ + +VK++DFG ++ + GT WMAPEVI ++P K Sbjct: 231 KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 290 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 D++SFG++LWELLTG+IPY+ + GV L +P + LL++CW Sbjct: 291 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSK 350 Query: 577 PAERPDFSEIL 609 P RP F +IL Sbjct: 351 PRNRPSFRQIL 361
>M3K12_MOUSE (Q60700) Mitogen-activated protein kinase kinase kinase 12 (EC| 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK) Length = 888 Score = 151 bits (382), Expect = 1e-36 Identities = 74/191 (38%), Positives = 112/191 (58%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F G CT+ P CI+ EF + G +Y+ L + + LV +M ++ GM+YLH + Sbjct: 205 NIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTP-SLLVDWSMGIAGGMNYLHLH 263 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDHK 396 IIHRDLK+ N+L+ + +VK++DFG ++ + GT WMAPEVI ++P K Sbjct: 264 KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 D++SFG++LWELLTG+IPY+ + GV L +P + LL++CW Sbjct: 324 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSK 383 Query: 577 PAERPDFSEIL 609 P RP F +IL Sbjct: 384 PRNRPSFRQIL 394
>ITK_MOUSE (Q03526) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK) Length = 625 Score = 151 bits (381), Expect = 2e-36 Identities = 78/200 (39%), Positives = 120/200 (60%), Gaps = 4/200 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G C + +C+V EFM G + DYL +G+F L+G+ +DV +GM+YL + Sbjct: 423 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKAC 482 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 +IHRDL N L+ EN ++KV+DFG+ R V T+ TGT +W +PEV Y Sbjct: 483 VIHRDLAARNCLVGENQVIKVSDFGMTRF-VLDDQYTSSTGTKFPVKWASPEVFSFSRYS 541 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV+SFG+L+WE+ + GKIPYE + + V + G R P+ A + +++ CW Sbjct: 542 SKSDVWSFGVLMWEVFSEGKIPYENRSNSE-VVEDISTGFRLYKPRLASCHVYQIMNHCW 600 Query: 568 QQDPAERPDFSEILEALKKI 627 ++ P +RP FS++L L +I Sbjct: 601 KEKPEDRPPFSQLLSQLAEI 620
>ITK_HUMAN (Q08881) Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2)| (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT) Length = 620 Score = 149 bits (377), Expect = 5e-36 Identities = 78/200 (39%), Positives = 119/200 (59%), Gaps = 4/200 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G C + +C+V EFM G + DYL +G+F L+G+ +DV +GM+YL + Sbjct: 418 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEAC 477 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 +IHRDL N L+ EN ++KV+DFG+ R V T+ TGT +W +PEV Y Sbjct: 478 VIHRDLAARNCLVGENQVIKVSDFGMTRF-VLDDQYTSSTGTKFPVKWASPEVFSFSRYS 536 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV+SFG+L+WE+ + GKIPYE + + V + G R P+ A + +++ CW Sbjct: 537 SKSDVWSFGVLMWEVFSEGKIPYENRSNSE-VVEDISTGFRLYKPRLASTHVYQIMNHCW 595 Query: 568 QQDPAERPDFSEILEALKKI 627 ++ P +RP FS +L L +I Sbjct: 596 KERPEDRPAFSRLLRQLAEI 615
>SRK1_SPOLA (P42686) Tyrosine-protein kinase isoform SRK1 (EC 2.7.10.2)| Length = 505 Score = 147 bits (370), Expect = 3e-35 Identities = 77/193 (39%), Positives = 115/193 (59%), Gaps = 4/193 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 ++Q CTK + IVTE M GS+ +YL G+ K+ LV VA V+ GMSYL Q N Sbjct: 295 LIQLYAVCTKEEPIYIVTELMKYGSLLEYLRGEDGVLKIEQLVDVAAQVASGMSYLEQQN 354 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 IHRDL N+L+ E+G+ KVADFG+ARV + + A TG +W APE + + Sbjct: 355 YIHRDLAARNILVGEHGICKVADFGLARV-IDEEIYEAHTGAKFPIKWTAPEAAMYNRFT 413 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV+SFG++L+E++T G+ PY +T + + +Q+ R P N + +++ CW Sbjct: 414 IKSDVWSFGVVLYEIITYGRFPYPGMTNPE-VLEKIQQNYRMPCPANCPKQFHDIMLDCW 472 Query: 568 QQDPAERPDFSEI 606 ++DPA RP F + Sbjct: 473 REDPASRPTFETL 485
>M3K9_HUMAN (P80192) Mitogen-activated protein kinase kinase kinase 9 (EC| 2.7.11.25) (Mixed lineage kinase 1) Length = 1104 Score = 146 bits (368), Expect = 6e-35 Identities = 83/208 (39%), Positives = 118/208 (56%), Gaps = 11/208 (5%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ G C K P LC+V EF GG + L + LV A+ +++GM+YLH Sbjct: 202 NIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKR--IPPDILVNWAVQIARGMNYLHDE 259 Query: 217 NI---IHRDLKTANLLM---DENG-----MVKVADFGVARVKVQSGVMTAETGTYRWMAP 363 I IHRDLK++N+L+ ENG ++K+ DFG+AR ++ M+A GTY WMAP Sbjct: 260 AIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWMAP 318 Query: 364 EVIEHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 EVI + +DV+S+G+LLWELLTG++P+ + L A GV L IP Sbjct: 319 EVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPF 378 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L++ CW DP RP F+ IL+ L I Sbjct: 379 AKLMEDCWNPDPHSRPSFTNILDQLTTI 406
>TEC_HUMAN (P42680) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 631 Score = 145 bits (366), Expect = 1e-34 Identities = 74/199 (37%), Positives = 119/199 (59%), Gaps = 3/199 (1%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G CT+ + IVTEFM G + ++L + +G F L+ + DV +GM YL +N+ Sbjct: 425 LVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNS 484 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY--RWMAPEVIEHKPYDH 393 IHRDL N L+ E G+VKV+DFG+AR + ++ + +W PEV + + Sbjct: 485 FIHRDLAARNCLVSEAGVVKVSDFGMARYFLDDQYTSSSGAKFPVKWCPPEVFNYSRFSS 544 Query: 394 KADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQ 570 K+DV+SFG+L+WE+ T G++P+E T + V +V +G R PK A + E++ +CWQ Sbjct: 545 KSDVWSFGVLMWEVFTEGRMPFEKYTNYE-VVTMVTRGHRLYQPKLASNYVYEVMLRCWQ 603 Query: 571 QDPAERPDFSEILEALKKI 627 + P RP F ++L + ++ Sbjct: 604 EKPEGRPSFEDLLRTIDEL 622
>TEC_MOUSE (P24604) Tyrosine-protein kinase Tec (EC 2.7.10.2)| Length = 630 Score = 144 bits (362), Expect = 3e-34 Identities = 77/200 (38%), Positives = 120/200 (60%), Gaps = 4/200 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G CT+ + IVTEFM G + ++L + +G F L+ + DV +GM YL +N+ Sbjct: 424 LVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDMLLSMCQDVCEGMEYLERNS 483 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 IHRDL N L++E G+VKV+DFG+AR V T+ +G +W PEV + + Sbjct: 484 FIHRDLAARNCLVNEAGVVKVSDFGMARY-VLDDQYTSSSGAKFPVKWCPPEVFNYSRFS 542 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV+SFG+L+WE+ T G++P+E T + V +V +G R PK A L E++ +CW Sbjct: 543 SKSDVWSFGVLMWEIFTEGRMPFEKNTNYE-VVTMVTRGHRLHRPKLATKYLYEVMLRCW 601 Query: 568 QQDPAERPDFSEILEALKKI 627 Q+ P RP ++L + ++ Sbjct: 602 QERPEGRPSLEDLLRTIDEL 621
>M3K13_HUMAN (O43283) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase) Length = 966 Score = 144 bits (362), Expect = 3e-34 Identities = 71/191 (37%), Positives = 107/191 (56%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F G CT+ P CI+ E+ + G +Y+ L + I LV + ++ GM+YLH + Sbjct: 215 NIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPR-LLVDWSTGIASGMNYLHLH 273 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDHK 396 IIHRDLK+ N+L+ VK++DFG ++ + GT WMAPEVI ++P K Sbjct: 274 KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 333 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 D++SFG++LWELLTG+IPY+ + GV L +P L+++ WQ Sbjct: 334 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSK 393 Query: 577 PAERPDFSEIL 609 P RP F + L Sbjct: 394 PRNRPSFRQTL 404
>M3KL4_HUMAN (Q5TCX8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase 4) Length = 1036 Score = 143 bits (361), Expect = 4e-34 Identities = 83/221 (37%), Positives = 123/221 (55%), Gaps = 24/221 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-----------FKLP--ALVGVA 177 N+++ G C + P LC+V EF GG++ L ++P LV A Sbjct: 182 NIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWA 241 Query: 178 MDVSKGMSYLHQNN---IIHRDLKTANLLMDE--------NGMVKVADFGVARVKVQSGV 324 + +++GM YLH+ I+HRDLK++N+L+ E N +K+ DFG+AR ++ Sbjct: 242 VQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTK 301 Query: 325 MTAETGTYRWMAPEVIEHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG 504 M+ GTY WMAPEVI+ + +D++S+G+LLWELLTG++PY + L A GV Sbjct: 302 MST-AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNK 360 Query: 505 LRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 L IP +L+++CWQQDP RP F+ ILE L I Sbjct: 361 LTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAI 401
>M3KSL_DROME (Q95UN8) Mitogen-activated protein kinase kinase kinase (EC| 2.7.11.25) (Mixed lineage kinase) (dMLK) (Protein slipper) Length = 1161 Score = 143 bits (361), Expect = 4e-34 Identities = 84/208 (40%), Positives = 116/208 (55%), Gaps = 11/208 (5%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+ G C +LC+V E+ GGS+ L G LV A+ +++GM+YLH Sbjct: 200 NIAALRGVCLNT-KLCLVMEYARGGSLNRIL---AGKIPPDVLVNWAIQIARGMNYLHNE 255 Query: 217 ---NIIHRDLKTANLLMDE--------NGMVKVADFGVARVKVQSGVMTAETGTYRWMAP 363 +IIHRDLK++N+L+ E +K+ DFG+AR + M+A GTY WM P Sbjct: 256 APMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSA-AGTYAWMPP 314 Query: 364 EVIEHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 EVI Y +DV+S+G+LLWEL+TG+ PY+ PL A GV L IPK Sbjct: 315 EVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETW 374 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 L++ CWQ DP +RP F EIL+ L+ I Sbjct: 375 GALMKSCWQTDPHKRPGFKEILKQLESI 402
>M3K13_PONPY (Q5R8X7) Mitogen-activated protein kinase kinase kinase 13 (EC| 2.7.11.25) Length = 966 Score = 142 bits (359), Expect = 6e-34 Identities = 70/191 (36%), Positives = 107/191 (56%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F G CT+ P CI+ E+ + G +Y+ L + I LV + ++ GM+YLH + Sbjct: 215 NIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPR-LLVDWSTGIASGMNYLHLH 273 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDHK 396 IIHRDLK+ N+L+ VK++DFG ++ + GT W+APEVI ++P K Sbjct: 274 KIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWLAPEVIRNEPVSEK 333 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 D++SFG++LWELLTG+IPY+ + GV L +P L+++ WQ Sbjct: 334 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSK 393 Query: 577 PAERPDFSEIL 609 P RP F + L Sbjct: 394 PRNRPSFRQTL 404
>ABL_MLVAB (P00521) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 746 Score = 142 bits (358), Expect = 8e-34 Identities = 77/200 (38%), Positives = 120/200 (60%), Gaps = 5/200 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHK-HKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+VQ +G CT+ P I+TEFM+ G++ DYL + ++ L+ +A +S M YL + Sbjct: 183 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEK 242 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 N IHRDL N L+ EN +VKVADFG++R+ + TA G +W APE + + Sbjct: 243 KNFIHRDLAARNCLVGENHLVKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLAYNK 301 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV++FG+LLWE+ T G PY + L +++K R P+ K+ EL++ Sbjct: 302 FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRA 360 Query: 562 CWQQDPAERPDFSEILEALK 621 CWQ +P++RP F+EI +A + Sbjct: 361 CWQWNPSDRPSFAEIHQAFE 380
>ABL1_MOUSE (P00520) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1123 Score = 142 bits (358), Expect = 8e-34 Identities = 77/200 (38%), Positives = 120/200 (60%), Gaps = 5/200 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHK-HKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+VQ +G CT+ P I+TEFM+ G++ DYL + ++ L+ +A +S M YL + Sbjct: 297 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEK 356 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 N IHRDL N L+ EN +VKVADFG++R+ + TA G +W APE + + Sbjct: 357 KNFIHRDLAARNCLVGENHLVKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLAYNK 415 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV++FG+LLWE+ T G PY + L +++K R P+ K+ EL++ Sbjct: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRA 474 Query: 562 CWQQDPAERPDFSEILEALK 621 CWQ +P++RP F+EI +A + Sbjct: 475 CWQWNPSDRPSFAEIHQAFE 494
>M3K11_HUMAN (Q16584) Mitogen-activated protein kinase kinase kinase 11 (EC| 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase) Length = 847 Score = 142 bits (358), Expect = 8e-34 Identities = 81/210 (38%), Positives = 119/210 (56%), Gaps = 13/210 (6%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLP--ALVGVAMDVSKGMSYLH 210 N++ C + P LC+V E+ +GG + L + +P LV A+ +++GM YLH Sbjct: 175 NIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRR----VPPHVLVNWAVQIARGMHYLH 230 Query: 211 QNN---IIHRDLKTANLLM--------DENGMVKVADFGVARVKVQSGVMTAETGTYRWM 357 +IHRDLK+ N+L+ E+ +K+ DFG+AR ++ M+A GTY WM Sbjct: 231 CEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSA-AGTYAWM 289 Query: 358 APEVIEHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 APEVI+ + +DV+SFG+LLWELLTG++PY + L A GV L IP Sbjct: 290 APEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPE 349 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CW QDP RPDF+ IL+ L+ + Sbjct: 350 PFAQLMADCWAQDPHRRPDFASILQQLEAL 379
>ABL1_HUMAN (P00519) Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2)| (p150) (c-ABL) (Abelson murine leukemia viral oncogene homolog 1) Length = 1130 Score = 142 bits (358), Expect = 8e-34 Identities = 77/200 (38%), Positives = 120/200 (60%), Gaps = 5/200 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHK-HKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+VQ +G CT+ P I+TEFM+ G++ DYL + ++ L+ +A +S M YL + Sbjct: 297 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK 356 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 N IHRDL N L+ EN +VKVADFG++R+ + TA G +W APE + + Sbjct: 357 KNFIHRDLAARNCLVGENHLVKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLAYNK 415 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV++FG+LLWE+ T G PY + L +++K R P+ K+ EL++ Sbjct: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRA 474 Query: 562 CWQQDPAERPDFSEILEALK 621 CWQ +P++RP F+EI +A + Sbjct: 475 CWQWNPSDRPSFAEIHQAFE 494
>ABL_FSVHY (P10447) Tyrosine-protein kinase transforming protein Abl (EC| 2.7.10.2) (V-abl) Length = 439 Score = 142 bits (357), Expect = 1e-33 Identities = 77/195 (39%), Positives = 118/195 (60%), Gaps = 5/195 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHK-HKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+VQ +G CT+ P I+TEFM+ G++ DYL + ++ L+ +A +S M YL + Sbjct: 246 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK 305 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 N IHRDL N L+ EN +VKVADFG++R+ + TA GT +W APE + + Sbjct: 306 KNFIHRDLAARNCLVGENHLVKVADFGLSRL-MTGDTYTAHAGTKFPIKWTAPESLAYNK 364 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV++FG+LLWE+ T G PY + L +++K R P+ K+ EL++ Sbjct: 365 FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRA 423 Query: 562 CWQQDPAERPDFSEI 606 CWQ +P++RP F+EI Sbjct: 424 CWQWNPSDRPAFAEI 438
>TXK_HUMAN (P42681) Tyrosine-protein kinase TXK (EC 2.7.10.2)| Length = 527 Score = 141 bits (355), Expect = 2e-33 Identities = 74/199 (37%), Positives = 114/199 (57%), Gaps = 3/199 (1%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G C + L IVTEFM G + +YL ++KG + L+ V D+ +GM YL +N Sbjct: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNG 385 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY--RWMAPEVIEHKPYDH 393 IHRDL N L+ +VK++DFG+ R + +++ + +W PEV Y Sbjct: 386 YIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSS 445 Query: 394 KADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQ 570 K+DV+SFG+L+WE+ T GK+P+E + LQ V + +G R P A + E++ CW Sbjct: 446 KSDVWSFGVLMWEVFTEGKMPFENKSNLQ-VVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504 Query: 571 QDPAERPDFSEILEALKKI 627 + P RP F+E+L A+ +I Sbjct: 505 EKPEGRPTFAELLRAVTEI 523
>ABL_DROME (P00522) Tyrosine-protein kinase Abl (EC 2.7.10.2) (Abelson protein)| (D-ash) Length = 1620 Score = 140 bits (354), Expect = 2e-33 Identities = 79/200 (39%), Positives = 116/200 (58%), Gaps = 5/200 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKH-KGIFKLPALVGVAMDVSKGMSYLHQ 213 N+VQ IG CT+ P I+TEFMS G++ D+L + AL+ +A ++ GMSYL Sbjct: 426 NLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLES 485 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 N IHRDL N L+ +N +VKVADFG+AR+ ++ TA G +W APE + + Sbjct: 486 RNYIHRDLAARNCLVGDNKLVKVADFGLARL-MRDDTYTAHAGAKFPIKWTAPEGLAYNK 544 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV++FG+LLWE+ T G PY + L + KG R P ++ +L+++ Sbjct: 545 FSTKSDVWAFGVLLWEIATYGMSPYPAI-DLTDVYHKLDKGYRMERPPGCPPEVYDLMRQ 603 Query: 562 CWQQDPAERPDFSEILEALK 621 CWQ D +RP F I AL+ Sbjct: 604 CWQWDATDRPTFKSIHHALE 623
>TXK_MOUSE (P42682) Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18)| (Resting lymphocyte kinase) Length = 527 Score = 140 bits (353), Expect = 3e-33 Identities = 73/199 (36%), Positives = 114/199 (57%), Gaps = 3/199 (1%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G C + L IVTEFM G + DYL + KG + L+ + D+ +GM+YL ++ Sbjct: 326 LVQLYGVCIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSC 385 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY--RWMAPEVIEHKPYDH 393 IHRDL N L+ +VK++DFG+AR + +++ + +W PEV Y Sbjct: 386 YIHRDLAARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSS 445 Query: 394 KADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQ 570 K+DV+SFG+L+WE+ T GK+P+E + LQ V + +G R P A + ++ CW Sbjct: 446 KSDVWSFGVLMWEVFTEGKMPFENKSNLQ-VVEAISQGFRLYRPHLAPMTIYRVMYSCWH 504 Query: 571 QDPAERPDFSEILEALKKI 627 + P RP F+E+L+ L +I Sbjct: 505 ESPKGRPTFAELLQVLTEI 523
>FLK_RAT (P09760) Tyrosine-protein kinase FLK (EC 2.7.10.2) (Fragment)| Length = 323 Score = 139 bits (351), Expect = 5e-33 Identities = 78/204 (38%), Positives = 117/204 (57%), Gaps = 8/204 (3%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + I+ E + GG +L K K KL LV ++DV+ GM YL Sbjct: 120 NIVKLIGVCTQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLVRFSLDVAAGMLYLEGK 179 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPEVIEHKP 384 N IHRDL N L+ EN +K++DFG++R + G + + +G +W APE + + Sbjct: 180 NCIHRDLAARNCLVGENNTLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEALNYGR 237 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G PY +T QA V++G R + P+N ++ ++ K Sbjct: 238 YSSESDVWSFGILLWETFSLGVCPYPGMTNQQAR-EQVERGYRMSAPQNCPEEIFTIMMK 296 Query: 562 CWQQDPAERPDFSEI---LEALKK 624 CW P RP FS++ L A+KK Sbjct: 297 CWDYKPENRPKFSDLHKELTAIKK 320
>KYK1_DICDI (P18160) Non-receptor tyrosine kinase spore lysis A (EC 2.7.10.2)| (Tyrosine-protein kinase 1) Length = 1584 Score = 139 bits (350), Expect = 7e-33 Identities = 81/217 (37%), Positives = 124/217 (57%), Gaps = 20/217 (9%) Frame = +1 Query: 37 NVVQFIGACTK--PPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGV--AMDVSKGMSY 204 NVVQF+GACT CIVTE+M GGS+ +L H + + + + A+D++KGM+Y Sbjct: 1346 NVVQFLGACTAGGEDHHCIVTEWMGGGSLRQFLTDHFNLLEQNPHIRLKLALDIAKGMNY 1405 Query: 205 LH--QNNIIHRDLKTANLLMDENG-------------MVKVADFGVARVKV-QSGVMTAE 336 LH I+HRDL + N+L+D N K++DFG++R+K Q+ MT Sbjct: 1406 LHGWTPPILHRDLSSRNILLDHNIDPKNPVVSSRQDIKCKISDFGLSRLKKEQASQMTQS 1465 Query: 337 TGTYRWMAPEVIEHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPT 516 G +MAPEV + K+DV+S+G++L+ELLT P + + P++ A + RP Sbjct: 1466 VGCIPYMAPEVFKGDSNSEKSDVYSYGMVLFELLTSDEPQQDMKPMKMAHLAAYESYRPP 1525 Query: 517 IPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 IP +K E+L +CW +P RP F +I+ LK++ Sbjct: 1526 IPLTTSSKWKEILTQCWDSNPDSRPTFKQIIVHLKEM 1562
>BTKL_DROME (P08630) Tyrosine-protein kinase Btk29A (EC 2.7.10.2) (Dsrc28C)| Length = 786 Score = 139 bits (350), Expect = 7e-33 Identities = 77/200 (38%), Positives = 121/200 (60%), Gaps = 6/200 (3%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG--IFKLPALVGVAMDVSKGMSYLH 210 N+VQ G C+K + IVTE+M GS+ +YL +H+ I + L+ + + VSKGM+YL Sbjct: 580 NLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLE 639 Query: 211 QNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHK 381 ++N IHRDL N L+ +VKVADFG+AR V T+ GT +W PEV+ + Sbjct: 640 RHNYIHRDLAARNCLVGSENVVKVADFGLARY-VLDDQYTSSGGTKFPIKWAPPEVLNYT 698 Query: 382 PYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQ 558 + K+DV+++G+L+WE+ T GK+PY L + V VQ+G+ PK+ ++ ++++ Sbjct: 699 RFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTE-VVERVQRGIILEKPKSCAKEIYDVMK 757 Query: 559 KCWQQDPAERPDFSEILEAL 618 CW P ERP F +++ L Sbjct: 758 LCWSHGPEERPAFRVLMDQL 777
>ABL2_HUMAN (P42684) Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine| leukemia viral oncogene homolog 2) (Tyrosine kinase ARG) Length = 1182 Score = 139 bits (349), Expect = 9e-33 Identities = 77/200 (38%), Positives = 117/200 (58%), Gaps = 5/200 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHK-HKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+VQ +G CT P IVTE+M G++ DYL + ++ L+ +A +S M YL + Sbjct: 343 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK 402 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 N IHRDL N L+ EN +VKVADFG++R+ + TA G +W APE + + Sbjct: 403 KNFIHRDLAARNCLVGENHVVKVADFGLSRL-MTGDTYTAHAGAKFPIKWTAPESLAYNT 461 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV++FG+LLWE+ T G PY + L +++KG R P+ K+ EL++ Sbjct: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 520 Query: 562 CWQQDPAERPDFSEILEALK 621 CW+ PA+RP F+E +A + Sbjct: 521 CWKWSPADRPSFAETHQAFE 540
>SRK4_SPOLA (P42690) Tyrosine-protein kinase isoform SRK4 (EC 2.7.10.2)| Length = 506 Score = 139 bits (349), Expect = 9e-33 Identities = 77/193 (39%), Positives = 111/193 (57%), Gaps = 4/193 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 ++Q CTK + IVTE M GS+ +YL KLP LV + V+ GMSYL Q N Sbjct: 295 LIQLYAVCTKEEPIYIVTELMKHGSLLEYLRGDGRSLKLPDLVDMCSQVASGMSYLEQQN 354 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 IHRDL N+L+ E+ + KVADFG+ARV + + A+ G +W APE + + Sbjct: 355 YIHRDLAARNILVGEHKICKVADFGLARV-IDEEIYEAKLGAKFPIKWTAPEAAMYSRFT 413 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV+SFGI+L+E++T G+ PY +T Q + +Q+ R P KL ++ CW Sbjct: 414 IKSDVWSFGIVLYEVITYGRFPYPGMTNAQ-VLEQIQQSYRMPRPMGCPEKLYAIMMDCW 472 Query: 568 QQDPAERPDFSEI 606 ++DPA RP F + Sbjct: 473 REDPASRPTFETL 485
>SRK2_SPOLA (P42688) Tyrosine-protein kinase SRK2 (EC 2.7.10.2) (Fragment)| Length = 362 Score = 139 bits (349), Expect = 9e-33 Identities = 74/192 (38%), Positives = 111/192 (57%), Gaps = 3/192 (1%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 ++Q CT+ + I+TE MS GS+ DYL G KLP L+ +A V+ GM+YL +N Sbjct: 150 LIQLYAVCTQGEPVYIITELMSKGSLLDYLQGEAGALKLPQLIDMAAQVAAGMAYLELHN 209 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY--RWMAPEVIEHKPYDH 393 IHRDL N+L+ +N + KVADFG+AR+ V E + +W APE + Sbjct: 210 YIHRDLAARNILVGDNNICKVADFGLARLIVSDDYNATEGAKFPIKWTAPEAALFNRFSI 269 Query: 394 KADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQ 570 K+DV+SFGIL+ EL+T G+IPY ++ + + KG R P L +++ CW+ Sbjct: 270 KSDVWSFGILITELVTYGRIPYPGMSNAEVLQN-LDKGYRMPCPVTTPESLYQIMLDCWK 328 Query: 571 QDPAERPDFSEI 606 ++PA+RP F + Sbjct: 329 RNPADRPTFEAL 340
>FER_HUMAN (P16591) Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2)| (p94-FER) (c-FER) Length = 822 Score = 139 bits (349), Expect = 9e-33 Identities = 74/199 (37%), Positives = 116/199 (58%), Gaps = 5/199 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + I+ E +SGG +L + K KL LV ++D + GM YL Sbjct: 619 NIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESK 678 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPEVIEHKP 384 N IHRDL N L+ EN ++K++DFG++R + G + + +G +W APE + + Sbjct: 679 NCIHRDLAARNCLVGENNVLKISDFGMSR--QEDGGVYSSSGLKQIPIKWTAPEALNYGR 736 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G PY +T QA V++G R + P++ +++++ K Sbjct: 737 YSSESDVWSFGILLWETFSLGVCPYPGMTNQQAR-EQVERGYRMSAPQHCPEDISKIMMK 795 Query: 562 CWQQDPAERPDFSEILEAL 618 CW P RP FSE+ + L Sbjct: 796 CWDYKPENRPKFSELQKEL 814
>FYN_XIPHE (P27446) Proto-oncogene tyrosine-protein kinase FYN (EC 2.7.10.2)| (P59-FYN) Length = 536 Score = 138 bits (347), Expect = 2e-32 Identities = 82/197 (41%), Positives = 126/197 (63%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L +G KLP LV +A V+ GM+Y+ + Sbjct: 325 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 383 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL++AN+L+ +N + K+ADFG+AR+ ++ TA G +W APE + + Sbjct: 384 NYIHRDLRSANILVGDNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 442 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL+T G++PY + + + V++G R P++ A L EL+ +C Sbjct: 443 TIKSDVWSFGILLTELVTKGRVPYPGMNN-REVLEQVERGYRMPCPQDCPASLHELMLQC 501 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 502 WKKDPEERPTF-EYLQA 517
>EPA4A_BRARE (O13148) Ephrin type-A receptor 4a (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK2) (EPH-like kinase 2) (Fragment) Length = 292 Score = 138 bits (347), Expect = 2e-32 Identities = 77/217 (35%), Positives = 128/217 (58%), Gaps = 14/217 (6%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G TK + I+TE+M GS+ +L K+ G F + LVG+ ++ GM Sbjct: 49 GQFDHPNIIRLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGILRGIASGM 108 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ---SGVMTAE-TGTY------ 348 YL + +HRDL N+L++ N + KV+DFG++RV + + T E TGTY Sbjct: 109 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEEDPDAAYTTREITGTYQSQGGK 168 Query: 349 ---RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPT 516 RW APE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R Sbjct: 169 IPIRWTAPEAITYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLP 227 Query: 517 IPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P + L +L+ CWQ++ AERP FS+I+ L K+ Sbjct: 228 PPMDCPVSLHQLMLDCWQKERAERPKFSQIVNMLDKL 264
>KRAF1_DROME (P11346) Raf homolog serine/threonine-protein kinase dRAF-1 (EC| 2.7.11.1) (Protein pole-hole) Length = 739 Score = 137 bits (346), Expect = 2e-32 Identities = 80/207 (38%), Positives = 123/207 (59%), Gaps = 10/207 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G C P L IVT++ G S+Y ++H + FKL L+ + V++GM YLH Sbjct: 484 NILLFMG-CVSKPSLAIVTQWCEGSSLYKHVHVSETKFKLNTLIDIGRQVAQGMDYLHAK 542 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRDLK+ N+ + E+ VK+ DFG+A K + SG A TG+ WMAPEVI E Sbjct: 543 NIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSGEKQANQPTGSILWMAPEVIRMQEL 602 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRP---TIPKNAHAKLT 546 PY ++DV++FGI+++ELL +PY +++ + +V +G LRP + +A L Sbjct: 603 NPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGRGLLRPDMSQVRSDAPQALK 662 Query: 547 ELLQKCWQQDPAERPDFSEILEALKKI 627 L + C + P +RP F +L L+ + Sbjct: 663 RLAEDCIKYTPKDRPLFRPLLNMLENM 689
>BRAF1_CHICK (Q04982) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Rmil serine/threonine-protein kinase) (c-Rmil) Length = 806 Score = 137 bits (344), Expect = 3e-32 Identities = 79/205 (38%), Positives = 128/205 (62%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TKP +L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 552 NILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 610 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 +IIHRDLK+ N+ + E+ VK+ DFG+A VK + SG E +G+ WMAPEVI + Sbjct: 611 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 670 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV++FGI+L+EL+TG++PY + + +V +G L P + K N + Sbjct: 671 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 730 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ +C ++ ERP F +IL +++ Sbjct: 731 RLMAECLKKKRDERPLFPQILASIE 755
>RMIL_AVEVR (P27966) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 450 Score = 137 bits (344), Expect = 3e-32 Identities = 79/205 (38%), Positives = 128/205 (62%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TKP +L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 138 NILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 196 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 +IIHRDLK+ N+ + E+ VK+ DFG+A VK + SG E +G+ WMAPEVI + Sbjct: 197 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 256 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV++FGI+L+EL+TG++PY + + +V +G L P + K N + Sbjct: 257 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 316 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ +C ++ ERP F +IL +++ Sbjct: 317 RLMAECLKKKRDERPLFPQILASIE 341
>CSK_CHICK (P41239) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 137 bits (344), Expect = 3e-32 Identities = 77/202 (38%), Positives = 117/202 (57%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPR-LCIVTEFMSGGSVYDYLHKH-KGIFKLPALVGVAMDVSKGMSYLH 210 N+VQ +G + L IVTE+M+ GS+ DYL + + L+ ++DV + M YL Sbjct: 247 NLVQLLGVIVEEKSGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 211 QNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVIEHKP 384 NN +HRDL N+L+ E+ + KV+DFG+ + T +TG +W APE + K Sbjct: 307 ANNFVHRDLAARNVLVSEDNIAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALREKK 362 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV+SFGILLWE+ + G++PY + PL+ V V+KG + P A + E+++K Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDPPDGCPAIVYEVMKK 421 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW DP RP F ++ E L I Sbjct: 422 CWTLDPGHRPSFHQLREQLVHI 443
>RMIL_AVII1 (P10533) Serine/threonine-protein kinase transforming protein Rmil| (EC 2.7.11.1) Length = 367 Score = 137 bits (344), Expect = 3e-32 Identities = 79/205 (38%), Positives = 128/205 (62%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TKP +L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 122 NILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 180 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 +IIHRDLK+ N+ + E+ VK+ DFG+A VK + SG E +G+ WMAPEVI + Sbjct: 181 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 240 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV++FGI+L+EL+TG++PY + + +V +G L P + K N + Sbjct: 241 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 300 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ +C ++ ERP F +IL +++ Sbjct: 301 RLMAECLKKKRDERPLFPQILASIE 325
>FGFR4_RAT (Q498D6) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) Length = 800 Score = 137 bits (344), Expect = 3e-32 Identities = 74/221 (33%), Positives = 123/221 (55%), Gaps = 24/221 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK---------------GIFKLPALVG 171 N++ +G CT+ L ++ E+ + G++ ++L + G PALV Sbjct: 530 NIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVS 589 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVAR--------VKVQSGVM 327 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR K +G + Sbjct: 590 CAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRL 649 Query: 328 TAETGTYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKG 504 +WMAPE + + Y H++DV+SFGILLWE+ T G PY + P++ ++++G Sbjct: 650 PV-----KWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLREG 703 Query: 505 LRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 R P N ++L L+++CW P++RP F +++EAL K+ Sbjct: 704 HRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKV 744
>BRAF1_HUMAN (P15056) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) Length = 766 Score = 137 bits (344), Expect = 3e-32 Identities = 79/205 (38%), Positives = 128/205 (62%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TKP +L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 512 NILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 570 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 +IIHRDLK+ N+ + E+ VK+ DFG+A VK + SG E +G+ WMAPEVI + Sbjct: 571 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 630 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV++FGI+L+EL+TG++PY + + +V +G L P + K N + Sbjct: 631 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 690 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ +C ++ ERP F +IL +++ Sbjct: 691 RLMAECLKKKRDERPLFPQILASIE 715
>BRAF1_COTJA (P34908) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RMIL serine/threonine-protein kinase) (c-RMIL) Length = 807 Score = 137 bits (344), Expect = 3e-32 Identities = 79/205 (38%), Positives = 128/205 (62%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TKP +L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 552 NILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 610 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 +IIHRDLK+ N+ + E+ VK+ DFG+A VK + SG E +G+ WMAPEVI + Sbjct: 611 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 670 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV++FGI+L+EL+TG++PY + + +V +G L P + K N + Sbjct: 671 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 730 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ +C ++ ERP F +IL +++ Sbjct: 731 RLMAECLKKKRDERPLFPQILASIE 755
>BRAF1_MOUSE (P28028) B-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Fragment) Length = 328 Score = 137 bits (344), Expect = 3e-32 Identities = 79/205 (38%), Positives = 128/205 (62%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TKP +L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 74 NILLFMGYSTKP-QLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAK 132 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 +IIHRDLK+ N+ + E+ VK+ DFG+A VK + SG E +G+ WMAPEVI + Sbjct: 133 SIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDK 192 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV++FGI+L+EL+TG++PY + + +V +G L P + K N + Sbjct: 193 NPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMK 252 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ +C ++ ERP F +IL +++ Sbjct: 253 RLMAECLKKKRDERPLFPQILASIE 277
>RAF1_RAT (P11345) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 136 bits (343), Expect = 4e-32 Identities = 76/205 (37%), Positives = 124/205 (60%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TK L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 404 NILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 462 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRD+K+ N+ + E VK+ DFG+A VK + SG E TG+ WMAPEVI ++ Sbjct: 463 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDN 522 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLR----PTIPKNAHAKLT 546 P+ ++DV+S+GI+L+EL+TG++PY ++ + +V +G + KN + Sbjct: 523 NPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMK 582 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ C ++ ERP F +IL +++ Sbjct: 583 RLVADCVKKVKEERPLFPQILSSIE 607
>RAF1_HUMAN (P04049) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 136 bits (343), Expect = 4e-32 Identities = 76/205 (37%), Positives = 124/205 (60%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TK L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 404 NILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 462 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRD+K+ N+ + E VK+ DFG+A VK + SG E TG+ WMAPEVI ++ Sbjct: 463 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDN 522 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLR----PTIPKNAHAKLT 546 P+ ++DV+S+GI+L+EL+TG++PY ++ + +V +G + KN + Sbjct: 523 NPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMK 582 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ C ++ ERP F +IL +++ Sbjct: 583 RLVADCVKKVKEERPLFPQILSSIE 607
>YES_CHICK (P09324) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 540 Score = 136 bits (342), Expect = 6e-32 Identities = 77/184 (41%), Positives = 117/184 (63%), Gaps = 5/184 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTEFM+ GS+ D+L + +G F KLP LV +A ++ GM+Y+ + N IHRDL+ AN+L+ Sbjct: 343 IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 402 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 +N + K+ADFG+AR+ ++ TA G +W APE + + K+DV+SFGILL E Sbjct: 403 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 461 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 L+T G++PY + + + V++G R P+ L EL++ CW++DP ERP F I Sbjct: 462 LVTKGRVPYPGMVN-REVLEQVERGYRMPCPQGCPESLHELMKLCWKKDPDERPTFEYIQ 520 Query: 610 EALK 621 L+ Sbjct: 521 SFLE 524
>YES_AVISY (P00527) Tyrosine-protein kinase transforming protein YES (EC| 2.7.10.2) (Fragment) Length = 528 Score = 136 bits (342), Expect = 6e-32 Identities = 77/184 (41%), Positives = 117/184 (63%), Gaps = 5/184 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTEFM+ GS+ D+L + +G F KLP LV +A ++ GM+Y+ + N IHRDL+ AN+L+ Sbjct: 336 IVTEFMTKGSLLDFLKEGEGKFLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 395 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 +N + K+ADFG+AR+ ++ TA G +W APE + + K+DV+SFGILL E Sbjct: 396 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 454 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 L+T G++PY + + + V++G R P+ L EL++ CW++DP ERP F I Sbjct: 455 LVTKGRVPYPGMVN-REVLEQVERGYRMPCPQGCPESLHELMKLCWKKDPDERPTFEYIQ 513 Query: 610 EALK 621 L+ Sbjct: 514 SFLE 517
>RAF1_CHICK (P05625) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (RAF-1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C-MIL) Length = 647 Score = 135 bits (341), Expect = 8e-32 Identities = 76/205 (37%), Positives = 123/205 (60%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TK L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 404 NILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 462 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRD+K+ N+ + E VK+ DFG+A VK + SG E TG+ WMAPEVI + Sbjct: 463 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDS 522 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLR----PTIPKNAHAKLT 546 P+ ++DV+S+GI+L+EL+TG++PY ++ + +V +G + KN + Sbjct: 523 NPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMK 582 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ C ++ ERP F +IL +++ Sbjct: 583 RLVADCLKKVREERPLFPQILSSIE 607
>EPHA7_MOUSE (Q61772) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1) Length = 998 Score = 135 bits (341), Expect = 8e-32 Identities = 77/208 (37%), Positives = 121/208 (58%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NVV G T+ + IV EFM G++ +L KH G F + LVG+ ++ GM Sbjct: 687 GQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGM 746 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV--KVQSGVMTAETG--TYRWMAPE 366 YL +HRDL N+L++ N + KV+DFG++RV V T G RW APE Sbjct: 747 RYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 806 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I+++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + A L Sbjct: 807 AIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPAPMDCPAGL 865 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ+D AERP F +I+ L K+ Sbjct: 866 HQLMLDCWQKDRAERPKFEQIVGILDKM 893
>M3K7_HUMAN (O43318) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 606 Score = 135 bits (341), Expect = 8e-32 Identities = 76/201 (37%), Positives = 116/201 (57%), Gaps = 7/201 (3%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI--FKLPALVGVAMDVSKGMSYLH 210 N+V+ GAC P +C+V E+ GGS+Y+ LH + + + + + S+G++YLH Sbjct: 88 NIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 145 Query: 211 QNN---IIHRDLKTANLLMDENGMV-KVADFGVARVKVQSGVMTAETGTYRWMAPEVIEH 378 +IHRDLK NLL+ G V K+ DFG A +Q+ MT G+ WMAPEV E Sbjct: 146 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA-CDIQTH-MTNNKGSAAWMAPEVFEG 203 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYL-TPLQAAVGVVQKGLRPTIPKNAHAKLTELL 555 Y K DVFS+GI+LWE++T + P++ + P + V G RP + KN + L+ Sbjct: 204 SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLM 263 Query: 556 QKCWQQDPAERPDFSEILEAL 618 +CW +DP++RP EI++ + Sbjct: 264 TRCWSKDPSQRPSMEEIVKIM 284
>M3K7_MOUSE (Q62073) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1) Length = 579 Score = 135 bits (341), Expect = 8e-32 Identities = 76/201 (37%), Positives = 116/201 (57%), Gaps = 7/201 (3%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI--FKLPALVGVAMDVSKGMSYLH 210 N+V+ GAC P +C+V E+ GGS+Y+ LH + + + + + S+G++YLH Sbjct: 88 NIVKLYGACLNP--VCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLH 145 Query: 211 QNN---IIHRDLKTANLLMDENGMV-KVADFGVARVKVQSGVMTAETGTYRWMAPEVIEH 378 +IHRDLK NLL+ G V K+ DFG A +Q+ MT G+ WMAPEV E Sbjct: 146 SMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA-CDIQTH-MTNNKGSAAWMAPEVFEG 203 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYL-TPLQAAVGVVQKGLRPTIPKNAHAKLTELL 555 Y K DVFS+GI+LWE++T + P++ + P + V G RP + KN + L+ Sbjct: 204 SNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLM 263 Query: 556 QKCWQQDPAERPDFSEILEAL 618 +CW +DP++RP EI++ + Sbjct: 264 TRCWSKDPSQRPSMEEIVKIM 284
>STK_HYDAT (P17713) Tyrosine-protein kinase STK (EC 2.7.10.2) (P57-STK)| Length = 509 Score = 135 bits (340), Expect = 1e-31 Identities = 78/200 (39%), Positives = 117/200 (58%), Gaps = 5/200 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQ 213 ++VQ C+ + IVTE+MSGGS+ DYL K +G+ +LP L+ +A V+ GM++L Sbjct: 294 HLVQLYAICSDREPIYIVTEYMSGGSLLDYLSKGEGVNLQLPTLIDMAAQVASGMAFLEA 353 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 IHRDL N+L+ EN + KVADFG+AR+ ++ TA G +W APE + Sbjct: 354 QGYIHRDLAARNILVGENYICKVADFGLARL-IEDDEYTAHEGAKFPIKWTAPEAALYNR 412 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV+SFGIL+ E++T G+IPY +T Q + V+KG R I L ++ + Sbjct: 413 FTIKSDVWSFGILMAEIVTKGRIPYPGMTNAQ-TIAEVEKGYRMPIMPGCPEPLYNIMLQ 471 Query: 562 CWQQDPAERPDFSEILEALK 621 W +DP RP F + L+ Sbjct: 472 TWNKDPENRPTFDYLQGVLE 491
>EPHA2_HUMAN (P29317) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) Length = 976 Score = 135 bits (340), Expect = 1e-31 Identities = 71/208 (34%), Positives = 119/208 (57%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G +K + I+TE+M G++ +L + G F + LVG+ ++ GM Sbjct: 668 GQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGM 727 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPE 366 YL N +HRDL N+L++ N + KV+DFG++RV T T RW APE Sbjct: 728 KYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE 787 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I ++ + +DV+SFGI++WE++T G+ PY L+ + + G R P + + + Sbjct: 788 AISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN-HEVMKAINDGFRLPTPMDCPSAI 846 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ +CWQQ+ A RP F++I+ L K+ Sbjct: 847 YQLMMQCWQQERARRPKFADIVSILDKL 874
>EPHA5_CHICK (P54755) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK7) Length = 1013 Score = 135 bits (339), Expect = 1e-31 Identities = 77/214 (35%), Positives = 120/214 (56%), Gaps = 5/214 (2%) Frame = +1 Query: 1 GKFIL*GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM 180 G+ + G+F N++ G TK + IVTE+M GS+ +L K+ G F + LVG+ Sbjct: 699 GEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLR 758 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TY 348 ++ GM YL +HRDL N+L++ N + KV+DFG++RV T G Sbjct: 759 GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPI 818 Query: 349 RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPK 525 RW APE I + + +DV+S+GI++WE+++ G+ PY +T Q + V++G R P Sbjct: 819 RWTAPEAIAFRKFTSASDVWSYGIVMWEVMSYGERPYWEMTN-QDVIKAVEEGYRLPSPM 877 Query: 526 NAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + A L +L+ CWQ+D RP F EI+ L K+ Sbjct: 878 DCPAALYQLMLDCWQKDRNSRPKFDEIVSMLDKL 911
>KRAF1_CAEEL (Q07292) Raf homolog serine/threonine-protein kinase (EC 2.7.11.1)| (Abnormal cell lineage protein 45) Length = 813 Score = 134 bits (338), Expect = 2e-31 Identities = 82/212 (38%), Positives = 124/212 (58%), Gaps = 15/212 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH--KHKGIFKLPALVGVAMDVSKGMSYLH 210 NV+ F+G + P + I+T++ G S+Y ++H + + F++ A++ + VS GM+YLH Sbjct: 536 NVLLFMG-WVREPEIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMNYLH 594 Query: 211 QNNIIHRDLKTANL-LMDENGMVKVADFGVARVKVQSGVMTAE-----TGTYRWMAPEVI 372 NIIHRDLKT N+ LMD+ VK+ DFG+A VK + V + TG+ WMAPEVI Sbjct: 595 SKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVI 654 Query: 373 ---EHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPKNAH-- 534 + PY ++DV+SFGI ++E+L+ +PY + + +V +G LRP K H Sbjct: 655 RMQDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDT 714 Query: 535 -AKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + +L C D ERP F E+LE L+ I Sbjct: 715 PKSMLKLYDNCIMFDRNERPVFGEVLERLRDI 746
>EPHA7_RAT (P54759) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) Length = 998 Score = 134 bits (337), Expect = 2e-31 Identities = 76/208 (36%), Positives = 121/208 (58%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NVV G T+ + IV EFM G++ +L KH G F + LVG+ ++ GM Sbjct: 687 GQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGM 746 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV--KVQSGVMTAETG--TYRWMAPE 366 YL +HRDL N+L++ N + KV+DFG++RV V T G RW APE Sbjct: 747 RYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 806 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I+++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + A L Sbjct: 807 AIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPAPMDCPAGL 865 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ++ AERP F +I+ L K+ Sbjct: 866 HQLMLDCWQKERAERPKFEQIVGILDKM 893
>EPHA7_HUMAN (Q15375) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein-tyrosine kinase HEK11) Length = 998 Score = 134 bits (337), Expect = 2e-31 Identities = 76/208 (36%), Positives = 121/208 (58%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NVV G T+ + IV EFM G++ +L KH G F + LVG+ ++ GM Sbjct: 687 GQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGM 746 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV--KVQSGVMTAETG--TYRWMAPE 366 YL +HRDL N+L++ N + KV+DFG++RV V T G RW APE Sbjct: 747 RYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 806 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I+++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + A L Sbjct: 807 AIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPAPMDCPAGL 865 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ++ AERP F +I+ L K+ Sbjct: 866 HQLMLDCWQKERAERPKFEQIVGILDKM 893
>EPHA5_MOUSE (Q60629) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7) Length = 877 Score = 134 bits (337), Expect = 2e-31 Identities = 77/214 (35%), Positives = 120/214 (56%), Gaps = 5/214 (2%) Frame = +1 Query: 1 GKFIL*GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM 180 G+ + G+F N++ G TK + IVTE+M GS+ +L K+ G F + LVG+ Sbjct: 562 GEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLR 621 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TY 348 ++ GM YL +HRDL N+L++ N + KV+DFG++RV T G Sbjct: 622 GIAAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPI 681 Query: 349 RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPK 525 RW APE I + + +DV+S+GI++WE+++ G+ PY +T Q + V++G R P Sbjct: 682 RWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTN-QDVIKAVEEGYRLPSPM 740 Query: 526 NAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + A L +L+ CWQ+D RP F EI+ L K+ Sbjct: 741 DCPAALYQLMLDCWQKDRNSRPKFDEIVNMLDKL 774
>YES_HUMAN (P07947) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 542 Score = 134 bits (336), Expect = 3e-31 Identities = 77/184 (41%), Positives = 114/184 (61%), Gaps = 5/184 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTEFMS GS+ D+L + G + KLP LV +A ++ GM+Y+ + N IHRDL+ AN+L+ Sbjct: 345 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 404 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 EN + K+ADFG+AR+ ++ TA G +W APE + + K+DV+SFGIL E Sbjct: 405 ENLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTE 463 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 L+T G++PY + + + V++G R P+ L EL+ CW++DP ERP F I Sbjct: 464 LVTKGRVPYPGMVN-REVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQ 522 Query: 610 EALK 621 L+ Sbjct: 523 SFLE 526
>EPHA5_HUMAN (P54756) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein-tyrosine kinase HEK7) Length = 1037 Score = 134 bits (336), Expect = 3e-31 Identities = 77/214 (35%), Positives = 120/214 (56%), Gaps = 5/214 (2%) Frame = +1 Query: 1 GKFIL*GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM 180 G+ + G+F N++ G TK + IVTE+M GS+ +L K+ G F + LVG+ Sbjct: 723 GEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLR 782 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TY 348 +S GM YL +HRDL N+L++ N + KV+DFG++RV T G Sbjct: 783 GISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPI 842 Query: 349 RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPK 525 RW APE I + + +DV+S+GI++WE+++ G+ PY +T Q + V++G R P Sbjct: 843 RWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTN-QDVIKAVEEGYRLPSPM 901 Query: 526 NAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + A L +L+ CWQ++ RP F EI+ L K+ Sbjct: 902 DCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKL 935
>YES_MOUSE (Q04736) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 540 Score = 134 bits (336), Expect = 3e-31 Identities = 77/184 (41%), Positives = 114/184 (61%), Gaps = 5/184 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTEFMS GS+ D+L + G + KLP LV +A ++ GM+Y+ + N IHRDL+ AN+L+ Sbjct: 343 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 402 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 EN + K+ADFG+AR+ ++ TA G +W APE + + K+DV+SFGIL E Sbjct: 403 ENLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTE 461 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 L+T G++PY + + + V++G R P+ L EL+ CW++DP ERP F I Sbjct: 462 LVTKGRVPYPGMVN-REVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQ 520 Query: 610 EALK 621 L+ Sbjct: 521 SFLE 524
>RAF_MSV36 (P00532) Serine/threonine-protein kinase transforming protein raf| (EC 2.7.11.1) Length = 323 Score = 133 bits (335), Expect = 4e-31 Identities = 75/205 (36%), Positives = 122/205 (59%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TK L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 79 NILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 137 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRD+K+ N+ + E VK+ DFG+A VK + SG E TG+ WMAPEVI + Sbjct: 138 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDD 197 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLR----PTIPKNAHAKLT 546 P+ ++DV+S+GI+L+EL+ G++PY ++ + +V +G + KN + Sbjct: 198 NPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAIK 257 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ C ++ ERP F +IL +++ Sbjct: 258 RLVADCVKKVKEERPLFPQILSSIE 282
>RAF1_MOUSE (Q99N57) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (Raf-1) (C-RAF) (cRaf) Length = 648 Score = 133 bits (335), Expect = 4e-31 Identities = 75/205 (36%), Positives = 122/205 (59%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TK L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 404 NILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 462 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRD+K+ N+ + E VK+ DFG+A VK + SG E TG+ WMAPEVI + Sbjct: 463 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDD 522 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLR----PTIPKNAHAKLT 546 P+ ++DV+S+GI+L+EL+ G++PY ++ + +V +G + KN + Sbjct: 523 NPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMK 582 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ C ++ ERP F +IL +++ Sbjct: 583 RLVADCVKKVKEERPLFPQILSSIE 607
>EPHA3_RAT (O08680) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor REK4) (TYRO-4) Length = 984 Score = 133 bits (335), Expect = 4e-31 Identities = 74/214 (34%), Positives = 120/214 (56%), Gaps = 5/214 (2%) Frame = +1 Query: 1 GKFIL*GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM 180 G+ + G+F N+++ G TK + IVTE+M GS+ +L KH F + LVG+ Sbjct: 670 GEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLR 729 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TY 348 ++ GM YL +HRDL N+L++ N + KV+DFG++RV T G Sbjct: 730 GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPV 789 Query: 349 RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPK 525 RW +PE ++ + +DV+S+GI+LWE+++ G+ PY ++ Q + V +G R +P Sbjct: 790 RWTSPEATAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSN-QDVIKAVDEGYRLPLPM 848 Query: 526 NAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + A L +L+ CWQ+D RP F +I+ L K+ Sbjct: 849 DCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKL 882
>EPHA3_HUMAN (P29320) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4) Length = 983 Score = 133 bits (335), Expect = 4e-31 Identities = 75/214 (35%), Positives = 120/214 (56%), Gaps = 5/214 (2%) Frame = +1 Query: 1 GKFIL*GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM 180 G+ + G+F N+++ G TK + IVTE+M GS+ +L KH F + LVG+ Sbjct: 669 GEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLR 728 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TY 348 ++ GM YL +HRDL N+L++ N + KV+DFG++RV T G Sbjct: 729 GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPI 788 Query: 349 RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPK 525 RW +PE I ++ + +DV+S+GI+LWE+++ G+ PY ++ Q + V +G R P Sbjct: 789 RWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSN-QDVIKAVDEGYRLPPPM 847 Query: 526 NAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + A L +L+ CWQ+D RP F +I+ L K+ Sbjct: 848 DCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKL 881
>FYN_XENLA (P13406) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 536 Score = 133 bits (334), Expect = 5e-31 Identities = 77/191 (40%), Positives = 119/191 (62%), Gaps = 5/191 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L +G KLP LV +A V++GM+Y+ + Sbjct: 325 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVARGMAYIERM 383 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL++AN+L+ + K+ADFG+AR+ ++ TA G +W APE + + Sbjct: 384 NYIHRDLRSANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 442 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL+T G++PY + + + V++G R P++ L EL+ C Sbjct: 443 TIKSDVWSFGILLTELVTKGRVPYPGMNN-REVLEQVERGYRMPCPQDCPISLHELMLNC 501 Query: 565 WQQDPAERPDF 597 W++DP ERP F Sbjct: 502 WKKDPEERPTF 512
>SRC2_XENLA (P13116) Tyrosine-protein kinase Src-2 (EC 2.7.10.2) (p60-Src-2)| Length = 531 Score = 133 bits (334), Expect = 5e-31 Identities = 79/197 (40%), Positives = 122/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 320 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERM 378 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 379 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 437 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P + L +L+ +C Sbjct: 438 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPDCPESLHDLMFQC 496 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 497 WRKDPEERPTF-EYLQA 512
>YES_CANFA (Q28923) Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2)| (p61-Yes) (c-Yes) Length = 538 Score = 133 bits (334), Expect = 5e-31 Identities = 77/184 (41%), Positives = 113/184 (61%), Gaps = 5/184 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTEFMS GS+ D+L + G + KLP LV +A ++ GM+Y+ + N IHRDL+ AN+L+ Sbjct: 341 IVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 400 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 EN + K+ADFG+AR+ ++ TA G +W APE + + K+DV+SFGIL E Sbjct: 401 ENLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTE 459 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 L T G++PY + + + V++G R P+ L EL+ CW++DP ERP F I Sbjct: 460 LTTKGRVPYPGMVN-REVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQ 518 Query: 610 EALK 621 L+ Sbjct: 519 SFLE 522
>CSK_HUMAN (P41240) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase CYL) Length = 450 Score = 132 bits (333), Expect = 6e-31 Identities = 75/202 (37%), Positives = 116/202 (57%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPR-LCIVTEFMSGGSVYDYLHKH-KGIFKLPALVGVAMDVSKGMSYLH 210 N+VQ +G + L IVTE+M+ GS+ DYL + + L+ ++DV + M YL Sbjct: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 211 QNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVIEHKP 384 NN +HRDL N+L+ E+ + KV+DFG+ + T +TG +W APE + K Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALREKK 362 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV+SFGILLWE+ + G++PY + PL+ V V+KG + P + E+++ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVYEVMKN 421 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW D A RP F ++ E L+ I Sbjct: 422 CWHLDAAMRPSFLQLREQLEHI 443
>MIL_AVIMH (P00531) Serine/threonine-protein kinase transforming protein mil| (EC 2.7.11.1) Length = 380 Score = 132 bits (333), Expect = 6e-31 Identities = 75/204 (36%), Positives = 121/204 (59%), Gaps = 10/204 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TK L IVT++ G S+Y +LH + F++ L+ +A ++GM YLH Sbjct: 137 NILLFMGYMTKD-NLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAK 195 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRD+K+ N+ + VK+ DFG+A VK + SG E TG+ WMAPEVI + Sbjct: 196 NIIHRDMKSNNIFLHGGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDS 255 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLR----PTIPKNAHAKLT 546 P+ ++DV+S+GI+L+EL+TG++PY ++ + +V +G + KN + Sbjct: 256 NPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMK 315 Query: 547 ELLQKCWQQDPAERPDFSEILEAL 618 L+ C ++ ERP F +IL ++ Sbjct: 316 RLVADCLKKVREERPLFPQILSSI 339
>EPHA2_MOUSE (Q03145) Ephrin type-A receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2) Length = 977 Score = 132 bits (333), Expect = 6e-31 Identities = 69/208 (33%), Positives = 118/208 (56%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N++ G +K + I+TE+M G++ +L + G F + LVG+ ++ GM Sbjct: 669 GQFSHHNIIPLEGVVSKYKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIASGM 728 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPE 366 YL N +HRDL N+L++ N + KV+DFG++RV T T RW APE Sbjct: 729 KYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE 788 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I ++ + +DV+S+GI++WE++T G+ PY L+ + + G R P + + + Sbjct: 789 AISYRKFTSASDVWSYGIVMWEVMTYGERPYWELSN-HEVMKAINDGFRLPTPMDCPSAI 847 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ +CWQQ+ + RP F++I+ L K+ Sbjct: 848 YQLMMQCWQQERSRRPKFADIVSILDKL 875
>SRC_AVIS2 (P15054) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 586 Score = 132 bits (333), Expect = 6e-31 Identities = 79/197 (40%), Positives = 121/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 321 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 379 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 380 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 438 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 439 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPESLHDLMCQC 497 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 498 WRKDPEERPTF-EYLQA 513
>SRC_AVIST (P14085) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 556 Score = 132 bits (333), Expect = 6e-31 Identities = 79/197 (40%), Positives = 121/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 321 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 379 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 380 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 438 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 439 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPESLHDLMCQC 497 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 498 WRKDPEERPTF-EYLQA 513
>SRC_CHICK (P00523) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 532 Score = 132 bits (333), Expect = 6e-31 Identities = 79/197 (40%), Positives = 121/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 321 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 379 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 380 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 438 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 439 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPESLHDLMCQC 497 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 498 WRKDPEERPTF-EYLQA 513
>EPHA5_RAT (P54757) Ephrin type-A receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) Length = 1005 Score = 132 bits (333), Expect = 6e-31 Identities = 75/208 (36%), Positives = 117/208 (56%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N++ G TK + IVTE+M GS+ +L K+ G F + LVG+ ++ GM Sbjct: 731 GQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGM 790 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TYRWMAPE 366 YL +HRDL N+L++ N + KV+DFG++RV T G RW APE Sbjct: 791 KYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 850 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I + + +DV+S+GI++WE+++ G+ PY +T Q + V++G R P + A L Sbjct: 851 AIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTN-QDVIKAVEEGYRLPSPMDCPAAL 909 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ+D RP F +I+ L K+ Sbjct: 910 YQLMLDCWQKDRNSRPKFDDIVNMLDKL 937
>EPHB5_CHICK (Q07497) Ephrin type-B receptor 5 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase CEK9) Length = 1002 Score = 132 bits (333), Expect = 6e-31 Identities = 72/210 (34%), Positives = 117/210 (55%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NV+ G TK + IVTEFM GS+ +L + +G F + LVG+ ++ GM Sbjct: 691 GQFEHPNVIHLEGVVTKSRPVMIVTEFMENGSLDSFLRQKEGQFSVLQLVGMLRGIAAGM 750 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT------YRWMA 360 YL N +HRDL N+L++ N + KV+DFG++R TG RW A Sbjct: 751 RYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDASNPTYTGALGCKIPIRWTA 810 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE ++++ + +DV+S+GI++WE+++ G+ PY ++ Q + + + R P + Sbjct: 811 PEAVQYRKFTSSSDVWSYGIVMWEVMSYGERPYWDMSN-QDVINAIDQDYRLPPPPDCPT 869 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L L+ CWQ+D +RP F +I+ AL K+ Sbjct: 870 VLHLLMLDCWQKDRVQRPKFEQIVSALDKM 899
>EPHA3_CHICK (P29318) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (CEK4) Length = 983 Score = 132 bits (333), Expect = 6e-31 Identities = 74/214 (34%), Positives = 119/214 (55%), Gaps = 5/214 (2%) Frame = +1 Query: 1 GKFIL*GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM 180 G+ + G+F N+++ G TK + IVTE+M GS+ +L KH F + LVG+ Sbjct: 669 GEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLR 728 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TY 348 ++ GM YL +HRDL N+L++ N + KV+DFG++RV T G Sbjct: 729 GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPI 788 Query: 349 RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPK 525 RW +PE I ++ + +D +S+GI+LWE+++ G+ PY ++ Q + V +G R P Sbjct: 789 RWTSPEAIAYRKFTSASDAWSYGIVLWEVMSYGERPYWEMS-FQDVIKAVDEGYRLPPPM 847 Query: 526 NAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + A L +L+ CWQ+D RP F +I+ L K+ Sbjct: 848 DCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKL 881
>BTK_CHICK (Q8JH64) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's tyrosine| kinase) Length = 657 Score = 132 bits (332), Expect = 8e-31 Identities = 71/200 (35%), Positives = 116/200 (58%), Gaps = 4/200 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G CTK + I+TE+M+ G + ++L + + F+ L+ + DV + M YL Sbjct: 455 LVQLYGVCTKQRPIFIITEYMANGCLLNFLRETQRRFQPAELLEMCKDVCEAMEYLESKQ 514 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 +HRDL N L+++ G+VKV+DFG++R V T+ G+ RW PEV+ + + Sbjct: 515 FLHRDLAARNCLVNDQGIVKVSDFGLSRY-VLDDEYTSSMGSKFPVRWSPPEVLLYSKFS 573 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV+SFG+L+WE+ + GK+PYE + V+Q GLR P+ A ++ ++ CW Sbjct: 574 SKSDVWSFGVLMWEVYSLGKMPYERFNNSETTEHVIQ-GLRLYRPQQASERVYAIMYSCW 632 Query: 568 QQDPAERPDFSEILEALKKI 627 + ERP FS +L ++ I Sbjct: 633 HEKAEERPTFSALLGSIVDI 652
>BTK_HUMAN (Q06187) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's tyrosine| kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) Length = 658 Score = 132 bits (332), Expect = 8e-31 Identities = 70/194 (36%), Positives = 112/194 (57%), Gaps = 4/194 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G CTK + I+TE+M+ G + +YL + + F+ L+ + DV + M YL Sbjct: 456 LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 515 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 +HRDL N L+++ G+VKV+DFG++R V T+ G+ RW PEV+ + + Sbjct: 516 FLHRDLAARNCLVNDQGVVKVSDFGLSRY-VLDDEYTSSVGSKFPVRWSPPEVLMYSKFS 574 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+D+++FG+L+WE+ + GK+PYE T + A + Q GLR P A K+ ++ CW Sbjct: 575 SKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQ-GLRLYRPHLASEKVYTIMYSCW 633 Query: 568 QQDPAERPDFSEIL 609 + ERP F +L Sbjct: 634 HEKADERPTFKILL 647
>ARAF_PIG (O19004) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-Raf-1) Length = 606 Score = 132 bits (331), Expect = 1e-30 Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G T+P I+T++ G S+Y +LH F + L+ VA ++GM YLH Sbjct: 365 NILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAK 423 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRDLK+ N+ + E VK+ DFG+A VK + SG E +G+ WMA EVI + Sbjct: 424 NIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDP 483 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV+++G++L+EL+TG +PY ++ + +V +G L P + K N + Sbjct: 484 NPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPKAMR 543 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 LL C + ERP F +IL ++ Sbjct: 544 RLLSDCLKFQREERPLFPQILATIE 568
>EPHA8_HUMAN (P29322) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3) Length = 1005 Score = 132 bits (331), Expect = 1e-30 Identities = 76/206 (36%), Positives = 115/206 (55%), Gaps = 6/206 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G T+ IVTE+M GS+ +L H G F + LVG+ V GM Sbjct: 689 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGM 748 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT-----YRWMAP 363 YL +HRDL N+L+D N + KV+DFG++RV ++ A T T RW AP Sbjct: 749 RYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRV-LEDDPDAAYTTTGGKIPIRWTAP 807 Query: 364 EVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAK 540 E I + + +DV+SFG+++WE+L G+ PY +T + + V++G R P Sbjct: 808 EAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTN-RDVISSVEEGYRLPAPMGCPHA 866 Query: 541 LTELLQKCWQQDPAERPDFSEILEAL 618 L +L+ CW +D A+RP FS+I+ L Sbjct: 867 LHQLMLDCWHKDRAQRPRFSQIVSVL 892
>FGFR4_MOUSE (Q03142) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) (Protein-tyrosine kinase receptor MPK-11) Length = 799 Score = 132 bits (331), Expect = 1e-30 Identities = 73/221 (33%), Positives = 121/221 (54%), Gaps = 24/221 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK---------------GIFKLPALVG 171 N++ +G CT+ L ++ E + G++ ++L + G PALV Sbjct: 529 NIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVS 588 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVAR--------VKVQSGVM 327 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR K +G + Sbjct: 589 CAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRL 648 Query: 328 TAETGTYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKG 504 +WMAPE + + Y H++DV+SF ILLWE+ T G PY + P++ ++++G Sbjct: 649 PV-----KWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGI-PVEELFSLLREG 702 Query: 505 LRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 R P N ++L L+++CW P++RP F +++EAL K+ Sbjct: 703 HRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKV 743
>CSK_RAT (P32577) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| Length = 450 Score = 131 bits (330), Expect = 1e-30 Identities = 74/202 (36%), Positives = 116/202 (57%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPR-LCIVTEFMSGGSVYDYLHKH-KGIFKLPALVGVAMDVSKGMSYLH 210 N+VQ +G + L IVTE+M+ GS+ DYL + + L+ ++DV + M YL Sbjct: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306 Query: 211 QNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVIEHKP 384 NN +HRDL N+L+ E+ + KV+DFG+ + T +TG +W APE + K Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALREKK 362 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV+SFGILLWE+ + G++PY + PL+ V V+KG + P + ++++ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW D A RP F ++ E L+ I Sbjct: 422 CWHLDAATRPTFLQLREQLEHI 443
>EPHB2_HUMAN (P29323) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen) Length = 1055 Score = 131 bits (330), Expect = 1e-30 Identities = 72/210 (34%), Positives = 119/210 (56%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NV+ G TK + I+TEFM GS+ +L ++ G F + LVG+ ++ GM Sbjct: 675 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 734 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 735 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 794 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I+++ + +DV+S+GI++WE+++ G+ PY +T Q + +++ R P + + Sbjct: 795 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN-QDVINAIEQDYRLPPPMDCPS 853 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F +I+ L K+ Sbjct: 854 ALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 883
>EPHB2_MOUSE (P54763) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3) Length = 994 Score = 131 bits (330), Expect = 1e-30 Identities = 72/210 (34%), Positives = 119/210 (56%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NV+ G TK + I+TEFM GS+ +L ++ G F + LVG+ ++ GM Sbjct: 683 GQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 742 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 743 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 802 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I+++ + +DV+S+GI++WE+++ G+ PY +T Q + +++ R P + + Sbjct: 803 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN-QDVINAIEQDYRLPPPMDCPS 861 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F +I+ L K+ Sbjct: 862 ALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 891
>SRC1_XENLA (P13115) Tyrosine-protein kinase Src-1 (EC 2.7.10.2) (p60-Src-1)| Length = 531 Score = 131 bits (330), Expect = 1e-30 Identities = 78/197 (39%), Positives = 122/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE++S GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 320 LVQLYAVVSEEP-IYIVTEYISKGSLLDFLKGEMGRYLRLPQLVDMAAQIASGMAYVERM 378 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 379 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 437 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P + L +L+ +C Sbjct: 438 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPDCPESLHDLMFQC 496 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 497 WRKDPEERPTF-EYLQA 512
>ARAF_RAT (P14056) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 131 bits (330), Expect = 1e-30 Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G T+P I+T++ G S+Y +LH F + L+ VA ++GM YLH Sbjct: 363 NILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAK 421 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRDLK+ N+ + E VK+ DFG+A VK + SG E +G+ WMA EVI + Sbjct: 422 NIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDP 481 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV+++G++L+EL+TG +PY ++ + +V +G L P + K N + Sbjct: 482 NPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMR 541 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 LL C + ERP F +IL ++ Sbjct: 542 RLLTDCLKFQREERPLFPQILATIE 566
>ARAF_MOUSE (P04627) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) Length = 604 Score = 131 bits (330), Expect = 1e-30 Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G T+P I+T++ G S+Y +LH F + L+ VA ++GM YLH Sbjct: 363 NILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAK 421 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRDLK+ N+ + E VK+ DFG+A VK + SG E +G+ WMA EVI + Sbjct: 422 NIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDP 481 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV+++G++L+EL+TG +PY ++ + +V +G L P + K N + Sbjct: 482 NPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMR 541 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 LL C + ERP F +IL ++ Sbjct: 542 RLLTDCLKFQREERPLFPQILATIE 566
>EPHA7_CHICK (O42422) Ephrin type-A receptor 7 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEPHA7) (Tyrosine-protein kinase receptor CEK11) Length = 993 Score = 131 bits (330), Expect = 1e-30 Identities = 74/208 (35%), Positives = 120/208 (57%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NVV G T+ + IV E+M G++ +L KH G F + LVG+ ++ GM Sbjct: 682 GQFDHPNVVHLEGVVTRGKPVMIVIEYMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGM 741 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV--KVQSGVMTAETG--TYRWMAPE 366 YL +HRDL N+L++ N + KV+DFG++RV V T G RW APE Sbjct: 742 RYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPE 801 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I+++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + A L Sbjct: 802 AIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPAPMDCPAGL 860 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ++ ERP F +I+ L K+ Sbjct: 861 HQLMLDCWQKERGERPKFEQIVGILDKM 888
>EPHA3_BRARE (O13146) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ZEK1) (EPH-like kinase 1) Length = 981 Score = 131 bits (330), Expect = 1e-30 Identities = 70/208 (33%), Positives = 121/208 (58%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G T+ + IVTE+M GS+ +L KH G F + L+G+ ++ GM Sbjct: 680 GQFDHPNIIRLEGVVTRCKPVMIVTEYMENGSLDTFLKKHDGQFTVIQLLGMLRGIAAGM 739 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TYRWMAPE 366 YL + N +HRDL N+L++ N + KV+DFG++RV T G RW APE Sbjct: 740 QYLSEMNYVHRDLAARNILVNRNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPE 799 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + V +G R P + L Sbjct: 800 AITYRKFTSASDVWSYGIVMWEVISYGERPYWEMSN-QDVIKAVDEGYRLPAPMDCPVVL 858 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CW+++ ++RP F +I+ L ++ Sbjct: 859 HQLMLDCWEKNRSDRPKFGQIVNTLDRL 886
>HCK_HUMAN (P08631) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p59-HCK/p60-HCK) (Hemopoietic cell kinase) Length = 525 Score = 131 bits (330), Expect = 1e-30 Identities = 74/198 (37%), Positives = 120/198 (60%), Gaps = 5/198 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFK-LPALVGVAMDVSKGMSYLHQN 216 +V+ TK P + I+TEFM+ GS+ D+L +G + LP L+ + +++GM+++ Q Sbjct: 316 LVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQR 374 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ + + K+ADFG+ARV ++ TA G +W APE I + Sbjct: 375 NYIHRDLRAANILVSASLVCKIADFGLARV-IEDNEYTAREGAKFPIKWTAPEAINFGSF 433 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL E++T G+IPY ++ + + +++G R P+N +L ++ +C Sbjct: 434 TIKSDVWSFGILLMEIVTYGRIPYPGMSNPE-VIRALERGYRMPRPENCPEELYNIMMRC 492 Query: 565 WQQDPAERPDFSEILEAL 618 W+ P ERP F I L Sbjct: 493 WKNRPEERPTFEYIQSVL 510
>BTK_MOUSE (P35991) Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton's tyrosine| kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) Length = 658 Score = 131 bits (330), Expect = 1e-30 Identities = 69/194 (35%), Positives = 112/194 (57%), Gaps = 4/194 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +VQ G CTK + I+TE+M+ G + +YL + + F+ L+ + DV + M YL Sbjct: 456 LVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 515 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 +HRDL N L+++ G+VKV+DFG++R V T+ G+ RW PEV+ + + Sbjct: 516 FLHRDLAARNCLVNDQGVVKVSDFGLSRY-VLDDEYTSSVGSKFPVRWSPPEVLMYSKFS 574 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+D+++FG+L+WE+ + GK+PYE T + A + Q GLR P A ++ ++ CW Sbjct: 575 SKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQ-GLRLYRPHLASERVYTIMYSCW 633 Query: 568 QQDPAERPDFSEIL 609 + ERP F +L Sbjct: 634 HEKADERPSFKILL 647
>SRC_AVISS (P14084) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 567 Score = 131 bits (329), Expect = 2e-30 Identities = 76/182 (41%), Positives = 114/182 (62%), Gaps = 5/182 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTE+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + N +HRDL+ AN+L+ Sbjct: 335 IVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG 394 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 EN + KVADFG+AR+ ++ TA G +W APE + + K+DV+SFGILL E Sbjct: 395 ENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 453 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 L T G++PY + + + V++G R P L +L+ +CW++DP ERP F E L Sbjct: 454 LTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTF-EYL 511 Query: 610 EA 615 +A Sbjct: 512 QA 513
>FGFR4_HUMAN (P22455) Fibroblast growth factor receptor 4 precursor (EC 2.7.10.1)| (FGFR-4) (CD334 antigen) Length = 802 Score = 131 bits (329), Expect = 2e-30 Identities = 72/221 (32%), Positives = 120/221 (54%), Gaps = 24/221 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK---------------GIFKLPALVG 171 N++ +G CT+ L ++ E + G++ ++L + G P LV Sbjct: 532 NIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVS 591 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVAR--------VKVQSGVM 327 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR K +G + Sbjct: 592 CAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRL 651 Query: 328 TAETGTYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKG 504 +WMAPE + + Y H++DV+SFGILLWE+ T G PY + P++ ++++G Sbjct: 652 PV-----KWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLREG 705 Query: 505 LRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 R P + +L L+++CW P++RP F +++EAL K+ Sbjct: 706 HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKV 746
>FYN_MOUSE (P39688) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 131 bits (329), Expect = 2e-30 Identities = 77/191 (40%), Positives = 118/191 (61%), Gaps = 5/191 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L +G KLP LV +A V+ GM+Y+ + Sbjct: 322 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 380 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL++AN+L+ + K+ADFG+AR+ ++ TA G +W APE + + Sbjct: 381 NYIHRDLRSANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 439 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL+T G++PY + + + V++G R P++ L EL+ C Sbjct: 440 TIKSDVWSFGILLTELVTKGRVPYPGMNN-REVLEQVERGYRMPCPQDCPISLHELMIHC 498 Query: 565 WQQDPAERPDF 597 W++DP ERP F Sbjct: 499 WKKDPEERPTF 509
>ARAF_HUMAN (P10398) A-Raf proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (A-raf-1) (Proto-oncogene Pks) Length = 606 Score = 131 bits (329), Expect = 2e-30 Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G T+P I+T++ G S+Y +LH F + L+ VA ++GM YLH Sbjct: 365 NILLFMGFMTRPG-FAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAK 423 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRDLK+ N+ + E VK+ DFG+A VK + SG E +G+ WMA EVI + Sbjct: 424 NIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDP 483 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKG-LRPTIPK---NAHAKLT 546 PY ++DV+++G++L+EL+TG +PY ++ + +V +G L P + K N + Sbjct: 484 NPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMR 543 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 LL C + ERP F +IL ++ Sbjct: 544 RLLSDCLKFQREERPLFPQILATIE 568
>SRC_HUMAN (P12931) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 131 bits (329), Expect = 2e-30 Identities = 78/197 (39%), Positives = 121/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 324 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 382 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 383 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 441 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 442 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPESLHDLMCQC 500 Query: 565 WQQDPAERPDFSEILEA 615 W+++P ERP F E L+A Sbjct: 501 WRKEPEERPTF-EYLQA 516
>EPHB1_RAT (P09759) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (ELK) Length = 984 Score = 131 bits (329), Expect = 2e-30 Identities = 71/210 (33%), Positives = 121/210 (57%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G TK + I+TEFM G++ +L ++ G F + LVG+ ++ GM Sbjct: 673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 732 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL + N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 733 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 792 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++ R P + A Sbjct: 793 PEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSN-QDVINAIEQDYRLPPPMDCPA 851 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F+EI+ L K+ Sbjct: 852 ALHQLMLDCWQKDRNSRPRFAEIVNTLDKM 881
>EPB1B_XENLA (Q91736) Ephrin type-B receptor 1-B (EC 2.7.10.1) (Tyrosine-protein| kinase receptor XELK) (Fragment) Length = 902 Score = 131 bits (329), Expect = 2e-30 Identities = 71/210 (33%), Positives = 120/210 (57%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G TK + I+TEFM G++ +L ++ G F + LVG+ ++ GM Sbjct: 591 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 650 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL + N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 651 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 710 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++ R P + A Sbjct: 711 PEAIRYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVINAIEQDYRLPPPMDCPA 769 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F EI+ L K+ Sbjct: 770 ALHQLMLDCWQKDRNSRPRFGEIVNTLDKM 799
>LCK_CHICK (P42683) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (Protein-tyrosine kinase C-TKL) (p56tk1) Length = 507 Score = 130 bits (328), Expect = 2e-30 Identities = 74/199 (37%), Positives = 120/199 (60%), Gaps = 5/199 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +V+ TK P + I+TE+M GS+ D+L +GI + L+ +A +++GM+++ Sbjct: 298 LVRLYAVVTKEP-IYIITEYMEKGSLVDFLKTSEGIKLSINKLLDMAAQIAEGMAFIEAK 356 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ E K+ADFG+AR+ ++ TA G +W APE I + + Sbjct: 357 NYIHRDLRAANILVSEALCCKIADFGLARL-IEDNEYTAREGAKFPIKWTAPEAINYGTF 415 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL E++T G+IPY +T + + +++G R P N +L EL+ +C Sbjct: 416 TIKSDVWSFGILLTEIVTYGRIPYPGMTNPE-VIQNLERGYRMPQPDNCPQELYELMMQC 474 Query: 565 WQQDPAERPDFSEILEALK 621 W++ P ERP F + L+ Sbjct: 475 WKEQPEERPTFEYMKSVLE 493
>SRC_RSVSA (P00524) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 130 bits (328), Expect = 2e-30 Identities = 79/197 (40%), Positives = 121/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 321 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 379 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 380 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 438 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 439 TIKSDVWSFGILLTELTTKGRVPYPGMGNGE-VLDRVERGYRMPCPPECPESLHDLMCQC 497 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 498 WRRDPEERPTF-EYLQA 513
>SRC_AVISR (P00525) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 130 bits (328), Expect = 2e-30 Identities = 79/197 (40%), Positives = 121/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 321 LVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 379 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 380 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 438 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 439 TIKSDVWSFGILLTELTTKGRVPYPGMGNGE-VLDRVERGYRMPCPPECPESLHDLMCQC 497 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 498 WRRDPEERPTF-EYLQA 513
>EPHB1_HUMAN (P54762) Ephrin type-B receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK) Length = 984 Score = 130 bits (328), Expect = 2e-30 Identities = 71/210 (33%), Positives = 121/210 (57%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G TK + I+TEFM G++ +L ++ G F + LVG+ ++ GM Sbjct: 673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 732 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL + N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 733 KYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 792 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++ R P + A Sbjct: 793 PEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSN-QDVINAIEQDYRLPPPMDCPA 851 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F+EI+ L K+ Sbjct: 852 ALHQLMLDCWQKDRNSRPRFAEIVNTLDKM 881
>EPA4B_XENLA (Q91694) Ephrin type-A receptor 4-B precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor PAG) (Pagliaccio) Length = 985 Score = 130 bits (328), Expect = 2e-30 Identities = 71/208 (34%), Positives = 119/208 (57%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N++ G TK + I+TE+M GS+ +L K+ G F + LVG+ + GM Sbjct: 674 GQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGM 733 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TYRWMAPE 366 YL + +HRDL N+L++ N + KV+DFG++RV T G RW APE Sbjct: 734 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 793 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + L Sbjct: 794 AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIAL 852 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ+D ++RP F +I+ L K+ Sbjct: 853 HQLMLDCWQKDRSDRPKFGQIVSMLDKL 880
>EPHB2_CHICK (P28693) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK5) Length = 1004 Score = 130 bits (327), Expect = 3e-30 Identities = 72/210 (34%), Positives = 118/210 (56%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NV+ G TK + I+TEFM GS+ +L ++ G F + LVG+ ++ GM Sbjct: 693 GQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 752 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 753 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 812 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I+++ + +DV+S+GI++WE+++ G+ PY +T Q + +++ R P + Sbjct: 813 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN-QDVINAIEQDYRLPPPMDCPN 871 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F +I+ L K+ Sbjct: 872 ALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 901
>SRC42_DROME (Q9V9J3) Tyrosine-protein kinase Src42A (EC 2.7.10.2) (Dsrc41)| Length = 517 Score = 130 bits (327), Expect = 3e-30 Identities = 72/196 (36%), Positives = 110/196 (56%), Gaps = 7/196 (3%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG---IFKLPALVGVAMDVSKGMSYLH 210 ++Q CT + I+TE M GS+ +YL G K+ L+ +A ++ GM+YL Sbjct: 303 LIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLE 362 Query: 211 QNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHK 381 N IHRDL N+L+ + +VK+ADFG+AR+ ++ A G +W APE + Sbjct: 363 SQNYIHRDLAARNVLVGDGNIVKIADFGLARL-IKEDEYEARVGARFPIKWTAPEAANYS 421 Query: 382 PYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQ 558 + K+DV+SFGILL EL+T G+IPY +T + + V+ G R P N +L E++ Sbjct: 422 KFSIKSDVWSFGILLTELVTYGRIPYPGMTNAE-VLTQVEHGYRMPQPPNCEPRLYEIML 480 Query: 559 KCWQQDPAERPDFSEI 606 +CW +DP RP F + Sbjct: 481 ECWHKDPMRRPTFETL 496
>YES_XENLA (P10936) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 536 Score = 130 bits (327), Expect = 3e-30 Identities = 74/184 (40%), Positives = 114/184 (61%), Gaps = 5/184 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTE+M GS+ D+L + G + KLP LV +A ++ GM+Y+ + N IHRDL+ AN+L+ Sbjct: 339 IVTEYMIKGSLLDFLKEGNGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVG 398 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 +N + K+ADFG+AR+ ++ TA G +W APE + + K+DV+SFGILL E Sbjct: 399 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 L+ G++PY + + + V++G R P+ L EL++ CW++DP ERP F I Sbjct: 458 LVAKGRVPYPGMVN-REVLEQVERGYRMPCPQRCPESLHELMKLCWKKDPDERPTFEYIQ 516 Query: 610 EALK 621 L+ Sbjct: 517 SFLE 520
>FYN_HUMAN (P06241) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) (Protooncogene Syn) (SLK) Length = 536 Score = 130 bits (327), Expect = 3e-30 Identities = 77/199 (38%), Positives = 121/199 (60%), Gaps = 5/199 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+M+ GS+ D+L +G KLP LV +A V+ GM+Y+ + Sbjct: 325 LVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 383 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL++AN+L+ + K+ADFG+AR+ ++ TA G +W APE + + Sbjct: 384 NYIHRDLRSANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 442 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL+T G++PY + + + V++G R P++ L EL+ C Sbjct: 443 TIKSDVWSFGILLTELVTKGRVPYPGMNN-REVLEQVERGYRMPCPQDCPISLHELMIHC 501 Query: 565 WQQDPAERPDFSEILEALK 621 W++DP ERP F + L+ Sbjct: 502 WKKDPEERPTFEYLQSFLE 520
>LYN_RAT (Q07014) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 130 bits (327), Expect = 3e-30 Identities = 75/198 (37%), Positives = 116/198 (58%), Gaps = 5/198 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +V+ TK + I+TEFM+ GS+ D+L +G LP L+ + +++GM+Y+ + Sbjct: 301 LVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGSKVLLPKLIDFSAQIAEGMAYIERK 360 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ E+ M K+ADFG+ARV ++ TA G +W APE I + Sbjct: 361 NYIHRDLRAANVLVSESLMCKIADFGLARV-IEDNEYTAREGAKFPIKWTAPEAINFGCF 419 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL+E++T GKIPY T + Q G R +N +L ++++ C Sbjct: 420 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQ-GYRMPRMENCPDELYDIMKMC 478 Query: 565 WQQDPAERPDFSEILEAL 618 W++ ERP F + L Sbjct: 479 WKESAEERPTFDYLQSVL 496
>ABL1_CAEEL (P03949) Tyrosine-protein kinase abl-1 (EC 2.7.10.2)| Length = 1224 Score = 130 bits (327), Expect = 3e-30 Identities = 71/195 (36%), Positives = 110/195 (56%), Gaps = 5/195 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHK-HKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+V+ +G CT I+TEFM G++ +YL + K + LV +A ++ GMSYL Sbjct: 366 NLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEA 425 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 + IHRDL N L+ E+ +VK+ADFG+AR ++ TA G +W APE + Sbjct: 426 RHFIHRDLAARNCLVSEHNIVKIADFGLARF-MKEDTYTAHAGAKFPIKWTAPEGLAFNT 484 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV++FG+LLWE+ T G PY + L G+++ G R P+ + L+ + Sbjct: 485 FSSKSDVWAFGVLLWEIATYGMAPYPGV-ELSNVYGLLENGFRMDGPQGCPPSVYRLMLQ 543 Query: 562 CWQQDPAERPDFSEI 606 CW P++RP F +I Sbjct: 544 CWNWSPSDRPRFRDI 558
>EPA4A_XENLA (Q91845) Ephrin type-A receptor 4-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK-1) (xSEK-1) Length = 986 Score = 130 bits (326), Expect = 4e-30 Identities = 70/208 (33%), Positives = 119/208 (57%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N++ G TK + I+TE+M GS+ +L K+ G F + LVG+ + GM Sbjct: 674 GQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGILRGIGSGM 733 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TYRWMAPE 366 YL + +HRDL N+L++ N + KV+DFG++RV T G RW APE Sbjct: 734 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 793 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + L Sbjct: 794 AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIAL 852 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ++ ++RP F +I+ L K+ Sbjct: 853 HQLMLDCWQKERSDRPKFGQIVSMLDKL 880
>YRK_CHICK (Q02977) Proto-oncogene tyrosine-protein kinase Yrk (EC 2.7.10.2)| (p60-Yrk) (Yes-related kinase) Length = 535 Score = 130 bits (326), Expect = 4e-30 Identities = 76/199 (38%), Positives = 120/199 (60%), Gaps = 5/199 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTEFMS GS+ D+L G + KLP LV +A ++ GM+Y+ + Sbjct: 324 LVQLYAVVSEEP-IYIVTEFMSQGSLLDFLKDGDGRYLKLPQLVDMAAQIAAGMAYIERM 382 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ +N + K+ADFG+AR+ ++ TA G +W APE + Sbjct: 383 NYIHRDLRAANILVGDNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALFGKF 441 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL+T G++PY + + + V++G R P L +++ +C Sbjct: 442 TIKSDVWSFGILLTELVTKGRVPYPGMNN-REVLEQVERGYRMQCPGGCPPSLHDVMVQC 500 Query: 565 WQQDPAERPDFSEILEALK 621 W+++P ERP F + L+ Sbjct: 501 WKREPEERPTFEYLQSFLE 519
>SRC_RSVSE (P63185) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 129 bits (325), Expect(2) = 5e-30 Identities = 78/197 (39%), Positives = 120/197 (60%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IV E+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 321 LVQLYAVVSEEP-IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 379 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 380 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 438 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 439 TIKSDVWSFGILLTELTTKGRVPYPGMGNGE-VLDRVERGYRMPCPPECPESLHDLMSQC 497 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 498 WRRDPEERPTF-EYLQA 513 Score = 21.2 bits (43), Expect(2) = 5e-30 Identities = 7/17 (41%), Positives = 11/17 (64%) Frame = +3 Query: 3 EVYIMRKVRHKXCCAIY 53 E +M+K+RHK +Y Sbjct: 309 EAQVMKKLRHKKLVQLY 325
>LYN_MOUSE (P25911) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 129 bits (325), Expect = 5e-30 Identities = 74/198 (37%), Positives = 117/198 (59%), Gaps = 5/198 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +V+ TK + I+TEFM+ GS+ D+L +G LP L+ + +++GM+Y+ + Sbjct: 301 LVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 360 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ E+ M K+ADFG+ARV ++ TA G +W APE I + Sbjct: 361 NYIHRDLRAANVLVSESLMCKIADFGLARV-IEDNEYTAREGAKFPIKWTAPEAINFGCF 419 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL+E++T GKIPY T + + +G R +N +L ++++ C Sbjct: 420 TIKSDVWSFGILLYEIVTYGKIPYPGRTNAD-VMSALSQGYRMPRMENCPDELYDIMKMC 478 Query: 565 WQQDPAERPDFSEILEAL 618 W++ ERP F + L Sbjct: 479 WKEKAEERPTFDYLQSVL 496
>SRC_RSVP (P00526) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 129 bits (325), Expect = 5e-30 Identities = 75/191 (39%), Positives = 116/191 (60%), Gaps = 5/191 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IV E+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 321 LVQLYAVVSEEP-IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 379 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 380 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 438 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 439 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPESLHDLMCQC 497 Query: 565 WQQDPAERPDF 597 W++DP ERP F Sbjct: 498 WRKDPEERPTF 508
>EPHA3_MOUSE (P29319) Ephrin type-A receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ETK1) (MEK4) Length = 983 Score = 129 bits (325), Expect = 5e-30 Identities = 73/214 (34%), Positives = 118/214 (55%), Gaps = 5/214 (2%) Frame = +1 Query: 1 GKFIL*GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM 180 G+ + G+F N+++ G TK IVTE+M GS+ +L KH F + LVG+ Sbjct: 669 GEASIMGQFDHPNIIRLEGVVTKSKPEMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLR 728 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TY 348 ++ GM YL +HRDL N+L++ N + KV+DFG++RV T G Sbjct: 729 GIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPI 788 Query: 349 RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPK 525 RW +PE + ++ + +DV+S+GI+LWE+++ G+ PY ++ Q + V + R P Sbjct: 789 RWTSPEAMSYRKFTSASDVWSYGIVLWEVMSYGERPYSQMSN-QDVIKAVDERYRLPPPM 847 Query: 526 NAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + A L +L+ CWQ+D RP F +I+ L K+ Sbjct: 848 DCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKL 881
>RAF1_XENLA (P09560) RAF proto-oncogene serine/threonine-protein kinase (EC| 2.7.11.1) (C-RAF) Length = 638 Score = 129 bits (324), Expect = 7e-30 Identities = 76/205 (37%), Positives = 124/205 (60%), Gaps = 10/205 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N++ F+G TK L IVT++ G S+Y +LH F++ L+ +A ++GM YLH Sbjct: 395 NILLFMGYMTKD-NLAIVTQWCEGSSLYYHLHVLDTKFQMFQLIDIARQTAQGMDYLHAK 453 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAE--TGTYRWMAPEVI---EH 378 NIIHRD+K+ N+ + E VK+ DFG+A VK + SG E TG+ WMAPEVI ++ Sbjct: 454 NIIHRDMKSNNIFLHEGLTVKIGDFGLATVKTRWSGSQQVEQLTGSILWMAPEVIRMQDN 513 Query: 379 KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQK-GLRPTIP---KNAHAKLT 546 P+ ++DV+S+GI+L+EL+TG++PY ++ + +V + G+ P + KN + Sbjct: 514 NPFSFQSDVYSYGIVLYELMTGELPYSHIRDRDQIIFLVGRGGVVPDLSKLYKNCPKAMK 573 Query: 547 ELLQKCWQQDPAERPDFSEILEALK 621 L+ ++ ERP F +IL +++ Sbjct: 574 RLVADSIKKLRDERPLFPQILSSIE 598
>EPHB2_COTJA (Q90344) Ephrin type-B receptor 2 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor QEK5) Length = 987 Score = 129 bits (324), Expect = 7e-30 Identities = 72/210 (34%), Positives = 117/210 (55%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NV+ G TK + I+TEFM GS+ +L ++ G F + LVG+ ++ GM Sbjct: 676 GQFDHPNVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 735 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL N +HRDL N L++ N + KV+DFG++R T+ G RW A Sbjct: 736 KYLADMNYVHRDLAARNTLVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTA 795 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I+++ + +DV+S+GI++WE+++ G+ PY +T Q + +++ R P + Sbjct: 796 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN-QDVINAIEQDYRLPPPMDCPN 854 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F +I+ L K+ Sbjct: 855 ALHQLMLDCWQKDRNHRPKFGQIVNTLDKM 884
>EPHA4_MOUSE (Q03137) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (MPK-3) Length = 986 Score = 129 bits (324), Expect = 7e-30 Identities = 70/208 (33%), Positives = 119/208 (57%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N++ G TK + I+TE+M GS+ +L K+ G F + LVG+ + GM Sbjct: 675 GQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGM 734 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TYRWMAPE 366 YL + +HRDL N+L++ N + KV+DFG++RV T G RW APE Sbjct: 735 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 794 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + L Sbjct: 795 AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIAL 853 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ++ ++RP F +I+ L K+ Sbjct: 854 HQLMLDCWQKERSDRPKFGQIVNMLDKL 881
>EPHA4_HUMAN (P54764) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8) Length = 986 Score = 129 bits (324), Expect = 7e-30 Identities = 70/208 (33%), Positives = 119/208 (57%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N++ G TK + I+TE+M GS+ +L K+ G F + LVG+ + GM Sbjct: 675 GQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGM 734 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TYRWMAPE 366 YL + +HRDL N+L++ N + KV+DFG++RV T G RW APE Sbjct: 735 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 794 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + L Sbjct: 795 AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIAL 853 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ++ ++RP F +I+ L K+ Sbjct: 854 HQLMLDCWQKERSDRPKFGQIVNMLDKL 881
>EPHA4_CHICK (Q07496) Ephrin type-A receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor CEK8) Length = 986 Score = 129 bits (324), Expect = 7e-30 Identities = 70/208 (33%), Positives = 119/208 (57%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N++ G TK + I+TE+M GS+ +L K+ G F + LVG+ + GM Sbjct: 675 GQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGM 734 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ--SGVMTAETG--TYRWMAPE 366 YL + +HRDL N+L++ N + KV+DFG++RV T G RW APE Sbjct: 735 KYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPE 794 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P + L Sbjct: 795 AIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVIKAIEEGYRLPPPMDCPIAL 853 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CWQ++ ++RP F +I+ L K+ Sbjct: 854 HQLMLDCWQKERSDRPKFGQIVNMLDKL 881
>HCK_MACFA (Q95M30) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 503 Score = 129 bits (324), Expect = 7e-30 Identities = 73/198 (36%), Positives = 119/198 (60%), Gaps = 5/198 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFK-LPALVGVAMDVSKGMSYLHQN 216 +V+ TK P + I+TEFM+ GS+ D+L +G + LP L+ + +++GM+++ Q Sbjct: 294 LVKLHAVVTKEP-IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQR 352 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ + + K+ADFG+AR+ ++ TA G +W APE I Sbjct: 353 NYIHRDLRAANILVSASLVCKIADFGLARI-IEDNEYTAREGAKFPIKWTAPEAINFGSS 411 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL E++T G+IPY ++ + + +++G R P+N +L ++ +C Sbjct: 412 TIKSDVWSFGILLMEIVTYGRIPYPGMSNPE-VIRALERGYRMPRPENCPEELYNIMMRC 470 Query: 565 WQQDPAERPDFSEILEAL 618 W+ P ERP F I L Sbjct: 471 WKNRPEERPTFEYIQSVL 488
>YES_XIPHE (P27447) Tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes)| Length = 543 Score = 129 bits (323), Expect = 9e-30 Identities = 73/184 (39%), Positives = 114/184 (61%), Gaps = 5/184 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTEFM GS+ D+L + G KLP LV +A ++ GM+++ + N IHRDL+ AN+L+ Sbjct: 346 IVTEFMGKGSLLDFLKEGDGKHLKLPQLVDMASQIADGMAFIERMNYIHRDLRAANILVA 405 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 +N + K+ADFG+AR+ ++ TA G +W APE + + K+DV+SFGILL E Sbjct: 406 DNLVCKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE 464 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 L+T G++PY + + + V +G R P+ L E++++CW+++P ERP F I Sbjct: 465 LVTKGRVPYPGMVN-REVLEQVDRGYRMPCPQGCPESLHEMMRQCWKKEPDERPTFEYIQ 523 Query: 610 EALK 621 L+ Sbjct: 524 SFLE 527
>SRC_MOUSE (P05480) Neuronal proto-oncogene tyrosine-protein kinase Src (EC| 2.7.10.2) (p60-Src) (c-Src) (pp60c-src) Length = 540 Score = 129 bits (323), Expect = 9e-30 Identities = 76/197 (38%), Positives = 121/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+M+ GS+ D+L G + +LP LV ++ ++ GM+Y+ + Sbjct: 329 LVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERM 387 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 388 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 446 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 447 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPESLHDLMCQC 505 Query: 565 WQQDPAERPDFSEILEA 615 W+++P ERP F E L+A Sbjct: 506 WRKEPEERPTF-EYLQA 521
>SRC_RSVPA (P31693) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 522 Score = 128 bits (322), Expect = 1e-29 Identities = 78/197 (39%), Positives = 120/197 (60%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IV E+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 318 LVQLYAMVSEEP-IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVEMAAQIASGMAYVERM 376 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 377 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARPGARFPVKWTAPEAALYGRF 435 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 436 TIKSDVWSFGILLTELTTKGRVPYPGMVNGE-VLDRVERGYRMPCPPECPESLHDLMCQC 494 Query: 565 WQQDPAERPDFSEILEA 615 W++DP ERP F E L+A Sbjct: 495 WRKDPEERPTF-EYLQA 510
>SRC_RAT (Q9WUD9) Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2)| (p60-Src) (c-Src) (pp60c-src) Length = 535 Score = 128 bits (322), Expect = 1e-29 Identities = 76/197 (38%), Positives = 121/197 (61%), Gaps = 5/197 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+M+ GS+ D+L G + +LP LV ++ ++ GM+Y+ + Sbjct: 324 LVQLYAVVSEEP-IYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVDRM 382 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 383 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 441 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++G R P L +L+ +C Sbjct: 442 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPESLHDLMCQC 500 Query: 565 WQQDPAERPDFSEILEA 615 W+++P ERP F E L+A Sbjct: 501 WRKEPEERPTF-EYLQA 516
>EPHA8_RAT (P29321) Ephrin type-A receptor 8 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EEK) (EPH- and ELK-related kinase) (Fragment) Length = 372 Score = 128 bits (321), Expect = 2e-29 Identities = 73/208 (35%), Positives = 110/208 (52%), Gaps = 5/208 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G T+ IVTE+M GS+ +L H G F + LVG+ V GM Sbjct: 56 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTILQLVGMLKGVGAGM 115 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPE 366 YL IHRDL N+L+D + KV+DFG++R T RW APE Sbjct: 116 RYLSDLGYIHRDLAARNILVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPE 175 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I + + +DV+SFG+++WE+L G+ PY +T Q + V++G R P L Sbjct: 176 AIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTN-QDVISSVEEGYRLPAPMGCPRAL 234 Query: 544 TELLQKCWQQDPAERPDFSEILEALKKI 627 +L+ CW +D A+RP FS ++ L+ + Sbjct: 235 HQLMLDCWHKDRAQRPRFSHVVSVLEAL 262
>EPHB1_CHICK (Q07494) Ephrin type-B receptor 1 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor EPH-2) (Tyrosine kinase CEK6 receptor) (Fragment) Length = 984 Score = 128 bits (321), Expect = 2e-29 Identities = 70/210 (33%), Positives = 120/210 (57%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G TK + I+TEFM G++ +L ++ G F + LVG+ ++ GM Sbjct: 673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 732 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL + N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 733 KYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 792 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++ R P + A Sbjct: 793 PEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSN-QDVINAIEQDYRLPPPMDCPA 851 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP +EI+ L K+ Sbjct: 852 ALHQLMLDCWQKDRNTRPRLAEIVNTLDKM 881
>HCK_RAT (P50545) Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK)| (Hemopoietic cell kinase) Length = 502 Score = 127 bits (320), Expect = 2e-29 Identities = 71/183 (38%), Positives = 111/183 (60%), Gaps = 5/183 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIFK-LPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTEFM+ GS+ D+L +G + LP L+ + +S+GM+++ Q N IHRDL+ AN+L+ Sbjct: 307 IVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVS 366 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 + + K+ADFG+AR+ ++ TA G +W APE I + K+DV+SFGILL E Sbjct: 367 ASLVCKIADFGLARI-IEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLME 425 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 ++T G+IPY ++ + + ++ G R P N +L ++ +CW+ P ERP F I Sbjct: 426 IVTYGRIPYPGMSNPE-VIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEERPTFEYIQ 484 Query: 610 EAL 618 L Sbjct: 485 SVL 487
>HCK_MOUSE (P08103) Tyrosine-protein kinase HCK (EC 2.7.10.2)| (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK) Length = 523 Score = 127 bits (320), Expect = 2e-29 Identities = 71/183 (38%), Positives = 111/183 (60%), Gaps = 5/183 (2%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLHKHKGIFK-LPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 IVTEFM+ GS+ D+L +G + LP L+ + +S+GM+++ Q N IHRDL+ AN+L+ Sbjct: 328 IVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVS 387 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYDHKADVFSFGILLWE 432 + + K+ADFG+AR+ ++ TA G +W APE I + K+DV+SFGILL E Sbjct: 388 ASLVCKIADFGLARI-IEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLME 446 Query: 433 LLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEIL 609 ++T G+IPY ++ + + ++ G R P N +L ++ +CW+ P ERP F I Sbjct: 447 IVTYGRIPYPGMSNPE-VIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQ 505 Query: 610 EAL 618 L Sbjct: 506 SVL 508
>FYN_CHICK (Q05876) Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2)| (p59-Fyn) Length = 533 Score = 127 bits (320), Expect = 2e-29 Identities = 76/191 (39%), Positives = 117/191 (61%), Gaps = 5/191 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTE+MS GS+ +L +G KLP LV +A V+ GM+Y+ + Sbjct: 322 LVQLYAVVSRRP-IYIVTEYMSKGSLLIFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 380 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL++AN+L+ + K+ADFG+AR+ ++ TA G +W APE + + Sbjct: 381 NYIHRDLRSANILVGNGLICKIADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 439 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL+T G++PY + + + V++G R P++ L EL+ C Sbjct: 440 TIKSDVWSFGILLTELVTKGRVPYPGMNN-REVLEQVERGYRMPCPQDCPISLHELMIHC 498 Query: 565 WQQDPAERPDF 597 W++DP ERP F Sbjct: 499 WKKDPEERPTF 509
>CEK3_CHICK (P18461) Tyrosine kinase receptor CEK3 precursor (EC 2.7.10.1)| Length = 823 Score = 127 bits (319), Expect = 3e-29 Identities = 71/216 (32%), Positives = 119/216 (55%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK--------GIFKLPA-------LVG 171 N++ +GACT+ L ++ E+ S G++ +YL + I ++P LV Sbjct: 548 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTFKDLVS 607 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 +++GM YL IHRDL N+L+ EN ++K+ADFG+AR T Sbjct: 608 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 667 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+L+WE+ T G PY + P++ ++++G R Sbjct: 668 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDK 726 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N +L +++ CWQ P++RP F +++E L +I Sbjct: 727 PANCTNELYMMMRDCWQAVPSQRPTFKQLVEDLDRI 762
>LYN_HUMAN (P07948) Tyrosine-protein kinase Lyn (EC 2.7.10.2)| Length = 511 Score = 127 bits (319), Expect = 3e-29 Identities = 73/198 (36%), Positives = 116/198 (58%), Gaps = 5/198 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +V+ T+ + I+TE+M+ GS+ D+L +G LP L+ + +++GM+Y+ + Sbjct: 301 LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 360 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ E+ M K+ADFG+ARV ++ TA G +W APE I + Sbjct: 361 NYIHRDLRAANVLVSESLMCKIADFGLARV-IEDNEYTAREGAKFPIKWTAPEAINFGCF 419 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL+E++T GKIPY T + Q G R +N +L ++++ C Sbjct: 420 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQ-GYRMPRVENCPDELYDIMKMC 478 Query: 565 WQQDPAERPDFSEILEAL 618 W++ ERP F + L Sbjct: 479 WKEKAEERPTFDYLQSVL 496
>SRC_RSVH1 (P25020) Tyrosine-protein kinase transforming protein Src (EC| 2.7.10.2) (p60-Src) (v-Src) (pp60v-src) Length = 525 Score = 127 bits (319), Expect = 3e-29 Identities = 74/191 (38%), Positives = 115/191 (60%), Gaps = 5/191 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IV E+MS GS+ D+L G + +LP LV +A ++ GM+Y+ + Sbjct: 321 LVQLYAVVSEEP-IYIVIEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERM 379 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N +HRDL+ AN+L+ EN + KVADFG+AR+ ++ TA G +W APE + + Sbjct: 380 NYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRF 438 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL T G++PY + + + V++ R P L +L+ +C Sbjct: 439 TIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERAYRMPCPPECPESLHDLMCQC 497 Query: 565 WQQDPAERPDF 597 W++DP ERP F Sbjct: 498 WRKDPEERPTF 508
>CEK2_CHICK (P18460) Tyrosine kinase receptor CEK2 precursor (EC 2.7.10.1)| Length = 806 Score = 127 bits (318), Expect = 4e-29 Identities = 72/216 (33%), Positives = 118/216 (54%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK--------GIFKLPA-------LVG 171 N++ +GACT+ L ++ E+ S G++ +YL + KLP LV Sbjct: 531 NIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKLPEEQLTFKDLVS 590 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR T Sbjct: 591 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNIDYYKKTTNGRL 650 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+LLWE+ T G PY + P++ ++++G R Sbjct: 651 PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDK 709 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N L ++++CW P++RP F +++E L ++ Sbjct: 710 PANCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRV 745
>EPHB3_XENLA (Q91735) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TCK) Length = 974 Score = 126 bits (317), Expect = 5e-29 Identities = 70/216 (32%), Positives = 124/216 (57%), Gaps = 7/216 (3%) Frame = +1 Query: 1 GKFIL*GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAM 180 G+ + G+F N+++ G T+ + I+TEFM G++ +L + G F + LVG+ Sbjct: 657 GEASIMGQFDHPNIIRLEGVVTRSRPVMILTEFMENGALDSFLRMNDGQFTVIQLVGILR 716 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQS---GVMTAETG--- 342 ++ GM YL + N +HRDL N+L++ N + KV+DFG++R S T+ G Sbjct: 717 GIASGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLENSRSDPTYTSALGGKI 776 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 RW APE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + +++ R Sbjct: 777 PIRWTAPEAISYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVINAIEQDYRLPP 835 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P + + L +L+ CW +D RP FS+I+ +L K+ Sbjct: 836 PMDCPSALHQLMLDCWLRDRNLRPKFSQIVSSLDKL 871
>LCK_HUMAN (P06239) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell-specific protein-tyrosine kinase) Length = 508 Score = 126 bits (317), Expect = 5e-29 Identities = 70/199 (35%), Positives = 120/199 (60%), Gaps = 5/199 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +V+ T+ P + I+TE+M GS+ D+L GI + L+ +A +++GM+++ + Sbjct: 299 LVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER 357 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ + K+ADFG+AR+ ++ TA G +W APE I + + Sbjct: 358 NYIHRDLRAANILVSDTLSCKIADFGLARL-IEDNEYTAREGAKFPIKWTAPEAINYGTF 416 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL E++T G+IPY +T + + +++G R P N +L +L++ C Sbjct: 417 TIKSDVWSFGILLTEIVTHGRIPYPGMTNPE-VIQNLERGYRMVRPDNCPEELYQLMRLC 475 Query: 565 WQQDPAERPDFSEILEALK 621 W++ P +RP F + L+ Sbjct: 476 WKERPEDRPTFDYLRSVLE 494
>FGFR1_XENLA (P22182) Fibroblast growth factor receptor 1 precursor (EC 2.7.10.1)| (FGFR-1) Length = 812 Score = 126 bits (317), Expect = 5e-29 Identities = 70/216 (32%), Positives = 117/216 (54%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG---------------IFKLPALVG 171 N++ +GACT+ L ++ E+ S G++ +YL + + LV Sbjct: 537 NIINLLGACTQDGPLYVIVEYTSKGNLREYLRARRPPAMEYCYNPTCVPDQLLSFKDLVS 596 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR T Sbjct: 597 CAYQVARGMDYLASKKCIHRDLAARNVLVTEDNIMKIADFGLARDIHHIDYYKKTTNGRL 656 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+LLWE+ T G PY + P++ ++++G R Sbjct: 657 PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PMEELFKLLKEGHRMDK 715 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N +L +++ CW P++RP F++++E L +I Sbjct: 716 PTNCTNELYMMMKDCWHAMPSQRPTFNQLVEDLDRI 751
>EPHA8_MOUSE (O09127) Ephrin type-A receptor 8 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) Length = 1004 Score = 126 bits (316), Expect = 6e-29 Identities = 72/205 (35%), Positives = 108/205 (52%), Gaps = 5/205 (2%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G T+ IVTE+M GS+ +L H G F + LVG+ V GM Sbjct: 688 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTHDGQFTIVQLVGMLRGVGAGM 747 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPE 366 YL IHRDL N+L+D + KV+DFG++R T RW APE Sbjct: 748 RYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDDPEAAYTTAGGKIPIRWTAPE 807 Query: 367 VIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL 543 I + + +DV+SFG+++WE+L G+ PY +T Q + V++G R P L Sbjct: 808 AIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTN-QDVISSVEEGYRLPAPMGCPRAL 866 Query: 544 TELLQKCWQQDPAERPDFSEILEAL 618 +L+ CW +D A+RP F+ ++ L Sbjct: 867 HQLMLDCWHKDRAQRPRFAHVVSVL 891
>BMX_HUMAN (P51813) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone| marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38) Length = 675 Score = 126 bits (316), Expect = 6e-29 Identities = 71/200 (35%), Positives = 113/200 (56%), Gaps = 4/200 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +V+F G C+K + IVTE++S G + +YL H + L+ + DV +GM++L + Sbjct: 472 LVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQ 531 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 IHRDL N L+D + VKV+DFG+ R V + GT +W APEV + Y Sbjct: 532 FIHRDLAARNCLVDRDLCVKVSDFGMTRY-VLDDQYVSSVGTKFPVKWSAPEVFHYFKYS 590 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV++FGIL+WE+ + GK PY+ Q + V Q G R P A + +++ CW Sbjct: 591 SKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQ-GHRLYRPHLASDTIYQIMYSCW 649 Query: 568 QQDPAERPDFSEILEALKKI 627 + P +RP F ++L +++ + Sbjct: 650 HELPEKRPTFQQLLSSIEPL 669
>FES_HUMAN (P07332) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2)| (C-Fes) Length = 822 Score = 126 bits (316), Expect = 6e-29 Identities = 71/202 (35%), Positives = 109/202 (53%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + IV E + GG +L ++ L+ + D + GM YL Sbjct: 618 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESK 677 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT----YRWMAPEVIEHKP 384 IHRDL N L+ E ++K++DFG++R + GV A G+ +W APE + + Sbjct: 678 CCIHRDLAARNCLVTEKNVLKISDFGMSREEA-DGVYAASGGSRQVPVKWTAPEALNYGR 736 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G PY L+ Q V+KG R P+ + L+++ Sbjct: 737 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQ 795 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW +P +RP FS I + L+ I Sbjct: 796 CWAYEPGQRPSFSTIYQELQSI 817
>FPS_AVISP (P00541) Tyrosine-protein kinase transforming protein Fps (EC| 2.7.10.2) Length = 533 Score = 126 bits (316), Expect = 6e-29 Identities = 67/199 (33%), Positives = 108/199 (54%), Gaps = 5/199 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + IV E + GG +L K+ L+ + + + GM YL Sbjct: 329 NIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSKGPHLKMKELIKMMENAAAGMEYLESK 388 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPEVIEHKP 384 + IHRDL N L+ E +K++DFG++R + + GV + G +W APE + + Sbjct: 389 HCIHRDLAARNCLVTEKNTLKISDFGMSR-QEEDGVYASTGGMKQIPVKWTAPEALNYGR 447 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G +PY L+ Q +++G+R P+ + L+Q+ Sbjct: 448 YSSESDVWSFGILLWEAFSLGAVPYANLSNQQTR-EAIEQGVRLEPPEQCPEDVYRLMQR 506 Query: 562 CWQQDPAERPDFSEILEAL 618 CW+ DP RP F + + L Sbjct: 507 CWEYDPRRRPSFGAVHQDL 525
>BMX_MOUSE (P97504) Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone| marrow tyrosine kinase gene in chromosome X protein homolog) Length = 651 Score = 126 bits (316), Expect = 6e-29 Identities = 71/200 (35%), Positives = 114/200 (57%), Gaps = 4/200 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 +V+F G C+K + IVTE+++ G + +YL H + L+ + DV +GM++L + Sbjct: 448 LVKFYGVCSKKYPIYIVTEYITNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLESHQ 507 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPYD 390 IHRDL N L+D + VKV+DFG+ R V + GT +W APEV + Y Sbjct: 508 FIHRDLAARNCLVDSDLSVKVSDFGMTRY-VLDDQYVSSVGTKFPVKWSAPEVFHYFKYS 566 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV++FGIL+WE+ + GK PY+ + V V Q G R P+ A + +++ CW Sbjct: 567 SKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQ-GHRLYRPQLASDTIYQIMYSCW 625 Query: 568 QQDPAERPDFSEILEALKKI 627 + P +RP F ++L A++ + Sbjct: 626 HELPEKRPTFQQLLSAIEPL 645
>CSK_MOUSE (P41241) Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase)| (Protein-tyrosine kinase MPK-2) (p50CSK) Length = 450 Score = 125 bits (315), Expect = 8e-29 Identities = 73/202 (36%), Positives = 115/202 (56%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPR-LCIVTEFMSGGSVYDYLHKH-KGIFKLPALVGVAMDVSKGMSYLH 210 N+VQ +G + L IVTE+M+ GS+ DYL + + L+ ++DV + M YL Sbjct: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVLEAMEYLE 306 Query: 211 QNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVIEHKP 384 NN +HRDL N+L+ E+ + KV+DFG+ + T +TG +W APE + K Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTK----EASSTQDTGKLPVKWTAPEALREKK 362 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV+SFGILLWE+ + G++PY + PL+ V V+KG + P + ++++ Sbjct: 363 FSTKSDVWSFGILLWEIYSFGRVPYPRI-PLKDVVPRVEKGYKMDAPDGCPPAVYDVMKN 421 Query: 562 CWQQDPAERPDFSEILEALKKI 627 C D A RP F ++ E L+ I Sbjct: 422 CSHLDAATRPTFLQLREQLEHI 443
>FES_FSVGA (P00542) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 609 Score = 125 bits (315), Expect = 8e-29 Identities = 70/202 (34%), Positives = 108/202 (53%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + IV E + GG +L ++ L+ + D + GM YL Sbjct: 405 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYLESK 464 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPEVIEHKP 384 IHRDL N L+ E ++K++DFG++R + G+ A G +W APE + + Sbjct: 465 CCIHRDLAARNCLVTEKNVLKISDFGMSR-EAADGIYAASGGLRQVPVKWTAPEALNYGR 523 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G PY L+ Q V+KG R P+ + L+++ Sbjct: 524 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQ 582 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW +P +RP FS I + L+ I Sbjct: 583 CWAYEPGQRPSFSAIYQELQSI 604
>FGFR1_MOUSE (P16092) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 125 bits (315), Expect = 8e-29 Identities = 71/216 (32%), Positives = 116/216 (53%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYL---------------HKHKGIFKLPALVG 171 N++ +GACT+ L ++ E+ S G++ +YL H + LV Sbjct: 543 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 602 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR T Sbjct: 603 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 662 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+LLWE+ T G PY + P++ ++++G R Sbjct: 663 PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDK 721 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N +L +++ CW P++RP F +++E L +I Sbjct: 722 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 757
>FGFR1_HUMAN (P11362) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 125 bits (315), Expect = 8e-29 Identities = 71/216 (32%), Positives = 116/216 (53%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYL---------------HKHKGIFKLPALVG 171 N++ +GACT+ L ++ E+ S G++ +YL H + LV Sbjct: 543 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 602 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR T Sbjct: 603 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 662 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+LLWE+ T G PY + P++ ++++G R Sbjct: 663 PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDK 721 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N +L +++ CW P++RP F +++E L +I Sbjct: 722 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 757
>LCK_AOTNA (Q5PXS1) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 125 bits (314), Expect = 1e-28 Identities = 70/199 (35%), Positives = 118/199 (59%), Gaps = 5/199 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +V+ T+ P + I+TE+M GS+ D+L GI + L+ +A +++GM+++ + Sbjct: 299 LVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEER 357 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ + K+ADFG+AR+ ++ TA G +W APE I + + Sbjct: 358 NYIHRDLRAANILVSDTLSCKIADFGLARL-IEDNEYTAREGAKFPIKWTAPEAINYGTF 416 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL E++T G+IPY +T + + +++G R P N +L L+ C Sbjct: 417 TIKSDVWSFGILLTEIVTHGRIPYPGMTNPE-VIQNLERGYRMVRPDNCPEELYHLMMLC 475 Query: 565 WQQDPAERPDFSEILEALK 621 W++ P +RP F + L+ Sbjct: 476 WKERPEDRPTFDYLRSVLE 494
>FES_FELCA (P14238) Proto-oncogene tyrosine-protein kinase FES/FPS (EC 2.7.10.2)| (C-FES) Length = 820 Score = 125 bits (314), Expect = 1e-28 Identities = 70/202 (34%), Positives = 108/202 (53%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + IV E + GG +L ++ L+ + D + GM YL Sbjct: 616 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYLESK 675 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPEVIEHKP 384 IHRDL N L+ E ++K++DFG++R + G+ A G +W APE + + Sbjct: 676 CCIHRDLAARNCLVTEKNVLKISDFGMSREEA-DGIYAASGGLRQVPVKWTAPEALNYGR 734 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G PY L+ Q V+KG R P+ + L+++ Sbjct: 735 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQ 793 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW +P +RP FS I + L+ I Sbjct: 794 CWAYEPGQRPSFSAIYQELQSI 815
>FGFR2_MOUSE (P21803) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor) Length = 821 Score = 125 bits (314), Expect = 1e-28 Identities = 70/216 (32%), Positives = 118/216 (54%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK--------GIFKLPA-------LVG 171 N++ +GACT+ L ++ E+ S G++ +YL + I ++P LV Sbjct: 546 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS 605 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 +++GM YL IHRDL N+L+ EN ++K+ADFG+AR T Sbjct: 606 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 665 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+L+WE+ T G PY + P++ ++++G R Sbjct: 666 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDK 724 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N +L +++ CW P++RP F +++E L +I Sbjct: 725 PTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 760
>FGFR2_HUMAN (P21802) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) (Keratinocyte growth factor receptor 2) (CD332 antigen) Length = 821 Score = 125 bits (314), Expect = 1e-28 Identities = 70/216 (32%), Positives = 118/216 (54%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK--------GIFKLPA-------LVG 171 N++ +GACT+ L ++ E+ S G++ +YL + I ++P LV Sbjct: 546 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS 605 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 +++GM YL IHRDL N+L+ EN ++K+ADFG+AR T Sbjct: 606 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 665 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+L+WE+ T G PY + P++ ++++G R Sbjct: 666 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDK 724 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N +L +++ CW P++RP F +++E L +I Sbjct: 725 PANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 760
>FPS_FUJSV (P00530) Tyrosine-protein kinase transforming protein FPS (EC| 2.7.10.2) Length = 873 Score = 125 bits (313), Expect = 1e-28 Identities = 67/199 (33%), Positives = 108/199 (54%), Gaps = 5/199 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + IV E + GG +L K+ L+ + + + GM YL Sbjct: 669 NIVRLIGVCTQKQPIYIVMELVQGGDFLSFLRSKGPRLKMKKLIKMMENAAAGMEYLESK 728 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPEVIEHKP 384 + IHRDL N L+ E +K++DFG++R + + GV + G +W APE + + Sbjct: 729 HCIHRDLAARNCLVTEKNTLKISDFGMSR-QEEDGVYASTGGMKQIPVKWTAPEALNYGW 787 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G +PY L+ Q +++G+R P+ + L+Q+ Sbjct: 788 YSSESDVWSFGILLWEAFSLGAVPYANLSNQQTR-EAIEQGVRLEPPEQCPEDVYRLMQR 846 Query: 562 CWQQDPAERPDFSEILEAL 618 CW+ DP RP F + + L Sbjct: 847 CWEYDPHRRPSFGAVHQDL 865
>STK24_HUMAN (Q9Y6E0) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| (STE20-like kinase MST3) (MST-3) (Mammalian STE20-like protein kinase 3) Length = 443 Score = 125 bits (313), Expect = 1e-28 Identities = 70/192 (36%), Positives = 107/192 (55%), Gaps = 1/192 (0%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 V ++ G+ K +L I+ E++ GGS D L G + + ++ KG+ YLH Sbjct: 94 VTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP--GPLDETQIATILREILKGLDYLHSEK 151 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGV-MTAETGTYRWMAPEVIEHKPYDHK 396 IHRD+K AN+L+ E+G VK+ADFGVA + + GT WMAPEVI+ YD K Sbjct: 152 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSK 211 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 AD++S GI EL G+ P+ L P++ + ++ K PT+ N L E ++ C ++ Sbjct: 212 ADIWSLGITAIELARGEPPHSELHPMK-VLFLIPKNNPPTLEGNYSKPLKEFVEACLNKE 270 Query: 577 PAERPDFSEILE 612 P+ RP E+L+ Sbjct: 271 PSFRPTAKELLK 282
>FGFR1_CHICK (P21804) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) Length = 819 Score = 125 bits (313), Expect = 1e-28 Identities = 71/216 (32%), Positives = 118/216 (54%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK--------GIFKLPA-------LVG 171 N++ +GACT+ L ++ E+ S G++ +YL + ++P LV Sbjct: 541 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGMEYCYNPTRIPEEQLSFKDLVS 600 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR T Sbjct: 601 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 660 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+LLWE+ T G PY + P++ ++++G R Sbjct: 661 PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDK 719 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N +L +++ CW P++RP F +++E L +I Sbjct: 720 PSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 755
>LCK_SAISC (Q95KR7) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) Length = 508 Score = 125 bits (313), Expect = 1e-28 Identities = 70/199 (35%), Positives = 119/199 (59%), Gaps = 5/199 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +V+ T+ P + I+TE+M GS+ D+L GI + L+ +A + +GM++L + Sbjct: 299 LVRLYAVVTEEP-IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIVEGMAFLEER 357 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ + K+ADFG+AR+ ++ TA G +W APE I + + Sbjct: 358 NYIHRDLRAANILVSDTLSCKIADFGLARL-IEDNEYTAREGAKFPIKWTAPEAINYGTF 416 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGIL+ E++T G+IPY +T + + +++G R P N +L +L+ +C Sbjct: 417 TIKSDVWSFGILMTEIVTHGRIPYPGMTNPE-VIQNLERGYRMPRPDNCPEELYKLMMQC 475 Query: 565 WQQDPAERPDFSEILEALK 621 W++ P +RP F + L+ Sbjct: 476 WRERPDDRPTFDYLRSVLE 494
>LCK_MOUSE (P06240) Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2)| (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) Length = 508 Score = 125 bits (313), Expect = 1e-28 Identities = 70/198 (35%), Positives = 117/198 (59%), Gaps = 5/198 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +V+ T+ P + I+TE+M GS+ D+L GI + L+ +A +++GM+++ + Sbjct: 299 LVRLYAVVTQEP-IYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQ 357 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ + K+ADFG+AR+ ++ TA G +W APE I + + Sbjct: 358 NYIHRDLRAANILVSDTLSCKIADFGLARL-IEDNEYTAREGAKFPIKWTAPEAINYGTF 416 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL E++T G+IPY +T + + +++G R P N +L L+ C Sbjct: 417 TIKSDVWSFGILLTEIVTHGRIPYPGMTNPE-VIQNLERGYRMVRPDNCPEELYHLMMLC 475 Query: 565 WQQDPAERPDFSEILEAL 618 W++ P +RP F + L Sbjct: 476 WKERPEDRPTFDYLRSVL 493
>EPB1A_XENLA (Q91571) Ephrin type-B receptor 1-A precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor XEK) Length = 985 Score = 125 bits (313), Expect = 1e-28 Identities = 68/208 (32%), Positives = 117/208 (56%), Gaps = 7/208 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G TK + I+TEFM G++ +L ++ G F + LVG+ ++ GM Sbjct: 674 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGM 733 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL + N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 734 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTA 793 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 E I ++ + +DV+S+GI++WE+++ G+ PY + Q + +++ R P + A Sbjct: 794 QEAIAYRKFTSASDVWSYGIVMWEVMSYGERPY-WTMSNQDVINAIEQDYRLPPPMDCPA 852 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALK 621 L +L+ CWQ+D RP +EI+ L+ Sbjct: 853 ALHQLMLDCWQKDRNSRPRLAEIVNTLR 880
>TIE2_BRARE (O73791) Tyrosine-protein kinase receptor Tie-2 precursor (EC| 2.7.10.1) Length = 1116 Score = 124 bits (312), Expect = 2e-28 Identities = 74/213 (34%), Positives = 116/213 (54%), Gaps = 16/213 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPA---------------LVG 171 N++ +GAC L + EF G++ D+L K + + PA L+ Sbjct: 876 NIIHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPAFAIAHRTASTLSSQQLLA 935 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYR 351 + DV++GMSYL Q IHRDL N+L+ EN + K+ADFG++R + T R Sbjct: 936 FSADVARGMSYLSQKQFIHRDLAARNVLVGENFVAKIADFGLSRGQEVYVKKTMGRLPVR 995 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKN 528 WMA E + + Y +DV+S+G+LLWE+++ G PY +T + + G R P N Sbjct: 996 WMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTPYCGMTCAE-LYEKLPLGFRLEKPLN 1054 Query: 529 AHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 ++ EL+Q+CW++ P ERP FS+IL +L ++ Sbjct: 1055 CDDEVYELMQQCWREKPFERPSFSQILLSLGRM 1087
>FES_MOUSE (P16879) Proto-oncogene tyrosine-protein kinase Fes/Fps (EC 2.7.10.2)| (C-Fes) Length = 820 Score = 124 bits (312), Expect = 2e-28 Identities = 71/202 (35%), Positives = 108/202 (53%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + IV E + GG +L ++ L+ + D + GM YL Sbjct: 616 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMMGDAAAGMEYLESK 675 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPEVIEHKP 384 IHRDL N L+ E ++K++DFG++R + G+ A +G +W APE + + Sbjct: 676 CCIHRDLAARNCLVTEKNVLKISDFGMSREEA-DGIYAACSGLRQVPVKWTAPEALNYGR 734 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G PY LT Q V+KG R P+ + L+++ Sbjct: 735 YSSESDVWSFGILLWETFSLGASPYPNLTNQQTR-EFVEKGHRLPCPELCPDAVFRLMEQ 793 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW +P +RP FS I + L I Sbjct: 794 CWAYEPGQRPSFSIICQELHSI 815
>FES_FSVST (P00543) Tyrosine-protein kinase transforming protein Fes (EC| 2.7.10.2) Length = 477 Score = 124 bits (311), Expect = 2e-28 Identities = 70/202 (34%), Positives = 107/202 (52%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+ IG CT+ + IV E + GG +L ++ L+ + D + GM YL Sbjct: 273 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRMKTLLQMVGDAAAGMEYLESK 332 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG----TYRWMAPEVIEHKP 384 IHRDL N L+ E ++K++DFG++R + GV A G +W APE + + Sbjct: 333 CCIHRDLAARNCLVTEKNVLKISDFGMSREEA-DGVYAASGGLRLVPVKWTAPEALNYGR 391 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y ++DV+SFGILLWE + G PY L+ Q V+KG R P+ + L+++ Sbjct: 392 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTR-EFVEKGGRLPCPELCPDAVFRLMEQ 450 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW +P +RP FS + L+ I Sbjct: 451 CWAYEPGQRPSFSAFYQELQSI 472
>STK24_MOUSE (Q99KH8) Serine/threonine-protein kinase 24 (EC 2.7.11.1)| Length = 431 Score = 124 bits (311), Expect = 2e-28 Identities = 70/192 (36%), Positives = 107/192 (55%), Gaps = 1/192 (0%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 V ++ G+ K +L I+ E++ GGS D L G + + ++ KG+ YLH Sbjct: 82 VTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP--GPLDEIQIATILREILKGLDYLHSEK 139 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGV-MTAETGTYRWMAPEVIEHKPYDHK 396 IHRD+K AN+L+ E+G VK+ADFGVA + + GT WMAPEVI+ YD K Sbjct: 140 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSK 199 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 AD++S GI EL G+ P+ L P++ + ++ K PT+ N L E ++ C ++ Sbjct: 200 ADIWSLGITAIELAKGEPPHSELHPMK-VLFLIPKNNPPTLEGNYSKPLKEFVEACLNKE 258 Query: 577 PAERPDFSEILE 612 P+ RP E+L+ Sbjct: 259 PSFRPTAKELLK 270
>SRMS_MOUSE (Q62270) Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70)| Length = 496 Score = 123 bits (309), Expect = 4e-28 Identities = 72/201 (35%), Positives = 117/201 (58%), Gaps = 5/201 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +++ C+ + IVTE M G++ YL +G LP L+G A V++GMSYL + Sbjct: 289 LIRLHAICSLGEPVYIVTELMGKGNLQVYLGSSEGKALSLPHLLGFACQVAEGMSYLEER 348 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 ++HRDL N+L+ ++ KVADFG+AR+ ++ V + +G+ +W APE ++ + Sbjct: 349 RVVHRDLAARNVLVGDDLTCKVADFGLARL-LKDDVYSPSSGSKIPVKWTAPEAANYRVF 407 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL+E+ T G+ PYE +T + + +G R P A++ L+ +C Sbjct: 408 SQKSDVWSFGILLYEVFTYGQCPYEGMTN-HETLQQISRGYRLPRPAVCPAEVYVLMVEC 466 Query: 565 WQQDPAERPDFSEILEALKKI 627 W+ P ERP F+ + E L I Sbjct: 467 WKGSPEERPTFAILREKLNAI 487
>FGFR2_XENLA (Q03364) Fibroblast growth factor receptor 2 precursor (EC 2.7.10.1)| (FGFR-2) Length = 813 Score = 123 bits (309), Expect = 4e-28 Identities = 69/221 (31%), Positives = 119/221 (53%), Gaps = 24/221 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK--------GIFKLPA-------LVG 171 N++ +GACT+ L ++ E+ + G++ YL + + ++P LV Sbjct: 536 NIINLLGACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQMTFKDLVS 595 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVAR--------VKVQSGVM 327 +++GM YL IHRDL N+L+ EN ++K+ADFG+AR K +G + Sbjct: 596 CTYQIARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTSNGRL 655 Query: 328 TAETGTYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKG 504 +WMAPE + + Y H++DV+SFG+L+WE+ T G PY + P++ ++++G Sbjct: 656 PV-----KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEG 709 Query: 505 LRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 R P N +L +++ CW P+ RP F +++E L +I Sbjct: 710 HRMDKPANCTNELYMMMRDCWHAIPSHRPTFKQLVEDLDRI 750
>EPHA6_HUMAN (Q9UF33) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 123 bits (309), Expect = 4e-28 Identities = 70/203 (34%), Positives = 115/203 (56%), Gaps = 12/203 (5%) Frame = +1 Query: 55 GACTKPPRL------CIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 G + PPR+ IV E+M GS+ +L KH G F + LVG+ ++ GM YL Sbjct: 732 GGGSLPPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDM 791 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT-----YRWMAPEVIEHK 381 +HRDL N+L++ N + KV+DFG++RV ++ A T T RW APE I ++ Sbjct: 792 GYVHRDLAARNILVNSNLVCKVSDFGLSRV-LEDDPEAAYTTTGGKIPIRWTAPEAIAYR 850 Query: 382 PYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQ 558 + +D +S+GI++WE+++ G+ PY ++ Q + +++G R P A L +L+ Sbjct: 851 KFSSASDAWSYGIVMWEVMSYGERPYWEMSN-QDVILSIEEGYRLPAPMGCPASLHQLML 909 Query: 559 KCWQQDPAERPDFSEILEALKKI 627 CWQ++ RP F++I+ L K+ Sbjct: 910 HCWQKERNHRPKFTDIVSFLDKL 932
>FGR_MOUSE (P14234) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 517 Score = 122 bits (306), Expect = 9e-28 Identities = 75/199 (37%), Positives = 116/199 (58%), Gaps = 5/199 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTEFM GS+ D+L +G LP LV +A V++GM+Y+ + Sbjct: 306 LVQLYAVVSEEP-IYIVTEFMCYGSLLDFLKDREGQNLMLPHLVDMAAQVAEGMAYMERM 364 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ E + K+ADFG+AR+ ++ + GT +W APE + Sbjct: 365 NYIHRDLRAANILVGEYLICKIADFGLARL-IEDNEYNPQQGTKFPIKWTAPEAALFGRF 423 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL+T G++PY + + + V+ G P A L E++++ Sbjct: 424 TVKSDVWSFGILLTELITKGRVPYPGMNN-REVLEQVEHGYHMPCPPGCPASLYEVMEQA 482 Query: 565 WQQDPAERPDFSEILEALK 621 W+ DP ERP F + L+ Sbjct: 483 WRLDPEERPTFEYLQSFLE 501
>FGFR1_RAT (Q04589) Basic fibroblast growth factor receptor 1 precursor (EC| 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 122 bits (306), Expect = 9e-28 Identities = 70/216 (32%), Positives = 115/216 (53%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYL---------------HKHKGIFKLPALVG 171 N++ +GACT+ L ++ E+ S G++ +YL H + LV Sbjct: 543 NIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 602 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR T Sbjct: 603 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRL 662 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+LLWE+ T G P + P++ ++++G R Sbjct: 663 PVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPNPGV-PVEELFKLLKEGHRMDK 721 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N +L +++ CW P++RP F +++E L +I Sbjct: 722 PSNCTNELYMMMRDCWNAVPSQRPTFKQLVEDLDRI 757
>EPHA6_RAT (P54758) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 122 bits (306), Expect = 9e-28 Identities = 69/198 (34%), Positives = 113/198 (57%), Gaps = 12/198 (6%) Frame = +1 Query: 70 PPRL------CIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNNIIHR 231 PPR+ IV E+M GS+ +L KH G F + LVG+ ++ GM YL +HR Sbjct: 737 PPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHR 796 Query: 232 DLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT-----YRWMAPEVIEHKPYDHK 396 DL N+L++ N + KV+DFG++RV ++ A T T RW APE I ++ + Sbjct: 797 DLAARNILVNSNLVCKVSDFGLSRV-LEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSA 855 Query: 397 ADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQ 573 +DV+S+GI++WE+++ G+ PY ++ Q + +++G R P L +L+ CWQ+ Sbjct: 856 SDVWSYGIVMWEVMSYGERPYWEMSN-QDVILSIEEGYRLPAPMGCPPSLHQLMLHCWQK 914 Query: 574 DPAERPDFSEILEALKKI 627 + RP F++I+ L K+ Sbjct: 915 ERNHRPKFTDIVSFLDKL 932
>SRMS_HUMAN (Q9H3Y6) Tyrosine-protein kinase Srms (EC 2.7.10.2)| Length = 488 Score = 122 bits (306), Expect = 9e-28 Identities = 69/201 (34%), Positives = 116/201 (57%), Gaps = 5/201 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYLHQN 216 +++ C+ + IVTE M G++ +L +G +LP L+G A V++GMSYL + Sbjct: 285 LIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQ 344 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 ++HRDL N+L+D+ KVADFG+AR+ ++ + + + + +W APE ++ + Sbjct: 345 RVVHRDLAARNVLVDDGLACKVADFGLARL-LKDDIYSPSSSSKIPVKWTAPEAANYRVF 403 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFG+LL E+ T G+ PYE +T + + +G R P A++ L+ +C Sbjct: 404 SQKSDVWSFGVLLHEVFTYGQCPYEGMTN-HETLQQIMRGYRLPRPAACPAEVYVLMLEC 462 Query: 565 WQQDPAERPDFSEILEALKKI 627 W+ P ERP F+ + E L I Sbjct: 463 WRSSPEERPSFATLREKLHAI 483
>FRK_HUMAN (P42685) Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear| tyrosine protein kinase RAK) Length = 505 Score = 122 bits (306), Expect = 9e-28 Identities = 71/196 (36%), Positives = 105/196 (53%), Gaps = 7/196 (3%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 ++Q CT + I+TE M GS+ +YL G L V +A V+ GM+YL Sbjct: 289 LIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESR 348 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG-----TYRWMAPEVIEHK 381 N IHRDL N+L+ E+ + KVADFG+ARV E+ +W APE I Sbjct: 349 NYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSN 408 Query: 382 PYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQ 558 + K+DV+SFGILL+E++T GK+PY +T Q + ++ + R P N + ++ Sbjct: 409 KFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQ-VIQMLAQNYRLPQPSNCPQQFYNIML 467 Query: 559 KCWQQDPAERPDFSEI 606 +CW +P ERP F + Sbjct: 468 ECWNAEPKERPTFETL 483
>TIE2_MOUSE (Q02858) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen) Length = 1122 Score = 122 bits (305), Expect = 1e-27 Identities = 71/213 (33%), Positives = 116/213 (54%), Gaps = 16/213 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPA---------------LVG 171 N++ +GAC L + E+ G++ D+L K + + PA L+ Sbjct: 882 NIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 941 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYR 351 A DV++GM YL Q IHRDL N+L+ EN + K+ADFG++R + T R Sbjct: 942 FAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVYVKKTMGRLPVR 1001 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKN 528 WMA E + + Y +DV+S+G+LLWE+++ G PY +T + + Q G R P N Sbjct: 1002 WMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ-GYRLEKPLN 1060 Query: 529 AHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 ++ +L+++CW++ P ERP F++IL +L ++ Sbjct: 1061 CDDEVYDLMRQCWREKPYERPSFAQILVSLNRM 1093
>TIE2_HUMAN (Q02763) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen) Length = 1124 Score = 122 bits (305), Expect = 1e-27 Identities = 71/213 (33%), Positives = 116/213 (54%), Gaps = 16/213 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPA---------------LVG 171 N++ +GAC L + E+ G++ D+L K + + PA L+ Sbjct: 884 NIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 943 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYR 351 A DV++GM YL Q IHRDL N+L+ EN + K+ADFG++R + T R Sbjct: 944 FAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVR 1003 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKN 528 WMA E + + Y +DV+S+G+LLWE+++ G PY +T + + Q G R P N Sbjct: 1004 WMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ-GYRLEKPLN 1062 Query: 529 AHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 ++ +L+++CW++ P ERP F++IL +L ++ Sbjct: 1063 CDDEVYDLMRQCWREKPYERPSFAQILVSLNRM 1095
>TIE2_BOVIN (Q06807) Angiopoietin-1 receptor precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor TIE-2) (CD202b antigen) Length = 1125 Score = 122 bits (305), Expect = 1e-27 Identities = 71/213 (33%), Positives = 116/213 (54%), Gaps = 16/213 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPA---------------LVG 171 N++ +GAC L + E+ G++ D+L K + + PA L+ Sbjct: 885 NIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLH 944 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYR 351 A DV++GM YL Q IHRDL N+L+ EN + K+ADFG++R + T R Sbjct: 945 FAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVR 1004 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKN 528 WMA E + + Y +DV+S+G+LLWE+++ G PY +T + + Q G R P N Sbjct: 1005 WMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ-GYRLEKPLN 1063 Query: 529 AHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 ++ +L+++CW++ P ERP F++IL +L ++ Sbjct: 1064 CDDEVYDLMRQCWREKPYERPSFAQILVSLNRM 1096
>EPHB4_MOUSE (P54761) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK-1) Length = 987 Score = 122 bits (305), Expect = 1e-27 Identities = 66/210 (31%), Positives = 119/210 (56%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G T + I+TEFM G++ +L + G F + LVG+ ++ GM Sbjct: 669 GQFEHPNIIRLEGVVTNSVPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGM 728 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSG---VMTAETG---TYRWMA 360 YL + + +HRDL N+L++ N + KV+DFG++R ++ T+ G + RW A Sbjct: 729 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKISIRWTA 788 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I + + +D +S+GI++WE+++ G+ PY ++ Q + +++ R P + Sbjct: 789 PEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSN-QDVINAIEQDYRLPPPPDCPT 847 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F +++ AL K+ Sbjct: 848 SLHQLMLDCWQKDRNARPRFPQVVSALDKM 877
>FGFR3_HUMAN (P22607) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (CD333 antigen) Length = 806 Score = 121 bits (304), Expect = 1e-27 Identities = 69/216 (31%), Positives = 117/216 (54%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK--------GIFKLPA-------LVG 171 N++ +GACT+ L ++ E+ + G++ ++L + K P LV Sbjct: 537 NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVS 596 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR T Sbjct: 597 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL 656 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTI 519 +WMAPE + + Y H++DV+SFG+LLWE+ T G PY + P++ ++++G R Sbjct: 657 PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDK 715 Query: 520 PKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P N L ++++CW P++RP F +++E L ++ Sbjct: 716 PANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRV 751
>SRK3_SPOLA (P42689) Tyrosine-protein kinase SRK3 (EC 2.7.10.2) (Fragment)| Length = 334 Score = 121 bits (304), Expect = 1e-27 Identities = 69/200 (34%), Positives = 113/200 (56%), Gaps = 5/200 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQ 213 N++Q CT + IVTE M GS+ +YL +G L +V ++ ++ GM+YL Sbjct: 120 NLLQLYAVCTIGEPIYIVTELMKYGSMLEYLKHGEGKNITLHQMVDMSAQIASGMTYLEA 179 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKP 384 ++ IHRDL N+L+ E + KVADFG+ARV ++ + GT +W APE + Sbjct: 180 HSYIHRDLAARNILVGEGNVCKVADFGLARV-IKEDIYNPREGTKFPIKWTAPEAALYNR 238 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + K+DV+SFG+L+ E++T G++PY +T Q + V +G R P+ L +++ Sbjct: 239 FTIKSDVWSFGVLISEIVTHGRMPYPGMTNRQ-VLEAVDRGYRMPCPEGCPDPLYKIMLS 297 Query: 562 CWQQDPAERPDFSEILEALK 621 CW+ +P +RP F + L+ Sbjct: 298 CWKHEPDDRPTFESLKNLLE 317
>EPHA1_HUMAN (P21709) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EPH) Length = 976 Score = 121 bits (304), Expect = 1e-27 Identities = 69/207 (33%), Positives = 115/207 (55%), Gaps = 4/207 (1%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F +++ G TK + I+TEFM G++ +L + + LV + ++ GM Sbjct: 678 GQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGM 737 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAETG--TYRWMAPEV 369 +YL +N +HRDL N+L+++N KV+DFG+ R+ G + G RW APE Sbjct: 738 NYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEA 797 Query: 370 IEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLT 546 I H+ + +DV+SFGI++WE+L+ G PY ++ Q + ++ G R P + A L Sbjct: 798 IAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSN-QEVMKSIEDGYRLPPPVDCPAPLY 856 Query: 547 ELLQKCWQQDPAERPDFSEILEALKKI 627 EL++ CW D A RP F ++ L+++ Sbjct: 857 ELMKNCWAYDRARRPHFQKLQAHLEQL 883
>FGFR3_MOUSE (Q61851) Fibroblast growth factor receptor 3 precursor (EC 2.7.10.1)| (FGFR-3) (Heparin-binding growth factor receptor) Length = 801 Score = 121 bits (303), Expect = 2e-27 Identities = 69/217 (31%), Positives = 118/217 (54%), Gaps = 20/217 (9%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHK--------GIFKLPA-------LVG 171 N++ +GACT+ L ++ E+ + G++ ++L + +LP LV Sbjct: 531 NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGMDYSFDACRLPEEQLTCKDLVS 590 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--- 342 A V++GM YL IHRDL N+L+ E+ ++K+ADFG+AR T Sbjct: 591 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL 650 Query: 343 TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT--GKIPYEYLTPLQAAVGVVQKGLRPT 516 +WMAPE + + Y H++DV+SFG+LLWE+ T G PY + P++ ++++G R Sbjct: 651 PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTPGGPSPYPGI-PVEELFKLLKEGHRMD 709 Query: 517 IPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P + L ++++CW P++RP F +++E L +I Sbjct: 710 KPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRI 746
>EPHB4_HUMAN (P54760) Ephrin type-B receptor 4 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HTK) Length = 987 Score = 121 bits (303), Expect = 2e-27 Identities = 66/210 (31%), Positives = 118/210 (56%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G T + I+TEFM G++ +L + G F + LVG+ ++ GM Sbjct: 669 GQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGM 728 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSG---VMTAETG---TYRWMA 360 YL + + +HRDL N+L++ N + KV+DFG++R ++ T+ G RW A Sbjct: 729 RYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTA 788 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I + + +D +S+GI++WE+++ G+ PY ++ Q + +++ R P + Sbjct: 789 PEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSN-QDVINAIEQDYRLPPPPDCPT 847 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CWQ+D RP F +++ AL K+ Sbjct: 848 SLHQLMLDCWQKDRNARPRFPQVVSALDKM 877
>FGR_HUMAN (P09769) Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2)| (P55-FGR) (C-FGR) Length = 529 Score = 121 bits (303), Expect = 2e-27 Identities = 74/198 (37%), Positives = 113/198 (57%), Gaps = 4/198 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +VQ ++ P + IVTEFM GS+ D+L +G +LP LV +A V++GM+Y+ + Sbjct: 318 LVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERM 376 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY--RWMAPEVIEHKPYD 390 N IHRDL+ AN+L+ E K+ADFG+AR+ + + +W APE + Sbjct: 377 NYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFT 436 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV+SFGILL EL+T G+IPY + + + V++G P A L E +++ W Sbjct: 437 IKSDVWSFGILLTELITKGRIPYPGMNK-REVLEQVEQGYHMPCPPGCPASLYEAMEQTW 495 Query: 568 QQDPAERPDFSEILEALK 621 + DP ERP F + L+ Sbjct: 496 RLDPEERPTFEYLQSFLE 513
>EPHA6_MOUSE (Q62413) Ephrin type-A receptor 6 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2) Length = 1035 Score = 121 bits (303), Expect = 2e-27 Identities = 68/198 (34%), Positives = 112/198 (56%), Gaps = 12/198 (6%) Frame = +1 Query: 70 PPRL------CIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNNIIHR 231 PPR+ IV E+M GS+ +L KH G F + LVG+ ++ GM YL +HR Sbjct: 737 PPRIPAGRPVMIVVEYMENGSLDSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHR 796 Query: 232 DLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT-----YRWMAPEVIEHKPYDHK 396 DL N+L++ N + KV+DFG++RV ++ A T T RW APE I ++ + Sbjct: 797 DLAARNILVNSNLVCKVSDFGLSRV-LEDDPEAAYTTTGGKIPIRWTAPEAIAYRKFSSA 855 Query: 397 ADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQ 573 +D +S+GI++WE+++ G+ PY ++ Q + +++G R P L +L+ CWQ+ Sbjct: 856 SDAWSYGIVMWEVMSYGERPYWEMSN-QDVILSIEEGYRLPAPMGCPPSLQQLMLHCWQK 914 Query: 574 DPAERPDFSEILEALKKI 627 + RP F++I+ L K+ Sbjct: 915 ERNHRPKFTDIVSFLDKL 932
>EPHB3_HUMAN (P54753) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor HEK-2) Length = 998 Score = 120 bits (302), Expect = 3e-27 Identities = 69/210 (32%), Positives = 117/210 (55%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G TK + I+TEFM ++ +L + G F + LVG+ ++ GM Sbjct: 687 GQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGM 746 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL + N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 747 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 806 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + V++ R P + Sbjct: 807 PEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVINAVEQDYRLPPPMDCPT 865 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CW +D RP FS+I+ L K+ Sbjct: 866 ALHQLMLDCWVRDRNLRPKFSQIVNTLDKL 895
>EPHB3_MOUSE (P54754) Ephrin type-B receptor 3 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4) Length = 993 Score = 120 bits (302), Expect = 3e-27 Identities = 69/210 (32%), Positives = 117/210 (55%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N+++ G TK + I+TEFM ++ +L + G F + LVG+ ++ GM Sbjct: 682 GQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGM 741 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL + N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 742 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTA 801 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + V++ R P + Sbjct: 802 PEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVINAVEQDYRLPPPMDCPT 860 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CW +D RP FS+I+ L K+ Sbjct: 861 ALHQLMLDCWVRDRNLRPKFSQIVNTLDKL 890
>STK39_HUMAN (Q9UEW8) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (DCHT) Length = 547 Score = 120 bits (302), Expect = 3e-27 Identities = 76/215 (35%), Positives = 115/215 (53%), Gaps = 23/215 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH------KHK-GIFKLPALVGVAMDVSKG 195 NVV + + L +V + +SGGS+ D + +HK G+ + + + +V +G Sbjct: 122 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 181 Query: 196 MSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE------TGTYRWM 357 + YLH+N IHRDLK N+L+ E+G V++ADFGV+ G +T GT WM Sbjct: 182 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 241 Query: 358 APEVIEH-KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAH 534 APEV+E + YD KAD++SFGI EL TG PY P++ + +Q PT+ Sbjct: 242 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPTLETGVE 300 Query: 535 AK---------LTELLQKCWQQDPAERPDFSEILE 612 K +LL C Q+DP++RP +E+L+ Sbjct: 301 DKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK 335
>STK39_MOUSE (Q9Z1W9) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) Length = 556 Score = 120 bits (302), Expect = 3e-27 Identities = 76/215 (35%), Positives = 115/215 (53%), Gaps = 23/215 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH------KHK-GIFKLPALVGVAMDVSKG 195 NVV + + L +V + +SGGS+ D + +HK G+ + + + +V +G Sbjct: 132 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 191 Query: 196 MSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE------TGTYRWM 357 + YLH+N IHRDLK N+L+ E+G V++ADFGV+ G +T GT WM Sbjct: 192 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 251 Query: 358 APEVIEH-KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAH 534 APEV+E + YD KAD++SFGI EL TG PY P++ + +Q PT+ Sbjct: 252 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPTLETGVE 310 Query: 535 AK---------LTELLQKCWQQDPAERPDFSEILE 612 K +LL C Q+DP++RP +E+L+ Sbjct: 311 DKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK 345
>STK39_RAT (O88506) STE20/SPS1-related proline-alanine-rich protein kinase (EC| 2.7.11.1) (Ste-20-related kinase) (Serine/threonine-protein kinase 39) (Pancreatic serine/threonine-protein kinase) (PS/TK) (PSTK1) Length = 553 Score = 120 bits (302), Expect = 3e-27 Identities = 76/215 (35%), Positives = 115/215 (53%), Gaps = 23/215 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH------KHK-GIFKLPALVGVAMDVSKG 195 NVV + + L +V + +SGGS+ D + +HK G+ + + + +V +G Sbjct: 129 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 188 Query: 196 MSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE------TGTYRWM 357 + YLH+N IHRDLK N+L+ E+G V++ADFGV+ G +T GT WM Sbjct: 189 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWM 248 Query: 358 APEVIEH-KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAH 534 APEV+E + YD KAD++SFGI EL TG PY P++ + +Q PT+ Sbjct: 249 APEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPTLETGVE 307 Query: 535 AK---------LTELLQKCWQQDPAERPDFSEILE 612 K +LL C Q+DP++RP +E+L+ Sbjct: 308 DKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK 342
>EPHB3_CHICK (Q07498) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor CEK10) (Fragment) Length = 988 Score = 120 bits (301), Expect = 3e-27 Identities = 67/210 (31%), Positives = 115/210 (54%), Gaps = 7/210 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F N++ G TK + I+TEFM ++ +L + G F + LVG+ ++ GM Sbjct: 677 GQFDHPNIIHLEGVVTKSRPVMIITEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGM 736 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT------YRWMA 360 YL + N +HRDL N+L++ N + KV+DFG++R T + RW A Sbjct: 737 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPADPTYTSSLGGKIPIRWTA 796 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I ++ + +DV+S+GI++WE+++ G+ PY ++ Q + V++ R P + Sbjct: 797 PEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSN-QDVINAVEQDYRLPPPMDCPT 855 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKKI 627 L +L+ CW +D RP F++I+ L K+ Sbjct: 856 ALHQLMLDCWVRDRNLRPKFAQIVNTLDKL 885
>FPS_DROME (P18106) Tyrosine-protein kinase Fps85D (EC 2.7.10.2) (dFer)| Length = 1325 Score = 120 bits (301), Expect = 3e-27 Identities = 71/207 (34%), Positives = 106/207 (51%), Gaps = 6/207 (2%) Frame = +1 Query: 4 KFIL*GRFVTX----NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVG 171 KF+ GR + N+V+ IG C + + IV E + GGS+ YL K+ +G Sbjct: 1105 KFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMG 1164 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTA-ETGTY 348 + D + GM YL N IHRDL N L+D VK++DFG++R + + V + Sbjct: 1165 MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPV 1224 Query: 349 RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPK 525 +W APE + Y DV+S+GIL+WE+ + G PY +T +A + G R PK Sbjct: 1225 KWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARER-IDTGYRMPTPK 1283 Query: 526 NAHAKLTELLQKCWQQDPAERPDFSEI 606 + ++ L+ +CW D RP F EI Sbjct: 1284 STPEEMYRLMLQCWAADAESRPHFDEI 1310
>OXSR1_MOUSE (Q6P9R2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 120 bits (300), Expect = 4e-27 Identities = 73/214 (34%), Positives = 113/214 (52%), Gaps = 23/214 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH------KHK-GIFKLPALVGVAMDVSKG 195 N+V + + L +V + +SGGSV D + +HK G+ P + + +V +G Sbjct: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEPTIATILREVLEG 133 Query: 196 MSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE------TGTYRWM 357 + YLH+N IHRD+K N+L+ E+G V++ADFGV+ G +T GT WM Sbjct: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193 Query: 358 APEVIEH-KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAH 534 APEV+E + YD KAD++SFGI EL TG PY P++ + +Q P++ Sbjct: 194 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPSLETGVQ 252 Query: 535 AK---------LTELLQKCWQQDPAERPDFSEIL 609 K +++ C Q+DP +RP +E+L Sbjct: 253 DKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELL 286
>FGFR1_DROME (Q07407) Fibroblast growth factor receptor homolog 1 precursor (EC| 2.7.10.1) (Protein heartless) Length = 729 Score = 120 bits (300), Expect = 4e-27 Identities = 67/220 (30%), Positives = 117/220 (53%), Gaps = 23/220 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFK------------LPA------ 162 N++ +G C++ L ++ E+ G++ D+L+K++ + PA Sbjct: 472 NIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEK 531 Query: 163 -LVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAET 339 L+ A +++GM YL IHRDL N+L+ ++ ++K+ADFG+AR + T Sbjct: 532 DLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT 591 Query: 340 G---TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGL 507 +WMAPE ++ K YD K+DV+S+GILLWE++T G+ PY + + + G Sbjct: 592 NGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQ 651 Query: 508 RPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 R P + L+++CW + +RP F+EI+E + K+ Sbjct: 652 RMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691
>EPHB3_BRARE (O13147) Ephrin type-B receptor 3 (EC 2.7.10.1) (Tyrosine-protein| kinase receptor ZEK3) (EPH-like kinase 3) (Fragment) Length = 500 Score = 120 bits (300), Expect = 4e-27 Identities = 70/209 (33%), Positives = 115/209 (55%), Gaps = 7/209 (3%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F NV+ G T+ + IVTEFM G++ +L + G F + LVG+ ++ GM Sbjct: 241 GQFDHPNVIHLEGVLTRSCPVLIVTEFMENGALDSFLRLNDGRFTVTQLVGMLRGIAAGM 300 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARV---KVQSGVMTAETG---TYRWMA 360 YL N +HRDL N+L++ N + KV+DFG++R T+ G RW A Sbjct: 301 KYLSDMNYVHRDLAARNVLVNSNLVCKVSDFGLSRFLDDNSSDPTYTSSLGGKIPIRWTA 360 Query: 361 PEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHA 537 PE I + + +DV+S+GI++WE+++ G+ PY ++ Q + V++ R P + A Sbjct: 361 PEAIAFRKFTSASDVWSYGIVMWEVMSFGERPYWDMSN-QDVMNAVEQDYRLPPPMDCPA 419 Query: 538 KLTELLQKCWQQDPAERPDFSEILEALKK 624 L +L+ +CW ++ RP F +I+ L K Sbjct: 420 VLHQLMLECWVKERNMRPRFGQIVSTLDK 448
>STK25_MOUSE (Q9Z2W1) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 119 bits (299), Expect = 6e-27 Identities = 68/192 (35%), Positives = 104/192 (54%), Gaps = 1/192 (0%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 + ++ G+ K +L I+ E++ GGS D L G + + + ++ KG+ YLH Sbjct: 78 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKGLDYLHSER 135 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGV-MTAETGTYRWMAPEVIEHKPYDHK 396 IHRD+K AN+L+ E G VK+ADFGVA + + GT WMAPEVI+ YD K Sbjct: 136 KIHRDIKAANVLLSEQGDVKMADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK 195 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 AD++S GI EL G+ P L P++ + ++ K PT+ + E ++ C +D Sbjct: 196 ADIWSLGITAIELAKGEPPNSDLHPMR-VLFLIPKNNPPTLEGHHSKPFKEFVEACLNKD 254 Query: 577 PAERPDFSEILE 612 P RP E+L+ Sbjct: 255 PRFRPTAKELLK 266
>STK25_HUMAN (O00506) Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Sterile| 20/oxidant stress-response kinase 1) (Ste20/oxidant stress response kinase 1) (SOK-1) (Ste20-like kinase) Length = 426 Score = 119 bits (299), Expect = 6e-27 Identities = 68/192 (35%), Positives = 103/192 (53%), Gaps = 1/192 (0%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 + ++ G+ K +L I+ E++ GGS D L G + + + ++ KG+ YLH Sbjct: 78 ITRYFGSYLKSTKLWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKGLDYLHSER 135 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGV-MTAETGTYRWMAPEVIEHKPYDHK 396 IHRD+K AN+L+ E G VK+ADFGVA + + GT WMAPEVI+ YD K Sbjct: 136 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK 195 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 AD++S GI EL G+ P L P++ + ++ K PT+ E ++ C +D Sbjct: 196 ADIWSLGITAIELAKGEPPNSDLHPMR-VLFLIPKNSPPTLEGQHSKPFKEFVEACLNKD 254 Query: 577 PAERPDFSEILE 612 P RP E+L+ Sbjct: 255 PRFRPTAKELLK 266
>CAD96_DROME (Q9VBW3) Tyrosine kinase receptor Cad96Ca precursor (EC 2.7.10.1)| (Cadherin 96Ca) (Tyrosine kinase receptor HD-14) Length = 773 Score = 119 bits (298), Expect = 7e-27 Identities = 70/213 (32%), Positives = 108/213 (50%), Gaps = 16/213 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYL------------HKHKGIFKLPALVGVAM 180 NVV +G CT ++ E+++ G + YL H + L Sbjct: 533 NVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHYGNTHGKSNVLTSCDLTSFMY 592 Query: 181 DVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG---TYR 351 V+KGM YL IIHRDL N+L+ ++ KVADFG AR + S + ++ R Sbjct: 593 QVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITSKIYERKSEGKLPIR 652 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKN 528 WMA E + + K+D++SFGIL+WE++T G PY ++ + V+ G R P++ Sbjct: 653 WMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAAD-VMRKVRDGYRLEKPEH 711 Query: 529 AHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 +L ++ CW DP ERP F+EI++ L K+ Sbjct: 712 CRRELYNIMYYCWSHDPQERPLFAEIIQMLDKL 744
>MST4_HUMAN (Q9P289) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) (Serine/threonine-protein kinase MASK) (Mst3 and SOK1-related kinase) Length = 416 Score = 119 bits (298), Expect = 7e-27 Identities = 69/192 (35%), Positives = 104/192 (54%), Gaps = 1/192 (0%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 V ++ G+ K +L I+ E++ GGS D L G F + + ++ KG+ YLH Sbjct: 82 VTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA--GPFDEFQIATMLKEILKGLDYLHSEK 139 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGV-MTAETGTYRWMAPEVIEHKPYDHK 396 IHRD+K AN+L+ E G VK+ADFGVA + + GT WMAPEVI+ YD K Sbjct: 140 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK 199 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 AD++S GI EL G+ P + P++ + ++ K PT+ + E + C +D Sbjct: 200 ADIWSLGITAIELAKGEPPNSDMHPMR-VLFLIPKNNPPTLVGDFTKSFKEFIDACLNKD 258 Query: 577 PAERPDFSEILE 612 P+ RP E+L+ Sbjct: 259 PSFRPTAKELLK 270
>MST4_MOUSE (Q99JT2) Serine/threonine-protein kinase MST4 (EC 2.7.11.1)| (STE20-like kinase MST4) (MST-4) (Mammalian STE20-like protein kinase 4) Length = 416 Score = 119 bits (297), Expect = 1e-26 Identities = 69/192 (35%), Positives = 104/192 (54%), Gaps = 1/192 (0%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNN 219 V ++ G+ K +L I+ E++ GGS D L G F + + ++ KG+ YLH Sbjct: 82 VTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA--GPFDEFQIATMLKEILKGLDYLHSEK 139 Query: 220 IIHRDLKTANLLMDENGMVKVADFGVARVKVQSGV-MTAETGTYRWMAPEVIEHKPYDHK 396 IHRD+K AN+L+ E G VK+ADFGVA + + GT WMAPEVI+ YD K Sbjct: 140 KIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK 199 Query: 397 ADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQD 576 AD++S GI EL G+ P + P++ + ++ K PT+ + E + C +D Sbjct: 200 ADIWSLGITAIELAKGEPPNSDMHPMR-VLFLIPKNNPPTLIGDFTKSFKEFIDACLNKD 258 Query: 577 PAERPDFSEILE 612 P+ RP E+L+ Sbjct: 259 PSFRPTAKELLK 270
>MATK_RAT (P41243) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase BATK) Length = 467 Score = 119 bits (297), Expect = 1e-26 Identities = 64/196 (32%), Positives = 117/196 (59%), Gaps = 2/196 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH-KHKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+V+ +G L IV E +S G++ ++L + + + L+ A+ V++GM YL Sbjct: 246 NLVRLLGVILHHG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLES 304 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDH 393 ++HRDL N+L+ E+ + KV+DFG+A+ +++ G+ ++ +W APE +++ + Sbjct: 305 KKLVHRDLAARNILVSEDLVAKVSDFGLAKAELRKGLDSSRL-PVKWTAPEALKNGRFSS 363 Query: 394 KADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQ 570 K+DV+SFG+LLWE+ + G+ PY ++ L+ V+KG R P + + L+ CW+ Sbjct: 364 KSDVWSFGVLLWEVFSYGRAPYPKMS-LKEVSEAVEKGYRMEPPDSCPGPVHTLMGSCWE 422 Query: 571 QDPAERPDFSEILEAL 618 +P+ RP F +I+E L Sbjct: 423 AEPSRRPPFRKIVEKL 438
>M3K3_ARATH (O22042) Mitogen-activated protein kinase kinase kinase 3 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 118 bits (296), Expect = 1e-26 Identities = 65/196 (33%), Positives = 108/196 (55%), Gaps = 4/196 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+++G + L I+ EF+ GGS+ L K G F P ++ + G+ YLH N Sbjct: 132 NIVRYLGTVRESDSLNILMEFVPGGSISSLLEKF-GSFPEPVIIMYTKQLLLGLEYLHNN 190 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMT---AETGTYRWMAPEVIEHKPY 387 I+HRD+K AN+L+D G +++ADFG ++ V+ + + GT WMAPEVI + Sbjct: 191 GIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGH 250 Query: 388 DHKADVFSFGILLWELLTGKIPY-EYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 AD++S G + E+ TGK P+ E A + + + P IP++ + + L KC Sbjct: 251 SFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKDFLMKC 310 Query: 565 WQQDPAERPDFSEILE 612 ++P+ R +E+L+ Sbjct: 311 LHKEPSLRLSATELLQ 326
>M3K7_DROME (Q9V3Q6) Mitogen-activated protein kinase kinase kinase 7 (EC| 2.7.11.25) (TGF-beta-activated kinase 1) (dTAK1) Length = 678 Score = 118 bits (295), Expect = 2e-26 Identities = 66/202 (32%), Positives = 107/202 (52%), Gaps = 5/202 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH-KHKGIFKLPALVGVAMDVSKGMSYLHQ 213 N++ G + ++ EF GGS++++LH K K + L + A ++G++YLH Sbjct: 71 NIIALHGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHA 130 Query: 214 NN---IIHRDLKTANLLMDENGM-VKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHK 381 +IHRD+K NLL+ G +K+ DFG K S +MT G+ WMAPEV E Sbjct: 131 MTPKPLIHRDVKPLNLLLTNKGRNLKICDFGTVADK--STMMTNNRGSAAWMAPEVFEGS 188 Query: 382 PYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 Y K D+FS+ I+LWE+L+ K P++ + + KG RP + ++ +L+ Sbjct: 189 KYTEKCDIFSWAIVLWEVLSRKQPFKGIDNAYTIQWKIYKGERPPLLTTCPKRIEDLMTA 248 Query: 562 CWQQDPAERPDFSEILEALKKI 627 CW+ P +RP I+ + +I Sbjct: 249 CWKTVPEDRPSMQYIVGVMHEI 270
>TIE1_HUMAN (P35590) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1138 Score = 117 bits (294), Expect = 2e-26 Identities = 71/206 (34%), Positives = 109/206 (52%), Gaps = 16/206 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPA---------------LVG 171 N++ +GAC L I E+ G++ D+L K + + PA L+ Sbjct: 899 NIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLR 958 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYR 351 A D + GM YL + IHRDL N+L+ EN K+ADFG++R + T R Sbjct: 959 FASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVR 1018 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKN 528 WMA E + + Y K+DV+SFG+LLWE+++ G PY +T + + Q G R P+N Sbjct: 1019 WMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ-GYRMEQPRN 1077 Query: 529 AHAKLTELLQKCWQQDPAERPDFSEI 606 ++ EL+++CW+ P ERP F++I Sbjct: 1078 CDDEVYELMRQCWRDRPYERPPFAQI 1103
>EPHA1_MOUSE (Q60750) Ephrin type-A receptor 1 precursor (EC 2.7.10.1)| (Tyrosine-protein kinase receptor ESK) Length = 977 Score = 117 bits (294), Expect = 2e-26 Identities = 68/207 (32%), Positives = 116/207 (56%), Gaps = 4/207 (1%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F ++++ G TK + I+TEFM G++ +L + + LV + + ++ GM Sbjct: 679 GQFNHPHILRLEGVITKRKPIMIITEFMENGALDAFLKEREDQLAPGQLVAMLLGIASGM 738 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-SGVMTAETG--TYRWMAPEV 369 + L +N +HRDL N+L+++N KV+DFG+ R+ G + G RW APE Sbjct: 739 NCLSGHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEA 798 Query: 370 IEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLT 546 I H+ + +DV+SFGI++WE+L+ G PY ++ Q + ++ G R P + A L Sbjct: 799 IAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSN-QEVMKSIEDGYRLPPPVDCPAPLY 857 Query: 547 ELLQKCWQQDPAERPDFSEILEALKKI 627 EL++ CW D A RP F ++ L+++ Sbjct: 858 ELMKNCWAYDRARRPHFLQLQAHLEQL 884
>TIE1_MOUSE (Q06806) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1134 Score = 117 bits (294), Expect = 2e-26 Identities = 71/206 (34%), Positives = 109/206 (52%), Gaps = 16/206 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPA---------------LVG 171 N++ +GAC L I E+ G++ D+L K + + PA L+ Sbjct: 895 NIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLR 954 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYR 351 A D + GM YL + IHRDL N+L+ EN K+ADFG++R + T R Sbjct: 955 FASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVR 1014 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKN 528 WMA E + + Y K+DV+SFG+LLWE+++ G PY +T + + Q G R P+N Sbjct: 1015 WMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ-GYRMEQPRN 1073 Query: 529 AHAKLTELLQKCWQQDPAERPDFSEI 606 ++ EL+++CW+ P ERP F++I Sbjct: 1074 CDDEVYELMRQCWRDRPYERPPFAQI 1099
>M3K2_ARATH (Q9FZ36) Mitogen-activated protein kinase kinase kinase 2 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 117 bits (294), Expect = 2e-26 Identities = 71/197 (36%), Positives = 107/197 (54%), Gaps = 5/197 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+++G + L I+ EF+ GGS+ L K G F + + G+ YLH + Sbjct: 132 NIVRYLGTVREDETLNILLEFVPGGSISSLLEKF-GAFPESVVRTYTNQLLLGLEYLHNH 190 Query: 217 NIIHRDLKTANLLMDENGMVKVADFG----VARVKVQSGVMTAETGTYRWMAPEVIEHKP 384 I+HRD+K AN+L+D G +K+ADFG VA + SG + + GT WMAPEVI Sbjct: 191 AIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMK-GTPYWMAPEVILQTG 249 Query: 385 YDHKADVFSFGILLWELLTGKIPY-EYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + AD++S G + E++TGK P+ + + A + P IP N + + L K Sbjct: 250 HSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPDNISSDANDFLLK 309 Query: 562 CWQQDPAERPDFSEILE 612 C QQ+P RP SE+L+ Sbjct: 310 CLQQEPNLRPTASELLK 326
>EPHAA_HUMAN (Q5JZY3) Ephrin type-A receptor 10 precursor (EC 2.7.10.1)| Length = 1008 Score = 117 bits (293), Expect = 3e-26 Identities = 67/206 (32%), Positives = 111/206 (53%), Gaps = 3/206 (1%) Frame = +1 Query: 19 GRFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGM 198 G+F ++V+ G T+ L IVTE+MS G++ +L +H+G L+G+ ++ M Sbjct: 699 GQFDHSHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAM 758 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVI 372 YL + +HR L ++L+ + + K++ FG V T +G W APE + Sbjct: 759 KYLSEMGYVHRGLAARHVLVSSDLVCKISGFGRGPRDRSEAVYTTMSGRSPALWAAPETL 818 Query: 373 EHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTE 549 + + +DV+SFGI++WE++ G+ PY ++ Q + V+ G R P+N L Sbjct: 819 QFGHFSSASDVWSFGIIMWEVMAFGERPYWDMSG-QDVIKAVEDGFRLPPPRNCPNLLHR 877 Query: 550 LLQKCWQQDPAERPDFSEILEALKKI 627 L+ CWQ+DP ERP FS+I L K+ Sbjct: 878 LMLDCWQKDPGERPRFSQIHSILSKM 903
>OXSR1_PONPY (Q5R495) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 117 bits (292), Expect = 4e-26 Identities = 72/214 (33%), Positives = 112/214 (52%), Gaps = 23/214 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH------KHK-GIFKLPALVGVAMDVSKG 195 N+V + + L +V + +SGGSV D + +HK G+ + + +V +G Sbjct: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133 Query: 196 MSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE------TGTYRWM 357 + YLH+N IHRD+K N+L+ E+G V++ADFGV+ G +T GT WM Sbjct: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193 Query: 358 APEVIEH-KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAH 534 APEV+E + YD KAD++SFGI EL TG PY P++ + +Q P++ Sbjct: 194 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPSLETGVQ 252 Query: 535 AK---------LTELLQKCWQQDPAERPDFSEIL 609 K +++ C Q+DP +RP +E+L Sbjct: 253 DKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELL 286
>OXSR1_HUMAN (O95747) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 527 Score = 117 bits (292), Expect = 4e-26 Identities = 72/214 (33%), Positives = 112/214 (52%), Gaps = 23/214 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH------KHK-GIFKLPALVGVAMDVSKG 195 N+V + + L +V + +SGGSV D + +HK G+ + + +V +G Sbjct: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133 Query: 196 MSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE------TGTYRWM 357 + YLH+N IHRD+K N+L+ E+G V++ADFGV+ G +T GT WM Sbjct: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193 Query: 358 APEVIEH-KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAH 534 APEV+E + YD KAD++SFGI EL TG PY P++ + +Q P++ Sbjct: 194 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPSLETGVQ 252 Query: 535 AK---------LTELLQKCWQQDPAERPDFSEIL 609 K +++ C Q+DP +RP +E+L Sbjct: 253 DKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELL 286
>OXSR1_PIG (Q863I2) Serine/threonine-protein kinase OSR1 (EC 2.7.11.1)| (Oxidative stress-responsive 1 protein) Length = 529 Score = 117 bits (292), Expect = 4e-26 Identities = 72/214 (33%), Positives = 112/214 (52%), Gaps = 23/214 (10%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH------KHK-GIFKLPALVGVAMDVSKG 195 N+V + + L +V + +SGGSV D + +HK G+ + + +V +G Sbjct: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEATIATILREVLEG 133 Query: 196 MSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE------TGTYRWM 357 + YLH+N IHRD+K N+L+ E+G V++ADFGV+ G +T GT WM Sbjct: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWM 193 Query: 358 APEVIEH-KPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAH 534 APEV+E + YD KAD++SFGI EL TG PY P++ + +Q P++ Sbjct: 194 APEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQND-PPSLETGVQ 252 Query: 535 AK---------LTELLQKCWQQDPAERPDFSEIL 609 K +++ C Q+DP +RP +E+L Sbjct: 253 DKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELL 286
>MATK_HUMAN (P42679) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase) Length = 507 Score = 116 bits (291), Expect = 5e-26 Identities = 64/198 (32%), Positives = 113/198 (57%), Gaps = 2/198 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH-KHKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+V+ +G L IV E +S G++ ++L + + + L+ ++ V++GM YL Sbjct: 287 NLVRLLGVILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLES 345 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDH 393 ++HRDL N+L+ E+ + KV+DFG+A K + + + +W APE ++H + Sbjct: 346 KKLVHRDLAARNILVSEDLVAKVSDFGLA--KAERKGLDSSRLPVKWTAPEALKHGKFTS 403 Query: 394 KADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQ 570 K+DV+SFG+LLWE+ + G+ PY ++ L+ V+KG R P+ + L+ CW+ Sbjct: 404 KSDVWSFGVLLWEVFSYGRAPYPKMS-LKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWE 462 Query: 571 QDPAERPDFSEILEALKK 624 +PA RP F ++ E L + Sbjct: 463 AEPARRPPFRKLAEKLAR 480
>ERBB4_HUMAN (Q15303) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) (p180erbB4) (Tyrosine kinase-type cell surface receptor HER4) Length = 1308 Score = 116 bits (290), Expect = 6e-26 Identities = 63/194 (32%), Positives = 109/194 (56%), Gaps = 4/194 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 ++V+ +G C P + +VT+ M G + +Y+H+HK L+ + ++KGM YL + Sbjct: 779 HLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER 837 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVAR-VKVQSGVMTAETG--TYRWMAPEVIEHKPY 387 ++HRDL N+L+ VK+ DFG+AR ++ A+ G +WMA E I ++ + Sbjct: 838 RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF 897 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 H++DV+S+G+ +WEL+T G PY+ + P + +++KG R P + ++ KC Sbjct: 898 THQSDVWSYGVTIWELMTFGGKPYDGI-PTREIPDLLEKGERLPQPPICTIDVYMVMVKC 956 Query: 565 WQQDPAERPDFSEI 606 W D RP F E+ Sbjct: 957 WMIDADSRPKFKEL 970
>PTK6_HUMAN (Q13882) Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor| kinase) (Tyrosine-protein kinase BRK) Length = 451 Score = 114 bits (285), Expect(2) = 7e-26 Identities = 65/181 (35%), Positives = 103/181 (56%), Gaps = 3/181 (1%) Frame = +1 Query: 85 IVTEFMSGGSVYDYLH-KHKGIFKLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMD 261 I+TE M+ GS+ + L + + + L+ +A V++GM YL N IHRDL N+L+ Sbjct: 262 IITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG 321 Query: 262 ENGMVKVADFGVARVKVQSGVMTAETG-TYRWMAPEVIEHKPYDHKADVFSFGILLWELL 438 EN + KV DFG+AR+ + ++ + Y+W APE + Y K+DV+SFGILL E+ Sbjct: 322 ENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMF 381 Query: 439 T-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEA 615 + G++PY ++ +A + V G R P + +L+ CW +DP +RP F + E Sbjct: 382 SRGQVPYPGMSNHEAFLR-VDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRER 440 Query: 616 L 618 L Sbjct: 441 L 441 Score = 22.7 bits (47), Expect(2) = 7e-26 Identities = 8/17 (47%), Positives = 12/17 (70%) Frame = +3 Query: 3 EVYIMRKVRHKXCCAIY 53 E+ M+K+RHK A+Y Sbjct: 235 EIQAMKKLRHKHILALY 251
>PHY1_CERPU (P25848) Light-sensor Protein kinase [Includes: Phytochrome; Protein| kinase (EC 2.7.11.1)] Length = 1307 Score = 115 bits (289), Expect = 8e-26 Identities = 69/185 (37%), Positives = 103/185 (55%), Gaps = 27/185 (14%) Frame = +1 Query: 148 FKLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLM-------DENGMV--KVADFGVA 300 F + +V + + S+GM+YLH+ IIHRDLK+ N+L+ E G V KVADFG++ Sbjct: 1099 FSILEVVDIILQTSEGMNYLHEKGIIHRDLKSMNILVKSVKVTKSEIGYVHVKVADFGLS 1158 Query: 301 RVKVQSGVMTAET---GTYRWMAPEVI---------------EHKPYDHKADVFSFGILL 426 + K S + +T GT RWMAPEVI + Y K+DV+SFG++ Sbjct: 1159 KTKDSSTRYSNQTWNRGTNRWMAPEVINLGYESTEGEISFDGKVPKYPLKSDVYSFGMVC 1218 Query: 427 WELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEI 606 +E+LTG +P+ +V +G+RP +P + +L L+ CW QDP +RP F+ I Sbjct: 1219 YEVLTGDVPFPEEKNPNNVKRMVLEGVRPDLPAHCPIELKALITDCWNQDPLKRPSFAVI 1278 Query: 607 LEALK 621 + LK Sbjct: 1279 CQKLK 1283
>BCK1_YEAST (Q01389) Serine/threonine-protein kinase BCK1/SLK1/SSP31 (EC| 2.7.11.1) Length = 1478 Score = 115 bits (289), Expect = 8e-26 Identities = 64/198 (32%), Positives = 112/198 (56%), Gaps = 7/198 (3%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+VQ++G K + E+++GGSV + + G F P + + V KG++YLH Sbjct: 1239 NIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMY-GRFDEPLIKHLTTQVLKGLAYLHSK 1297 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVK--VQSGVMTAETGTYRWMAPEVIEHKP-Y 387 I+HRD+K NLL+D++G+ K++DFG++R + S GT WMAPE+++ K Y Sbjct: 1298 GILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNSDMTMRGTVFWMAPEMVDTKQGY 1357 Query: 388 DHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTEL----L 555 K D++S G ++ E+ GK P+ L + A + + P IP++ ++++ L Sbjct: 1358 SAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFL 1417 Query: 556 QKCWQQDPAERPDFSEIL 609 C++ +P +RP +E+L Sbjct: 1418 DACFEINPEKRPTANELL 1435
>BLK_HUMAN (P51451) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 504 Score = 115 bits (289), Expect = 8e-26 Identities = 70/200 (35%), Positives = 116/200 (58%), Gaps = 6/200 (3%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +V+ TK P + IVTE+M+ G + D+L +G LP L+ ++ +++GM+Y+ + Sbjct: 295 LVRLYAVVTKEP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERM 353 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ E K+ADFG+AR + TA+ G +W APE I + Sbjct: 354 NSIHRDLRAANILVSEALCCKIADFGLAR--IIDSEYTAQEGAKFPIKWTAPEAIHFGVF 411 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTE-LLQK 561 KADV+SFG+LL E++T G++PY ++ + + +++G R P +L ++ + Sbjct: 412 TIKADVWSFGVLLMEVVTYGRVPYPGMSNPE-VIRNLERGYRMPRPDTCPPELYRGVIAE 470 Query: 562 CWQQDPAERPDFSEILEALK 621 CW+ P ERP F + L+ Sbjct: 471 CWRSRPEERPTFEFLQSVLE 490
>ERBB4_RAT (Q62956) Receptor tyrosine-protein kinase erbB-4 precursor (EC| 2.7.10.1) Length = 1308 Score = 115 bits (289), Expect = 8e-26 Identities = 63/194 (32%), Positives = 109/194 (56%), Gaps = 4/194 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 ++V+ +G C P + +VT+ M G + +Y+H+HK L+ + ++KGM YL + Sbjct: 779 HLVRLLGVCLSPT-IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER 837 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVAR-VKVQSGVMTAETG--TYRWMAPEVIEHKPY 387 ++HRDL N+L+ VK+ DFG+AR ++ A+ G +WMA E I ++ + Sbjct: 838 RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF 897 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 H++DV+S+G+ +WEL+T G PY+ + P + +++KG R P + ++ KC Sbjct: 898 THQSDVWSYGVTIWELMTFGGKPYDGI-PTREIPDLLEKGERLPQPPICTIDVYIVMVKC 956 Query: 565 WQQDPAERPDFSEI 606 W D RP F E+ Sbjct: 957 WMIDADSRPKFKEL 970
>TIE1_BOVIN (Q06805) Tyrosine-protein kinase receptor Tie-1 precursor (EC| 2.7.10.1) Length = 1136 Score = 115 bits (288), Expect = 1e-25 Identities = 70/206 (33%), Positives = 108/206 (52%), Gaps = 16/206 (7%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPA---------------LVG 171 N++ +GAC L I E+ G++ D+L K + + PA L+ Sbjct: 897 NIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLR 956 Query: 172 VAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYR 351 A D + GM YL + IHRDL N+L+ EN K+ADFG++R + T R Sbjct: 957 FASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVR 1016 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKN 528 WMA E + + Y K+DV+SFG+LLWE+++ G PY +T + + Q R P+N Sbjct: 1017 WMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQ-AYRMEQPRN 1075 Query: 529 AHAKLTELLQKCWQQDPAERPDFSEI 606 ++ EL+++CW+ P ERP F++I Sbjct: 1076 CDDEVYELMRQCWRDRPYERPPFAQI 1101
>BLK_MOUSE (P16277) Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte| kinase) (p55-BLK) Length = 498 Score = 115 bits (288), Expect = 1e-25 Identities = 69/200 (34%), Positives = 116/200 (58%), Gaps = 6/200 (3%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +V+ T+ P + IVTE+M+ G + D+L +G LP L+ ++ V++GM+Y+ + Sbjct: 289 LVRLYAVVTREP-IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQVAEGMAYIERM 347 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 N IHRDL+ AN+L+ E K+ADFG+AR + TA+ G +W APE I + Sbjct: 348 NSIHRDLRAANILVSETLCCKIADFGLAR--IIDSEYTAQEGAKFPIKWTAPEAIHFGVF 405 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKL-TELLQK 561 KADV+SFG+LL ++T G++PY ++ + + ++ G R P+ +L +++ + Sbjct: 406 TIKADVWSFGVLLMVIVTYGRVPYPGMSNPE-VIRSLEHGYRMPCPETCPPELYNDIITE 464 Query: 562 CWQQDPAERPDFSEILEALK 621 CW+ P ERP F + L+ Sbjct: 465 CWRGRPEERPTFEFLQSVLE 484
>MATK_MOUSE (P41242) Megakaryocyte-associated tyrosine-protein kinase (EC| 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK) Length = 505 Score = 115 bits (287), Expect = 1e-25 Identities = 65/196 (33%), Positives = 112/196 (57%), Gaps = 2/196 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH-KHKGIFKLPALVGVAMDVSKGMSYLHQ 213 N+V+ +G L IV E +S G++ ++L + + + L+ A+ V++GM YL Sbjct: 285 NLVRLLGVILHHG-LYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEGMEYLES 343 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHKPYDH 393 ++HRDL N+L+ E+ + KV+DFG+A K + + + +W APE +++ + Sbjct: 344 KKLVHRDLAARNILVSEDLVAKVSDFGLA--KAERKGLDSSRLPVKWTAPEALKNGRFSS 401 Query: 394 KADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQ 570 K+DV+SFG+LLWE+ + G+ PY ++ L+ V+KG R P + L+ CW+ Sbjct: 402 KSDVWSFGVLLWEVFSYGRAPYPKMS-LKEVSEAVEKGYRMEPPDGCPGSVHTLMGSCWE 460 Query: 571 QDPAERPDFSEILEAL 618 +PA RP F +I+E L Sbjct: 461 AEPARRPPFRKIVEKL 476
>LIMK1_RAT (P53669) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 115 bits (287), Expect = 1e-25 Identities = 74/215 (34%), Positives = 111/215 (51%), Gaps = 18/215 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 NV++FIG K RL +TE++ GG++ + + V A D++ GM+YLH Sbjct: 395 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM 454 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE---------------TGTYR 351 NIIHRDL + N L+ EN V VADFG+AR+ + + + G Sbjct: 455 NIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPY 514 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLTGKI--PYEYLTPLQAAVGVVQKG-LRPTIP 522 WMAPE+I + YD K DVFSFGI+L E++ G++ +YL P G+ +G L P Sbjct: 515 WMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNADPDYL-PRTMDFGLNVRGFLDRYCP 572 Query: 523 KNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 N + +C DP +RP F ++ + L+ + Sbjct: 573 PNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETL 607
>LIMK1_MOUSE (P53668) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (KIZ-1)| Length = 647 Score = 115 bits (287), Expect = 1e-25 Identities = 74/215 (34%), Positives = 111/215 (51%), Gaps = 18/215 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 NV++FIG K RL +TE++ GG++ + + V A D++ GM+YLH Sbjct: 395 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSM 454 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE---------------TGTYR 351 NIIHRDL + N L+ EN V VADFG+AR+ + + + G Sbjct: 455 NIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKNQSEDLRSLKKPDRKKRYTVVGNPY 514 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLTGKI--PYEYLTPLQAAVGVVQKG-LRPTIP 522 WMAPE+I + YD K DVFSFGI+L E++ G++ +YL P G+ +G L P Sbjct: 515 WMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNADPDYL-PRTMDFGLNVRGFLDRYCP 572 Query: 523 KNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 N + +C DP +RP F ++ + L+ + Sbjct: 573 PNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETL 607
>SRC64_DROME (P00528) Tyrosine-protein kinase Src64B (EC 2.7.10.2) (Dsrc64)| Length = 552 Score = 114 bits (286), Expect = 2e-25 Identities = 67/198 (33%), Positives = 107/198 (54%), Gaps = 6/198 (3%) Frame = +1 Query: 22 RFVTXNVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF-KLPALVGVAMDVSKGM 198 +F +V C++ + IV E+MS GS+ D+L + G + L+ +A V+ GM Sbjct: 333 KFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGM 392 Query: 199 SYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY--RWMAPEVI 372 YL +IHRDL N+L+ EN + K+ DFG+ARV + + +W APE I Sbjct: 393 EYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAI 452 Query: 373 EHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAH--AKL 543 + + K+DV+S+GILL EL T G++PY + + + +++G R P N + + Sbjct: 453 IYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHS-REVIENIERGFRMPKPTNHYFPDNI 511 Query: 544 TELLQKCWQQDPAERPDF 597 +LL +CW P +RP F Sbjct: 512 YQLLLQCWDAVPEKRPTF 529
>LIMK1_HUMAN (P53667) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1)| Length = 647 Score = 114 bits (286), Expect = 2e-25 Identities = 78/216 (36%), Positives = 113/216 (52%), Gaps = 21/216 (9%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 NV++FIG K RL +TE++ GG++ + + V A D++ GM+YLH Sbjct: 395 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM 454 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQ-----SGVMTAE----------TGTYR 351 NIIHRDL + N L+ EN V VADFG+AR+ V G+ + + G Sbjct: 455 NIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY 514 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLTGKI--PYEYLTPLQAAVGVVQKG-LRPTIP 522 WMAPE+I + YD K DVFSFGI+L E++ G++ +YL P G+ +G L P Sbjct: 515 WMAPEMINGRSYDEKVDVFSFGIVLCEII-GRVNADPDYL-PRTMDFGLNVRGFLDRYCP 572 Query: 523 KNAHAKLTELLQKCWQQDPAERPDFSEI---LEALK 621 N + +C DP +RP F ++ LE L+ Sbjct: 573 PNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLR 608
>VGFR1_MOUSE (P35969) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) (Embryonic receptor kinase 2) Length = 1333 Score = 114 bits (285), Expect = 2e-25 Identities = 62/170 (36%), Positives = 97/170 (57%), Gaps = 4/170 (2%) Frame = +1 Query: 121 DYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVA 300 DY K + L+ + V++GM +L IHRDL N+L+ EN +VK+ DFG+A Sbjct: 985 DYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLA 1044 Query: 301 R--VKVQSGVMTAETG-TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLT 468 R K V +T +WMAPE I K Y K+DV+S+G+LLWE+ + G PY + Sbjct: 1045 RDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQ 1104 Query: 469 PLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEAL 618 + +++G+R P+ A ++ +++ CW +DP ERP F+E++E L Sbjct: 1105 MDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL 1154 Score = 32.3 bits (72), Expect = 1.2 Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 1/53 (1%) Frame = +1 Query: 37 NVVQFIGACTKP-PRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSK 192 NVV +GACTK L ++ E+ G++ +YL + +F L + M++ K Sbjct: 891 NVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALHMELKK 943
>MET_OTOGA (Q2QLH6) Hepatocyte growth factor receptor precursor (EC 2.7.10.1)| (HGF receptor) (Scatter factor receptor) (SF receptor) (HGF/SF receptor) (Met proto-oncogene tyrosine kinase) (c-Met) Length = 1382 Score = 114 bits (285), Expect = 2e-25 Identities = 68/204 (33%), Positives = 104/204 (50%), Gaps = 7/204 (3%) Frame = +1 Query: 37 NVVQFIGACTKPPRL-CIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQ 213 NV+ +G C + +V +M G + +++ + L+G + V+KGM YL Sbjct: 1139 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS 1198 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT-----YRWMAPEVIEH 378 +HRDL N ++DEN VKVADFG+AR + T +WMA E ++ Sbjct: 1199 KKFVHRDLAARNCMLDENFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQT 1258 Query: 379 KPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELL 555 + + K+DV+SFG+LLWEL+T G PY + V ++Q G R P+ L E++ Sbjct: 1259 QKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQ-GRRLLQPEYCPDPLYEVM 1317 Query: 556 QKCWQQDPAERPDFSEILEALKKI 627 KCW RP FSE++ + I Sbjct: 1318 LKCWHPKAEMRPSFSELVSRISAI 1341
>FGR_FSVGR (P00544) Tyrosine-protein kinase transforming protein Fgr (EC| 2.7.10.2) Length = 545 Score = 114 bits (285), Expect = 2e-25 Identities = 71/199 (35%), Positives = 112/199 (56%), Gaps = 5/199 (2%) Frame = +1 Query: 40 VVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGI-FKLPALVGVAMDVSKGMSYLHQN 216 +VQ + P + IVTEFM GS+ ++L +G LP LV +A V++GM+Y+ + Sbjct: 341 LVQLYAVVPEEP-IYIVTEFMCHGSLLEFLKDQEGQDLTLPQLVDMAAQVAEGMAYMERM 399 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT---YRWMAPEVIEHKPY 387 + IHRDL+ AN+L+ E + K+ADFG+AR+ ++ G +W APE + Sbjct: 400 DYIHRDLRAANILVGERLVCKIADFGLARL-IEDNEYNPRQGAKFPIKWTAPEAALFGRF 458 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 K+DV+SFGILL EL++ G++PY + + + V+ G P A L E +++ Sbjct: 459 TIKSDVWSFGILLTELISKGRVPYPGMNN-REVLEQVEHGYHMPCPPGCPASLYEAMEQT 517 Query: 565 WQQDPAERPDFSEILEALK 621 W+ DP ERP F + L+ Sbjct: 518 WRLDPEERPTFEYLQSFLE 536
>ERBB_AVIEU (P11273) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 540 Score = 114 bits (285), Expect = 2e-25 Identities = 65/201 (32%), Positives = 109/201 (54%), Gaps = 4/201 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 +V + +G C + ++T+ M G + DY+ +HK L+ + ++KGM+YL + Sbjct: 193 HVCRLLGICLTST-VQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEER 251 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVAR-VKVQSGVMTAETG--TYRWMAPEVIEHKPY 387 +++HRDL N+L+ VK+ DFG+A+ + AE G +WMA E I H+ Y Sbjct: 252 HMVHRDLAARNVLVKTPQHVKITDFGLAKQLGADEKEYHAEGGKVPIKWMALESILHRIY 311 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 H++DV+S+G+ +WEL+T G PY+ + P V++KG R P + ++ KC Sbjct: 312 THQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSVLEKGERLPQPPICTIDVYMIMVKC 370 Query: 565 WQQDPAERPDFSEILEALKKI 627 W D RP F E++ K+ Sbjct: 371 WMSDADSRPKFRELIAEFSKM 391
>PGFRB_MOUSE (P05622) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1098 Score = 114 bits (285), Expect = 2e-25 Identities = 60/159 (37%), Positives = 94/159 (59%), Gaps = 4/159 (2%) Frame = +1 Query: 163 LVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG 342 LVG + V+ GM +L N +HRDL N+L+ E +VK+ DFG+AR ++ ++ Sbjct: 802 LVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGS 861 Query: 343 TY---RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLR 510 TY +WMAPE I + Y +DV+SFGILLWE+ T G PY L +++G R Sbjct: 862 TYLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYR 921 Query: 511 PTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P +A ++ E++QKCW++ RP FS+++ L+++ Sbjct: 922 MAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERL 960 Score = 41.6 bits (96), Expect = 0.002 Identities = 18/38 (47%), Positives = 25/38 (65%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF 150 NVV +GACTK + I+TE+ G + DYLH++K F Sbjct: 662 NVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTF 699
>BYR2_SCHPO (P28829) Protein kinase byr2 (EC 2.7.11.25) (Protein kinase ste8)| (MAPK kinase kinase) (MAPKKK) Length = 659 Score = 114 bits (285), Expect = 2e-25 Identities = 66/199 (33%), Positives = 108/199 (54%), Gaps = 8/199 (4%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 ++VQ++G+ L I E++ GGSV L + G F+ + KG+ YLH Sbjct: 458 HIVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMY-GSFEETLVKNFIKQTLKGLEYLHSR 516 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYR--------WMAPEVI 372 I+HRD+K AN+L+D G +K++DFG+++ K++ + +TG R WMAPEV+ Sbjct: 517 GIVHRDIKGANILVDNKGKIKISDFGISK-KLELNSTSTKTGGARPSFQGSSFWMAPEVV 575 Query: 373 EHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTEL 552 + + K D++S G L+ E+LT K PY +Q A+ + + + P P N + + Sbjct: 576 KQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQ-AIFRIGENILPEFPSNISSSAIDF 634 Query: 553 LQKCWQQDPAERPDFSEIL 609 L+K + D RP SE+L Sbjct: 635 LEKTFAIDCNLRPTASELL 653
>VGFR1_RAT (P53767) Vascular endothelial growth factor receptor 1 precursor (EC| 2.7.10.1) (VEGFR-1) (Tyrosine-protein kinase receptor FLT) (FLT-1) Length = 1336 Score = 114 bits (285), Expect = 2e-25 Identities = 62/170 (36%), Positives = 97/170 (57%), Gaps = 4/170 (2%) Frame = +1 Query: 121 DYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVA 300 DY K + L+ + V++GM +L IHRDL N+L+ EN +VK+ DFG+A Sbjct: 985 DYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLA 1044 Query: 301 R--VKVQSGVMTAETG-TYRWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLT 468 R K V +T +WMAPE I K Y K+DV+S+G+LLWE+ + G PY + Sbjct: 1045 RDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQ 1104 Query: 469 PLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEAL 618 + +++G+R P+ A ++ +++ CW +DP ERP F+E++E L Sbjct: 1105 MDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL 1154 Score = 30.4 bits (67), Expect = 4.5 Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 1/53 (1%) Frame = +1 Query: 37 NVVQFIGACTKP-PRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSK 192 NVV +GACTK L ++ E+ G++ +YL + F L + M+ K Sbjct: 890 NVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDFFCLNKDAALHMEPKK 942
>FAK2_RAT (P70600) Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion| kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) Length = 1009 Score = 114 bits (284), Expect = 3e-25 Identities = 66/200 (33%), Positives = 109/200 (54%), Gaps = 3/200 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 ++V+ IG + P IV E G + YL ++K K+P LV A+ + K M+YL Sbjct: 485 HIVKLIGIIEEEPTW-IVMELYPYGELGHYLERNKNSLKVPTLVLYALQICKAMAYLESI 543 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVIEHKPYD 390 N +HRD+ N+L+ VK+ DFG++R A +WM+PE I + + Sbjct: 544 NCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFT 603 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 +DV+ F + +WE+L+ GK P+ +L + +GV++KG R P+ L L+ +CW Sbjct: 604 TASDVWMFAVCMWEILSFGKQPFFWLEN-KDVIGVLEKGDRLPKPELCPPVLYTLMTRCW 662 Query: 568 QQDPAERPDFSEILEALKKI 627 DP++RP F+E++ +L I Sbjct: 663 DYDPSDRPRFTELVCSLSDI 682
>M3K1_ARATH (O22040) Mitogen-activated protein kinase kinase kinase 1 (EC| 2.7.11.25) (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 113 bits (283), Expect = 4e-25 Identities = 68/196 (34%), Positives = 104/196 (53%), Gaps = 4/196 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+V+++G + L I+ EF+ GGS+ L K G F + + G+ YLH + Sbjct: 133 NIVRYLGTVREDDTLNILLEFVPGGSISSLLEKF-GPFPESVVRTYTRQLLLGLEYLHNH 191 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMT---AETGTYRWMAPEVIEHKPY 387 I+HRD+K AN+L+D G +K+ADFG ++ + MT + GT WMAPEVI + Sbjct: 192 AIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVILQTGH 251 Query: 388 DHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVV-QKGLRPTIPKNAHAKLTELLQKC 564 AD++S G + E++TGK P+ AA+ + P IP + + L KC Sbjct: 252 SFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKDFLLKC 311 Query: 565 WQQDPAERPDFSEILE 612 Q+ P RP SE+L+ Sbjct: 312 LQEVPNLRPTASELLK 327
>PTK6_MOUSE (Q64434) Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related| intestinal kinase) Length = 451 Score = 112 bits (281), Expect(2) = 4e-25 Identities = 66/200 (33%), Positives = 105/200 (52%), Gaps = 3/200 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLH-KHKGIFKLPALVGVAMDVSKGMSYLHQ 213 +++ T + I+TE M G++ L + + LV A V++GM YL Sbjct: 246 HILSLYAVATAGDPVYIITELMPKGNLLQLLRDSDEKALPILELVDFASQVAEGMCYLES 305 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGT-YRWMAPEVIEHKPYD 390 N IHRDL N+L+ EN + KV DFG+AR+ + ++ E Y+W APE + Y Sbjct: 306 QNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSHEHNVPYKWTAPEALSRGHYS 365 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 K+DV+SFG+LL E+ + G++PY ++ + + V G R P + +L+ CW Sbjct: 366 IKSDVWSFGVLLHEIFSRGQMPYPGMSNHETFLR-VDAGYRMPCPLECPPNIHKLMLSCW 424 Query: 568 QQDPAERPDFSEILEALKKI 627 +DP +RP F ++ E L I Sbjct: 425 SRDPKQRPCFKDLCEKLTGI 444 Score = 21.6 bits (44), Expect(2) = 4e-25 Identities = 7/17 (41%), Positives = 12/17 (70%) Frame = +3 Query: 3 EVYIMRKVRHKXCCAIY 53 E+ M+K+RHK ++Y Sbjct: 235 EIQAMKKLRHKHILSLY 251
>PGFRB_CANFA (Q6QNF3) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1103 Score = 113 bits (282), Expect = 5e-25 Identities = 65/192 (33%), Positives = 102/192 (53%), Gaps = 4/192 (2%) Frame = +1 Query: 64 TKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQNNIIHRDLKT 243 T P R C T L + LVG + V+ GM +L N +HRDL Sbjct: 781 TAPERTCRAT-----------LINESPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAA 829 Query: 244 ANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY---RWMAPEVIEHKPYDHKADVFSF 414 N+L+ E +VK+ DFG+AR ++ ++ T+ +WMAPE I + Y +DV+SF Sbjct: 830 RNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSF 889 Query: 415 GILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCWQQDPAERP 591 GILLWE+ T G PY L + +++G R P +A ++ E++QKCW++ RP Sbjct: 890 GILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRP 949 Query: 592 DFSEILEALKKI 627 FS+++ L+++ Sbjct: 950 PFSQLVLLLERL 961 Score = 41.6 bits (96), Expect = 0.002 Identities = 18/38 (47%), Positives = 25/38 (65%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF 150 NVV +GACTK + I+TE+ G + DYLH++K F Sbjct: 663 NVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTF 700
>ACK1_HUMAN (Q07912) Activated CDC42 kinase 1 (EC 2.7.10.2) (ACK-1) (Tyrosine| kinase non-receptor protein 2) Length = 1036 Score = 113 bits (282), Expect = 5e-25 Identities = 64/199 (32%), Positives = 103/199 (51%), Gaps = 5/199 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+++ G PP + +VTE GS+ D L KH+G F L L A+ V++GM YL Sbjct: 188 NLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESK 246 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSG----VMTAETGTYRWMAPEVIEHKP 384 IHRDL NLL+ +VK+ DFG+ R Q+ + + W APE ++ + Sbjct: 247 RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRT 306 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + H +D + FG+ LWE+ T G+ P+ L Q + ++G R P++ + ++ + Sbjct: 307 FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQ 366 Query: 562 CWQQDPAERPDFSEILEAL 618 CW P +RP F + + L Sbjct: 367 CWAHKPEDRPTFVALRDFL 385
>ERBB_AVIER (P00535) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 604 Score = 113 bits (282), Expect = 5e-25 Identities = 65/201 (32%), Positives = 108/201 (53%), Gaps = 4/201 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 +V + +G C + ++T+ M G + DY+ +HK L+ + ++KGM+YL + Sbjct: 193 HVCRLLGICLTST-VQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEER 251 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVAR-VKVQSGVMTAETG--TYRWMAPEVIEHKPY 387 ++HRDL N+L+ VK+ DFG+A+ + AE G +WMA E I H+ Y Sbjct: 252 RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIY 311 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 H++DV+S+G+ +WEL+T G PY+ + P V++KG R P + ++ KC Sbjct: 312 THQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSVLEKGERLPQPPICTIDVYMIMVKC 370 Query: 565 WQQDPAERPDFSEILEALKKI 627 W D RP F E++ K+ Sbjct: 371 WMIDADSRPKFRELIAEFSKM 391
>ERBB_ALV (P00534) Tyrosine-protein kinase transforming protein erbB (EC| 2.7.10.1) Length = 634 Score = 113 bits (282), Expect = 5e-25 Identities = 65/201 (32%), Positives = 108/201 (53%), Gaps = 4/201 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 +V + +G C + ++T+ M G + DY+ +HK L+ + ++KGM+YL + Sbjct: 193 HVCRLLGICLTST-VQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEER 251 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVAR-VKVQSGVMTAETG--TYRWMAPEVIEHKPY 387 ++HRDL N+L+ VK+ DFG+A+ + AE G +WMA E I H+ Y Sbjct: 252 RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIY 311 Query: 388 DHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKC 564 H++DV+S+G+ +WEL+T G PY+ + P V++KG R P + ++ KC Sbjct: 312 THQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSVLEKGERLPQPPICTIDVYMIMVKC 370 Query: 565 WQQDPAERPDFSEILEALKKI 627 W D RP F E++ K+ Sbjct: 371 WMIDADSRPKFRELIAEFSKM 391
>FAK1_RAT (O35346) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1055 Score = 112 bits (281), Expect = 7e-25 Identities = 64/200 (32%), Positives = 104/200 (52%), Gaps = 3/200 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 ++V+ IG T+ P + I+ E + G + +L K L +L+ A +S ++YL Sbjct: 482 HIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK 540 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVIEHKPYD 390 +HRD+ N+L+ N VK+ DFG++R S A G +WMAPE I + + Sbjct: 541 RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT 600 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 +DV+ FG+ +WE+L G P++ + +G ++ G R +P N L L+ KCW Sbjct: 601 SASDVWMFGVCMWEILMHGVKPFQGVKN-NDVIGRIENGERLPMPPNCPPTLYSLMTKCW 659 Query: 568 QQDPAERPDFSEILEALKKI 627 DP+ RP F+E+ L I Sbjct: 660 AYDPSRRPRFTELKAQLSTI 679
>ACK2_BOVIN (O02742) Activated CDC42 kinase 2 (EC 2.7.10.2) (ACK-2)| Length = 747 Score = 112 bits (281), Expect = 7e-25 Identities = 64/199 (32%), Positives = 103/199 (51%), Gaps = 5/199 (2%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 N+++ G PP + +VTE GS+ D L KH+G F L L A+ V++GM YL Sbjct: 188 NLIRLYGVVLTPP-MKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLEAK 246 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSG----VMTAETGTYRWMAPEVIEHKP 384 IHRDL NLL+ +VK+ DFG+ R Q+ + + W APE ++ + Sbjct: 247 RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRT 306 Query: 385 YDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQK 561 + H +D + FG+ LWE+ T G+ P+ L Q + ++G R P++ + ++ + Sbjct: 307 FSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQ 366 Query: 562 CWQQDPAERPDFSEILEAL 618 CW P +RP F + + L Sbjct: 367 CWAHKPEDRPTFVALRDFL 385
>LIMK1_CHICK (Q8QFP8) LIM domain kinase 1 (EC 2.7.11.1) (LIMK-1) (chLIMK1)| Length = 662 Score = 112 bits (281), Expect = 7e-25 Identities = 74/215 (34%), Positives = 108/215 (50%), Gaps = 18/215 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 NV++FIG K RL +TE++ GG++ + + V A D++ GM+YLH Sbjct: 402 NVLKFIGVLYKEKRLNFITEYIKGGTLRGLIKSMDSHYPWSQRVSFAKDIAAGMAYLHSM 461 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAE---------------TGTYR 351 NIIHRDL + N L+ EN V VADFG+AR+ V G Sbjct: 462 NIIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKNQPEHLQNLKKPDRKKRYTVVGNPY 521 Query: 352 WMAPEVIEHKPYDHKADVFSFGILLWELLTGKIPY--EYLTPLQAAVGVVQKG-LRPTIP 522 WMAPE+I + YD K D+FSFGI+L E++ G++ +YL P G+ +G L P Sbjct: 522 WMAPEMINGRSYDEKVDIFSFGIVLCEII-GRVSADPDYL-PRTTDFGLNVRGFLERYCP 579 Query: 523 KNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 + C DP +RP FS++ + L+ + Sbjct: 580 PACPPSFFPIAACCCDLDPEKRPSFSKLEQWLETL 614
>FAK1_HUMAN (Q05397) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| (Protein-tyrosine kinase 2) Length = 1052 Score = 112 bits (281), Expect = 7e-25 Identities = 64/200 (32%), Positives = 104/200 (52%), Gaps = 3/200 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 ++V+ IG T+ P + I+ E + G + +L K L +L+ A +S ++YL Sbjct: 482 HIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK 540 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVIEHKPYD 390 +HRD+ N+L+ N VK+ DFG++R S A G +WMAPE I + + Sbjct: 541 RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT 600 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 +DV+ FG+ +WE+L G P++ + +G ++ G R +P N L L+ KCW Sbjct: 601 SASDVWMFGVCMWEILMHGVKPFQGVKN-NDVIGRIENGERLPMPPNCPPTLYSLMTKCW 659 Query: 568 QQDPAERPDFSEILEALKKI 627 DP+ RP F+E+ L I Sbjct: 660 AYDPSRRPRFTELKAQLSTI 679
>PGFRB_HUMAN (P09619) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) (CD140b antigen) Length = 1106 Score = 112 bits (281), Expect = 7e-25 Identities = 59/159 (37%), Positives = 95/159 (59%), Gaps = 4/159 (2%) Frame = +1 Query: 163 LVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG 342 LVG + V+ GM +L N +HRDL N+L+ E +VK+ DFG+AR ++ ++ Sbjct: 803 LVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGS 862 Query: 343 TY---RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLR 510 T+ +WMAPE I + Y +DV+SFGILLWE+ T G PY L + +++G R Sbjct: 863 TFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYR 922 Query: 511 PTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P +A ++ E++QKCW++ RP FS+++ L+++ Sbjct: 923 MAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLERL 961 Score = 41.6 bits (96), Expect = 0.002 Identities = 18/38 (47%), Positives = 25/38 (65%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF 150 NVV +GACTK + I+TE+ G + DYLH++K F Sbjct: 663 NVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTF 700
>FAK1_MOUSE (P34152) Focal adhesion kinase 1 (EC 2.7.10.2) (FADK 1) (pp125FAK)| Length = 1090 Score = 112 bits (281), Expect = 7e-25 Identities = 64/200 (32%), Positives = 104/200 (52%), Gaps = 3/200 (1%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 ++V+ IG T+ P + I+ E + G + +L K L +L+ A +S ++YL Sbjct: 520 HIVKLIGVITENP-VWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESK 578 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG--TYRWMAPEVIEHKPYD 390 +HRD+ N+L+ N VK+ DFG++R S A G +WMAPE I + + Sbjct: 579 RFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFT 638 Query: 391 HKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELLQKCW 567 +DV+ FG+ +WE+L G P++ + +G ++ G R +P N L L+ KCW Sbjct: 639 SASDVWMFGVCMWEILMHGVKPFQGVKN-NDVIGRIENGERLPMPPNCPPTLYSLMTKCW 697 Query: 568 QQDPAERPDFSEILEALKKI 627 DP+ RP F+E+ L I Sbjct: 698 AYDPSRRPRFTELKAQLSTI 717
>PGFRB_RAT (Q05030) Beta platelet-derived growth factor receptor precursor (EC| 2.7.10.1) (PDGF-R-beta) Length = 1097 Score = 112 bits (281), Expect = 7e-25 Identities = 59/159 (37%), Positives = 94/159 (59%), Gaps = 4/159 (2%) Frame = +1 Query: 163 LVGVAMDVSKGMSYLHQNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETG 342 LVG + V+ GM +L N +HRDL N+L+ E +VK+ DFG+AR ++ ++ Sbjct: 802 LVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGS 861 Query: 343 TY---RWMAPEVIEHKPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLR 510 T+ +WMAPE I + Y +DV+SFGILLWE+ T G PY L +++G R Sbjct: 862 TFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYR 921 Query: 511 PTIPKNAHAKLTELLQKCWQQDPAERPDFSEILEALKKI 627 P +A ++ E++QKCW++ RP FS+++ L+++ Sbjct: 922 MAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERL 960 Score = 41.6 bits (96), Expect = 0.002 Identities = 18/38 (47%), Positives = 25/38 (65%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIF 150 NVV +GACTK + I+TE+ G + DYLH++K F Sbjct: 662 NVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTF 699
>RON_HUMAN (Q04912) Macrophage-stimulating protein receptor precursor (EC| 2.7.10.1) (MSP receptor) (p185-Ron) (CDw136 antigen) [Contains: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] Length = 1400 Score = 112 bits (280), Expect = 9e-25 Identities = 66/204 (32%), Positives = 110/204 (53%), Gaps = 7/204 (3%) Frame = +1 Query: 37 NVVQFIGACTKPPRLC-IVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQ 213 NV+ IG P L ++ +M G + ++ + + L+ + V++GM YL + Sbjct: 1142 NVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAE 1201 Query: 214 NNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTY-----RWMAPEVIEH 378 +HRDL N ++DE+ VKVADFG+AR + + + + +WMA E ++ Sbjct: 1202 QKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQT 1261 Query: 379 KPYDHKADVFSFGILLWELLT-GKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTELL 555 + K+DV+SFG+LLWELLT G PY ++ P + Q G R P+ L +++ Sbjct: 1262 YRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQ-GRRLPQPEYCPDSLYQVM 1320 Query: 556 QKCWQQDPAERPDFSEILEALKKI 627 Q+CW+ DPA RP F ++ +++I Sbjct: 1321 QQCWEADPAVRPTFRVLVGEVEQI 1344
>KSR2_HUMAN (Q6VAB6) Kinase suppressor of ras-2 (hKSR2)| Length = 829 Score = 112 bits (280), Expect = 9e-25 Identities = 66/216 (30%), Positives = 115/216 (53%), Gaps = 19/216 (8%) Frame = +1 Query: 37 NVVQFIGACTKPPRLCIVTEFMSGGSVYDYLHKHKGIFKLPALVGVAMDVSKGMSYLHQN 216 NVV F+GAC PP L I+T G ++Y + K + + +A ++ KGM YLH Sbjct: 600 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK 659 Query: 217 NIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTA---------ETGTYRWMAPEV 369 I+H+DLK+ N+ D NG V + DFG+ + SGV+ A + G +APE+ Sbjct: 660 GILHKDLKSKNVFYD-NGKVVITDFGLFSI---SGVLQAGRREDKLRIQNGWLCHLAPEI 715 Query: 370 I---------EHKPYDHKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIP 522 I + P+ +DVF+ G + +EL + P++ P +A + + G++P + Sbjct: 716 IRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFK-TQPAEAIIWQMGTGMKPNLS 774 Query: 523 KNAHAK-LTELLQKCWQQDPAERPDFSEILEALKKI 627 + K ++++L CW + ERP F+++++ L+K+ Sbjct: 775 QIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL 810
>ILK1_HUMAN (Q13418) Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59| kDa serine/threonine-protein kinase) (p59ILK) Length = 452 Score = 112 bits (280), Expect = 9e-25 Identities = 67/205 (32%), Positives = 116/205 (56%), Gaps = 8/205 (3%) Frame = +1 Query: 37 NVVQFIGACTKPP--RLCIVTEFMSGGSVYDYLHKHKG-IFKLPALVGVAMDVSKGMSYL 207 NV+ +GAC PP ++T +M GS+Y+ LH+ + V A+D+++GM++L Sbjct: 249 NVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFL 308 Query: 208 H--QNNIIHRDLKTANLLMDENGMVKVADFGVARVKVQSGVMTAETGTYRWMAPEVIEHK 381 H + I L + ++++DE+ +++ V G M A W+APE ++ K Sbjct: 309 HTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPA----WVAPEALQKK 364 Query: 382 PYD---HKADVFSFGILLWELLTGKIPYEYLTPLQAAVGVVQKGLRPTIPKNAHAKLTEL 552 P D AD++SF +LLWEL+T ++P+ L+ ++ + V +GLRPTIP + +L Sbjct: 365 PEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKL 424 Query: 553 LQKCWQQDPAERPDFSEILEALKKI 627 ++ C +DPA+RP F I+ L+K+ Sbjct: 425 MKICMNEDPAKRPKFDMIVPILEKM 449 Database: uniprot_sprot.fasta Posted date: May 25, 2006 5:36 PM Number of letters in database: 80,573,946 Number of sequences in database: 219,361 Lambda K H 0.318 0.135 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 96,057,544 Number of Sequences: 219361 Number of extensions: 2090131 Number of successful extensions: 9918 Number of sequences better than 10.0: 500 Number of HSP's better than 10.0 without gapping: 6879 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 7317 length of database: 80,573,946 effective HSP length: 107 effective length of database: 57,102,319 effective search space used: 5767334219 frameshift window, decay const: 50, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)
