>SGPL_ARATH (Q9C509) Sphingosine-1-phosphate lyase (EC 4.1.2.27) (SP-lyase)|
           (SPL) (Sphingosine-1-phosphate aldolase)
          Length = 544

 Score =  199 bits (505), Expect = 6e-51
 Identities = 91/122 (74%), Positives = 109/122 (89%)
 Frame = +2

Query: 2   EVSKKIQKGIDDISGLFVIGKPDMTVVAFGSDAVDIFEVNDIMSSKGWHLNALQRPNSLH 181
           E SK++++G+ +I  LFVIGKPDMT+VAFGS A+DIFEVNDIMSSKGWHLNALQRPNS+H
Sbjct: 421 EASKRLEEGVREIHELFVIGKPDMTIVAFGSKALDIFEVNDIMSSKGWHLNALQRPNSIH 480

Query: 182 ICVTLQHTAIYEEFLKDLEDSVNTVKANPGPISGGMAPIYGAAGKMPDRGTVKELLVEFM 361
           IC+TLQH  + ++FL+DL ++V TVKANPGPI+GG+APIYGAAGKMPDRG V ELLV FM
Sbjct: 481 ICITLQHVPVVDDFLRDLREAVETVKANPGPITGGLAPIYGAAGKMPDRGMVNELLVSFM 540

Query: 362 DS 367
           DS
Sbjct: 541 DS 542

>SGPL1_HUMAN (O95470) Sphingosine-1-phosphate lyase 1 (EC 4.1.2.27) (SP-lyase)|
           (hSPL) (Sphingosine-1-phosphate aldolase)
          Length = 568

 Score =  102 bits (253), Expect = 1e-21
 Identities = 49/124 (39%), Positives = 78/124 (62%), Gaps = 2/124 (1%)
 Frame = +2

Query: 2   EVSKKIQKGIDDISGLFVIGKPDMTVVAFGSDAVDIFEVNDIMSSKGWHLNALQRPNSLH 181
           + ++ ++  +++I G+FV G P ++V+A GS   DI+ ++++M++KGW+LN LQ P S+H
Sbjct: 425 KTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIH 484

Query: 182 ICVTLQHT--AIYEEFLKDLEDSVNTVKANPGPISGGMAPIYGAAGKMPDRGTVKELLVE 355
            C+TL H    +  +FLKD+ +SV  +  NP   + GM  IYG A    DR  V EL   
Sbjct: 485 FCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSV 544

Query: 356 FMDS 367
           F+DS
Sbjct: 545 FLDS 548

>SGPL1_RAT (Q8CHN6) Sphingosine-1-phosphate lyase 1 (EC 4.1.2.27) (SP-lyase)|
           (SPL) (Sphingosine-1-phosphate aldolase)
          Length = 568

 Score =  100 bits (249), Expect = 3e-21
 Identities = 47/124 (37%), Positives = 79/124 (63%), Gaps = 2/124 (1%)
 Frame = +2

Query: 2   EVSKKIQKGIDDISGLFVIGKPDMTVVAFGSDAVDIFEVNDIMSSKGWHLNALQRPNSLH 181
           + ++ ++  +++I  +F++G P ++V+A GS+  DI+ ++++MS+KGW+ N LQ P S+H
Sbjct: 425 KTARFLKSELENIKNIFILGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIH 484

Query: 182 ICVTLQHT--AIYEEFLKDLEDSVNTVKANPGPISGGMAPIYGAAGKMPDRGTVKELLVE 355
            C+TL HT   +  +FLKD+ +SV  +  NP   + GM  IYG A    DR  V E+   
Sbjct: 485 FCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKMVAEISSV 544

Query: 356 FMDS 367
           F+DS
Sbjct: 545 FLDS 548

>SGPL_DROME (Q9V7Y2) Sphingosine-1-phosphate lyase (EC 4.1.2.27) (SP-lyase)|
           (SPL) (Sphingosine-1-phosphate aldolase)
          Length = 545

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 48/125 (38%), Positives = 79/125 (63%), Gaps = 3/125 (2%)
 Frame = +2

Query: 2   EVSKKIQKGIDDISGLFVIGKPDMTVVAFGSDAVDIFEVNDIMSSKGWHLNALQRPNSLH 181
           + ++ I++G+ DI G+F+ GKP  +V+A GS+  DIF ++D +   GW+LNALQ P+ +H
Sbjct: 414 DTARYIERGVRDIDGIFIFGKPATSVIALGSNVFDIFRLSDSLCKLGWNLNALQFPSGIH 473

Query: 182 ICVTLQHT--AIYEEFLKDLEDSVNTVKANPG-PISGGMAPIYGAAGKMPDRGTVKELLV 352
           +CVT  HT   + ++F+ D+      +  +PG P+ G MA +YG A  +PDR  + E+  
Sbjct: 474 LCVTDMHTQPGVADKFIADVRSCTAEIMKDPGQPVVGKMA-LYGMAQSIPDRSVIGEVTR 532

Query: 353 EFMDS 367
            F+ S
Sbjct: 533 LFLHS 537

>SGPL1_MOUSE (Q8R0X7) Sphingosine-1-phosphate lyase 1 (EC 4.1.2.27) (SP-lyase)|
           (mSPL) (Sphingosine-1-phosphate aldolase)
          Length = 568

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 46/123 (37%), Positives = 77/123 (62%), Gaps = 2/123 (1%)
 Frame = +2

Query: 2   EVSKKIQKGIDDISGLFVIGKPDMTVVAFGSDAVDIFEVNDIMSSKGWHLNALQRPNSLH 181
           + ++ ++  +++I  +F+ G P ++V+A GS+  DI+ ++++MS+KGW+ N LQ P S+H
Sbjct: 425 KTARFLKSELENIKNIFIFGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIH 484

Query: 182 ICVTLQHT--AIYEEFLKDLEDSVNTVKANPGPISGGMAPIYGAAGKMPDRGTVKELLVE 355
            C+TL HT   +  +FLKD+ +SV  +  NP   + GM  IYG A    DR  V E+   
Sbjct: 485 FCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKLVAEISSV 544

Query: 356 FMD 364
           F+D
Sbjct: 545 FLD 547

>SGPL_YEAST (Q05567) Sphingosine-1-phosphate lyase (EC 4.1.2.27) (SP-lyase)|
           (ySPL) (Sphingosine-1-phosphate aldolase) (Bestowed of
           sphingosine tolerance 1)
          Length = 589

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 42/121 (34%), Positives = 70/121 (57%), Gaps = 2/121 (1%)
 Frame = +2

Query: 11  KKIQKGIDDISGLFVIGKPDMTVVAFGSDAVDIFEVNDIMSSKGWHLNALQRPNSLHICV 190
           K IQ+ I D++   ++G P  +V++F S  ++I E++D +S KGWH NALQ+P +LH+  
Sbjct: 459 KYIQENIPDLN---IMGNPRYSVISFSSKTLNIHELSDRLSKKGWHFNALQKPVALHMAF 515

Query: 191 TLQHTAIYEEFLKDLEDSVNTVK--ANPGPISGGMAPIYGAAGKMPDRGTVKELLVEFMD 364
           T     + +E    L  +V  +K  +N  P   G + +YG AG +   G   +L+V F+D
Sbjct: 516 TRLSAHVVDEICDILRTTVQELKSESNSKPSPDGTSALYGVAGSVKTAGVADKLIVGFLD 575

Query: 365 S 367
           +
Sbjct: 576 A 576

>SGPL_CAEEL (Q9Y194) Sphingosine-1-phosphate lyase (EC 4.1.2.27) (SP-lyase)|
           (SPL) (Sphingosine-1-phosphate aldolase)
          Length = 552

 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 40/124 (32%), Positives = 71/124 (57%), Gaps = 3/124 (2%)
 Frame = +2

Query: 8   SKKIQKGIDDISGLFVIGKPDMTVVAFGSDAVDIFEVNDIMSSKGWHLNALQRPNSLHIC 187
           ++ + + I+ I  +   GK D+++VAF  + V+I+EV+D M   GW+LN LQ P ++HIC
Sbjct: 421 TRMLAEKIEKIKWIKPYGKSDVSLVAFSGNGVNIYEVSDKMMKLGWNLNTLQNPAAIHIC 480

Query: 188 VTLQ--HTAIYEEFLKDLEDSVNTVKA-NPGPISGGMAPIYGAAGKMPDRGTVKELLVEF 358
           +T+   +  +   F  DLE     + A        GMA +YG A ++P +  V E++  +
Sbjct: 481 LTINQANEEVVNAFAVDLEKICEELAAKGEQKADSGMAAMYGMAAQVP-KSVVDEVIALY 539

Query: 359 MDSS 370
           +D++
Sbjct: 540 IDAT 543

>MFNA_METTH (O27188) L-tyrosine decarboxylase (EC 4.1.1.25) (TDC)|
          Length = 363

 Score = 32.7 bits (73), Expect = 0.73
 Identities = 22/82 (26%), Positives = 45/82 (54%), Gaps = 4/82 (4%)
 Frame = +2

Query: 5   VSKKIQKGIDDISGLFVIGKPDMTVVAFGSDAVDIFEVNDIMSSKGWHLNALQRPNSLHI 184
           V+++++ G+ ++    V+ +P++ +VAF   A+   E+ D +   GW ++    P ++ +
Sbjct: 279 VTRRLRDGLVELDYQLVV-EPELNIVAFNHPAMGPHELADRLEELGWAVSVSSCPPAIRV 337

Query: 185 CVTLQHTAIYEE----FLKDLE 238
            V + H  I EE     L+DLE
Sbjct: 338 -VLMPH--IMEEHIELLLRDLE 356

>Y087_DEIRA (Q9RY63) UPF0168 protein DR0087|
          Length = 157

 Score = 32.0 bits (71), Expect = 1.2
 Identities = 18/42 (42%), Positives = 22/42 (52%)
 Frame = -1

Query: 307 RAVDRSHPPADRPWIRFHGVYRILEILEEFLVNCRVLKCHAD 182
           RA+    P  D  +IRF  VYR  + LE F+   R LK H D
Sbjct: 108 RAMTFLRPLDDVAYIRFASVYRDFDSLERFIEEIRGLKGHED 149

>SMG1_CAEBR (Q61CW2) Serine/threonine-protein kinase smg-1 (EC 2.7.11.1)|
           (Suppressor with morphogenetic effect on genitalia
           protein 1)
          Length = 2319

 Score = 30.0 bits (66), Expect = 4.7
 Identities = 15/58 (25%), Positives = 30/58 (51%), Gaps = 6/58 (10%)
 Frame = -1

Query: 364 VHELYK*LLDRASVWHLPSRAVDRSHPPADRP------WIRFHGVYRILEILEEFLVN 209
           +  L K +++R S    P    +   PPA  P      W+R H + +++E+LE+ +++
Sbjct: 776 IKRLAKEVINRKSSDKKPKSTTEDVPPPATPPLKFSIQWLRVHLLLKLIEVLEKIMIS 833

>IFRD2_HUMAN (Q12894) Interferon-related developmental regulator 2 (SKMC15|
           protein)
          Length = 442

 Score = 29.3 bits (64), Expect = 8.0
 Identities = 15/34 (44%), Positives = 19/34 (55%)
 Frame = -3

Query: 140 LLMTLCHSPQICRPRPTQRPRQSCLVSQSQINLR 39
           LL+T+C S QI      Q PR   L+S   +NLR
Sbjct: 244 LLLTICPSTQISHILDRQLPRLPQLLSSESVNLR 277


  Database: uniprot_sprot.fasta
    Posted date:  May 25, 2006  5:36 PM
  Number of letters in database: 80,573,946
  Number of sequences in database:  219,361
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,580,147
Number of Sequences: 219361
Number of extensions: 1737429
Number of successful extensions: 4624
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 4509
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4618
length of database: 80,573,946
effective HSP length: 106
effective length of database: 57,321,680
effective search space used: 4643056080
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)